The DOI matches its Crossref record; 87 of the 94 references it cites were found in a registry or an index.
Environmental and cultural stimulants in the production of carotenoids from microorganisms
Abstract
Commercial production of carotenoids from microorganisms competes mainly with synthetic manufacture by chemical procedures. Efficient stimulation of carotenoid biosynthesis is expected to promote accumulation of carotenoid by microbes. This review describes the variety of environmental and cultural stimulants studied during the last few decades which enhance volumetric production and cellular accumulation of commercially important carotenoids from microalgae, fungi and bacteria. Stimulation of carotenoid production by white-light illumination and temperature fluctuation is discussed along with supplementation of metal ions, salts, organic solvents, preformed precursors and several other chemicals in the culture broth. Reports on the improvements in yield are reviewed and assessed from a biotechnology point of view.
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“Some microalgae are capable of generating high amounts of carotenes in response to external stimuli that cause stress, so that they can adapt to new changes [150].”
From The Potential of Seaweeds as a Source of Functional Ingredients of Prebiotic and Antioxidant Value (2019) · cites this paper as [150]
Citations
Cites
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
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Can dietary beta-carotene materially reduce human cancer rates?
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Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration
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Lycopene: A Biologically Important Carotenoid for Humans?
Stahl, W., & Sies, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0525 · Cited by 712 · cited 2×
“…in which free radicals are thought to play a role in initiation, such as arteriosclerosis, cataracts, age-related macular degeneration, multiple sclerosis, and, perhaps most importantly, cancer (Peto et al. 1981; Greenberg et al. 1990; Stahl and Sies 1996; Henneckens 1997; Moeller et al. 2000).”
BackgroundCarotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response
Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591
Astaxanthin Accumulation in the Green Alga Haematococcus pluvialis1
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A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin
Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231204 · Cited by 482 · cited 1×
“…in which free radicals are thought to play a role in initiation, such as arteriosclerosis, cataracts, age-related macular degeneration, multiple sclerosis, and, perhaps most importantly, cancer (Peto et al. 1981; Greenberg et al. 1990; Stahl and Sies 1996; Henneckens 1997; Moeller et al. 2000).”
BackgroundMolecular breeding of carotenoid biosynthetic pathways
Schmidt‐Dannert, C., Umeno, D., & Arnold, F. H. (2000) · Nature Biotechnology · doi:10.1038/77319 · Cited by 341
Del Campo, J. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(99)00178-9 · Cited by 323
Metabolic engineering towards biotechnological production of carotenoids in microorganisms
P., L., & C., S.-D. (2002) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-002-1101-x · Cited by 309
Cited by
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Metabolites from algae with economical impact
Cardozo, K. H. M., Guaratini, T., Barros, M. P., Falcão, V. D. R., Tonon, Â. P., Lopes, N. P., Campos, S. C. G., Torres, M. A., Souza, A. D. O., Colepicolo, P., et al. (2006) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2006.05.007 · Cited by 960
Carotenoids from microalgae: A review of recent developments
Gong, M., & Bassi, A. S. (2016) · Biotechnology Advances · doi:10.1016/j.biotechadv.2016.10.005 · Cited by 747
Carotenoids and their cleavage products: Biosynthesis and functions
Walter, M. H., & Strack, D. (2011) · Natural Product Reports · doi:10.1039/c0np00036a · Cited by 580
Bernstein, P. S., Li, B., Vachali, P. P., Gorusupudi, A., Shyam, R., Henriksen, B. S., & Nolan, J. M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.10.003 · Cited by 570
Bacterial pigments and their applications
Venil, C. K., Zakaria, Z. A., & Ahmad, W. A. (2013) · Process Biochemistry · doi:10.1016/j.procbio.2013.06.006 · Cited by 465
Metadata
- Authors
- Bhosale, P.
- Affiliations
- University of Utah (US)
- Corresponding author
- Bhosale, P.
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2004-01-01
- Volume
- 63
- Issue
- 4
- Pages
- 351-361
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W2008784761
- Cited by
- 341
- References
- 94
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 23 · 2020: 24 · 2019: 18 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 21 · 2012: 15
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Applied Microbiology and Biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- carotenoid production, microbial carotenoids, microalgae, fungi, bacteria, white light illumination, temperature fluctuations, metal ions, organic solvents, precursors, carotenoid biosynthesis, carotenoid accumulation
- MeSH terms
- Bacteria, Biotechnology, Carotenoids, Culture Media, Fungi, Light, Temperature, Bioreactors, Eukaryota
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