Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling

Kraft, Lisa; Erdenesukh, Tugs; Sauter, Martina; Tschöpe, Carsten; Klingel, Karin

doi:10.1007/s00395-019-0719-0

Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling

Coxsackieviruses of group B (CVB) are well-known causes of acute and chronic myocarditis. Chronic myocarditis can evolve into dilated cardiomyopathy (DCM) characterized by fibrosis and cardiac remodeling. Interleukin-1β (IL-1β) plays a decisive role in the induction of the inflammatory response a…