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Cited by 12Vestibular and auditory disordersNausea and vomiting managementGastrointestinal motility and disorders

Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sickness

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Arshian, Milad S., Puterbaugh, Sonya R., Miller, Daniel J., Catanzaro, Michael F., Hobson, Candace E., McCall, Andrew A., Yates, Bill J.·2013·Experimental Brain Research
DOI 10.1007/s00221-013-3568-3PMC PMC3706452
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Abstract

Neurons located in the caudal aspect of the vestibular nucleus complex have been shown to receive visceral inputs and project to brainstem regions that participate in generating emesis, such as nucleus tractus solitarius and the "vomiting region" in the lateral tegmental field (LTF). Consequently, it has been hypothesized that neurons in the caudal vestibular nuclei participate in triggering motion sickness and that visceral inputs to the vestibular nucleus complex can affect motion sickness susceptibility. To obtain supporting evidence for this hypothesis, we determined the effects of intragastric infusion of copper sulfate (CuSO4) on responses of neurons in the inferior and caudal medial vestibular nuclei to rotations in vertical planes. CuSO4 readily elicits nausea and emesis by activating gastrointestinal (GI) afferents. Infusion of CuSO4 produced a >30 % change in spontaneous firing rate of approximately one-third of neurons in the caudal aspect of the vestibular nucleus complex. These changes in firing rate developed over several minutes, presumably in tandem with the emetic response. The gains of responses to vertical vestibular stimulation of a larger fraction (approximately two-thirds) of caudal vestibular nucleus neurons were altered over 30 % by administration of CuSO4. The response gains of some units went up, and others went down, and there was no significant relationship with concurrent spontaneous firing rate change. These findings support the notion that the effects of visceral inputs on motion sickness susceptibility are mediated in part through the caudal vestibular nuclei. However, our previous studies showed that infusion of CuSO4 produced larger changes in response to vestibular stimulation of LTF neurons, as well as parabrachial nucleus neurons that are believed to participate in generating nausea. Thus, integrative effects of GI inputs on the processing of labyrinthine inputs must occur at brain sites that participate in eliciting motion sickness in addition to the caudal vestibular nuclei. It seems likely that the occurrence of motion sickness requires converging inputs to brain areas that generate nausea and vomiting from a variety of regions that process vestibular signals.

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  • Other areas of the vestibular system are even more affected by copper sulfate ingestion, with neuronal discharge levels increased.

    “Other areas of the vestibular system are even more affected by copper sulfate ingestions, with neuronal discharge levels increased.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Arshian et al. 2013

    The Results report that intragastric copper sulfate altered firing rates in 15 of 47 vestibular nucleus neurons, so the paper supports an effect on neuronal discharge. But firing increased in only eight units and decreased in seven; the median change across the sampled neurons was approximately zero. The paper does not support a general increase in discharge levels or the claim that these areas were 'even more affected' than other areas. (LLM, conf=0.88)

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  • Visceral afferents modulate, both up and down, the activity level of neurons in the caudal vestibular nucleus during vertical oscillation.

    “These afferents also modulate, both up and down, the activity level of neurons in the caudal vestibular nucleus during vertical oscillation.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Arshian et al. 2013

  • Intragastric delivery of copper sulfate activates visceral afferents and can evoke both nausea and vomiting.

    “Intragastric delivery of copper sulfate activates visceral afferents and can evoke both nausea and vomiting.”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Arshian et al. 2013

  • Visceral stimulation strongly influences the vestibular system.

    “Yates and his collaborators have shown that there is a strong influence of visceral stimulation on the vestibular system (Arshian et al. 2013).”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Arshian et al. 2013

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Authors
Arshian, M. S., Puterbaugh, S. R., Miller, D. J., Catanzaro, M. F., Hobson, C. E., McCall, A. A., & Yates, B. J.
Affiliations
University of Pittsburgh (US)
Corresponding author
Yates, Bill J.
ORCID
Venue
Experimental Brain Research
Publisher
Springer Science and Business Media LLC
Published
2013-05-28
Volume
228
Issue
3
Pages
353-363
ISSN
  • 0014-4819 (ISSN-L)
  • 1432-1106
DOI
10.1007/s00221-013-3568-3
PMC
PMC3706452
OpenAlex
W2043914543
Cited by
12
References
71
Citations by year
2022: 1 · 2021: 2 · 2020: 2 · 2015: 1 · 2014: 6
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Experimental Brain Research (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute on Deafness and Other Communication Disorders (R01DC003732, T32DC011499)
Topics
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Health Sciences › Medicine › Surgery › Nausea and vomiting management
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
motion sickness, inferior vestibular nucleus, copper sulfate, nausea, vomiting, vestibular signal processing, lateral tegmental field, nucleus tractus solitarius, parabrachial nucleus, vertical rotation, response gain
MeSH terms
Action Potentials, Afferent Pathways, Animals, Cats, Female, Male, Motion Sickness, Neurons, Vestibule, Labyrinth, Vestibular Nuclei, Copper Sulfate

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