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Cited by 72Vestibular and auditory disordersMotor Control and AdaptationMultisensory perception and integration

Convergence of limb, visceral, and vertical semicircular canal or otolith inputs onto vestibular nucleus neurons

Jian, B. J., Shintani, T., Emanuel, B. A., Yates, B. J.·2002·Experimental Brain Research
DOI 10.1007/s00221-002-1042-8
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Abstract

The major goal of this study was to determine the patterns of convergence of non-labyrinthine inputs from the limbs and viscera onto vestibular nucleus neurons receiving signals from vertical semicircular canals or otolith organs. A secondary aim was to ascertain whether the effects of non-labyrinthine inputs on the activity of vestibular nucleus neurons is affected by bilateral peripheral vestibular lesions. The majority (72%) of vestibular nucleus neurons in labyrinth-intact animals whose firing was modulated by vertical rotations responded to electrical stimulation of limb and/or visceral nerves. The activity of even more vestibular nucleus neurons (93%) was affected by limb or visceral nerve stimulation in chronically labyrinthectomized preparations. Some neurons received non-labyrinthine inputs from a variety of peripheral sources, including antagonist muscles acting at the same joint, whereas others received inputs from more limited sources. There was no apparent relationship between the spatial and dynamic properties of a neuron's responses to tilts in vertical planes and the non-labyrinthine inputs that it received. These data suggest that non-labyrinthine inputs elicited during movement will modulate the processing of information by the central vestibular system, and may contribute to the recovery of spontaneous activity of vestibular nucleus neurons following peripheral vestibular lesions. Furthermore, some vestibular nucleus neurons with non-labyrinthine inputs may be activated only during particular behaviors that elicit a specific combination of limb and visceral inputs.

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Crossref · 10.1007/s00221-002-1042-8

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  • Somatic limb afferent stimulation and visceral afferent stimulation affect responses of cells in the vestibular nuclei during vertical rotation of the body in cats; in labyrinthectomized cats, a larger percentage of cells are affected.

    “Jian et al. (2002, 2005) have found that both somatic limb afferent stimulation and visceral afferent stimulation affect responses of cells in the vestibular nuclei during vertical rotation of the body in cats. In labyrinthectomized cats, even a larger percentage of the cells are affected.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Jian et al. 2002

  • Inputs of non-labyrinthine origin may be associated with and triggered by particular active behaviors.

    “As the authors point out, the inputs of non-labyrinthine origin may be associated with and triggered by particular active behaviors.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Jian et al. 2002

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Authors
Jian, B. J., Shintani, T., Emanuel, B. A., & Yates, B. J.
Affiliations
University of Pittsburgh (US)
Corresponding author
Yates, B. J.
ORCID
Yates, B. J.
Venue
Experimental Brain Research
Publisher
Springer Science and Business Media LLC
Published
2002-03-05
Volume
144
Issue
2
Pages
247-257
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
DOI
10.1007/s00221-002-1042-8
OpenAlex
W2003397695
Cited by
72
References
31
Citations by year
2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 4 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 2 · 2012: 5
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Aeronautics and Space Administration
  • National Institutes of Health
  • National Eye Institute (EY08098, P30EY008098)
  • National Institute on Deafness and Other Communication Disorders (R01DC003732, R01 DC03732, R01DC000693, P01-DC03417, R01-DC-00693, P01DC003417)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
vertical semicircular canal, otolith organs, labyrinthectomy, peripheral vestibular lesions, antagonist muscle activity, spontaneous neuronal activity
MeSH terms
Animals, Cats, Efferent Pathways, Electric Stimulation, Electrodes, Implanted, Extremities, Female, Functional Laterality, Male, Microelectrodes, Neurons, Orientation, Otolithic Membrane, Peripheral Nerves, Rotation, Semicircular Canals, Stereotaxic Techniques, Vestibular Nuclei

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