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Cited by 230Circadian rhythm and melatoninSleep and related disordersSleep and Work-Related Fatigue

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality

Howatson, Glyn, Bell, Phillip G., Tallent, Jamie, Middleton, Benita, McHugh, Malachy P., Ellis, Jason·2012·European Journal of Nutrition
DOI 10.1007/s00394-011-0263-7
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Abstract

Background Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans.Purpose The aim of our investigation was to ascertain whether ingestion of a tart cherry juice concentrate would increase the urinary melatonin levels in healthy adults and improve sleep quality.Methods In a randomised, double-blind, placebo-controlled, crossover design, 20 volunteers consumed either a placebo or tart cherry juice concentrate for 7 days. Measures of sleep quality recorded by actigraphy and subjective sleep questionnaires were completed. Sequential urine samples over 48 h were collected and urinary 6-sulfatoxymelatonin (major metabolite of melatonin) determined; cosinor analysis was used to determine melatonin circadian rhythm (mesor, acrophase and amplitude). In addition, total urinary melatonin content was determined over the sampled period. Trial differences were determined using a repeated measures ANOVA.Results Total melatonin content was significantly elevated (P < 0.05) in the cherry juice group, whilst no differences were shown between baseline and placebo trials. There were significant increases in time in bed, total sleep time and sleep efficiency total (P < 0.05) with cherry juice supplementation. Although there was no difference in timing of the melatonin circardian rhythm, there was a trend to a higher mesor and amplitude.Conclusions These data suggest that consumption of a tart cherry juice concentrate provides an increase in exogenous melatonin that is beneficial in improving sleep duration and quality in healthy men and women and might be of benefit in managing disturbed sleep.

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Crossref · 10.1007/s00394-011-0263-7

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27 of 27 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. Herxheimer A, Pertrie KJ (2002) Melatonin for the prevention of jet lag. Cochrane Database Syst Rev 9:11–24

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Metadata

Authors
Howatson, G., Bell, P. G., Tallent, J., Middleton, B., McHugh, M. P., & Ellis, J.
Affiliations
  • University of Johannesburg (ZA)
  • Northumbria University (GB)
  • University of Surrey (GB)
  • Lenox Hill Hospital (US)
Corresponding author
Howatson, Glyn
ORCID
Venue
European Journal of Nutrition
Publisher
Springer Science and Business Media LLC
Published
2011-10-30
Volume
51
Issue
8
Pages
909-916
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
DOI
10.1007/s00394-011-0263-7
OpenAlex
W2130083497
Cited by
230
References
27
Citations by year
2026: 15 · 2025: 23 · 2024: 19 · 2023: 22 · 2022: 21 · 2021: 22 · 2020: 22 · 2019: 19 · 2018: 19 · 2017: 6 · 2016: 7 · 2015: 17 · 2014: 11 · 2013: 7
FWCI
2.66
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • Open Research (University of Surrey) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
  • Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
  • Northumbria Research Link (Northumbria University) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
tart cherry juice, Montmorency cherry, sour cherry, melatonin, urinary 6-sulfatoxymelatonin, sleep quality, sleep duration, exogenous melatonin, dietary supplementation, sleep disorders
MeSH terms
Adolescent, Adult, Beverages, Double-Blind Method, Female, Fruit, Humans, Male, Melatonin, Surveys and Questionnaires, Sleep, Sleep Wake Disorders, Cross-Over Studies, Dietary Supplements, Prunus, Young Adult, Actigraphy

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