Adhäsionseigenschaften der Basalmembranen der Bruchschen Membran. Immunhistochemische Untersuchungen der altersabhängigen Veränderungen von Adhäsionsmolekülen und Lipidablagerungen
Abstract
Background In addition to deposition of debris between the plasma and basal membrane of the RPE, different types of early and late AMD-like drusen, choroidal neovascularization and pigment epithelial detachments are characterized by splitting of Bruch's membrane between the basement membrane of the RPE and the inner collagenous layer. Because these layers are normally attached by adhesion molecules, the possible age-related regression of these adhesion molecules in this structure was examined.Methods The presence of the adhesion molecules laminin, fibronectin, collagen IV and of lipid deposits was examined in 44 macular specimen (age 4-88 years).Results Age-related regression of the adhesion molecules laminin, fibronectin and collagen IV was observed in the basement membrane of the RPE and the endothelium cells of the choriocapillaris. This effect correlated with an increase in lipid deposits.Conclusion The regression of adhesion molecules, especially in the basement membrane of the RPE in association with increased lipid deposits in Bruch's membrane, may explain the development of a "cleavage edge" for the splitting of Bruch's membrane between the basement membrane of the RPE and the inner collagenous layer.
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BrM thickening with age is likely due to the accumulation of lipids, including esterified cholesterol, fatty acids, and triglycerides, which reduces its permeability.
“This phenomenon is likely due to the accumulation of lipids, including esterified cholesterol, fatty acids, and triglycerides [48,49], which reduces its permeability [50,51].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [48]
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Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
- Authors
- Pauleikhoff, D., Wojteki, S., Müller, D., Bornfeld, N., & Heiligenhaus, A.
- Affiliations
- St. Franziskus Hospital (DE)
- Essen University Hospital (DE)
- Venue
- Der Ophthalmologe
- Published
- 2000-04-18
- Volume
- 97
- Issue
- 4
- Pages
- 243-250
- ISSN
- 0941-293X (ISSN-L)
- 1433-0423
- OpenAlex
- W2041267856
- Cited by
- 26
- References
- 16
- Citations by year
- 2025: 1 · 2023: 1 · 2020: 1 · 2018: 1 · 2014: 2 · 2012: 2
- FWCI
- 0.38
- Type
- journal article
- Language
- de
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Der Ophthalmologe (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal and Macular Surgery
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- Bruch's membrane, adhesion molecules, laminin, fibronectin, type IV collagen, age-related macular degeneration, drusen, lipid deposits, choroidal neovascularization
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Basement Membrane, Child, Child, Preschool, Collagen, Fibronectins, Humans, Immunohistochemistry, Laminin, Macular Degeneration, Membrane Glycoproteins, Membrane Lipids, Middle Aged, Pigment Epithelium of Eye, Bruch Membrane
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