CoChat
Sign Up
Cited by 28Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAdrenal Hormones and Disorders

Endocrine function in children acutely following severe traumatic brain injury

Srinivas, Ravi, Brown, S. Danielle, Chang, Yue-Fang, Garcia-Fillion, Pamela, Adelson, P. David·2010·Child s Nervous System
DOI 10.1007/s00381-009-1038-9
Open this paper in CoChat — free account

Abstract

Purpose Despite the prevalence of frontal injury following traumatic brain injury (TBI) in adults and children with potentially concomitant hypothalamic and pituitary involvement, endocrine dysfunction acutely following TBI has not been well studied in children.Methods To study the acute pediatric endocrine response after severe TBI (Glasgow Coma Scale <or= 8), an endocrine panel, including cortisol, ACTH, TSH, T3, T4, free T4, GH, and prolactin levels, were obtained in 37 children (1-17 years) on the day of injury and post-injury days (PID) 3 and 7. Outcome was determined at 6-month follow-up using the Glasgow Outcome Score (GOS) extended modified for pediatric patients (GOS-E Peds) to compare "good" (GOS-E Peds 1-2) to "poor" (GOS-E Peds 3-5) outcomes.Results Our results showed that following severe TBI in children, cortisol was significantly elevated (24.46 +/- 13.41 microg/dL) on PID 1 along with ACTH but then returned to normal (10.14-19.92 microg/dL) by PID 3; 46% and 14% of children had a low cortisol and ACTH (<10.14 and <2, respectively) in the acute period.Conclusions In summary, the cortisol response to trauma and stress in the acute period following severe TBI in the majority of children was altered, though seemingly appropriate cortisol was abnormally low in a significant percentage of children. Further study as to the significance of these findings is needed, but this study provides preliminary insight into the potential impact of severe TBI on the acute response of the hypothalamic-pituitary axis in children.

Integrity signals

Registry

Crossref · 10.1007/s00381-009-1038-9

Cites

17 of 17 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In 37 children studied on the first, third, and seventh days after severe TBI, cortisol was elevated on day one, but 46% had a low cortisol on day three, suggestive of ACTH 'fatigue' due to persistent stress.

    “In 37 children studied on the first, third, and seventh days after severe TBI, cortisol was elevated on day one, but 46% had a low cortisol on day three, suggestive of ACTH “fatigue” due to persistent stress [33].”

    From Update of Endocrine Dysfunction following Pediatric Traumatic Brain Injury (2015) · cites this paper as [33]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Srinivas, R., Brown, S. D., Chang, Y.-F., Garcia-Fillion, P., & Adelson, P. D.
Affiliations
  • University of Pittsburgh Medical Center (US)
  • Phoenix Children's Hospital (US)
Corresponding author
Adelson, P. David
ORCID
Venue
Child s Nervous System
Publisher
Springer Science and Business Media LLC
Published
2009-11-24
Volume
26
Issue
5
Pages
647-653
ISSN
  • 0256-7040 (ISSN-L)
  • 1433-0350
DOI
10.1007/s00381-009-1038-9
OpenAlex
W1980217620
Cited by
28
References
17
Citations by year
2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 1
FWCI
1.06
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Child s Nervous System (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Public Health Service (R49 CCR323155)
  • National Institute of Neurological Disorders and Stroke (R01NS052478)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
traumatic brain injury, pediatric patients, endocrine dysfunction, hypothalamic-pituitary axis, cortisol, ACTH, hypothalamic-pituitary-adrenal axis, stress response, hypothalamic-pituitary dysfunction, Glasgow Outcome Scale
MeSH terms
Adolescent, Adrenocorticotropic Hormone, Brain Injuries, Child, Child, Preschool, Endocrine System, Female, Humans, Hydrocortisone, Infant, Male, Thyrotropin, Thyroxine, Triiodothyronine, Glasgow Coma Scale, Recovery of Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review