The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
Pseudomonas putida—a versatile host for the production of natural products
Open accessAbstract
The biosynthesis of natural products by heterologous expression of biosynthetic pathways in amenable production strains enables biotechnological access to a variety of valuable compounds by conversion of renewable resources. Pseudomonas putida has emerged as a microbial laboratory work horse, with elaborated techniques for cultivation and genetic manipulation available. Beyond that, this bacterium offers several particular advantages with regard to natural product biosynthesis, notably a versatile intrinsic metabolism with diverse enzymatic capacities as well as an outstanding tolerance to xenobiotics. Therefore, it has been applied for recombinant biosynthesis of several valuable natural products. This review provides an overview of applications of P. putida as a host organism for the recombinant biosynthesis of such natural products, including rhamnolipids, terpenoids, polyketides and non-ribosomal peptides, and other amino acid-derived compounds. The focus is on de novo natural product synthesis from intrinsic building blocks by means of heterologous gene expression and strain engineering. Finally, the future potential of the bacterium as a chassis organism for synthetic microbiology is pointed out.
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Cites
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Biosynthesis of Nonribosomal Peptides
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Cited by
Nikel, P. I., & de Lorenzo, V. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.05.005 · Cited by 480
Ikeda-Ohtsubo, W., Brugman, S., Warden, C. H., Rebel, J. M. J., Folkerts, G., & Pieterse, C. M. J. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00090 · Cited by 115
Löwe, H., Hobmeier, K., Moos, M., Kremling, A., & Pflüger-Grau, K. (2017) · Biotechnology for Biofuels · doi:10.1186/s13068-017-0875-0 · Cited by 114
Schmidt, M., Pearson, A. N., Incha, M. R., Thompson, M. G., Baidoo, E. E. K., Kakumanu, R., Mukhopadhyay, A., Shih, P. M., Deutschbauer, A. M., Blank, L. M., et al. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.02430-21 · Cited by 28
Schmidt, M., Pearson, A. N., Incha, M. R., Thompson, M. G., Baidoo, E. E. K., Kakumanu, R., Mukhopadhyay, A., Shih, P. M., Deutschbauer, A. M., Blank, L. M., et al. (2021) · doi:10.1101/2021.12.09.472016 · Cited by 2
Metadata
- Authors
- Loeschcke, A., & Thies, S.
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2015-06-23
- Volume
- 99
- Issue
- 15
- Pages
- 6197-6214
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- OpenAlex
- W745226941
- Cited by
- 293
- References
- 118
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
