Th17 cytokines and arthritis.

Lubberts, Erik

doi:10.1007/s00281-009-0189-9

Cited by 173Psoriasis: Treatment and PathogenesisRheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Th17 cytokines and arthritis.

Open access

Lubberts, Erik·2010·Seminars in Immunopathology

DOI 10.1007/s00281-009-0189-9PMC PMC2836464

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Abstract

Th17 cells are implicated in human autoimmune diseases, such as rheumatoid arthritis (RA), although it has not been established whether this persistent destructive arthritis is driven by Th1 and/or Th17 cells. Interleukin-17A (IL-17A) contributes to the pathogenesis of arthritis as has been shown in several experimental arthritis models. Importantly, recent data from first clinical trials with anti-IL-17A antibody treatment in psoriatic arthritis patients and RA patients looks promising. This review summarizes the findings about the role of Th17 cells in arthritis and discusses the impact of the different Th17 cytokines in the pathogenesis of this disease. However, further studies are needed to unravel the interplay between IL-17A and other Th17 cytokines such as IL-17F, IL-22, and IL-21 in the pathoimmunological process of this crippling disease, in particular, whether regulating Th17 cell activity or specific combinations of Th17 cytokines will have additional value compared to neutralizing IL-17A activity alone. Moreover, tumor necrosis factor-positive Th17 cells are discussed as potential dangerous cells in driving persistent arthritis in human early RA.

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TH1 and TH17 cells are key drivers of pathogenic immunity in RA.
“TH1 and TH17 cells have been identified as key drivers of the pathogenic immunity in RA [38,39].”
From T-cell aging in rheumatoid arthritis (2014) · cites this paper as [38]

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Authors: Lubberts, E.
Affiliations: Erasmus MC (NL)
Corresponding author: Lubberts, Erik
ORCID: Lubberts, Erik
Venue: Seminars in Immunopathology
Publisher: Springer Science and Business Media LLC
Published: 2010-02-04
Volume: 32
Issue: 1
Pages: 43-53
ISSN: 1863-2297 (ISSN-L)
1863-2300
DOI: 10.1007/s00281-009-0189-9
PMC: PMC2836464
OpenAlex: W2151006266
Cited by: 173
References: 100
Citations by year: 2026: 3 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 11 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 17 · 2014: 19 · 2013: 18 · 2012: 27
FWCI: 10.70
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Seminars in Immunopathology (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: Th17 cells, rheumatoid arthritis, psoriatic arthritis, IL-17A, IL-17F, IL-22, IL-21, Th1 cells, arthritis pathogenesis, anti-IL-17A therapy, autoimmune disease
MeSH terms: Interleukin-22, Animals, Arthritis, Experimental, Arthritis, Rheumatoid, T-Lymphocytes, Helper-Inducer, Humans, Interleukins, Autoimmunity, T-Lymphocyte Subsets, Interleukin-17

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