The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Oxygen in Wound Healing—More than a Nutrient
Abstract
This article provides an overview of the role of oxygen in wound healing. The understanding of this role has undergone a major evolution from its long‐recognized importance as an essential factor for oxidative metabolism, to its recognition as an important cell signal interacting with growth factors and other signals to regulate signal transduction pathways. Our laboratory has been engaged in thestudy of animal models of skin ischemia to explore in vivo the impact of hypoxia as well as the use of oxygen as a therapeutic agent either alone or in combination with other agents such as growth factors. We have demonstrated a synergistic effect of systemic hyperbaric oxygen and growth factors that has been substantiated by Hunt’s group. Within the past 10 years research in the field of wound healing has given new insight into the mechanism of action of hypoxia and hyperoxia as modifiers of the normal time‐course of wound healing. The article concludes with a discussion of why hypoxia and hyperoxia intercurrently play an important role in wound healing. Hypoxia‐inducible factor 1 is crucial in that interplay.
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Citations
Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822
General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.
Wang, G. L., & Semenza, G. L. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.9.4304 · Cited by 1,468
Tissue oxygenation, anemia, and perfusion in relation to wound healing in surgical patients.
JONSSON, K., JENSEN, J. A., GOODSON, W. H., SCHEUENSTUHL, H., WEST, J., HOPF, H. W., & HUNT, T. K. (1991) · Annals of Surgery · doi:10.1097/00000658-199111000-00011 · Cited by 462
Constant, J. S., Feng, J. J., Zabel, D. D., Yuan, H., Suh, D. Y., Scheuenstuhl, H., Hunt, T. K., & Hussain, M. Z. (2000) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2000.00353.x · Cited by 163 · cited 2×
“It has been shown that free H2O2 increases VEGF levels [30].”
Background
Cited by
Factors affecting wound healing
Guo, S., & DiPietro, L. A. (2010) · Journal of Dental Research · doi:10.1177/0022034509359125 · Cited by 5,792
Guan, Y., Niu, H., Liu, Z., Dang, Y., Shen, J., Zayed, M., Ma, L., & Guan, J. (2021) · Science Advances · doi:10.1126/sciadv.abj0153 · Cited by 631
Stabilization of HIF-1α is critical to improve wound healing in diabetic mice
Botusan, I. R., Sunkari, V. G., Savu, O., Catrina, A. I., Grünler, J., Lindberg, S., Pereira, T., Ylä-Herttuala, S., Poellinger, L., Brismar, K., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805230105 · Cited by 533
Fehrer, C., Brunauer, R., Laschober, G., Unterluggauer, H., Reitinger, S., Kloss, F., Gülly, C., Gaßner, R., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498
Nitric Oxide Therapy for Diabetic Wound Healing
Malone‐Povolny, M. J., Maloney, S. E., & Schoenfisch, M. H. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801210 · Cited by 498
Metadata
- Authors
- Tandara, A. A., & Mustoe, T. A.
- Venue
- World Journal of Surgery
- Publisher
- Wiley
- Published
- 2004-02-17
- Volume
- 28
- Issue
- 3
- Pages
- 294-300
- ISSN
- 0364-2313 (ISSN-L)
- 1432-2323
- OpenAlex
- W1988894267
- Cited by
- 547
- References
- 5
- FWCI
- 13.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
