Activation of transposable elements during aging and neuronal decline in Drosophila
Open accessAbstract
We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DNA damage-mediated cell death might be a predominant cause of deleterious effects exerted by retrotransposons in flies.
“DNA damage-mediated cell death104 might thus be a predominant cause of deleterious effects exerted by retrotransposons in flies.”
From The role of retrotransposable elements in ageing and age-associated diseases (2021) · cites this paper as [104]
The passage labeled Abstract (page not provided) says transposable-element activation can cause Chk2-mediated DNA damage-induced cell death in the fly germline, and that neuronal Chk2 disruption delays mortality. It also says a causal role for transposable-element-induced DNA damage in neuronal decline remains unproven; it does not establish cell death as the predominant cause of retrotransposons’ deleterious effects in flies. (LLM, conf=0.84)
Experimental — accuracy not yet measuredSample sizes are similar to or greater than those reported in previous publications.
“Sample sizes are similar to or greater than those reported in previous publications4,5,10.”
From Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies (2018) · cites this paper as [4]
Age-associated increases in transposable element activation contributing to genomic instability have been noted in yeast, flies, and mammals.
“studies in yeast, flies and mammals have noted an age-associated increase in the activation of transposable elements, contributing to genomic instability49–51.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [50]
With aging, the efficacy of these surveillance systems is reduced, providing a genomic environment in which TEs may become activated and contribute to somatic mutagenesis.
“with aging, the efficacy of these systems is known to be reduced, providing a genomic environment in which TEs may become activated and contribute to somatic mutagenesis [244, 245]”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [245]
Neuropathologies such as tau have been observed to promote activation of TEs.
“Neuropathologies such as tau have been observed to promote activation of TEs”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [245]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition
Muotri, A. R., Chu, V. T., Marchetto, M. C. N., Deng, W., Moran, J. V., & Gage, F. H. (2005) · Nature · doi:10.1038/nature03663 · Cited by 942 · see citing works
Genetic dissection of consolidated memory in Drosophila
Tully, T., Preat, T., Boynton, S. C., & Del Vecchio, M. (1994) · Cell · doi:10.1016/0092-8674(94)90398-0 · Cited by 924 · see citing works
L1 retrotransposition in human neural progenitor cells
Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Yeo, G. W., Mu, Y., Lovci, M. T., Morell, M., O’Shea, K. S., Moran, J. V., & Gage, F. H. (2009) · Nature · doi:10.1038/nature08248 · Cited by 814 · see citing works
Small RNA sorting: matchmaking for Argonautes
Czech, B., & Hannon, G. J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2916 · Cited by 692 · see citing works
Somatic retrotransposition alters the genetic landscape of the human brain
Baillie, J. K., Barnett, M. W., Upton, K. R., Gerhardt, D. J., Richmond, T. A., De Sapio, F., Brennan, P. M., Rizzu, P., Smith, S., Fell, M., et al. (2011) · Nature · doi:10.1038/nature10531 · Cited by 684 · see citing works
Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites
Goodier, J. L., & Kazazian, H. H. (2008) · Cell · doi:10.1016/j.cell.2008.09.022 · Cited by 627 · see citing works
L1 retrotransposition in neurons is modulated by MeCP2
Muotri, A. R., Marchetto, M. C. N., Coufal, N. G., Oefner, R., Yeo, G., Nakashima, K., & Gage, F. H. (2010) · Nature · doi:10.1038/nature09544 · Cited by 626 · see citing works
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration
Kaneko, H., Dridi, S., Tarallo, V., Gelfand, B. D., Fowler, B. J., Cho, W. G., Kleinman, M. E., Ponicsan, S. L., Hauswirth, W. W., Chiodo, V. A., et al. (2011) · Nature · doi:10.1038/nature09830 · Cited by 601 · see citing works
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila
Liu, N., Landreh, M., Cao, K., Abe, M., Hendriks, G., Kennerdell, J. R., Zhu, Y., Wang, L., & Bonini, N. M. (2012) · Nature · doi:10.1038/nature10810 · Cited by 394 · see citing works
Douville, R. N., Liu, J., Rothstein, J., & Nath, A. (2010) · Annals of Neurology · doi:10.1002/ana.22149 · Cited by 318 · see citing works
Mammalian non-LTR retrotransposons: For better or worse, in sickness and in healthPreprint
Belancio, V. P., Hedges, D. J., & Deininger, P. L. (2008) · Genome Research · doi:10.1101/gr.5558208 · Cited by 317 · see citing works
Song, S. U., Gerasimova, T., Kurkulos, M. M., Boeke, J. D., & Corces, V. G. (1994) · Genes & Development · doi:10.1101/gad.8.17.2046 · Cited by 275 · see citing works
Coufal, N. G., Garcia-Perez, J. L., Peng, G. E., Marchetto, M. C. N., Muotri, A. R., Mu, Y., Carson, C. T., Macia, A., Moran, J. V., & Gage, F. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100273108 · Cited by 229 · see citing works
Gamma Neurons Mediate Dopaminergic Input during Aversive Olfactory Memory Formation in Drosophila
Qin, H., Cressy, M., Li, W., Coravos, J. S., Izzi, S. A., & Dubnau, J. (2012) · Current Biology · doi:10.1016/j.cub.2012.02.014 · Cited by 205 · see citing works
Self-citationTransposable Elements in TDP-43-Mediated Neurodegenerative Disorders
Li, W., Jin, Y., Prazak, L., Hammell, M., & Dubnau, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044099 · Cited by 195 · see citing works
Self-citationExtinction Antagonizes Olfactory Memory at the Subcellular Level
Schwärzel, M., Heisenberg, M., & Zars, T. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00832-2 · Cited by 182 · see citing works
Chen, Y., Pane, A., & Schüpbach, T. (2007) · Current Biology · doi:10.1016/j.cub.2007.02.027 · Cited by 174 · see citing works
Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration
Tan, H., Qurashi, A., Poidevin, M., Nelson, D. L., Li, H., & Jin, P. (2012) · Human Molecular Genetics · doi:10.1093/hmg/ddr437 · Cited by 78 · see citing works
Systems memory consolidation in Drosophila
Dubnau, J., & Chiang, A. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.09.006 · Cited by 62 · see citing works
Self-citationJeong, B., Lee, Y.-J., Carp, R. I., & Kim, Y. (2009) · Journal of Clinical Virology · doi:10.1016/j.jcv.2009.11.016 · Cited by 56 · see citing works
Lim, D., Oh, C.-T., Lee, L., Hong, J.-S., Noh, S.-H., Hwang, S., Kim, S., Han, S., & Lee, Y. S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.034 · Cited by 54 · see citing works
Identification of Synaptic Targets of Drosophila Pumilio
Chen, G., Li, W., Zhang, Q., Regulski, M., Sinha, N., Barditch, J., Tully, T., Krainer, A. R., Zhang, M. Q., & Dubnau, J. (2008) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000026 · Cited by 50 · see citing works
Self-citationDifferential Display Detects Host Nucleic Acid Motifs Altered in Scrapie-Infected Brain
Lathe, R., & Harris, A. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.07.045 · Cited by 19 · see citing works
Labrador, M., Sha, K., Li, A., & Corces, V. G. (2008) · Genetics · doi:10.1534/genetics.108.094318 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Regulatory activities of transposable elements: from conflicts to benefits
Chuong, E. B., Elde, N. C., & Feschotte, C. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.139 · Cited by 1,343 · see citing works
Pal, S., & Tyler, J. K. (2016) · Science Advances · doi:10.1126/sciadv.1600584 · Cited by 860 · see citing works
Stem cell aging: mechanisms, regulators and therapeutic opportunities
Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works
Jin, Y., Tam, O. H., Paniagua, E., & Hammell, M. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv422 · Cited by 709 · see citing works
Epigenetic regulation of ageing: linking environmental inputs to genomic stability
Benayoun, B. A., Pollina, E. A., & Brunet, A. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4048 · Cited by 610 · see citing works
Booth, L. N., & Brunet, A. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.013 · Cited by 499 · see citing works
Restricting retrotransposons: a review
Goodier, J. L. (2016) · Mobile DNA · doi:10.1186/s13100-016-0070-z · Cited by 436 · see citing works
The role of retrotransposable elements in ageing and age-associated diseases
Gorbunova, V., Seluanov, A., Mita, P., McKerrow, W., Fenyö, D., Boeke, J. D., Linker, S. B., Gage, F. H., Kreiling, J. A., Petrashen, A. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03542-y · Cited by 457 · see citing works
Resurrection of endogenous retroviruses during aging reinforces senescence
Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390 · see citing works
Self-citationTransposable elements become active and mobile in the genomes of aging mammalian somatic tissues
De Cecco, M., Criscione, S. W., Peterson, A. L., Neretti, N., Sedivy, J. M., & Kreiling, J. A. (2013) · Aging · doi:10.18632/aging.100621 · Cited by 365 · see citing works
Ubiquitous L1 Mosaicism in Hippocampal Neurons
Upton, K. R., Gerhardt, D. J., Jesuadian, J. S., Richardson, S. R., Sánchez-Luque, F. J., Bodea, G. O., Ewing, A. D., Salvador-Palomeque, C., van der Knaap, M. S., Brennan, P. M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.03.026 · Cited by 320 · see citing works
The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes
Richardson, S. R., Doucet, A. J., Kopera, H. C., Moldovan, J. B., Garcia-Perez, J. L., & Moran, J. V. (2015) · Microbiology Spectrum · doi:10.1128/microbiolspec.mdna3-0061-2014 · Cited by 313 · see citing works
Tau Activates Transposable Elements in Alzheimer’s Disease
Guo, C., Jeong, H.-H., Hsieh, Y.-C., Klein, H.-U., Bennett, D. A., De Jager, P. L., Liu, Z., & Shulman, J. M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.004 · Cited by 315 · see citing works
Sun, W., Samimi, H., Gamez, M., Zare, H., & Frost, B. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0194-1 · Cited by 315 · see citing works
Cytoplasmic DNA: sources, sensing, and role in aging and disease
Miller, K. N., Victorelli, S. G., Salmonowicz, H., Dasgupta, N., Liu, T., Passos, J. F., & Adams, P. D. (2021) · Cell · doi:10.1016/j.cell.2021.09.034 · Cited by 288 · see citing works
Mobile DNA elements in the generation of diversity and complexity in the brain
Erwin, J. A., Marchetto, M. C., & Gage, F. H. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3730 · Cited by 264 · see citing works
Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
Liu, E. Y., Russ, J., Cali, C. P., Phan, J. M., Amlie-Wolf, A., & Lee, E. B. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.003 · Cited by 231 · see citing works
“Furthermore, activation of transposable elements has been observed in an age-dependent fashion in Drosophila brain, contributing to memory decline and mortality (Li et al., 2013).”
BackgroundPetersen, M., Armisén, D., Gibbs, R. A., Hering, L., Khila, A., Mayer, G., Richards, S., Niehuis, O., & Misof, B. Y. (2019) · BMC Ecology and Evolution · doi:10.1186/s12862-018-1324-9 · Cited by 231 · see citing works
Wood, J. G., Jones, B. C., Jiang, N., Chang, C., Hosier, S., Wickremesinghe, P., Garcia, M., Hartnett, D. A., Burhenn, L., Neretti, N., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1604621113 · Cited by 214 · see citing works
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
Krug, L., Chatterjee, N., Borges-Monroy, R., Hearn, S., Liao, W.-W., Morrill, K., Prazak, L., Rozhkov, N., Theodorou, D., Hammell, M., et al. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006635 · Cited by 201 · see citing works
Self-citationHe, J., Babarinde, I. A., Sun, L., Xu, S., Chen, R., Shi, J., Wei, Y., Li, Y., Ma, G., Zhuang, Q., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21808-x · Cited by 197 · see citing works
SQuIRE reveals locus-specific regulation of interspersed repeat expression
Yang, W. R., Ardeljan, D., Pacyna, C. N., Payer, L. M., & Burns, K. H. (2019) · Nucleic Acids Research · doi:10.1093/nar/gky1301 · Cited by 189 · see citing works
Gene expression hallmarks of cellular ageing
Frenk, S., & Houseley, J. M. (2018) · Biogerontology · doi:10.1007/s10522-018-9750-z · Cited by 180 · see citing works
The Metabolic Impact on Histone Acetylation and Transcription in Ageing
Peleg, S., Feller, C., Ladurner, A. G., & Imhof, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.008 · Cited by 178 · see citing works
L1 Retrotransposons and Somatic Mosaicism in the Brain
Richardson, S. R., Morell, S., & Faulkner, G. J. (2014) · Annual Review of Genetics · doi:10.1146/annurev-genet-120213-092412 · Cited by 178 · see citing works
The Role of Transposable Elements in Health and Diseases of the Central Nervous System
Reilly, M. T., Faulkner, G. J., Dubnau, J., Ponomarev, I., & Gage, F. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3369-13.2013 · Cited by 175 · see citing works
Self-citationPopulation Genomics of Transposable Elements in Drosophila
Barrón, M. G., Fiston-Lavier, A.-S., Petrov, D. A., & González, J. (2014) · Annual Review of Genetics · doi:10.1146/annurev-genet-120213-092359 · Cited by 168 · see citing works
TRIM28 Represses Transcription of Endogenous Retroviruses in Neural Progenitor Cells
Fasching, L., Kapopoulou, A., Sachdeva, R., Petri, R., Jönsson, M. E., Männe, C., Turelli, P., Jern, P., Cammas, F., Trono, D., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.12.004 · Cited by 138 · see citing works
Stress and the dynamic genome: Steroids, epigenetics, and the transposome
Hunter, R. G., Gagnidze, K., McEwen, B. S., & Pfaff, D. W. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411260111 · Cited by 133 · see citing works
Widespread sex dimorphism in aging and age-related diseases
Sampathkumar, N. K., Bravo, J. I., Chen, Y., Danthi, P. S., Donahue, E. K., Lai, R. W., Lu, R. J., Randall, L. T., Vinson, N. M., & Benayoun, B. A. (2019) · Human Genetics · doi:10.1007/s00439-019-02082-w · Cited by 127 · see citing works
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan
Jones, B. C., Wood, J. G., Chang, C., Tam, A. D., Franklin, M. J., Siegel, E. R., & Helfand, S. L. (2016) · Nature Communications · doi:10.1038/ncomms13856 · Cited by 130 · see citing works
Chromatin structure and transposable elements in organismal aging
Wood, J. G., & Helfand, S. L. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00274 · Cited by 124 · see citing works
Gamdzyk, M., Doycheva, D. M., Araujo, C., Ocak, U., Luo, Y., Tang, J., & Zhang, J. H. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01904-7 · Cited by 127 · see citing works
Genetic architecture of Alzheimer's disease
Neuner, S. M., TCW, J., & Goate, A. M. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104976 · Cited by 126 · see citing works
“However, with aging, the efficacy of these systems is known to be reduced, providing a genomic environment in which TEs may become activated and contribute to somatic mutagenesis (Maxwell et al., 2011; Li et al., 2013).”
BackgroundRepetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients
Prudencio, M., Gonzales, P. K., Cook, C. N., Gendron, T. F., Daughrity, L. M., Song, Y., Ebbert, M. T. W., van Blitterswijk, M., Zhang, Y.-J., Jansen-West, K., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx233 · Cited by 122 · see citing works
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders
Jönsson, M. E., Garza, R., Johansson, P. A., & Jakobsson, J. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.05.004 · Cited by 122 · see citing works
Kuintzle, R., Chow, E. S., Westby, T. N., Gvakharia, B. O., Giebultowicz, J. M., & Hendrix, D. A. (2017) · Nature Communications · doi:10.1038/ncomms14529 · Cited by 119 · see citing works
Are there roles for brain cell senescence in aging and neurodegenerative disorders?
Tan, F. C. C., Hutchison, E. R., Eitan, E., & Mattson, M. P. (2014) · Biogerontology · doi:10.1007/s10522-014-9532-1 · Cited by 116 · see citing works
Chronic social isolation signals starvation and reduces sleep in Drosophila
Li, W., Wang, Z., Syed, S., Lyu, C., Lincoln, S., O'Neil, J. L., Nguyen, A. D., Feng, I., & Young, M. W. (2021) · Nature · doi:10.1038/s41586-021-03837-0 · Cited by 112 · see citing works
Self-citationUnique transposon landscapes are pervasive acrossDrosophila melanogastergenomes
Rahman, R., Chirn, G., Kanodia, A., Sytnikova, Y. A., Brembs, B., Bergman, C., & Lau, N. C. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1193 · Cited by 111 · see citing works
L1 Mosaicism in Mammals: Extent, Effects, and Evolution
Faulkner, G. J., & Garcia-Perez, J. L. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.07.004 · Cited by 110 · see citing works
Chen, H., Zheng, X., Xiao, D., & Zheng, Y. (2016) · Aging Cell · doi:10.1111/acel.12465 · Cited by 107 · see citing works
The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders
Angelova, M. T., Dimitrova, D. G., Dinges, N., Lenče, T., Worpenberg, L., Carré, C., & Roignant, J. (2018) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2018.00046 · Cited by 106 · see citing works
Aging in the Brain: New Roles of Epigenetics in Cognitive Decline
Barter, J., & Foster, T. C. (2018) · The Neuroscientist · doi:10.1177/1073858418780971 · Cited by 103 · see citing works
Brusslan, J. A., Bonora, G., Alvarez-Canterbury, A. M. R., Tariq, F., Jaroszewicz, A., & Pellegrini, M. A. (2015) · PLANT PHYSIOLOGY · doi:10.1104/pp.114.252999 · Cited by 101 · see citing works
Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain
Nandi, S., Chandramohan, D., Fioriti, L., Melnick, A. M., Hébert, J. M., Mason, C. E., Rajasethupathy, P., & Kandel, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609287113 · Cited by 96 · see citing works
Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE‐1 repression
de Thé, F.-X. B., Rekaik, H., Pezé-Heidsieck, E., Massiani-Beaudoin, O., Joshi, R. L., Fuchs, J., & Prochiantz, A. (2018) · The EMBO Journal · doi:10.15252/embj.201797374 · Cited by 94 · see citing works
The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology
Mohseni, Y. R., Tung, S. L., Dudreuilh, C., Lechler, R. I., Fruhwirth, G. O., & Lombardi, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01608 · Cited by 94 · see citing works
Hazen, J. L., Faust, G. G., Rodriguez, A. R., Ferguson, W. C., Shumilina, S., Clark, R. A., Boland, M. J., Martin, G., Chubukov, P., Tsunemoto, R. K., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.004 · Cited by 92 · see citing works
Epigenetic Mechanisms Impacting Aging: A Focus on Histone Levels and Telomeres
Song, S., & Johnson, F. B. (2018) · Genes · doi:10.3390/genes9040201 · Cited by 91 · see citing works
Piwi Is Required to Limit Exhaustion of Aging Somatic Stem Cells
Sousa‐Victor, P., Ayyaz, A., Hayashi, R., Qi, Y., Madden, D. T., Lunyak, V. V., & Jasper, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.059 · Cited by 90 · see citing works
Role of Transposable Elements in Genome Stability: Implications for Health and Disease
Bhat, A., Ghatage, T., Bhan, S., Lahane, G. P., Dhar, A., Kumar, R., PANDITA, R. K., Bhat, K. M., Ramos, K. S., & Pandita, T. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147802 · Cited by 83 · see citing works
Dysregulation of RNA Splicing in Tauopathies
Apicco, D. J., Zhang, C., Maziuk, B. F., Jiang, L., Ballance, H. I., Boudeau, S., Ung, C. Y., Li, H., & Wolozin, B. L. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.093 · Cited by 79 · see citing works
Ancient Endo-siRNA Pathways Reveal New Tricks
Claycomb, J. M. (2014) · Current Biology · doi:10.1016/j.cub.2014.06.009 · Cited by 84 · see citing works
Resolving the prevalence of somatic transposition in Drosophila
Treiber, C. D., & Waddell, S. (2017) · eLife · doi:10.7554/elife.28297 · Cited by 81 · see citing works
Activation of endogenous retroviruses during brain development causes an inflammatory response
Jönsson, M. E., Garza, R., Sharma, Y., Petri, R., Södersten, E., Johansson, J. G., Johansson, P. A., Atacho, D. A., Pircs, K., Madsen, S., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2020106423 · Cited by 80 · see citing works
L1 retrotransposition in the soma: a field jumping ahead
Faulkner, G. J., & Billon, V. (2018) · Mobile DNA · doi:10.1186/s13100-018-0128-1 · Cited by 78 · see citing works
Ramirez, P., Zuniga, G., Sun, W., Beckmann, A., Ochoa, E., DeVos, S. L., Hyman, B., Chiu, G., Roy, E. R., Cao, W., et al. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102181 · Cited by 79 · see citing works
The Y chromosome may contribute to sex-specific ageing in Drosophila
Brown, E. J., Nguyen, A. H., & Bachtrog, D. (2020) · Nature Ecology & Evolution · doi:10.1038/s41559-020-1179-5 · Cited by 78 · see citing works
Retrotransposon-induced mosaicism in the neural genome
Bodea, G. O., McKelvey, E. G. Z., & Faulkner, G. J. (2018) · Open Biology · doi:10.1098/rsob.180074 · Cited by 76 · see citing works
Epigenetic mechanisms related to cognitive decline during aging
Harman, M. F., & Martín, M. G. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24436 · Cited by 79 · see citing works
The Epigenetic Control of the Transposable Element Life Cycle in Plant Genomes and Beyond
Liu, P., Cuerda-Gil, D., Shahid, S., & Slotkin, R. K. (2022) · Annual Review of Genetics · doi:10.1146/annurev-genet-072920-015534 · Cited by 67 · see citing works
LINE‐1 retrotransposons in healthy and diseased human brain
Suarez, N. A., Macia, Á., & Muotri, A. R. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22567 · Cited by 74 · see citing works
Direct interrogation of the role of H3K9 in metazoan heterochromatin function
Penke, T. J. R., McKay, D. J., Strahl, B. D., Matera, A. G., & Duronio, R. J. (2016) · Genes & Development · doi:10.1101/gad.286278.116 · Cited by 74 · see citing works
Functional conservation in genes and pathways linking ageing and immunity
Fabian, D. K., Fuentealba, M., Dönertaş, H. M., Partridge, L., & Thornton, J. M. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00232-1 · Cited by 72 · see citing works
Pathogenic tau–induced transposable element–derived dsRNA drives neuroinflammation
Ochoa, E., Ramirez, P., Gonzalez, E., De Mange, J., Ray, W. J., Bieniek, K. F., & Frost, B. (2023) · Science Advances · doi:10.1126/sciadv.abq5423 · Cited by 73 · see citing works
Terry, D. M., & Devine, S. E. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2019.01244 · Cited by 71 · see citing works
Repetitive elements in aging and neurodegeneration
Copley, K. E., & Shorter, J. (2023) · Trends in Genetics · doi:10.1016/j.tig.2023.02.008 · Cited by 70 · see citing works
The evolutionary arms race between transposable elements and piRNAs in Drosophila melanogaster
Luo, S., Zhang, H., Duan, Y., Yao, X., Clark, A. G., & Lü, J. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-1580-3 · Cited by 70 · see citing works
Chang, Y.-H., & Dubnau, J. (2019) · Current Biology · doi:10.1016/j.cub.2019.07.071 · Cited by 68 · see citing works
Self-citationAbe, M., Naqvi, A., Hendriks, G.-J., Feltzin, V., Zhu, Y., Grigoriev, A., & Bonini, N. M. (2014) · Genes & Development · doi:10.1101/gad.226654.113 · Cited by 68 · see citing works
Transposable elements as new players in neurodegenerative diseases
Ravel‐Godreuil, C., Znaidi, R., Bonnifet, T., Joshi, R. L., & Fuchs, J. (2021) · FEBS Letters · doi:10.1002/1873-3468.14205 · Cited by 67 · see citing works
Endogenous retroviruses in development and health
Wang, J., Lu, X., Zhang, W., & Liu, G. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.09.006 · Cited by 68 · see citing works
The mechanism of ageing: primary role of transposable elements in genome disintegration
Sturm, Á., Ivics, Z., & Vellai, T. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1896-0 · Cited by 68 · see citing works
Impact of transposable elements on insect genomes and biology
Maumus, F., Fiston-Lavier, A.-S., & Quesneville, H. (2015) · Current Opinion in Insect Science · doi:10.1016/j.cois.2015.01.001 · Cited by 63 · see citing works
The exonuclease Nibbler regulates age‐associated traits and modulates pi RNA length in D rosophila
Feltzin, V., Khaladkar, M., Abe, M., Parisi, M. J., Hendriks, G., Kim, J., & Bonini, N. M. (2015) · Aging Cell · doi:10.1111/acel.12323 · Cited by 62 · see citing works
Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain
Sapiro, A. L., Shmueli, A., Henry, G. L., Li, Q., Shalit, T., Yaron, O., Paas, Y., Li, J. B., & Shohat-Ophir, G. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811768116 · Cited by 63 · see citing works
Cell Cycle Re-entry in the Nervous System: From Polyploidy to Neurodegeneration
Nandakumar, S., Rozich, E., & Buttitta, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698661 · Cited by 62 · see citing works
Gorbunova, V. A., Boeke, J. D., Helfand, S. L., & Sedivy, J. M. (2014) · Science · doi:10.1126/science.aaa3177 · Cited by 62 · see citing works
Death by transposition – the enemy within?
Sedivy, J. M., Kreiling, J. A., Neretti, N., Cecco, M. D., Criscione, S. W., Hofmann, J. W., Zhao, X., Ito, T., & Peterson, A. L. (2013) · BioEssays · doi:10.1002/bies.201300097 · Cited by 61 · see citing works
Dynamic expression of long noncoding RNAs and repeat elements in synaptic plasticity
Mååg, J. L. V., Panja, D., Sporild, I., Patil, S. S., Kaczorowski, D. C., Bramham, C. R., Dinger, M. E., & Wibrand, K. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00351 · Cited by 58 · see citing works
Scopa, C., Barnada, S. M., Cicardi, M. E., Singer, M., Trotti, D., & Trizzino, M. (2023) · Nature Communications · doi:10.1038/s41467-023-43728-8 · Cited by 58 · see citing works
Böhne, A., Sengstag, T., & Salzburger, W. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu200 · Cited by 57 · see citing works
Andrenacci, D., Cavaliere, V., & Lattanzi, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100995 · Cited by 58 · see citing works
Analysis of RNA-Seq Data Using TEtranscripts
Jin, Y., & Hammell, M. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7710-9_11 · Cited by 55 · see citing works
Unraveling the features of somatic transposition in the Drosophila intestine
Siudeja, K., van den Beek, M., Riddiford, N., Boumard, B., Wurmser, A., Stefanutti, M., Lameiras, S., & Bardin, A. J. (2021) · The EMBO Journal · doi:10.15252/embj.2020106388 · Cited by 52 · see citing works
RNA editing regulates transposon-mediated heterochromatic gene silencing
Savva, Y. A., Jepson, J. E. C., Chang, Y.-J., Whitaker, R., Jones, B. C., Laurent, G. S., Tackett, M., Kapranov, P., Jiang, N., Du, G., et al. (2013) · Nature Communications · doi:10.1038/ncomms3745 · Cited by 53 · see citing works
The aging proteostasis decline: From nematode to human
Meller, A., & Shalgi, R. (2021) · Experimental Cell Research · doi:10.1016/j.yexcr.2021.112474 · Cited by 50 · see citing works
Yan, Z., Zhou, Z., Wu, Q., Chen, Z., Koo, E. H., & Zhong, S. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.084 · Cited by 51 · see citing works
Endogenous retroviruses are associated with hippocampus-based memory impairment
Sankowski, R., Strohl, J. J., Huerta, T. S., Nasiri, E., Mazzarello, A. N., d’Abramo, C., Cheng, K. F., Staszewski, O., Prinz, M., Huerta, P. T., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1822164116 · Cited by 50 · see citing works
tRNA 2′-O-methylation by a duo of TRM7/FTSJ1 proteins modulates small RNA silencing in Drosophila
Angelova, M. T., Dimitrova, D. G., Silva, B. D., Marchand, V., Jacquier, C., Achour, C., Brazane, M., Goyenvalle, C., Bourguignon‐Igel, V., Shehzada, S., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa002 · Cited by 50 · see citing works
Chang, Y.-H., & Dubnau, J. (2023) · Nature Communications · doi:10.1038/s41467-023-36649-z · Cited by 49 · see citing works
Self-citationSilencing of Transposable Elements by piRNAs in Drosophila : An Evolutionary Perspective
Luo, S., & Lü, J. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.01.006 · Cited by 48 · see citing works
The Role of Transposable Elements of the Human Genome in Neuronal Function and Pathology
Chesnokova, E., Beletskiy, A., & Kolosov, P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105847 · Cited by 48 · see citing works
The Piwi‐pi RNA pathway: road to immortality
Sturm, Á., Perczel, A., Ivics, Z., & Vellai, T. (2017) · Aging Cell · doi:10.1111/acel.12630 · Cited by 48 · see citing works
Retrotransposons in the development and progression of amyotrophic lateral sclerosis
Savage, A. L., Schumann, G. G., Breen, G. D., Bubb, V. J., Al‐Chalabi, A., & Quinn, J. P. (2018) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2018-319210 · Cited by 47 · see citing works
Romano, G., Klima, R., & Feiguin, F. (2020) · BMC Biology · doi:10.1186/s12915-020-00816-1 · Cited by 47 · see citing works
Viruses and Endogenous Retroviruses as Roots for Neuroinflammation and Neurodegenerative Diseases
Römer, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.648629 · Cited by 47 · see citing works
Nguyen, A. H., & Bachtrog, D. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009438 · Cited by 47 · see citing works
The Physiology of Homeoprotein Transduction
Nardo, A. A. D., Fuchs, J., Joshi, R. L., Moya, K. L., & Prochiantz, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00018.2017 · Cited by 41 · see citing works
- Authors
- Li, W., Prazak, L., Chatterjee, N., Grüninger, S., Krug, L., Theodorou, D., & Dubnau, J.
- Affiliations
- Cold Spring Harbor Laboratory (US)
- University of Zurich (CH)
- Sorbonne Paris Cité (FR)
- Corresponding author
- Dubnau, Josh
- ORCID
- Venue
- Nature Neuroscience
- Published
- 2013-04-07
- Volume
- 16
- Issue
- 5
- Pages
- 529-531
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC3821974
- OpenAlex
- W2089023364
- Cited by
- 346
- References
- 24
- Citations by year
- 2026: 15 · 2025: 25 · 2024: 30 · 2023: 22 · 2022: 32 · 2021: 39 · 2020: 38 · 2019: 27 · 2018: 23 · 2017: 22 · 2016: 22 · 2015: 25 · 2014: 20 · 2013: 6
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.zora.uzh.ch
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Institute of Neurological Disorders and Stroke (TR01 5R01NS067690-03, R01NS067690)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- transposable elements, transposon activation, aging, Argonaute 2, RNA interference, memory impairment, lifespan, Drosophila brain, age-related neurodegeneration
- MeSH terms
- Aging, Analysis of Variance, Animals, Avoidance Learning, Brain, Conditioning, Classical, DNA Transposable Elements, Drosophila, Longevity, Mutation, Neurons, Drosophila Proteins, Animals, Genetically Modified, Green Fluorescent Proteins, Argonaute Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
