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Cited by 227Probiotics and Fermented FoodsAntifungal resistance and susceptibilityBacterial biofilms and quorum sensing

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

Probiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation

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Matsubara, Victor Haruo, Wang, Yi, Bandara, H. M. H. N., Mayer, Marcia Pinto Alves, Samaranayake, Lakshman P.·2016·Applied Microbiology and Biotechnology
DOI 10.1007/s00253-016-7527-3
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Abstract

We evaluated the inhibitory effects of the probiotic Lactobacillus species on different phases of Candida albicans biofilm development. Quantification of biofilm growth and ultrastructural analyses were performed on C. albicans biofilms treated with Lactobacillus rhamnosus, Lactobacillus casei, and Lactobacillus acidophilus planktonic cell suspensions as well as their supernatants. Planktonic lactobacilli induced a significant reduction (p < 0.05) in the number of biofilm cells (25.5-61.8 %) depending on the probiotic strain and the biofilm phase. L. rhamnosus supernatants had no significant effect on the mature biofilm (p > 0.05), but significantly reduced the early stages of Candida biofilm formation (p < 0.01). Microscopic analyses revealed that L. rhamnosus suspensions reduced Candida hyphal differentiation, leading to a predominance of budding growth. All lactobacilli negatively impacted C. albicans yeast-to-hyphae differentiation and biofilm formation. The inhibitory effects of the probiotic Lactobacillus on C. albicans entailed both cell-cell interactions and secretion of exometabolites that may impact on pathogenic attributes associated with C. albicans colonization on host surfaces and yeast filamentation. This study clarifies, for the first time, the mechanics of how Lactobacillus species may antagonize C. albicans host colonization. Our data elucidate the inhibitory mechanisms that define the probiotic candicidal activity of lactobacilli, thus supporting their utility as an adjunctive therapeutic mode against mucosal candidal infections.

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Metadata

Authors
Matsubara, V. H., Wang, Y., Bandara, H. M. H. N., Mayer, M. P. A., & Samaranayake, L. P.
Affiliations
The University of Queensland (AU)
Corresponding author
Wang, Yi
ORCID
Venue
Applied Microbiology and Biotechnology
Publisher
Springer Science and Business Media LLC
Published
2016-04-18
Volume
100
Issue
14
Pages
6415-6426
ISSN
  • 0175-7598 (ISSN-L)
  • 1432-0614
DOI
10.1007/s00253-016-7527-3
OpenAlex
W2341432746
Cited by
206
References
57
Citations by year
2026: 15 · 2025: 19 · 2024: 17 · 2023: 23 · 2022: 26 · 2021: 28 · 2020: 22 · 2019: 20 · 2018: 15 · 2017: 15 · 2016: 6
FWCI
23.51
Type
journal article
Language
en
Open access
Licence
Locations
  • Applied Microbiology and Biotechnology (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (publishedVersion, other-oa)
  • Explore Bristol Research (submittedVersion, other-oa)
Funders
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords
probiotics, Lactobacillus, Candida albicans, biofilm formation, filamentation, cell adhesion, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus acidophilus, exometabolites, candidiasis, host colonization, antagonism
MeSH terms
Antibiosis, Candida albicans, Cell Adhesion, Culture Media, Lactobacillus acidophilus, Biofilms, Probiotics, Hyphae, Lacticaseibacillus rhamnosus

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