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Cited by 214Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration MechanismsTryptophan and brain disorders

Control of autoimmune CNS inflammation by astrocytes

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Rothhammer, Veit, Quintana, Francisco J.·2015·Seminars in Immunopathology
DOI 10.1007/s00281-015-0515-3PMC PMC4618768
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Abstract

Multiple sclerosis is a neurologic disease caused by immune cell infiltration into the central nervous system, resulting in gray and white matter inflammation, progressive demyelination, and neuronal loss. Astrocytes, the most abundant cell population in the central nervous system (CNS), have been considered inert scaffold or housekeeping cells for many years. However, recently, it has become clear that this cell population actively modulates the immune response in the CNS at multiple levels. While being exposed to a plethora of cytokines during ongoing autoimmune inflammation, astrocytes modulate local CNS inflammation by secreting cytokines and chemokines, among other factors. This review article gives an overview of the most recent understanding about cytokine networks operational in astrocytes during autoimmune neuroinflammation and highlights potential targets for immunomodulatory therapies for multiple sclerosis.

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Cited by

Sorted by citations

Authors
Rothhammer, V., & Quintana, F. J.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Quintana, Francisco J.
ORCID
Venue
Seminars in Immunopathology
Publisher
Springer Science and Business Media LLC
Published
2015-07-30
Volume
37
Issue
6
Pages
625-638
ISSN
  • 1863-2297 (ISSN-L)
  • 1863-2300
DOI
10.1007/s00281-015-0515-3
PMC
PMC4618768
OpenAlex
W1002209064
Cited by
214
References
8
Citations by year
2026: 8 · 2025: 23 · 2024: 15 · 2023: 19 · 2022: 38 · 2021: 23 · 2020: 25 · 2019: 21 · 2018: 16 · 2017: 16 · 2016: 8 · 2015: 1
FWCI
2.00
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Seminars in Immunopathology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Multiple Sclerosis Society
  • Mallinckrodt Pharmaceuticals
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R01AI093903)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
astrocytes, multiple sclerosis, autoimmune neuroinflammation, cytokines, chemokines, demyelination, immunomodulatory therapy, neuroinflammation
MeSH terms
Astrocytes, Central Nervous System, Humans, Inflammation, Multiple Sclerosis, Autoimmunity, Cytokines

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