Cited by 341Microbial Metabolism and ApplicationsAlgal biology and biofuel productionMicrobial Metabolic Engineering and Bioproduction

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Environmental and cultural stimulants in the production of carotenoids from microorganisms

Bhosale, P.·2004·Applied Microbiology and Biotechnology

DOI 10.1007/s00253-003-1441-1

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Abstract

Commercial production of carotenoids from microorganisms competes mainly with synthetic manufacture by chemical procedures. Efficient stimulation of carotenoid biosynthesis is expected to promote accumulation of carotenoid by microbes. This review describes the variety of environmental and cultural stimulants studied during the last few decades which enhance volumetric production and cellular accumulation of commercially important carotenoids from microalgae, fungi and bacteria. Stimulation of carotenoid production by white-light illumination and temperature fluctuation is discussed along with supplementation of metal ions, salts, organic solvents, preformed precursors and several other chemicals in the culture broth. Reports on the improvements in yield are reviewed and assessed from a biotechnology point of view.

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Can dietary beta-carotene materially reduce human cancer rates?
Peto, R., Doll, R., Buckley, J. D., & Sporn, M. B. (1981) · Nature · doi:10.1038/290201a0 · Cited by 1,563
Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration
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Lycopene: A Biologically Important Carotenoid for Humans?
Stahl, W., & Sies, H. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0525 · Cited by 712 · cited 2×
“…in which free radicals are thought to play a role in initiation, such as arteriosclerosis, cataracts, age-related macular degeneration, multiple sclerosis, and, perhaps most importantly, cancer (Peto et al. 1981; Greenberg et al. 1990; Stahl and Sies 1996; Henneckens 1997; Moeller et al. 2000).”
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Boussiba, S., & Vonshak, A. (1991) · Plant and Cell Physiology · doi:10.1093/oxfordjournals.pcp.a078171 · Cited by 496
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Authors: Bhosale, P.
Affiliations: University of Utah (US)
Corresponding author: Bhosale, P.
Venue: Applied Microbiology and Biotechnology
Publisher: Springer Science and Business Media LLC
Published: 2004-01-01
Volume: 63
Issue: 4
Pages: 351-361
ISSN: 0175-7598 (ISSN-L)
1432-0614
DOI: 10.1007/s00253-003-1441-1
OpenAlex: W2008784761
Cited by: 341
References: 94
Citations by year: 2026: 10 · 2025: 16 · 2024: 18 · 2023: 19 · 2022: 23 · 2021: 23 · 2020: 24 · 2019: 18 · 2018: 12 · 2017: 16 · 2016: 13 · 2015: 17 · 2014: 18 · 2013: 21 · 2012: 15
FWCI: 7.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Applied Microbiology and Biotechnology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Keywords: carotenoid production, microbial carotenoids, microalgae, fungi, bacteria, white light illumination, temperature fluctuations, metal ions, organic solvents, precursors, carotenoid biosynthesis, carotenoid accumulation
MeSH terms: Bacteria, Biotechnology, Carotenoids, Culture Media, Fungi, Light, Temperature, Bioreactors, Eukaryota

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Environmental and cultural stimulants in the production of carotenoids from microorganisms

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