The DOI matches its Crossref record; 100 of the 101 references it cites were found in a registry or an index.
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
Open accessAbstract
Assessment of Alzheimer's disease (AD)-related neurofibrillary pathology requires a procedure that permits a sufficient differentiation between initial, intermediate, and late stages. The gradual deposition of a hyperphosphorylated tau protein within select neuronal types in specific nuclei or areas is central to the disease process. The staging of AD-related neurofibrillary pathology originally described in 1991 was performed on unconventionally thick sections (100 mum) using a modern silver technique and reflected the progress of the disease process based chiefly on the topographic expansion of the lesions. To better meet the demands of routine laboratories this procedure is revised here by adapting tissue selection and processing to the needs of paraffin-embedded sections (5-15 mum) and by introducing a robust immunoreaction (AT8) for hyperphosphorylated tau protein that can be processed on an automated basis. It is anticipated that this revised methodological protocol will enable a more uniform application of the staging procedure.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accumulation of Aβ plaques and NFTs follows distinct regional progressions across brain regions as AD advances.”
From National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach (2012) · cites this paper as [14]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“consistent with the stereotypical hierarchical accumulation of NFTs along neural networks20,21”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [21]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“They were categorized into the stage C of amyloid deposition and the stage VI of neurofibrillary degeneration, following the Braak's staging (13).”
From Microglia express ABI3 in the brains of Alzheimer's disease and Nasu-Hakola disease (2017) · cites this paper as [13]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“by definition, the primary visual cortex (V1 region) bears NFTs only in Braak NFT stage VI20,21”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“we rank ordered the five brain regions based on their known vulnerability to neurofibrillary degeneration20,21 (that is, EC > ITG > PFC > V2 > V1)”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [21]
The cited source says what the claim attributes to it.
In the citing paper
“the distinguishing feature between Braak NFT stages V and VI is not just the presence of NFTs in the primary visual (V1), motor and sensory cortical areas, but more severe neurofibrillary degeneration21 and atrophy throughout the cortical mantle51”
From Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer’s disease (2024) · cites this paper as [21]
In the citing paper
“A further pathological determinant is loss of neurons, which occurs predominantly in the cortex, the hippocampal formation, and the nucleus basalis of Meynert [2, 3, 18, 22, 25].”
From Transient intraneuronal Aβ rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice (2008) · cites this paper as [2]
In the citing paper
“We consider it to be an important clue that most brains from elderly human subjects show abnormalities that fall somewhere along particular continua of pathologic severity (60, 96-100).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [99]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Neuropathological stageing of Alzheimer-related changes.
Braak, H., & Braak, E. (1991) · Acta Neuropathologica · doi:10.1007/bf00308809 · Cited by 16,123
Self-citationNeurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668
Staging of alzheimer's disease-related neurofibrillary changes
Braak, H., & Braak, E. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00021-6 · Cited by 2,357
Self-citationFrequency of Stages of Alzheimer-Related Lesions in Different Age Categories
Braak, H., & Braak, E. (1997) · Neurobiology of Aging · doi:10.1016/s0197-4580(97)00056-0 · Cited by 1,656
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542
(1964) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1964.tb115841.x · Cited by 1,411
Arnold, S. E., Hyman, B. T., Flory, J., Damasio, A. R., & Van Hoesen, G. W. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.103 · Cited by 1,380
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease.
Delacourte, A., David, J. P., Sergeant, N., Buée, L., Wattez, A., Vermersch, P., Ghozali, F., Fallet-Bianco, C., Pasquier, F., Lebert, F., et al. (1999) · Neurology · doi:10.1212/wnl.52.6.1158 · Cited by 828
Bancher, C., Brunner, C., Lassmann, H., Budka, H., Jellinger, K., Wiche, G., Seitelberger, F., Grundke-Iqbal, I., Iqbal, K., & Wisniewski, H. M. (1989) · Brain Research · doi:10.1016/0006-8993(89)91396-6 · Cited by 818
Braak, F., Braak, H., & Mandelkow, E. (1994) · Acta Neuropathologica · doi:10.1007/bf00293315 · Cited by 769
Self-citation
Research works printed but not linked: 7
- Alzheimer A (1906) Über einen eigenartigen schweren Erkrankungsprozeß der Hirnrinde. Neurolog Centralbl 23:1129–1136
- Bielschowsky M (1902) Die Silberimprägnation der Axenzylinder. Neurol Centralb 13:579–584
- Bielschowsky M (1903) Die Silberimprägnation der Neurofibrillen. Neurol Centralb 21:997–1006
- Bielschowsky M (1904) Die Silberimprägnation der Neurofibrillen. Einige Bemerkungen zu der von mir angegebenen Methode und den von ihr gelieferten Bildern. J Psychol Neurol 3:169–189
- Bielschowsky M (1905) Die Darstellung der Axenzylinder peripherischer Nervenfasern und der Axenzylinder zentraler markhaltiger Nervenfasern. Ein Nachtrag zu der von mir angegebenen Imprägnationsmethode der Neurofibrillen. J Psychol Neurol 4:228–231
- Bielschowsky M (1909) Eine Modifikation meines Silberimprägnations-verfahrens zur Darstellung der Neurofibrillen. J Psychol Neurol 12:135–137
- Duyckaerts C, He Y, Seilhean D, Delaère P, Piette F, Braak H, Hauw JJ (1994) Diagnosis and staging of Alzheimer’s disease in a prospective study involving aged individuals. Neurobiol Aging 15(Suppl 1):140–141
Cited by
Sorted by citations
Items 901–1,000 of 1,028
The night’s watch: Exploring how sleep protects against neurodegeneration
Parhizkar, S., & Holtzman, D. M. (2025) · Neuron · doi:10.1016/j.neuron.2025.02.004 · Cited by 54
Absence of amyloid-beta in lenses of Alzheimer patients: A confocal Raman microspectroscopic study
Michael, R., Otto, C., Lenferink, A. T. M., Gelpí, E., Montenegro, G. A., Rosandić, J., Tresserra, F., Barraquer, R. I., & Vrensen, G. F. J. M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.11.016 · Cited by 48
Torpedo Formation and Purkinje Cell Loss: Modeling their Relationship in Cerebellar Disease
Louis, E. D., Kuo, S., Vonsattel, J., & Faust, P. L. (2014) · The Cerebellum · doi:10.1007/s12311-014-0556-5 · Cited by 46
Kerchner, G., Bernstein, J. D., Fenesy, M. C., Deutsch, G., Saranathan, M., Zeineh, M. M., & Rutt, B. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1915-13.2013 · Cited by 44
Li, H., Jia, X., Qi, Z., Fan, X., Ma, T., Ni, H., Li, C. R., & Li, K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00127 · Cited by 45
Uemura, M. T., Ihara, M., Maki, T., Nakagomi, T., Kaji, S., Uemura, K., Matsuyama, T., Kalaria, R. N., Kinoshita, A., & Takahashi, R. (2017) · Brain Pathology · doi:10.1111/bpa.12523 · Cited by 46
Mixed neuropathologies and associations with domain-specific cognitive decline
Brenowitz, W. D., Hubbard, R. A., Keene, C. D., Hawes, S. E., Longstreth, W. T., Woltjer, R. L., & Kukull, W. A. (2017) · Neurology · doi:10.1212/wnl.0000000000004567 · Cited by 49
Phospho-Tau Changes in the Human CA1 During Alzheimer’s Disease Progression
Regalado-Reyes, M., Furcila, D., Hernández, F., Ávila, J., DeFelipe, J., & León‐Espinosa, G. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181263 · Cited by 50
Multi-scale graph-based grading for Alzheimer’s disease prediction
Hett, K., Ta, V., Oğuz, İ., Manjón, J. V., & Pierrick Coupé, A. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101850 · Cited by 48
Abey, A. S., Davies, D., Goldsbury, C. S., Buckland, M. E., Valenzuela, M., & Duncan, T. (2020) · Brain Pathology · doi:10.1111/bpa.12893 · Cited by 46
Arbabyazd, L., Shen, K., Wang, Z., Hofmann‐Apitius, M., Ritter, P., McIntosh, A. R., Battaglia, D. A., & Jirsa, V. (2021) · eNeuro · doi:10.1523/eneuro.0475-20.2021 · Cited by 44
TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
Latimer, C. S., Stair, J. G., Hincks, J. C., Currey, H. N., Bird, T. D., Keene, C. D., Kraemer, B. C., & Liachko, N. F. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049323 · Cited by 50
Auditory Delta Event-Related Oscillatory Responses are Decreased in Alzheimer’s Disease
Yener, G., Güntekin, B., Örken, D. N., Tülay, E. E., Forta, H., & Başar, E. (2012) · Behavioural Neurology · doi:10.1155/2012/810173 · Cited by 46
Ceravolo, R., Borghetti, D., Kiferle, L., Tognoni, G., Giorgetti, A., Neglia, D., Sassi, N., Frosini, D., Rossi, C. A., Petrozzi, L., et al. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.01.010 · Cited by 46
Differences in cognitive impairment in primary age-related tauopathy versus Alzheimer disease
Besser, L. M., Mock, C., Teylan, M. A., Hassenstab, J., Kukull, W. A., & Crary, J. F. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly132 · Cited by 45
Kim, S. H., Lee, P., Oh, K. T., Byun, M. S., Yi, D., Lee, J. H., Kim, Y. K., Ye, B. S., Yun, M., Lee, D. Y., et al. (2021) · EJNMMI Research · doi:10.1186/s13550-021-00798-3 · Cited by 45
Frigerio, I., Bouwman, M. M. A., Noordermeer, R. T. G. M. M., Podobnik, E., Popovic, M. M., Timmermans, E., Rozemüller, A. J. M., van de Berg, W. D. J., & Jonkman, L. E. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01711-w · Cited by 43
Stereo-seq of the prefrontal cortex in aging and Alzheimer’s disease
Gong, Y., Haeri, M., Zhang, X., Li, Y., Liu, A., Wu, D., Zhang, Q., Jazwinski, S. M., Zhou, X., Wang, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54715-y · Cited by 52
Fernández-Echevarría, C., Díaz, M. L., Ferrer, I., Canerina‐Amaro, A., & Marín, R. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.07.079 · Cited by 44
Neuropathological subtypes of Alzheimer’s disease
Jellinger, K. A. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0889-9 · Cited by 45
Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.
Villar-Menéndez, I., Díaz-Sánchez, S., Blanch, M., Albasanz, J. L., Pereira-Veiga, T., Monje, A., Planchat, L. M., Ferrer, I., Martín, M., & Barrachina, M. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.12.013 · Cited by 44
Köhler, C. N., Dinekov, M., & Götz, J. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.010 · Cited by 45
Overk, C., Lu, P.-Y., Wang, Y.-T., Choi, J. W., Shaw, J. W., Thatcher, G. R. J., & Mufson, E. J. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.08.035 · Cited by 45
Cerebellar Pathology in Early Onset and Late Onset Essential Tremor
Kuo, S., Wang, J., Tate, W. J., Pan, M., Kelly, G. C., Gutierrez, J., Cortes, E. P., Vonsattel, J., Louis, E. D., & Faust, P. L. (2016) · The Cerebellum · doi:10.1007/s12311-016-0826-5 · Cited by 45
Gratuze, M., Khoury, N. B. E., Turgeon, A., Julien, C., Marcouiller, F., Morin, F., Whittington, R. A., Marette, A., Calon, F., & Planel, E. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.10.004 · Cited by 47
Neuronal sphingosine kinase 2 subcellular localization is altered in Alzheimer’s disease brain
Dominguez, G., Maddelein, M.-L., Pucelle, M., Nicaise, Y., Maurage, C.-A., Duyckaerts, C., Cuvillier, O., & Delisle, M.-B. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0527-z · Cited by 43
Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
Kang, S. S., Ahn, E. H., & Ye, K. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00494-7 · Cited by 46
Bengoa‐Vergniory, N., Velentza‐Almpani, E., Silva, A. M., Scott, C., Vargas‐Caballero, M., Sastre, M., Wade‐Martins, R., & Alegre‐Abarrategui, J. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01117-y · Cited by 48
Rasagiline effects on glucose metabolism, cognition, and tau in Alzheimer's dementia
Matthews, D. C., Ritter, A. R., Thomas, R. G., Andrews, R. D., Lukic, A. S., Revta, C., Kinney, J. W., Tousi, B., Leverenz, J. B., Fillit, H. M., et al. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12106 · Cited by 44
Comparative neuropathology in aging primates: A perspective
Freire‐Cobo, C., Edler, M. K., Varghese, M., Munger, E. L., Laffey, J., Raia, S., In, S. S., Wicinski, B. A., Medalla, M., Perez, S. E., et al. (2021) · American Journal of Primatology · doi:10.1002/ajp.23299 · Cited by 46
Young, C. B., Landau, S. M., Harrison, T. M., Poston, K. L., & Mormino, E. C. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118553 · Cited by 46
Delpech, J.-C., Pathak, D., Varghese, M., Kalavai, S. V., Hays, E. C., Hof, P. R., Johnson, W. E., Ikezu, S., Medalla, M., Luebke, J. I., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe8455 · Cited by 46
Neumann, P., Lenz, D. E., Streit, W. J., & Bechmann, I. (2022) · Glia · doi:10.1002/glia.24282 · Cited by 47
Logsdon, B. A., Perumal, T. M., Swarup, V., Wang, M., Funk, C. C., Gaiteri, C., Allen, M., Wang, X., Dammer, E. B., Srivastava, G. P., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/510420 · Cited by 46
Tok, S., Ahnaou, A., & Drinkenburg, W. H. I. M. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210397 · Cited by 45
Winslow, W., McDonough, I., Tallino, S., Decker, A., Vural, A. S., & Velázquez, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.720214 · Cited by 42
Kok, F. K., van Leerdam, S., & de Lange, E. C. M. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-210607 · Cited by 46
Pezzoli, S., Giorgio, J., Martersteck, A., Dobyns, L., Harrison, T. M., & Jagust, W. J. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13438 · Cited by 42
Tau follows principal axes of functional and structural brain organization in Alzheimer’s disease
Ottoy, J., Kang, M. S., Tan, J. X. M., Boone, L., de Wael, R. V., Park, B., Bezgin, G., Lussier, F. Z., Pascoal, T. A., Rahmouni, N., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49300-2 · Cited by 56
Current concepts and molecular pathology of neurodegenerative diseases
Forrest, S. L., & Kovács, G. G. (2024) · Pathology · doi:10.1016/j.pathol.2024.10.006 · Cited by 44
TDP ‐43 in amyotrophic lateral sclerosis – is it a prion disease?
Ludolph, A. C., & Brettschneider, J. (2015) · European Journal of Neurology · doi:10.1111/ene.12706 · Cited by 45
Yokota, O., Davidson, Y. S., Arai, T., Hasegawa, M., Akiyama, H., Ishizu, H., Terada, S., Sikkink, S. K., Pickering-Brown, S. M., & Mann, D. M. A. (2010) · Acta Neuropathologica · doi:10.1007/s00401-010-0731-9 · Cited by 44
Neuroinflammation in the dorsolateral prefrontal cortex in elderly chronic schizophrenia
López‐González, I., Pinacho, R., Vila, È., Escanilla, A., Ferrer, I., & Ramos, B. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.12.011 · Cited by 43
Kovács, G. G. (2019) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000664 · Cited by 45
The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ 42 and Alzheimer Amyloid Plaques
Dolfe, L., Tambaro, S., Tigro, H., del Campo, M., Hoozemans, J. J. M., Wiehager, B., Graff, C., Winblad, B. G., Ankarcrona, M., Kaldmäe, M., et al. (2018) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-170051 · Cited by 44
Gibbons, G. S., Kim, S., Robinson, J. L., Changolkar, L. N., Irwin, D. J., Shaw, L. M. J., Lee, V. M. ‐., & Trojanowski, J. Q. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0687-5 · Cited by 44
Targeting neurons in the gastrointestinal tract to treat Parkinson's disease
Hauser, R. A., Sutherland, D., Madrid, J. A., Rol, M. A., Frucht, S., Isaacson, S., Pagan, F., Maddux, B. N., Li, G., Tse, W., et al. (2019) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2019.06.001 · Cited by 44
Xia, Y., Sorrentino, Z. A., Kim, J. D., Strang, K. H., Riffe, C. J., & Giasson, B. I. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010178 · Cited by 48
Scott, M. R., Hampton, O. L., Buckley, R. F., Chhatwal, J. P., Hanseeuw, B. J., Jacobs, H. I. L., Properzi, M. J., Sanchez, J. S., Johnson, K. A., Sperling, R. A., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116991 · Cited by 46
Gamma subunit of complement component 8 is a neuroinflammation inhibitor
Kim, J., Afridi, R., Han, J., Jung, H., Kim, S.-C., Hwang, E. M., Shim, H. S., Ryu, H., Choe, Y., Hoe, H., et al. (2020) · Brain · doi:10.1093/brain/awaa425 · Cited by 45
Perspectives on ROCK2 as a Therapeutic Target for Alzheimer’s Disease
Weber, A. J., & Herskowitz, J. H. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.636017 · Cited by 42
Memory performance is related to amyloid and tau pathology in the hippocampus
Reitz, C., Honig, L. S., Vonsattel, J. P., Tang, M.-X., & Mayeux, R. P. (2009) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2008.154146 · Cited by 49
Transmembrane protein 97 is a potential synaptic amyloid beta receptor in human Alzheimer’s disease
Colom-Cadena, M., Toombs, J., Simzer, E., Holt, K., McGeachan, R., Tulloch, J., Jackson, R. J., Catterson, J. H., Spires-Jones, M. P., Rose, J., et al. (2024) · Acta Neuropathologica · doi:10.1007/s00401-023-02679-6 · Cited by 44
Suelves, N., Saleki, S., Ibrahim, T., Palomares, D., Moonen, S., Koper, M. J., Vrancx, C., Vadukul, D. M., Papadopoulos, N., Viceconte, N., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01578-x · Cited by 43
Neuropathology of the Alzheimer's continuum: an update
Jellinger, K. A. (2020) · Free Neuropathology · doi:10.17879/freeneuropathology-2020-3050 · Cited by 52
Samidurai, M., Palanisamy, B. N., Bargues-Carot, A., Hepker, M., Kondru, N. C., Manne, S., Zenitsky, G. D., Jin, H., Anantharam, V., Kanthasamy, A. G., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.661505 · Cited by 45
Morphological and Molecular Profiling of Amyloid-β Species in Alzheimer’s Pathogenesis
Almeida, Z. L., Vaz, D. C., & Brito, R. M. M. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04543-4 · Cited by 49
Miners, J. S., Moulding, H., de Silva, R., & Love, S. (2014) · Brain Pathology · doi:10.1111/bpa.12130 · Cited by 45
Elevated brain harmane (1-methyl-9H-pyrido[3,4-b]indole) in essential tremor cases vs. controls
Louis, E. D., Factor-Litvak, P. R., Liu, X., Vonsattel, J., Galecki, M., Jiang, W., & Zheng, W. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.07.002 · Cited by 43
Yamazaki, Y., Matsubara, T., Takahashi, T., Kurashige, T., Dohi, E., Hiji, M., Nagano, Y., Yamawaki, T., & Matsumoto, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026996 · Cited by 45
Comparison of olfactory and gustatory disorders in Alzheimer’s disease
Kouzuki, M., Suzuki, T., Nagano, M., Nakamura, S., Katsumata, Y., Takamura, A., & Urakami, K. (2017) · Neurological Sciences · doi:10.1007/s10072-017-3187-z · Cited by 44
Patel, T., Brookes, K. J., Turton, J. C., Chaudhury, S., Guetta‐Baranes, T., Guerreiro, R. J., Brás, J., Hernandez, D. G., Singleton, A., Francis, P. T., et al. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12452 · Cited by 46
Pontecorvo, M. J., Keene, C. D., Beach, T. G., Montine, T. J., Arora, A., Devous, M. D., Navitsky, M. A., Kennedy, I. A., Joshi, A. D., Lu, M., et al. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00653-x · Cited by 44
The combined effect of amyloid-β and tau biomarkers on brain atrophy in dementia with Lewy bodies
Ruiz, C. A., Ferreira, D., Oppedal, K., Cavallin, L., Bousiges, O., Wahlund, L., Hort, J., Nedelská, Z., Padovani, A., Pilotto, A., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102333 · Cited by 43
Evaluation of a visual interpretation method for tau‐PET with 18 F‐flortaucipir
Sonni, I., Lesman‐Segev, O. H., Baker, S. L., Iaccarino, L., Korman, D., Rabinovici, G. D., Jagust, W. J., Landau, S. M., Joie, R. L., & Initiative, A. D. N. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12133 · Cited by 45
Study, T. C. F. A. A., Bury, J. J., Chambers, A., Heath, P. R., Ince, P. G., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., & Wharton, S. B. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01109-y · Cited by 44
Pablo‐Fernández, E. D., Courtney, R. J., Rockliffe, A., Gentleman, S., Holton, J. L., & Warner, T. T. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12728 · Cited by 43
Quantifying regional α ‐synuclein, amyloid β, and tau accumulation in lewy body dementia
Miller, R. L., Dhavale, D. D., O’Shea, J. Y., Andruska, K. M., Liu, J., Franklin, E. E., Buddhala, C., Loftin, S. K., Cirrito, J. R., Perrin, R. J., et al. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51482 · Cited by 43
Cerebral correlates of psychotic syndromes in neurodegenerative diseases
Jellinger, K. A. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01311.x · Cited by 43
Personality traits distinguishing dementia with Lewy bodies from Alzheimer disease
Galvin, J., Malcom, H. M., Johnson, D. K., & Morris, J. (2007) · Neurology · doi:10.1212/01.wnl.0000263131.80945.ad · Cited by 41
Baker, S. L., & Götz, J. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0300-0 · Cited by 42
Zhong, G., Naismith, S. L., Rogers, N. L., & Lewis, S. J. G. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.04.020 · Cited by 39
Implication of type 4 NADPH oxidase (NOX4) in tauopathy
Luengo, E., Trigo-Alonso, P., Fernández‐Mendívil, C., Núñez, Á., del Campo, M., Porrero, C., García‐Magro, N., Negredo, P., Senar, S., Sánchez‐Ramos, C., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.redox.2021.102210 · Cited by 44
Leuzy, A., Binette, A. P., Vogel, J. W., Klein, G., Borroni, E., Tonietto, M., Strandberg, O. T., Mattsson, N., Palmqvist, S., Pontecorvo, M. J., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.1067 · Cited by 43
Plasma biomarkers for prediction of Alzheimer’s disease neuropathologic change
Bermudez, C. L., Graff‐Radford, J., Syrjanen, J. A., Stricker, N. H., Algeciras‐Schimnich, A., Kouri, N., Kremers, W. K., Petersen, R. C., Jack, C. R., Knopman, D. S., et al. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02594-w · Cited by 43
L-3-n-butylphthalide improves cognitive impairment of APP/PS1 mice by BDNF/TrkB/PI3K/AKT pathway.
Xiang, J., Pan, J., Chen, F., Zheng, L., Chen, Y., Zhang, S., & Feng, W. (2014) · Europe PMC (PubMed Central) · Cited by 42
Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer’s Disease Pathology
Rosenberger, A. F. N., Hilhorst, R., Coart, E., Barrado, L. G., Naji, F., Rozemüller, A. J. M., van der Flier, W. M., Scheltens, P., Hoozemans, J. J. M., & van der Vies, S. M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150429 · Cited by 44
Diagnostic value of MIBG cardiac scintigraphy for differential dementia diagnosis
Slaets, S., Acker, F. V., Versijpt, J. J., Hauth, L., Goeman, J., Martin, J., Deyn, P. P. D., & Engelborghs, S. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4229 · Cited by 42
Armstrong, R., Kotzbauer, P. T., Perlmutter, J., Campbell, M. C., Hurth, K., Schmidt, R., & Cairns, N. (2013) · Journal of neural transmission · doi:10.1007/s00702-013-1084-z · Cited by 44
Decreased Reelin Expression in the Left Prefrontal Cortex (BA9) in Chronic Schizophrenia Patients
Habl, G., Schmitt, A., Zink, M., von Wilmsdorff, M., Yeganeh-Doost, P., Jatzko, A., Schneider-Axmann, T., Bauer, M., & Falkai, P. (2012) · Neuropsychobiology · doi:10.1159/000337129 · Cited by 42
Bastard, N. L., Aerts, L., Sleegers, K., Martin, J., Broeckhoven, C. V., Deyn, P. P. D., & Engelborghs, S. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-110029 · Cited by 41
Effects of (−)Epicatechin on the Pathology of APP/PS1 Transgenic Mice
Yue-Qin, Z., Wang, Y., & Zhou, X. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00069 · Cited by 43
Tang, W., Tam, J. H. K., Seah, C., Chiu, J., Tyrer, A. E., Cregan, S. P., Meakin, S. O., & Pasternak, S. (2015) · Molecular Brain · doi:10.1186/s13041-015-0129-7 · Cited by 42
Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice
Khoury, N. B. E., Gratuze, M., Petry, F. R., Papon, M.-A., Julien, C., Marcouiller, F., Morin, F., Nicholls, S. B., Calon, F., Hébert, S. S., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.005 · Cited by 42
Initiative, A. D. N., Luo, X., Jiaerken, Y., Huang, P., Xu, X. J., Qiu, T., Jia, Y., Shen, Z., Guan, X., Zhou, J., et al. (2017) · Brain Imaging and Behavior · doi:10.1007/s11682-017-9680-4 · Cited by 42
de la Torre, A. V., Gay, M., Vilaprinyó-Pascual, S., Mazzucato, R., Serra-Batiste, M., Vilaseca, M., & Carulla, N. (2018) · Analytical Chemistry · doi:10.1021/acs.analchem.7b04936 · Cited by 42
Timmers, M., Tesseur, I. C., Bogert, J., Zetterberg, H., Blennow, K., Börjesson‐Hanson, A., Baquero, M., Boada, M., RANDOLPH, C. C., Tritsmans, L., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.03.016 · Cited by 43
Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions
Wisse, L. E. M., Ravikumar, S., Ittyerah, R., Lim, S., Lane, J., Bedard, M. L., Xie, L., Das, S. R., Schuck, T., Grossman, M., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01225-3 · Cited by 43
Urdánoz‐Casado, A., de Gordoa, J. S., Robles, M., Acha, B., Roldán, M., Zelaya, M. V., Blanco‐Luquin, I., & Mendióroz, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179205 · Cited by 42
Associating Alzheimer’s disease pathology with its cerebrospinal fluid biomarkers
Bridel, C., Somers, C., Sieben, A., Rozemüller, A. J. M., Niemantsverdriet, E., Struyfs, H., Vermeiren, Y., Broeckhoven, C. V., Deyn, P. P. D., Bjerke, M., et al. (2022) · Brain · doi:10.1093/brain/awac013 · Cited by 39
Rodríguez, J. L., Oltmer, J., Greve, D. N., Williams, E. M., Slepneva, N., Wang, R., Champion, S., Lang-Orsini, M., Fischl, B. R., Frosch, M. P., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215567 · Cited by 44
Biomarker A+T−: is this Alzheimer’s disease or not? A combined CSF and pathology study
Vromen, E. M., de Boer, S. C. M., Teunissen, C. E., Rozemüller, A. J. M., Sieben, A., Bjerke, M., Initiative, A. D. N., Visser, P. J., Bouwman, F. H., Engelborghs, S., et al. (2022) · Brain · doi:10.1093/brain/awac158 · Cited by 45
Thal, D. R., Ronisz, A., Tousseyn, T., Upadhaya, A. R., Balakrishnan, K., Vandenberghe, R. R., Vandenbulcke, M., Arnim, C. A. F. V., Otto, M., Beach, T. G., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0837-9 · Cited by 44
Li, Y., Grupe, A., Rowland, C. M., Holmans, P., Segurado, R., Abraham, R., Jones, L., Catanese, J. J., Ross, D. A., Mayo, K., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm348 · Cited by 43
Terni, B., Rey, M. J., Boluda, S., Torrejón-Escribano, B., Sabate, M. P., Calopa, M., van Leeuwen, F. W., & Ferrer, I. (2007) · Acta Neuropathologica · doi:10.1007/s00401-006-0192-3 · Cited by 42
The Prion-Like Behavior of Assembled Tau in Transgenic MicePreprint
Clavaguera, F., Tolnay, M., & Goedert, M. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a024372 · Cited by 45
Network Diffusion Modeling Explains Longitudinal Tau PET Data
Schäfer, A., Mormino, E. C., & Ellen Kuhl, A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.566876 · Cited by 42
Neurophysiological and Brain Structural Markers of Cognitive Frailty Differ from Alzheimer's Disease
Kocagöncü, E., Nesbitt, D., Emery, T., Hughes, L. E., Henson, R. N., Cam-CAN, & Rowe, J. B. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0697-21.2021 · Cited by 45
Nakaya, M., Sato, N., Matsuda, H., Maikusa, N., Shigemoto, Y., Sone, D., Yamao, T., Ogawa, M., Kimura, Y., Chiba, E., et al. (2022) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1002/trc2.12356 · Cited by 41
The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease
Chiariello, A., Valente, S., Pasquinelli, G., Baracca, A., Sgarbi, G., Solaini, G., Medici, V., Fantini, V., Poloni, T. E., Tognocchi, M., et al. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1058665 · Cited by 40
Metadata
- Authors
- Braak, H., Alafuzoff, I., Arzberger, T., Kretzschmar, H., & Del Tredici, K.
- Affiliations
- Goethe University Frankfurt (DE)
- Kuopio University Hospital (FI)
- Institut für Neuropathologie (DE)
- Corresponding author
- Braak, Heiko
- Venue
- Acta Neuropathologica
- Published
- 2006-08-12
- Volume
- 112
- Issue
- 4
- Pages
- 389-404
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC3906709
- OpenAlex
- W2093650784
- Cited by
- 3,172
- References
- 101
- Citations by year
- 2026: 218 · 2025: 259 · 2024: 334 · 2023: 254 · 2022: 251 · 2021: 261 · 2020: 228 · 2019: 205 · 2018: 157 · 2017: 135 · 2016: 140 · 2015: 118 · 2014: 134 · 2013: 95 · 2012: 77
- FWCI
- 34.69
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Acta Neuropathologica (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission (LSHM-CT-2004-503039)
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, neurofibrillary pathology, disease staging, AT8 antibody, immunocytochemistry, paraffin sections, silver staining
- MeSH terms
- Alzheimer Disease, Humans, Immunohistochemistry, Amyloid beta-Peptides, Paraffin Embedding, Tissue Fixation, Neurofibrillary Tangles, tau Proteins, Disease Progression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
