Impact of repetitive transcranial magnetic stimulation of the parietal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat
Abstract
Transcranial magnetic stimulation (TMS) is increasingly utilized in clinical neurology and neuroscience. However, detailed knowledge of the impact and specificity of the effects of TMS on brain activity remains unresolved. We have used 14C-labeled deoxyglucose (14C-2DG) mapping during repetitive TMS (rTMS) of the posterior and inferior parietal cortex in anesthetized cats to study, with exquisite spatial resolution, the local and distant effects of rTMS on brain activity. High-frequency rTMS decreases metabolic activity at the primary site of stimulation with respect to homologue areas in the unstimulated hemisphere. In addition, rTMS induces specific distant effects on cortical and subcortical regions known to receive substantial efferent projections from the stimulated cortex. The magnitude of this distal impact is correlated with the strength of the anatomical projections. Thus, in the anesthetized animal, the impact of rTMS is upon a distributed network of structures connected to the primary site of application.
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The effects of TMS spread to other regions via connections from the target region.
“Nevertheless, the effects of TMS spread to other regions via connections from the target region (12).”
From Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments (2010) · cites this paper as [12]
Studies in animal models have revealed that 30 min of low-frequency TMS leads to suppression of activity in the target brain region for ≈15 min, with a complete return to baseline after 30 min.
“studies in animal models have revealed that 30 min of low-frequency TMS leads to suppression of activity in the target brain region for ≈15 min, with a complete return to baseline after 30 min (11, 12).”
From Disruption of the right temporoparietal junction with transcranial magnetic stimulation reduces the role of beliefs in moral judgments (2010) · cites this paper as [12]
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- Authors
- Valero-Cabré, A., Payne, B. R., Rushmore, J., Lomber, S. G., & Pascual-Leone, A.
- Affiliations
- Boston University (US)
- The University of Texas at Dallas (US)
- Venue
- Experimental Brain Research
- Published
- 2005-02-02
- Volume
- 163
- Issue
- 1
- Pages
- 1-12
- ISSN
- 0014-4819 (ISSN-L)
- 1432-1106
- OpenAlex
- W2030182194
- Cited by
- 132
- References
- 65
- Citations by year
- 2026: 5 · 2025: 8 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 11 · 2013: 8 · 2012: 12
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Experimental Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1f31ns044624-01)
- National Institute of Neurological Disorders and Stroke (NS44624, R01NS047754, NS47754, NS32137, R01NS032137)
- National Center for Research Resources (K24RR018875)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- repetitive transcranial magnetic stimulation, parietal cortex, brain glucose metabolism, 14C-deoxyglucose, high-frequency stimulation, efferent projections, subcortical activation, cortical networks, cats
- MeSH terms
- Anesthesia, Animals, Brain Mapping, Carbon Radioisotopes, Cats, Deoxyglucose, Electric Stimulation, Electromyography, Energy Metabolism, Female, Parietal Lobe, Perceptual Disorders, Evoked Potentials, Motor, Transcranial Magnetic Stimulation
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