Adhesion mechanisms mediated by probiotics and prebiotics and their potential impact on human health
Open accessAbstract
Adhesion ability to the host is a classical selection criterion for potential probiotic bacteria that could result in a transient colonisation that would help to promote immunomodulatory effects, as well as stimulate gut barrier and metabolic functions. In addition, probiotic bacteria have a potential protective role against enteropathogens through different mechanisms including production of antimicrobial compounds, reduction of pathogenic bacterial adhesion and competition for host cell binding sites. The competitive exclusion by probiotic bacteria has a beneficial effect not only on the gut but also in the urogenital tract and oral cavity. On the other hand, prebiotics may also act as barriers to pathogens and toxins by preventing their adhesion to epithelial receptors. In vitro studies with different intestinal cell lines have been widely used along the last decades to assess the adherence ability of probiotic bacteria and pathogen antagonism. However, extrapolation of these results to in vivo conditions still remains unclear, leading to the need of optimisation of more complex in vitro approaches that include interaction with the resident microbiota to address the current limitations. The aim of this mini review is to provide a comprehensive overview on the potential effect of the adhesive properties of probiotics and prebiotics on the host by focusing on the most recent findings related with adhesion and immunomodulatory and antipathogenic effect on human health.
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Probiotics may prevent gastrointestinal infections by competing for nutrients or receptors on the intestinal epithelium.
“Probiotics may be active in preventing gastrointestinal infections by making it more difficult for pathogens to colonize the gastrointestinal tract, either by competing for nutrients or by competing for receptors. In this case, probiotics compete for a limited number of receptors on the surface of the intestinal epithelium [224,225].”
From Lactic Acid Bacteria in Raw-Milk Cheeses: From Starter Cultures to Probiotic Functions (2022) · cites this paper as [224]
The Introduction and ‘Antagonism against pathogens > Probiotics’ section say probiotics may protect against enteropathogens by competing for host-cell binding sites, supporting the receptor-competition part of the claim. Our copy does not say they prevent gastrointestinal infections by competing with pathogens for nutrients; its mention of nutrients concerns prebiotics feeding beneficial microorganisms. No page numbers are available in the indexed passages. (LLM, conf=0.88)
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- Authors
- Monteagudo-Mera, A., Rastall, R. A., Gibson, G. R., Charalampopoulos, D., & Chatzifragkou, A.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Monteagudo-Mera, Andrea
- Chatzifragkou, Afroditi
- Venue
- Applied Microbiology and Biotechnology
- Published
- 2019-07-02
- Volume
- 103
- Issue
- 16
- Pages
- 6463-6472
- ISSN
- 0175-7598 (ISSN-L)
- 1432-0614
- PMC
- PMC6667406
- OpenAlex
- W2954311903
- Cited by
- 743
- References
- 98
- Citations by year
- 2026: 84 · 2025: 141 · 2024: 122 · 2023: 104 · 2022: 95 · 2021: 124 · 2020: 69 · 2019: 3 · 2018: 1
- FWCI
- 6.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Applied Microbiology and Biotechnology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (submittedVersion, cc-by)
- Funders
- University of Reading
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, prebiotics, bacterial adhesion, competitive exclusion, immunomodulation, intestinal barrier, antimicrobial agents, urogenital tract, oral cavity, resident microbiota, human health
- MeSH terms
- Antibiosis, Bacterial Adhesion, Epithelial Cells, Humans, Immunologic Factors, Probiotics, Prebiotics
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