Unexpected association between joint hypermobility syndrome/Ehlers–Danlos syndrome hypermobility type and obsessive–compulsive personality disorder
Abstract
Joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type (JHS/EDS-HT) is a largely unrecognized, heritable connective tissue disorder, mainly characterized by joint instability complications, widespread musculoskeletal pain, and minor skin features. In a case-control study, 47 consecutive JHS/EDS-HT patients were investigated for the prevalence of psychiatric disorders and compared to 45 healthy controls in a single center. The psychiatric evaluation consisted of structured clinical interview for DSM-IV criteria by using the SCID-I and the SCID-II. Symptom severity was assessed using the Hamilton Anxiety Rating Scale (HAM-A), the Hamilton Depression Rating Scale (HAM-D), and the Brief Psychiatric Rating Scale (BPRS). The Global Assessment of Functioning Scale (GAF) was used to assess the overall severity of psychological, social, and occupational functions. JHS/EDS-HT patients had significantly higher mean scores for all questionnaires: HAM-A (6.7 vs. 3.8), HAM-D (6.4 vs. 2.7), GAF (75.0 vs. 86.1), and BPRS (27.5 vs. 25.6). The JHS/EDS-HT group had a 4.3 higher risk of being affected by any psychiatric disorder, and in particular, a 5.8 higher risk of having a personality disorder. In particular, 5 JHS/EDS-HT suffered from obsessive-compulsive personality disorder with an observed prevalence rate of 10.6 % (3.6-23.1). Psychiatric assessment of JHS/EDS-HT patients showed an extremely high prevalence of personality disorders (21 %), and of Axis-I disorders (38 %), mostly depressive. This study did not confirm the previously reported increased rate of panic disorders in JHS/EDS-HT.
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EDS and HSD are associated with increased risk of depression, anxiety, and interpersonal issues compared to the general population.
“EDS and HSD have been associated with increased risk of conditions such as depression and anxiety as well as interpersonal issues when compared to the general population [17–21].”
From Psychological interventions for individuals with Ehlers-Danlos syndrome and hypermobility spectrum disorder: a scoping review (2023) · cites this paper as [20]
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- Authors
- Pasquini, M., Celletti, C., Berardelli, I., Roselli, V., Mastroeni, S., Castori, M., Biondi, M., & Camerota, F.
- Affiliations
- Policlinico Umberto I (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- Corresponding author
- Celletti, Claudia
- ORCID
- Venue
- Rheumatology International
- Published
- 2013-11-23
- Volume
- 34
- Issue
- 5
- Pages
- 631-636
- ISSN
- 0172-8172 (ISSN-L)
- 1437-160X
- OpenAlex
- W2031112145
- Cited by
- 51
- References
- 29
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 5 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 1
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Rheumatology International (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- joint hypermobility syndrome, Ehlers-Danlos syndrome hypermobility type, obsessive-compulsive personality disorder, psychiatric comorbidity, connective tissue diseases, personality disorders, depressive disorders, anxiety disorders, Global Assessment of Functioning, prevalence of mental disorders
- MeSH terms
- Adult, Compulsive Personality Disorder, Ehlers-Danlos Syndrome, Humans, Joint Instability, Male, Psychiatric Status Rating Scales, Surveys and Questionnaires, Risk Factors, Rome, Severity of Illness Index, Prevalence, Case-Control Studies, Risk Assessment, Young Adult
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