Sphingolipids in neuroinflammation: a potential target for diagnosis and therapy

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Sphingosine 1-Phosphate Receptors and Metabolic Enzymes as Druggable Targets for Brain Diseases

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A Therapeutic Strategy for Alzheimer's Disease Focused on Immune-inflammatory Modulation

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Sphingolipids and Diagnosis, Prognosis, and Organ Damage in Systemic Lupus Erythematosus

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Hepatic encephalopathy: investigational drugs in preclinical and early phase development

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Sphingolipids and their role in health and disease in the central nervous system

Leal, A. F., Súarez, D. A., Echeverri-Peña, O. Y., Albarracín, S. L., Alméciga-Díaz, C. J., & Espejo-Mojica, A. J. (2022) · Advances in Biological Regulation · doi:10.1016/j.jbior.2022.100900 · Cited by 13 · see citing works

Neuroinflammation and Neurometabolomic Profiling in Fentanyl Overdose Mouse Model Treated with Novel β-Lactam, MC-100093, and Ceftriaxone

Alasmari, M. S., Alasmari, F. F., AlSharari, S. D., Alasmari, A. F., Ali, N., Ahamad, S. R., Alghamdi, A. M., Kadi, A. A., Hammad, A. M., Ali, Y. S. M., et al. (2024) · Toxics · doi:10.3390/toxics12080604 · Cited by 12 · see citing works

A Novel Sphingosine Kinase Inhibitor Suppresses Chikungunya Virus Infection

Oyewole, O. O., Dunnavant, K., Bhattarai, S., Kharel, Y., Lynch, K. R., Santos, W. L., & Reid, S. P. (2022) · Viruses · doi:10.3390/v14061123 · Cited by 12 · see citing works

The balancing act between lipid droplets and lysosomes for membrane functionality in age-related neurodegeneration and inflammation

Tsap, M. I., & Shcherbata, H. R. (2025) · Progress in Lipid Research · doi:10.1016/j.plipres.2025.101341 · Cited by 11 · see citing works

Lipids from ocular meibum and tears may serve as biomarkers for depression and post‐traumatic stress disorder

Gary, A. A., Prislovsky, A., Tovar, A., Locatelli, E. V. T., Felix, E. R., Stephenson, D., Chalfant, C. E., Lai, J. M., Kim, C. K., Mandal, N. A., et al. (2023) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14343 · Cited by 10 · see citing works

Circulating sphingolipids in relation to cognitive decline and incident dementia: The Cardiovascular Health Study

Moseholm, K. F., Cronjé, H. T., Koch, M., Fitzpatrick, A. L., López, O. L., Otto, M. C. D. O., Longstreth, W. T., Hoofnagle, A. N., Mukamal, K. J., Lemaître, R. N., et al. (2024) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12623 · Cited by 8 · see citing works

Protective mechanisms against Alzheimer's disease in APOE3‐Christchurch homozygous astrocytes

Tian, X., Rivera, E. K., Hwang, I., Nikitina, A. A., Smith, J. A., Cho, Y. J., Sala‐Jarque, J., DuBose, A., Andriola, C., Gollan‐Myers, T., et al. (2025) · Alzheimer's &amp; Dementia · doi:10.1002/alz.70589 · Cited by 7 · see citing works

Quinolone as a Privileged Scaffold: A Brief Overview on Early Classical and Recent Advanced Synthetic Pathways, Innovative Neuroprotective Potential, and Structure‐Activity Relationships

Moustafa, E. A., El-Sayed, N. N. E., Fouad, M. A., Kerdawy, A. M. E., Ezzat, M. A. F., & Allam, H. A. (2025) · Drug Development Research · doi:10.1002/ddr.70132 · Cited by 7 · see citing works

Cocaine Induces Sex-Associated Changes in Lipid Profiles of Brain Extracellular Vesicles

Landfield, Q., Saito, M., Hashim, A., Canals‐Baker, S., Sershen, H. W., Levy, E., & Saito, M. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03395-x · Cited by 7 · see citing works

Lipidomics Analysis of Human HMC3 Microglial Cells in an In Vitro Model of Metabolic Syndrome

Chmielarz, M., Bromke, M. A., Olbromski, M., Środa-Pomianek, K., Frej−Mądrzak, M., Dzięgiel, P., & Sobieszczańska, B. (2024) · Biomolecules · doi:10.3390/biom14101238 · Cited by 6 · see citing works

Exogenous Antioxidants in Remyelination and Skeletal Muscle Recovery

Cabezas-Pérez, R., Ávila-Rodriguez, M., & Salazar, D. H. R. (2022) · Biomedicines · doi:10.3390/biomedicines10102557 · Cited by 6 · see citing works

Glycolipids in Parkinson's disease: beyond neuronal function

Spanos, F., & Deleidi, M. (2023) · FEBS Open Bio · doi:10.1002/2211-5463.13651 · Cited by 6 · see citing works

Intravenous immunoglobulin alleviates Japanese encephalitis virus-induced peripheral neuropathy by inhibiting the ASM/ceramide pathway

Zhang, N., Wang, G., Yang, L., Zhang, J., Yuan, Y., Ma, L., & Wang, Z. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112083 · Cited by 5 · see citing works

Sphingosine kinase-dependent regulation of pro-resolving lipid mediators in Alzheimer's disease

Ayub, M., Jin, H. K., & Bae, J. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159126 · Cited by 5 · see citing works

Frataxin deficiency in proprioceptive neurons is causal to inflammatory and glial responses in dorsal root gangliaPreprint

Meriau, P., Weill, L., Puccio, H. M., & Agulhon, C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.16.589410 · Cited by 5 · see citing works

Puerariae Lobatae Radix-Gastrodiae Rhizoma ameliorates nitroglycerin-induced chronic migraine by modulating p38 MAPK/CREB signaling pathway in the prefrontal cortex-thalamus neural circuit

Wang, Z., Zhu, T., Ren, K., Ouyang, H., Pan, Q., Feng, Y., & Yang, S. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.121043 · Cited by 4 · see citing works

Metabolomic alterations in human brain microvascular endothelial cells induced by traumatic injury

Cela, E., Tweddell, D., Patterson, E. K., Daley, M., Cepinskas, G., & Fraser, D. D. (2025) · Metabolomics · doi:10.1007/s11306-025-02286-4 · Cited by 4 · see citing works

Relationship between sphingolipids-mediated neuroinflammation and alcohol use disorder

Cui, X., Li, J., Wang, C., Ishaq, H. M., Zhang, R., & Yang, F. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173695 · Cited by 4 · see citing works

Monocyte inflammation and resilience to Alzheimer’s disease: novel genetic risk genes identified by transcriptome-wide association study

Mustafa, Y., Main, L. R., Mews, M., Janve, V. A., Hohman, T. J., Haines, J. L., Song, Y. E., Griswold, A. J., Pericak‐Vance, M. A., Scott, W. K., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03698-5 · Cited by 3 · see citing works

Plasma biomarkers in drug-naïve schizophrenia with severe cognitive impairment via targeted metabolomics

Dong, Y., Wang, S., Qiu, Y., Su, Q., Sun, X., Li, M., & Li, J. (2025) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2025.107711 · Cited by 3 · see citing works

Sphingolipids in Emotional Well‐Being

Kalinichenko, L. S., Zoicas, I., Muehle, C., Kornhuber, J., & Müller, C. P. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70379 · Cited by 3 · see citing works

The Effect of Spinal Cord Stimulation on Spinal Dorsal Horn Lipid Expression in Experimental Painful Diabetic Polyneuropathy: A Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging Study

de Geus, T. J., Franken, G., Flinders, B., Cuypers, E., & Joosten, E. A. J. (2024) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2024.09.005 · Cited by 2 · see citing works

Context-Dependent Roles of Four Classes of Bioactive Lipids in Neuroglia-Mediated Regulation of Neuroinflammation

Sun, S., Hu, S., Wang, Y., Sun, M., & Zhao, L. (2025) · Journal of Pain Research · doi:10.2147/jpr.s536220 · Cited by 2 · see citing works

From Genome-Wide SNPs to Neuroimmune Crosstalk: Mapping the Genetic Landscape of IBD and Its Brain Overlap

Tripathi, U., Stern, Y., Dagan, I., Nayak, R., Romanovsky, E., Zittan, E., & Stern, S. (2025) · Biology · doi:10.3390/biology14101433 · Cited by 2 · see citing works

Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

Bai, H., Zeng, H.-M., Zhang, Q., Hu, Y.-Z., & Deng, F. (2024) · World Journal of Clinical Cases · doi:10.12998/wjcc.v12.i6.1063 · Cited by 2 · see citing works

Inhibition of Sphingosine Kinase 1 Reduces Sphingosine-1-Phosphate and Exacerbates Amyloid-Beta-Induced Neuronal Cell Death in Mixed-Glial-Cell Culture

Minamihata, T., Takano-Kawabe, K., & Moriyama, M. (2024) · Neurology International · doi:10.3390/neurolint16040054 · Cited by 2 · see citing works

Integrating Drug Target Information in Deep Learning Models to Predict the Risk of Adverse Events in Patients with Comorbid Post-Traumatic Stress Disorder and Alcohol Use Disorder

Miranda, O., Qi, X., Brannock, M. D., Whitworth, R., Kosten, T. R., Ryan, N. D., Haas, G. L., Kirisci, L., & Wang, L. (2024) · Biomedicines · doi:10.3390/biomedicines12122772 · Cited by 2 · see citing works

Mass Spectrometry Imaging Shows Modafinil, A Student Study Drug, Changes the Lipid Composition of the Fly Brain

Philipsen, M. H., Ranjbari, E., Gu, C., & Ewing, A. G. (2021) · Angewandte Chemie · doi:10.1002/ange.202105004 · Cited by 2 · see citing works

Integrated Lipidomics and Network Pharmacology Reveal Mechanism of Memory Impairment Improvement by Yuanzhi San

Zhao, F., Li, P., Deng, F., Wang, J., Cheng, Y., Pei, K., Wang, Y., & Wang, Y. (2023) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200920 · Cited by 1 · see citing works

Neuroinflammation underlies the development of social stress induced cognitive deficit in male sickle cell mice

DeVeaux, S. A., Vyshnya, S., Propsom, K., Gbotosho, O. T., Singh, A. S., Horning, R. Z., Sharma, M., Jegga, A. G., Niu, L., Botchwey, E. A., et al. (2024) · Experimental Biology and Medicine · doi:10.3389/ebm.2024.10361 · Cited by 1 · see citing works

An exploratory study of plasma ceramides in comorbidities in Down syndrome

Worley, G., Byeon, S. K., Smith, P. B., Hart, S. J., Young, S. P., Pandey, A., & Kishnani, P. S. (2023) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.63325 · Cited by 1 · see citing works

Circulating sphingolipids and subclinical brain pathology: the cardiovascular health study

Moseholm, K. F., Horn, J. W., Fitzpatrick, A. L., Djoussé, L., Longstreth, W. T., Jr., López, O. L., Hoofnagle, A. N., Jensen, M. K., Lemaître, R. N., & Mukamal, K. J. (2024) · Frontiers in Neurology · doi:10.3389/fneur.2024.1385623 · Cited by 1 · see citing works

Machine learning models to identify lead compound and substitution optimization to have derived energetics and conformational stability through docking and MD simulations for sphingosine kinase 1

Dhanabalan, A. K., Velmurugan, D., Haribabu, J., & Gunasekaran, K. (2024) · Molecular Diversity · doi:10.1007/s11030-024-10997-4 · Cited by 1 · see citing works

Sphingolipids and Cell Signaling: Relationship Between Health and Disease in the Central Nervous SystemPreprint

Leal, A. F., Súarez, D. A., Echeverri-Peña, O. Y., Albarracín, S. L., Alméciga-Díaz, C. J., & Espejo-Mojica, A. J. (2021) · Preprints.org · doi:10.20944/preprints202104.0161.v1 · Cited by 1 · see citing works

Detection of Lipids in the MALDI Negative Ion Mode for Diagnostics, Food Quality Control, and Antimicrobial Resistance

Liu, Y., Pizzato, J., & Larrouy-Maumus, G. J. (2023) · doi:10.1002/9781119814085.ch15 · Cited by 1 · see citing works

Analysis of Immune Dysfunction and Predictors of Poor Prognosis in Patients with Alzheimer's DiseasePreprint

Liu, L., Zeng, H., Zhang, Q., Deng, F., & Bai, H. (2021) · Research Square · doi:10.21203/rs.3.rs-839108/v1

Japanese Encephalitis Virus-Induced Peripheral Neuropathy in the Rat ModelPreprint

Zhang, N., Yuan, Y., Yang, L., Wang, G., Yang, H., Wang, Z., Li, X., Yu, L., Zhang, D., Wang, H., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1324807/v1

Sphingolipids as Oxygen Sensors and Major Orchestrators of Cellular Responses to Hypoxia

Mrad, M., Dargham, T. B., Moumneh, M. B., & Dbaibo, G. S. (2022) · Springer eBooks · doi:10.1007/978-3-030-80962-1_98-1

Neuroinflammation underlies the development of social stress induced cognitive deficit in sickle cell diseasePreprint

DeVeaux, S. A., Vyshnya, S., Propsom, K., Gbotosho, O. T., Singh, A. S., Horning, R. Z., Sharma, M., Jegga, A. G., Niu, L., Botchwey, E. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577074

Metabolic Characteristics and Biomarker Screening of Poultry Eggs from Different SpeciesPreprint

li, H., Qin, S., Li, J., Zhao, X., Liang, J., Li, X., Zhang, A., Xu, L., Tang, D., & Li, F. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5253493

Sphingolipids as Oxygen Sensors and Major Orchestrators of Cellular Responses to Hypoxia

Mrad, M., Dargham, T. B., Moumneh, M. B., & Dbaibo, G. S. (2025) · Springer eBooks · doi:10.1007/978-3-032-00761-2_98

Impaired insulin signaling in the context of diabetes and neurodegeneration: novel biomarkers to mitigate the threat of the deadly duo

Banik, S. P., Ghosh, R. B., Kaur, K., Bagchi, M., & Bagchi, D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33355-2.00020-7

Causality of blood metabolites and narcolepsy type 1: A Mendelian randomization study

Shen, B., Jin, H., Li, W., Yang, J., & Song, J. (2025) · Medicine · doi:10.1097/md.0000000000046307

Interactions propriocepteurs et cellules satellites gliales dans l’ataxie de Friedreich

Meriau, P. (2022) · theses.fr (ABES) · doi:10.70675/7b9be03cz60c9z4774z9d6cz72cd5c3f9788

Sphingosine-1-Phosphate as an Immune-Metabolic Biomarker in Neurodegenerative Diseases

Kim, S. H., Jin, H. K., & Bae, J. (2026) · Journal of Clinical Neurology · doi:10.3988/jcn.2026.0158

The riddle of sphingolipid structure-function relationship in the nervous system

Muñoz-Gil, S., & Spassieva, S. D. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113258

The critical role of ceramide in mental health and psychiatric diseases

Xu, X., Li, H., Zhu, Y., Fu, X., Hu, Q., & Dong, X. (2026) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2026.109093

Early Metabolomic Changes During Extracorporeal Membrane Oxygenation Are Associated with Subsequent Acute Brain Injury

Yang, B. S. K., Ahmad, Y., Chen, H., Khanduja, S., Soulé, Z., Leal, R., Choi, H. A., McCullough, L. D., Dinh, K., Akkanti, B. H., et al. (2026) · Cells · doi:10.3390/cells15171593

Enzyme−Targeted Therapeutics for Neurological Disorders

Massignan, L., Lokesh, K., Ziadat, S., Uehling, D., Weaver, D. F., & Reed, M. A. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01274

Identification of fluid endocannabinoid and sphingolipid biomarkers in schizophrenia. A machine learning approach toward clinical value

Hoffmann, A., Allwright, M., Guennewig, B., Rohleder, C., Jieu, B., Koethe, D., Dammann, I., del Castillo, A. A., Mueller, J. K., Enning, F., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03933-5

Sphingolipids in Neuroinflammation

Davies, L., Fassbender, K. C., & Walter, S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-7091-1511-4_21 · Cited by 12 · see citing works

Modulation of Neuroinflammation in the Central Nervous System: Role of Chemokines and Sphingolipids

Gualtierotti, R., Guarnaccia, L., Beretta, M., Navone, S. E., Campanella, R., Riboni, L., Rampini, P. M., & Marfia, G. (2017) · Advances in Therapy · doi:10.1007/s12325-016-0474-7 · Cited by 55 · see citing works

Novelty of Sphingolipids in the Central Nervous System Physiology and Disease: Focusing on the Sphingolipid Hypothesis of Neuroinflammation and Neurodegeneration

Ayub, M., Jin, H.-K., & Bae, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147353 · Cited by 51 · see citing works

Sphingolipids as Regulators of Neuro-Inflammation and NADPH Oxidase 2

Arsenault, E. J., McGill, C. M., & Barth, B. M. (2021) · NeuroMolecular Medicine · doi:10.1007/s12017-021-08646-2 · Cited by 31 · see citing works

Sphingolipids and Brain Resident Macrophages in Neuroinflammation: An Emerging Aspect of Nervous System Pathology

Assi, E., Cazzato, D., Palma, C. D., Perrotta, C., Clementi, E., & Cervia, D. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/309302 · Cited by 49 · see citing works