Integrative responses of neurons in nucleus tractus solitarius to visceral afferent stimulation and vestibular stimulation in vertical planes
Open accessAbstract
Anatomical studies have demonstrated that the vestibular nuclei project to nucleus tractus solitarius (NTS), but little is known about the effects of vestibular inputs on NTS neuronal activity. Furthermore, lesions of NTS abolish vomiting elicited by a variety of different triggering mechanisms, including vestibular stimulation, suggesting that emetic inputs may converge on the same NTS neurons. As such, an emetic stimulus that activates gastrointestinal (GI) receptors could alter the responses of NTS neurons to vestibular inputs. In the present study, we examined in decerebrate cats the responses of NTS neurons to rotations of the body in vertical planes before and after the intragastric administration of the emetic compound copper sulfate. The activity of more than one-third of NTS neurons was modulated by vertical vestibular stimulation, with most of the responsive cells having their firing rate altered by rotations in the head-up or head-down directions. These responses were aligned with head position in space, as opposed to the velocity of head movements. The activity of NTS neurons with baroreceptor, pulmonary, and GI inputs could be modulated by vertical plane rotations. However, injection of copper sulfate into the stomach did not alter the responses to vestibular stimulation of NTS neurons that received GI inputs, suggesting that the stimuli did not have additive effects. These findings show that the detection and processing of visceral inputs by NTS neurons can be altered in accordance with the direction of ongoing movements.
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Brain areas active during the development of nausea have been identified in imaging studies.
“Recently, the brain areas active during the development of nausea have been identified in imaging studies (Napadow et al. 2013; Sugiyama et al. 2011; Suzuki et al. 2012; Yates 1996a, b; Yates et al. 1995a, b; Yates and Bronstein 2005; Yates and Miller 2009).”
From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Sugiyama et al. 2011
The Abstract and Discussion identify the nucleus tractus solitarius as involved in nausea and vomiting and report responses of its neurons to emetic and vestibular stimulation in decerebrate cats. They do not report imaging studies or identify brain areas active during the development of nausea; the study used neuronal recordings. (LLM, conf=0.87)
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Motion sickness: more than nausea and vomiting
Lackner, J. R. (2014) · Experimental Brain Research · doi:10.1007/s00221-014-4008-8 · Cited by 314 · see citing works
“Recently, the brain areas active during the development of nausea have been identified in imaging studies (Napadow et al. 2013; Sugiyama et al. 2011; Suzuki et al. 2012; Yates 1996a, b; Yates et al. 1995a, b; Yates and Bronstein 2005; Yates and Miller 2009).”
BackgroundVestibulo‐Sympathetic Responses
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- Authors
- Sugiyama, Y., Suzuki, T., DeStefino, V. J., & Yates, B. J.
- Affiliations
- Departments of 1Otolaryngology and
- University of Pittsburgh (US)
- Corresponding author
- Yates, Bill J.
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2011-11
- Volume
- 301
- Issue
- 5
- Pages
- R1380-R1390
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- PMC
- PMC3213930
- OpenAlex
- W2154268533
- Cited by
- 30
- References
- 61
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2020: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2014: 7 · 2013: 1 · 2012: 3
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (R01DC003732, R01 DC03732, R01DC000693, P30DC005205, R01-DC-00693, P30 DC 05205)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Surgery › Nausea and vomiting management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- nucleus tractus solitarius, vestibular stimulation, copper sulfate, vomiting, baroreceptors, head position, vestibular nuclei, neuronal firing rate
- MeSH terms
- Action Potentials, Animals, Blood Pressure, Cats, Decerebrate State, Disease Models, Animal, Female, Male, Nausea, Neural Pathways, Phrenic Nerve, Posture, Rotation, Time Factors, Vestibule, Labyrinth, Vomiting, Solitary Nucleus, Baroreflex, Visceral Afferents, Copper Sulfate, Head Movements, Gastrointestinal Tract
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