The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Association between Pain Sensitivity, Central Sensitization, and Functional Disability in Adolescents With Joint Hypermobility
Abstract
Purpose The purpose of this study was to examine the association between pain sensitivity, central sensitization, and functional disability in adolescents with joint hypermobility.Design and methods A cross-sectional descriptive design was utilized for this study. A sample of 40 adolescents being evaluated for chronic pain and autonomic nervous system dysfunction were recruited. Subjects were evaluated for pain, function, central sensitization, and sensitivity on pain and touch sensory nerve fiber types. Data were analyzed to detect associations between variables.Results Joint hypermobility had a moderately significant correlation with central sensitization measured by the Central Sensitization Inventory, as well as increased pain sensitivity as evidenced by hypersensitivity of Aδ sensory nerve fibers. The presence of central sensitization was also positively associated with level of functional disability.Conclusions Findings implicate joint hypermobility as a possible antecedent to pain hypersensitivity and central sensitization syndromes that when recognized and addressed effectively may reduce functional disability in those affected.Practice implications It is important for pediatric nurses that work with adolescents that have chronic pain to understand variables that may impact pain and functional disability in order to develop methods to increase function, reduce pain, and increase perceived quality of life.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Findings show elevated central sensitisation inventory scores in HSD/hEDS, which correlate positively with functional disability.
“This assumption is in line with findings of elevated central sensitisation inventory scores in HSD/hEDS, which correlate positively with functional disability. 18”
From Rome IV Functional Gastrointestinal Disorders and Health Impairment in Subjects With Hypermobility Spectrum Disorders or Hypermobile Ehlers-Danlos Syndrome (2021) · cites this paper as [18]
Citations
Cites
Discovering Statistics Using SPSS
Field, A. P., & Miles, J. N. V. (2000) · Medical Entomology and Zoology · Cited by 28,269
Pain assessment: global use of the Brief Pain Inventory.
Cs, C., & Km, R. (1994) · PubMed · Cited by 5,178
Articular mobility in an African population.
Beighton, P., Solomon, L., & Soskolne, C. L. (1973) · Annals of the Rheumatic Diseases · doi:10.1136/ard.32.5.413 · Cited by 1,727
The Development and Psychometric Validation of the Central Sensitization Inventory
Mayer, T. G., Neblett, R., Cohen, H. M., Howard, K. J., Choi, Y. H., Williams, M. J., Perez, Y., & Gatchel, R. J. (2011) · Pain Practice · doi:10.1111/j.1533-2500.2011.00493.x · Cited by 1,017
The functional disability inventory: Measuring a neglected dimension of child health status
Walker, L. S., & Greene, J. W. (1991) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/16.1.39 · Cited by 881
Neblett, R., Cohen, H., Choi, Y., Hartzell, M. M., Williams, M., Mayer, T. G., & Gatchel, R. J. (2013) · The Journal of Pain · doi:10.1016/j.jpain.2012.11.012 · Cited by 757
Identification of Spinal Circuits Transmitting and Gating Mechanical Pain
Duan, B., Cheng, L., Bourane, S., Britz, O., Padilla, C., Garcia-Campmany, L., Krashes, M., Knowlton, W., Velasquez, T., Ren, X., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.003 · Cited by 582
Self-citationClaar, R. L., & Walker, L. S. (2006) · Pain · doi:10.1016/j.pain.2005.12.002 · Cited by 421
Geber, C., Klein, T. C., Azad, S. C., Birklein, F., Gierthmühlen, J., Huge, V., Lauchart, M., Nitzsche, D., Stengel, M., Valet, M., et al. (2011) · Pain · doi:10.1016/j.pain.2010.11.013 · Cited by 326
Tinkle, B. T., Bird, H. A., Grahame, R., Lavallee, M., Levy, H. P., & Sillence, D. (2009) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.33070 · Cited by 290
Peripheral input and its importance for central sensitization
Baron, R., Hans, G. H., & Dickenson, A. H. (2013) · Annals of Neurology · doi:10.1002/ana.24017 · Cited by 280
Zernikow, B., Wager, J., Hechler, T., Hasan, C., Rohr, U., Dobe, M., Meyer, A., Hübner-Möhler, B., Wamsler, C., & Blankenburg, M. (2012) · BMC Pediatrics · doi:10.1186/1471-2431-12-54 · Cited by 214
Castori, M., Morlino, S., Celletti, C., Celli, M., Morrone, A., Colombi, M., Camerota, F., & Grammatico, P. (2012) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.35483 · Cited by 162
Tobias, J. H., Deere, K., Palmer, S., Clark, E. M., & Clinch, J. (2013) · Arthritis & Rheumatism · doi:10.1002/art.37836 · Cited by 145
Fisher, E., Heathcote, L. C., Eccleston, C., Simons, L. E., & Palermo, T. M. (2017) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsx103 · Cited by 128
Small fiber neuropathy is a common feature of Ehlers-Danlos syndromes
Cazzato, D., Castori, M., Lombardi, R., Caravello, F., Bella, E. D., Petrucci, A., Grammatico, P., Dordoni, C., Colombi, M., & Lauria, G. (2016) · Neurology · doi:10.1212/wnl.0000000000002847 · Cited by 122
Ehlers–Danlos Syndrome and Postural Tachycardia Syndrome: A relationship study
Wallman, D., Weinberg, J., & Hohler, A. D. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.03.002 · Cited by 100
Di Stefano, G., Celletti, C., Baron, R., Castori, M., Di Franco, M., La Cesa, S., Leone, C., Pepe, A., Cruccu, G., Truini, A., et al. (2016) · European Journal of Pain · doi:10.1002/ejp.856 · Cited by 100
Rombaut, L., Scheper, M., De Wandele, I., De Vries, J., Meeus, M., Malfait, F., Engelbert, R., & Calders, P. (2015) · Clinical Rheumatology · doi:10.1007/s10067-014-2499-0 · Cited by 91
Cerebral Palsy and Chronic Pain
Engel, J. M., Petrina, T. J., Dudgeon, B. J., & McKearnan, K. A. (2006) · Physical & Occupational Therapy In Pediatrics · doi:10.1080/j006v25n04_06 · Cited by 60
Pasquini, M., Celletti, C., Berardelli, I., Roselli, V., Mastroeni, S., Castori, M., Biondi, M., & Camerota, F. (2014) · Rheumatology International · doi:10.1007/s00296-013-2901-2 · Cited by 51
Sinclair, C. M., Meredith, P., Strong, J., & Feeney, R. (2016) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0000000000000300 · Cited by 49
Inhibitory regulation of the pain gate and how its failure causes pathological pain
Price, T. J., & Prescott, S. A. (2015) · Pain · doi:10.1097/j.pain.0000000000000139 · Cited by 37
Cerebral Palsy and Chronic Pain
Engel, J. M., Petrina, T. J., Dudgeon, B. J., et al. (2006) · Physical & Occupational Therapy In Pediatrics · doi:10.1300/j006v25n04_06 · Cited by 36
Central Sensitization in Functional Chronic Pain Syndromes: Overview and Clinical Application
Bettini, L., & Moore, K. (2016) · Pain Management Nursing · doi:10.1016/j.pmn.2016.05.008 · Cited by 34
Self-citationChronic widespread pain and neurophysiological symptoms in joint hypermobility syndrome (JHS)
Clark, C., Khattab, A., & Carr, E. (2014) · International Journal of Therapy and Rehabilitation · doi:10.12968/ijtr.2014.21.2.60 · Cited by 28
Cho, Y. W., Kang, M.-S., Kim, K. T., Do, S. Y., Lim, J., Lee, S. Y., & Motamedi, G. K. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.03.003 · Cited by 28
Rombaut, L., Scheper, M. C., Wandele, I. D., de Vries, J., Meeus, M., Malfait, F., Engelbert, R., & Calders, P. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.02.769 · Cited by 18
Koo, B. K., Ohn, J. H., Kwak, S., & Moon, M. K. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.4.285 · Cited by 14
Armon, K. (2014) · Archives of Disease in Childhood · doi:10.1136/archdischild-2014-306556 · Cited by 13
Buskila, D., & Ablin, J. N. (2012) · Reumatismo · doi:10.4081/reumatismo.2012.230 · Cited by 12
Joint Hypermobility and Headache
Tinkle, B. T. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12416 · Cited by 6
Ehlers-Danlos syndromes: Revised nosology, Villefranche, 1997
Beighton, P., Paepe, A. D., Steinmann, B., Tsipouras, P., & Wenstrup, R. J. (1998) · American Journal of Medical Genetics · doi:10.1002/(sici)1096-8628(19980428)77:1
Flagged first, then by citations
Research works printed but not linked: 1
- Ting, 2014, The role of joint hypermobility in the pain or fibromyalgia: An observational study, Pediatric Rheumatology, 10, 2
Cited by
Sorted by citations
Lam, C. Y., Palsson, O. S., Whitehead, W. E., Sperber, A. D., Tornblom, H., Simren, M., & Aziz, I. (2021) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2020.02.034 · Cited by 71
Neblett, R., Sanabria‐Mazo, J. P., Luciano, J. V., Mirčić, M., Čolović, P., Bojanić, M., Jeremić-Knežević, M., Aleksandrić, T., & Knežević, A. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105612 · Cited by 58
Blajwajs, L., Williams, J., Timmons, W., & Sproule, J. (2023) · Rheumatology International · doi:10.1007/s00296-023-05338-x · Cited by 35
Andias, R., & Silva, A. G. (2020) · Pain Practice · doi:10.1111/papr.12875 · Cited by 29
Are menstrual symptoms associated with central sensitization inventory? A cross‐sectional study
de Arruda, G. T., Driusso, P., Rodrigues, J. C., de Godoy, A. G., Degani, A. M., Danna‐dos‐Santos, A., & Ávila, M. A. (2022) · European Journal of Pain · doi:10.1002/ejp.1999 · Cited by 26
Ocay, D. D., Larche, C. L., Betinjane, N., Jolicoeur, A., Beaulieu, M. J., Saran, N., Ouellet, J. A., Ingelmo, P. M., & Ferland, C. E. (2022) · Journal of Pain Research · doi:10.2147/jpr.s352607 · Cited by 18
Ocay, D. D., Ye, D.-L., Larche, C. L., Potvin, S., Marchand, S., & Ferland, C. E. (2022) · PAIN Reports · doi:10.1097/pr9.0000000000001032 · Cited by 15
Esin, O. R., Esin, R. G., Gorobets, E. A., Хайруллин, И. Х., Makaricheva, E. V., Gamirova, R., & Shamsutdinova, R. F. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro202112111272 · Cited by 7
LaVigne, T. W., Laake, L. M., & Ibeziako, P. I. (2020) · Clinical Child Psychology and Psychiatry · doi:10.1177/1359104520931579 · Cited by 4
Scheurich, J. A., Beals‐Erickson, S. E., Wallace, D. P., Cramer, E., Fox, E. J., Black, W., Jones, J. T., & Hoffart, C. M. (2025) · Rheumatology International · doi:10.1007/s00296-025-05947-8 · Cited by 2
ESTUDO DE PREVALÊNCIA CARDIOVASCULAR EM CABO VERDE (ESTUDO PREVCARDIO.CV) - ILHA DO MAIO
COELHO, P. M. D. S. C., Rodrigues, F., & Adrião, L. L. D. S. (2021) · doi:10.22533/at.ed.5892117059 · Cited by 1
Hanzlíková, I., Masters, R. S. W., & Hébert‐Losier, K. (2021) · The Journal of Sport and Exercise Science · doi:10.36905/jses.2021.01.03 · Cited by 1
Translational Research – Interventions for Promoting Health in Children
Christian, B. J. (2018) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2018.08.005
Douleurs et hyperlaxité : est-ce un syndrome d’Ehlers-Danlos hypermobile (SEDh) ?
Bénistan, K., & Dugué, S. (2020) · Douleur et Analgésie · doi:10.3166/dea-2020-0132
ESCLEROSE MÚLTIPLA: UMA REVISÃO DE LITERATURA
Vieira, L. A. M., Coelho, C. M., Martins, I. N., Cunha, L. F. G., Ferreira, L. D. M., Rosado, L. C., de Sá, C. V., Figueiredo, B. A. P., Resende, A. G. A., Matioli, M. L. N., et al. (2021) · doi:10.22533/at.ed.5892117058
IMPACTO DA ALTERAÇÃO DO PROTOCOLO DE MORTE ENCEFÁLICA: DOAÇÃO DE ÓRGÃOS E TECIDOS EM SANTA CATARINA
do Canto, M. C., Scarpari, B. F., Nery, G. B., de Oliveira, G. V., & Madeira, K. (2021) · doi:10.22533/at.ed.58921170510
O TRANSTORNO DO ESPECTRO AUTISMO – O PARADIGMA DO DIAGNÓSTICO
Gonçalves, C. C., Pessoa, F. M. D. L., & Aguilar, C. P. C. (2021) · doi:10.22533/at.ed.58921170513
INFARTO AGUDO DO MIOCÁRDIO: UM ESTUDO ANATÔMICO E SUAS ABORDAGENS TERAPÊUTICAS
Nepomuceno, F. C. L., Montenegro, B. V., Viegas, E. L. D. M., & Lima, L. S. D. S. (2021) · doi:10.22533/at.ed.58921170511
ALTERAÇÕES COGNITIVAS E COMPORTAMENTAIS APÓS UM TRAUMATISMO CRÂNIO ENCEFÁLICO
Camelini, L. C., Carias, G. B., Gandolfo, J. L., Bonfá, M. C., Rocha, M. C., Carrilho, N. S. R., & de Figueiredo, P. A. D. (2021) · doi:10.22533/at.ed.5892117053
Zampieri, V. Y., & Veronez, D. A. D. L. (2021) · doi:10.22533/at.ed.58921170512
QUIMIOTERAPIA PALIATIVA BENEFICIA PACIENTES COM CANCER AVANÇADO E BAIXO PERFORMANCE?
de Vasconcellos, V. F., Bonadio, R. R. D. C. C., Avanço, G., Negrao, M. V., Felippe, L. V., Senra, J. G., & Riechelmann, R. P. (2021) · doi:10.22533/at.ed.58921170517
DIAGNÓSTICO E MANEJO DO OLHO VERMELHO PARA O MÉDICO GENERALISTA : UMA REVISÃO NARRATIVA
Magalhães, V. S., da Cunha, C. E. X., Castro, L. R., Ribeiro, M. V. M. R., Júnior, A. J. D. V. C., Ferreira, M. M. A. G., Barros, M. K. L., Torres, I. P., da Silva, F. K. S., Mendonça, I. M., et al. (2021) · doi:10.22533/at.ed.5892117057
PREVALÊNCIA DE LESÃO RENAL AGUDA EM UNIDADE DE TERAPIA INTENSIVA
Nascimento, F. D. C., & Ferreira, V. (2021) · doi:10.22533/at.ed.58921170516
PLANO DE CONTIGÊNCIA PARA SÍFILIS NO MUNICÍPIO DE SANTARÉM/PA
Ponte, A. R., de Aragão, C. R. B., Trindade, G. B. D. M., Alcântara, L. D. M., Leite, L. V., Pantoja, J. V. S., & de Mendonça, M. H. R. (2021) · doi:10.22533/at.ed.58921170515
CONDIÇÕES ASSOCIADAS A DOENÇA DO REFLUXO GASTROESOFÁGICO EM UM HOSPITAL UNIVERSITÁRIO DO AMAZONAS
de Sá, Y. Q. P., Storino, A. D. V. C. E. S., de Figueiredo, A. B. D. C. L., Ale, A. C. C., Júnior, A. D. H. G., Rodrigues, B. T., Neto, L. P. B. S., Mendes, K. B. D. M., Loma, W. A., Ramos, W. M., et al. (2021) · doi:10.22533/at.ed.5892117056
RESSECÇÃO DE GLIOMA INSULAR: A CIRURGIA E O PÓS-OPERATÓRIO – UMA REVISÃO BIBLIOGRÁFICA
Moura, L. S. C., Pereira, P. B., Prosdócimi, F. C., & Brooks, J. B. B. (2021) · doi:10.22533/at.ed.58921170520
TÉCNICA CIRÚRGICA NO TRATAMENTO DE OBESIDADE MORBIDA NA SÍNDROME DE PRADER WILLI
Pereira, F. K., Pereira, L. F. M., & Cenatti, A. (2021) · doi:10.22533/at.ed.58921170523
de Paulo, T. M., Vieira, C. M., Souto, D. N., Teotonio, E. D. O., de Queiroz, J. M., Soares, J. B., de Sá, J. D., Ganças, L. F. N., de Paula, M. R., Silva, N. N. D. D. L. E., et al. (2021) · doi:10.22533/at.ed.58921170522
Perencini, A. B., Coutinho, I. D. S., Cabral, I. A., Liporoni, J. R., Moreti, M. P., Tellini, N., & Trigo, Á. A. (2021) · doi:10.22533/at.ed.5892117051
de Melo, R. R., Coelho, V. F. P., Muniz, L. D. P., Rosa, C. G., Felten, C. C., & Silva, V. M. R. (2021) · doi:10.22533/at.ed.5892117054
RELAÇÃO ENTRE OBESIDADE E RISCO DE GRAVIDADE DO CÂNCER DE PRÓSTATA
Mota, M. J. S., de Andrade, T. V., de Carvalho, A. S., Vieira, A. C. A., & Júnior, E. D. A. (2021) · doi:10.22533/at.ed.58921170518
EXPERIÊNCIAS DE PERDA DENTÁRIA E QUALIDADE DE VIDA EM PACIENTES TRANSPLANTADOS RENAIS HOSPITALIZADOS
Sousa, L. B., dos Santos, D. L. N., Almondes, C. M. S., & Lopes, F. F. (2021) · doi:10.22533/at.ed.7852113095
Hypermobility: assessment, health risks, and prevention strategies – a scoping review
Meiliana, A., Defi, I. R., Rosdianto, A. M., Tjitraresmi, A., & Barliana, M. I. (2025) · Physiotherapy Quarterly · doi:10.5114/pq/196497
Huft, K., Gaydos, E. F., White, J. N., Pascual‐Diaz, S., Schubert-Hjalmarsson, E., Harrison, N., Moua, L., Hoeppli, M., Biggs, E. E., Stinson, J., et al. (2026) · Pain · doi:10.1097/j.pain.0000000000003999
Linking central sensitization to multisystemic manifestations in hypermobile Ehlers-Danlos syndrome
Zarazúa, A. P. M., Elizondo-Solís, C., García, C. A., Estrella, D. J. P., Guerra, O. I., Arana-Guajardo, A., Purón-González, E., Luna, K. S., Plata, L. I. L., Pompermayer, M. R. G., et al. (2026) · Frontiers in Pain Research · doi:10.3389/fpain.2026.1799439
Metadata
- Authors
- Bettini, E. A., Moore, K., Wang, Y., Hinds, P. S., & Finkel, J. C.
- Affiliations
- Children's National (US)
- University of Arizona (US)
- Corresponding author
- Bettini, Elizabeth A.
- Venue
- Journal of Pediatric Nursing
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 42
- Pages
- 34-38
- ISSN
- 0882-5963 (ISSN-L)
- OpenAlex
- W2810461576
- Cited by
- 36
- References
- 32
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 22 · 2020: 4 · 2018: 1
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pediatric Nursing (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pediatric Pain Management Techniques
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- joint hypermobility, central sensitization, pain sensitivity, functional disability, adolescents, chronic pain, autonomic dysfunction, tactile sensitivity, Central Sensitization Inventory, pediatric nursing
- MeSH terms
- Adolescent, Female, Humans, Joint Instability, Male, Nursing Assessment, Pain Measurement, Pediatric Nursing, Quality of Life, Central Nervous System Sensitization, Chronic Pain
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
