Inflammatory profile in subcutaneous and epicardial adipose tissue in men with and without diabetes
Abstract
In recent years, evidence has emerged indicating that insulin resistance and diabetes mellitus type 2 are associated with inflammation of adipose tissue (AT). Interest has been focused on epicardial AT (EAT) because of its possible involvement with atherosclerosis and cardiovascular diseases. The aim of this study was to characterize adipocyte size and inflammatory profile in subcutaneous (SAT) and EAT among subjects with or without diabetes. Biopsies were collected from SAT and EAT in 34 men undergoing elective cardiac surgery. Weight, height, body mass index, waist circumference, as well as serum levels of glucose, insulin, lipids, adiponectin, and leptin were determined in all subjects. Adiponectin, MCP-1, and CD68 mRNA levels present within cells from AT biopsies were determined by real-time polymerase chain reaction. Adipocyte size was determined by optic microscopy and morphometry. Regarding the experimental group as a whole, gene-expression levels within EAT were significantly lower for adiponectin and higher, albeit not significantly, for MCP-1, when compared with that of SAT. In addition, adipocytes in EAT were significantly smaller than those in SAT. Subjects with diabetes showed lower adiponectin gene-expression levels in both SAT and EAT when compared with subjects without diabetes. By contrast, MCP-1 and CD68 gene-expression levels were higher in both tissue types of diabetic subjects. Adipocyte size in EAT was significantly larger in diabetic subjects than in nondiabetic subjects. Our data revealed a predominantly inflammatory profile in both SAT and EAT in subjects with diabetes in comparison with those without diabetes.
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In diabetic subjects, EAT adipocyte size is significantly larger than in non-diabetic subjects, and both SAT and EAT have a predominantly inflammatory profile.
“In a bioptical study comparing SAT and EAT among subjects with or without diabetes, adipocyte size in EAT was significantly larger in diabetic than non-diabetic subjects, and both SAT and EAT were featured in diabetic group by a predominantly inflammatory profile [62].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [62]
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Epicardial Adipose Tissue and Cardiac Arrhythmias
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Epicardial adipose tissue, inflammation, fibrosis and coronary artery diseasesPreprint
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- Authors
- Bambace, C., Sepe, A., Zoico, E., Telesca, M., Olioso, D., Venturi, S., Rossi, A., Corzato, F., Faccioli, S., Cominacini, L., Santini, F., & Zamboni, M.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Bambace, Clara
- Venue
- Heart and Vessels
- Published
- 2013-01-08
- Volume
- 29
- Issue
- 1
- Pages
- 42-48
- ISSN
- 0910-8327 (ISSN-L)
- 1615-2573
- OpenAlex
- W2087513437
- Cited by
- 73
- References
- 32
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 7 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 3
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Heart and Vessels (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- epicardial adipose tissue, subcutaneous adipose tissue, type 2 diabetes, adipose tissue inflammation, adipocyte size, adiponectin, MCP-1, CD68, gene expression, insulin resistance, atherosclerosis, cardiovascular disease, men
- MeSH terms
- CD68 Molecule, Aged, Aged, 80 and over, Biopsy, Diabetes Mellitus, Gene Expression Regulation, Genetic Markers, Humans, Inflammation, Male, Middle Aged, Pericardium, Risk Factors, RNA, Messenger, Sex Factors, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Adipocytes, Inflammation Mediators, Chemokine CCL2, Cell Size, Subcutaneous Fat, Adiponectin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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