Increased Epicardial Adipose Tissue Thickness in Type 2 Diabetes Mellitus and Obesity
Open accessAbstract
BACKGROUND: Epicardial adipose tissue (EAT) is suggested to play an important role in the progression of metabolic syndrome. We aimed to establish a simple method to measure EAT and examine the differences in EAT thickness according to the presence of type 2 diabetes mellitus or obesity. METHODS: A total of 94 patients (42.6% type 2 diabetes mellitus, 53.2% obese, mean age 61±13) who underwent multidetector computed tomography were enrolled. Thickness of EAT was measured on the parasternal short and horizontal long axis view. Epicardial fat area (EFA) was measured at the level of left main coronary artery (LMCA). RESULTS: All EAT thicknesses were correlated with EFA at the LMCA level (r=0.235 to 0.613, all Ps<0.05), and EAT thickness in the left atrioventricular groove (LAVG) had the highest correlation coefficient (r=0.613). EFA, and EAT thicknesses in the LAVG and the left ventricular apex were higher in the group with type 2 diabetes mellitus than in the group without type 2 diabetes mellitus when adjusted only for body mass index. When adjusted only for type 2 diabetes mellitus, EFA, and EAT thicknesses in the LAVG and the right atrioventricular groove were higher in obese group than in nonobese group. CONCLUSION: In conclusion, EAT thickness can be easily measured and represent EFA. EAT thickness, especially in LAVG, was higher in groups with type 2 diabetes mellitus and obesity independently. These findings implicate that EAT thickness may be a useful indicator for type 2 diabetes mellitus and obesity.
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An enlarged EAT mass in T2DM is associated with obesity and metabolic syndrome and its components.
“Various studies indicate that an enlarged EAT mass in T2DM is associated with obesity and metabolic syndrome and its components [21,56].”
From Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes (2022) · cites this paper as [56]
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Liver–Spleen Ratio: Can It Be Used for the Prediction of Coronary Artery Disease?
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Retracted: Deep Learning for Quantification of Epicardial Fat from Non-Contrast CT
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RetractedAI-Driven segmentation and morphogeometric profiling of epicardial adipose tissue in type 2 diabetes
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Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage‐Related Mechanisms
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Is there a paradigm shift in preventing diabetic heart failure? A review of SGLT2 inhibitors
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EAT-Mamba: Epicardial Adipose Tissue Segmentation from Multi-modal Dixon MRI
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Can Cardiovascular Risk Be Simply Estimated in Nonalcoholic Fatty Liver Disease Patients?
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- Authors
- Song, D. K., Hong, Y. S., Lee, H., Oh, J.-Y., Sung, Y.-A., & Kim, Y.
- Affiliations
- Ewha Womans University (KR)
- Corresponding author
- Hong, Young Sun
- Venue
- Diabetes & Metabolism Journal
- Publisher
- Korean Diabetes Association
- Published
- 2015
- Volume
- 39
- Issue
- 5
- Pages
- 405
- ISSN
- 2233-6079 (ISSN-L)
- 2233-6087
- PMC
- PMC4641970
- OpenAlex
- W2109815357
- Cited by
- 80
- References
- 39
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 7 · 2023: 7 · 2022: 12 · 2021: 3 · 2020: 7 · 2019: 10 · 2018: 10 · 2017: 4 · 2016: 5
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Diabetes & Metabolism Journal (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- epicardial adipose tissue, type 2 diabetes, obesity, metabolic syndrome, coronary artery imaging
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