Cited by 31Genetics, Aging, and Longevity in Model OrganismsChromosomal and Genetic VariationsTelomeres, Telomerase, and Senescence

What might retrotransposons teach us about aging?

Open access
Maxwell, Patrick H.·2016·Current Genetics

Abstract

Retrotransposons are activated as organisms age, based on work from several model systems. Since these mobile DNA elements can promote genome instability, this has raised the possibility that they can contribute to loss of cellular function with age. Many questions remain to be addressed about the relationship between retrotransposons and aging, so it is unclear if changes in their activity will be found to contribute to aging or to be a consequence of aging. A few broad perspectives are presented regarding how continued work on these elements could provide important insights into the aging process, regardless of whether their mobility is ultimately found to significantly contribute to reduced lifespan and healthspan.

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  • Transposable elements make up approximately 50% of the human genome and contribute significantly to genetic variation at the population level.

    “TEs make up approximately 50% of the human genome and contribute significantly to genetic variation at the population level (Maxwell, 2016).”

    From Cytoplasmic DNA: sources, sensing, and role in aging and disease (2021) · cites this paper as Maxwell, 2016

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Authors
Maxwell, P. H.
Affiliations
Rensselaer Polytechnic Institute (US)
Corresponding author
Maxwell, Patrick H.
Venue
Current Genetics
Published
2015-11-18
Volume
62
Issue
2
Pages
277-282
ISSN
  • 0172-8083 (ISSN-L)
  • 1432-0983
OpenAlex
W2174377540
Cited by
31
References
49
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 7 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3
FWCI
0.21
Type
journal article
Language
en
Open access
Locations
  • Current Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (R00AG031911)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords
retrotransposons, aging, mobile DNA elements, genomic instability, cellular senescence, lifespan, healthspan, transposon activation
MeSH terms
Aging, Animals, Humans, Retroelements

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