The DOI matches its Crossref record; 239 of the 241 references it cites were found in a registry or an index.
The clinical implications of ageing for rational drug therapy
Abstract
Introduction The proportion of the elderly is constantly increasing and by the year 2025 20% of the population will be above 65 years of age. With advanced age, subjects will develop multiple diseases and often need to take several drugs.Discussion This polypharmacy increases the risk for drug interactions and adverse effects. In addition, age-related physiological changes affect different biological systems and can contribute to alterations in pharmacokinetics and pharmacodynamics in older patients, which are more often seen in the frail than in the fit elderly. These features will complicate drug therapy in the elderly, and a careful dose titration is advisable. Furthermore, inappropriate drug prescription and non-adherence to medication represent common therapeutic challenges in elderly subjects. To date, there is no evidence of any effective antiageing agent.Conclusion This review summarizes present knowledge of age-related problems in drug action and their clinical implications for an increasingly important population.
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“Older adults show greater sensitivity to drugs acting upon the central nervous system and their side effects [11, 12].”
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Metadata
- Authors
- Shi, S., Mörike, K., & Klotz, U.
- Affiliations
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- University of Tübingen (DE)
- Corresponding author
- Klotz, Ulrich
- ORCID
- Klotz, Ulrich
- Venue
- European Journal of Clinical Pharmacology
- Published
- 2008-01-05
- Volume
- 64
- Issue
- 2
- Pages
- 183-199
- ISSN
- 0031-6970 (ISSN-L)
- 1432-1041
- OpenAlex
- W2027764308
- Cited by
- 244
- References
- 241
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 11 · 2023: 9 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 15 · 2018: 14 · 2017: 12 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 21 · 2012: 18
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Clinical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Robert Bosch Stiftung
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- aging, older adults, polypharmacy, drug interactions, adverse drug reactions, age-related physiological changes, pharmacokinetics, pharmacodynamics, frail elderly, dose titration, inappropriate prescribing, medication non-adherence
- MeSH terms
- Aged, Aging, Drug Therapy, Humans, Pharmacokinetics, Practice Patterns, Physicians', Risk Factors, Comorbidity, Treatment Refusal, Frail Elderly, Polypharmacy, Drug-Related Side Effects and Adverse Reactions
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