The pathological process underlying Alzheimer’s disease in individuals under thirty
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- Pathology of the Aging Brain in Domestic and Laboratory Animals, and Animal Models of Human Neurodegenerative DiseasesSameh A. Youssef, Maria Tresa Capucchio, Jaime Rofina, James Kenn CHAMBERS, Kazuyuki Uchida, Hiroyuki Nakayama, Elizabeth Head · 2016 · Veterinary Pathology
- Frontotemporal Dementia: Implications for Understanding Alzheimer DiseaseMichel Goedert, Bernardino Francesco Ghetti, M. G. Spillantini · 2011 · Cold Spring Harbor Perspectives in Medicine
- Neuromelanin, aging, and neuronal vulnerability in Parkinson's diseaseMiquel Vila · 2019 · Movement Disorders
- Prion-like Mechanisms in the Pathogenesis of Tauopathies and SynucleinopathiesMichel Goedert, Ben Falcon, Florence Clavaguera, Markus Tolnay · 2014 · Current Neurology and Neuroscience Reports
- Ushering in the study and treatment of preclinical Alzheimer diseaseJessica B. S. Langbaum, Adam Fleisher, Kewei Chen, Napatkamon Ayutyanont, Francisco Javier Lopera, Yakeel T. Quiroz, Richard J. Caselli, Pierre N. Tariot, Eric M. Reiman · 2013 · Nature Reviews Neurology
- Targeting norepinephrine in mild cognitive impairment and Alzheimer's diseaseTermpanit Chalermpalanupap, Becky L. Kinkead, William T. Hu, Markus P. Kummer, Thea Hammerschmidt, Michael Thomas Heneka, David Weinshenker, Allan I. Levey · 2013 · Alzheimer s Research & Therapy
- Hallmarks of Alzheimer disease are evolving relentlessly in Metropolitan Mexico City infants, children and young adults. APOE4 carriers have higher suicide risk and higher odds of reaching NFT stage V at ≤ 40 years of ageLilian Calderón‐Garcidueñas, Angélica González-Maciel, Rafael Reynoso-Robles, Ricardo Delgado‐Chávez, Partha S. Mukherjee, Randy Joseph Kulesza, Ricardo Torres‐Jardón, José Ávila-Ramírez, Rodolfo Villarreal-Ríos · 2018 · Environmental Research
- Cell-to-Cell Transmission of Tau and α-SynucleinUemura, Norihito, Uemura, Maiko T., Luk, Kelvin C., Lee, Virginia M.-Y., Trojanowski, John Q. · 2020 · Trends in Molecular Medicine
- Dystrophic microglia in late‐onset Alzheimer's diseaseStreit, Wolfgang J., Khoshbouei, Habibeh, Bechmann, Ingo · 2020 · Glia
- Meta-Review of CSF Core Biomarkers in Alzheimer’s Disease: The State-of-the-Art after the New Revised Diagnostic CriteriaDaniel Ferreira, Lilisbeth Perestelo‐Pérez, Eric Westman, Lars‐Olof Wahlund, Antonio Sarría‐Santamera, Pedro Serrano‐Aguilar · 2014 · Frontiers in Aging Neuroscience
- The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndromeYvonne S. Davidson, Andrew Robinson, V. P. Prasher, David M. A. Mann · 2018 · Acta Neuropathologica Communications
- Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathologyLong Niu, Feng Zhang, Xiaojiao Xu, Yuting Yang, Song Li, Hui Liu, Weidong Le · 2021 · Brain Pathology
- Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluidHeiko Braak, Henrik Zetterberg, Kelly Del Tredici, Kaj Blennow · 2013 · Acta Neuropathologica
- Contemplating Alzheimer’s Disease and the Contribution of White Matter HyperintensitiesAdam M. Brickman · 2013 · Current Neurology and Neuroscience Reports
- Intercellular Spread of Protein Aggregates in Neurodegenerative DiseaseDavis, Albert A., Leyns, Cheryl E.G., Holtzman, David M. · 2018 · Annual Review of Cell and Developmental Biology
- Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjectsToledo, Jon B., Zetterberg, Henrik, van Harten, Argonde C., Glodzik, Lidia, Martinez-Lage, Pablo, Bocchio-Chiavetto, Luisella, Rami, Lorena, Hansson, Oskar, Sperling, Reisa, Engelborghs, Sebastiaan et al. · 2015 · Brain
- Human P301L-Mutant Tau Expression in Mouse Entorhinal-Hippocampal Network Causes Tau Aggregation and Presynaptic Pathology but No Cognitive DeficitsJulie A. Harris, Akihiko Koyama, Sumihiro Maeda, Kaitlyn Ho, Nino Devidze, Dena B. Dubal, Gui-Qiu Yu, Eliezer Masliah, Lennart Mucke · 2012 · PLoS ONE
- Locus Coeruleus Ablation Exacerbates Cognitive Deficits, Neuropathology, and Lethality in P301S Tau Transgenic MiceChalermpalanupap, Termpanit, Schroeder, Jason P., Rorabaugh, Jacki M., Liles, L. Cameron, Lah, James J., Levey, Allan I., Weinshenker, David · 2018 · The Journal of Neuroscience
- Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging schemeMichael Louis Alosco, Jonathan D. Cherry, Bertrand R. Huber, Yorghos Tripodis, Zachary Baucom, Neil W. Kowall, Nicole A. Saltiel, Lee E. Goldstein, Douglas I. Katz, Brigid C. Dwyer et al. · 2020 · Acta Neuropathologica
- Therapeutic strategies for tau mediated neurodegenerationYasumasa Yoshiyama, Virginia M.‐Y. Lee, John Q. Trojanowski · 2012 · Journal of Neurology Neurosurgery & Psychiatry
- Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's DiseasesHeiko Braak, Kelly Del Tredici · 2016 · Cold Spring Harbor Perspectives in Biology
- Cardiovascular risk factors, cortisol, and amyloid‐β deposition in Alzheimer's Disease Neuroimaging InitiativeJon B. Toledo, Estefanía Toledo, Michael Walter Weiner, Clifford R. Jack, William Jagust, Virginia M.‐Y. Lee, Leslie M. J. Shaw, John Q. Trojanowski · 2012 · Alzheimer s & Dementia
- “Prion‐Like” Templated Misfolding in TauopathiesFlorence Clavaguera, Isabelle Lavenir, Ben Falcon, Stephan Frank, Michel Goedert, Markus Tolnay · 2013 · Brain Pathology
- Hyperphosphorylation determines both the spread and the morphology of tau pathologyWen Hui Hu, Xinhua Zhang, Yunn Chyn Tung, Shu-Tao Xie, Fei Liu, Khalid Iqbal · 2016 · Alzheimer s & Dementia
- Interaction between pathogenic proteins in neurodegenerative disordersK. A. Jellinger · 2011 · Journal of Cellular and Molecular Medicine
- Aluminum’s Involvement in the Progression of Alzheimer’s DiseaseJudie R. Walton · 2013 · Journal of Alzheimer s Disease
- Imaging in-vivo tau pathology in Alzheimer’s disease with THK5317 PET in a multimodal paradigmKonstantinos Chiotis, Laure Saint‐Aubert, Irina Savitcheva, Vesna Jelić, Pia Andersen, My Jonasson, Jonas Eriksson, Mark Lubberink, Ove Almkvist, Anders E. Wall et al. · 2016 · European Journal of Nuclear Medicine and Molecular Imaging
- Early Alzheimer’s and Parkinson’s Disease Pathology in Urban Children: Friend versus Foe Responses—It Is Time to Face the EvidenceLilian Calderón‐Garcidueñas, Maricela Franco-Lira, Antonieta Mora-Tiscareño, Humberto Medina‐Cortina, Ricardo Torres‐Jardón, Michael Kavanaugh · 2013 · BioMed Research International
- White Matter Hyperintensities, Systemic Inflammation, Brain Growth, and Cognitive Functions in Children Exposed to Air PollutionLilian Calderón‐Garcidueñas, Antonieta Mora-Tiscareño, Martin Andreas Styner, Gilberto Gómez-Garza, Hongtu Zhu B, Ricardo Torres‐Jardón, Esperanza Carlos, Edelmira Solorio, Humberto Medina‐Cortina, Michael Kavanaugh et al. · 2012 · Journal of Alzheimer s Disease
- Rates of β-amyloid accumulation are independent of hippocampal neurodegenerationClifford R. Jack, Heather J. Wiste, David S. Knopman, Prashanthi Vemuri, Michelle M. Mielke, Stephen D. Weigand, Matthew L. Senjem, Jeffrey L. Gunter, Val J. Lowe, Brian E. Gregg et al. · 2014 · Neurology
- Stages of granulovacuolar degeneration: their relation to Alzheimer’s disease and chronic stress responseDietmar Rudolf Thal, Kelly Del Tredici, Albert Christian Ludolph, Jeroen J.M. Hoozemans, Annemieke J.M. Rozemüller, Heiko Braak, Uwe Knippschild · 2011 · Acta Neuropathologica
- Chronic Aluminum Intake Causes Alzheimer's Disease: Applying Sir Austin Bradford Hill's Causality CriteriaJudie R. Walton · 2014 · Journal of Alzheimer s Disease
- Basal forebrain atrophy correlates with amyloid β burden in Alzheimer's diseaseGeorg M. Kerbler, Jürgen Fripp, Christopher Cleon Rowe, Victor L. Villemagne, Olivier Salvado, Stephen Rose, Elizabeth Jane Coulson · 2014 · NeuroImage Clinical
- A single ultrasensitive assay for detection and discrimination of tau aggregates of Alzheimer and Pick diseasesMichael A. Metrick, Natalia Ferreira, Eri Saijo, Allison Kraus, Kathy L. Newell, Gianluigi Zanusso, Michele Vendruscolo, Bernardino Francesco Ghetti, Byron W. Caughey · 2020 · Acta Neuropathologica Communications
- Genome instability in Alzheimer diseaseHou, Yujun, Song, Hyundong, Croteau, Deborah L., Akbari, Mansour, Bohr, Vilhelm A. · 2017 · Mechanisms of Ageing and Development
- Aβ-induced acceleration of Alzheimer-related τ-pathology spreading and its association with prion proteinGomes, Luis Aragão, Hipp, Silvia Andrea, Rijal Upadhaya, Ajeet, Balakrishnan, Karthikeyan, Ospitalieri, Simona, Koper, Marta J., Largo-Barrientos, Pablo, Uytterhoeven, Valerie, Reichwald, Julia, Rabe, Sabine et al. · 2019 · Acta Neuropathologica
- The Locus Coeruleus in Aging and Alzheimer’s Disease: A Postmortem and Brain Imaging ReviewRebecca Beardmore, Ruihua H. Hou, Angela Darekar, Clive Holmes, Delphine Boche · 2021 · Journal of Alzheimer s Disease
- Neurons in Vulnerable Regions of the Alzheimer’s Disease Brain Display Reduced ATM SignalingXuting Shen, Jianmin Chen, Jiali Li, Julia Kofler, Karl Herrup · 2016 · eNeuro
- Pathogenesis of the TauopathiesMichel Goedert, Maria Grazia Spillantini · 2011 · Journal of Molecular Neuroscience
- Alzheimer diseaseJustin M. Nussbaum, Matthew E. Seward, George S. Bloom · 2013 · Prion
- Alzheimer diseaseAna Laura Calderón‐Garcidueñas, Charles J. Duyckaerts · 2017 · Handbook of clinical neurology
- Potential Contribution of Exosomes to the Prion-Like Propagation of Lesions in Alzheimer’s DiseaseVingtdeux, Valérie, Sergeant, Nicolas, Buée, Luc · 2012 · Frontiers in Physiology
- Progress and Developments in Tau Aggregation Inhibitors for Alzheimer DiseaseBruno Bulic, Marcus Pickhardt, Eckhard Mandelkow� · 2013 · Journal of Medicinal Chemistry
- Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer’s diseaseSyed Faraz Kazim, Khalid Iqbal · 2016 · Molecular Neurodegeneration
- Synaptic tau: A pathological or physiological phenomenon?Miranda Robbins, Emma L. Clayton, Gabriele S. Kaminski Schierle · 2021 · Acta Neuropathologica Communications
- Altered sleep and EEG power in the P301S Tau transgenic mouse modelJerrah K. Holth, Thomas E. Mahan, Grace O. Robinson, Andréia Silva da Rocha, David M. Holtzman · 2017 · Annals of Clinical and Translational Neurology
- Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer’s Disease PathogenesisPanos Theofilas, Sara Rose Dunlop, Helmut Heinsen, Lea T. Grinberg · 2015 · Journal of Alzheimer s Disease
- Selective Loss of Noradrenaline Exacerbates Early Cognitive Dysfunction and Synaptic Deficits in APP/PS1 MiceThea Hammerschmidt, Markus P. Kummer, Dick Terwel, Ana Martinez, Ali Gorji, Hans‐Christian Pape, Karen S. Rommelfanger, Jason P. Schroeder, Monika Stoll, Joachim Ludwig Schultze et al. · 2012 · Biological Psychiatry
- The therapeutics of Alzheimer's disease: Where we stand and where we are headingDennis J. Selkoe · 2013 · Annals of Neurology
- Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer’s diseaseKontsekova, Eva, Zilka, Norbert, Kovacech, Branislav, Skrabana, Rostislav, Novak, Michal · 2014 · Alzheimer's Research & Therapy
- DNA methylation signature of human hippocampus in Alzheimer’s disease is linked to neurogenesisMiren Altuna, Amaya Urdánoz‐Casado, Javier Sánchez‐Ruiz de Gordoa, María Victoria Zelaya, Alberto Labarga, Julie M. J. Lepesant, Miren Roldán, Idoia Blanco‐Luquin, Álvaro Perdones-Montero, R Larumbe et al. · 2019 · Clinical Epigenetics
- Alzheimer's disease and alpha-synuclein pathology in the olfactory bulbs of infants, children, teens and adults ≤ 40 years in Metropolitan Mexico City. APOE4 carriers at higher risk of suicide accelerate their olfactory bulb pathologyCalderón-Garcidueñas, Lilian, González-Maciel, Angélica, Reynoso-Robles, Rafael, Kulesza, Randy J., Mukherjee, Partha S., Torres-Jardón, Ricardo, Rönkkö, Topi, Doty, Richard L. · 2018 · Environmental Research
- Dura mater is a potential source of Aβ seedsGábor Géza Kovács, Mirjam I. Lutz, Gerda Ricken, Thomas Ströbel, Romana Höftberger, Matthias Preusser, Günther Regelsberger, Selma Hönigschnabl, Angelika Reiner, Peter A. Fischer et al. · 2016 · Acta Neuropathologica
- Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficitsAndrew M. Ward, Elizabeth C. Mormino, Willem Huijbers, Aaron P. Schultz, Trey Hedden, Reisa Anne Sperling · 2014 · Neurobiology of Aging
- Longitudinal changes of tau PET imaging in relation to hypometabolism in prodromal and Alzheimer’s disease dementiaKonstantinos Chiotis, Laure Saint‐Aubert, Elena Rodriguez‐Vieitez, Antoine Leuzy, Ove Almkvist, Irina Savitcheva, My Jonasson, Mark Lubberink, A. Wall, Gunnar Antoni et al. · 2017 · Molecular Psychiatry
- Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease PathophysiologyGordon, Brian A., Blazey, Tyler, Su, Yi, Fagan, Anne M., Holtzman, David M., Morris, John C., Benzinger, Tammie L. S. · 2016 · JAMA Neurology
- Effects of ketone bodies in Alzheimer's disease in relation to neural hypometabolism, β‐amyloid toxicity, and astrocyte functionLeif Hertz, Ye Chen, Helle S. Waagepetersen · 2015 · Journal of Neurochemistry
- A critical review of chronic traumatic encephalopathyIverson, Grant L., Gardner, Andrew J., McCrory, Paul, Zafonte, Ross, Castellani, Rudy J. · 2015 · Neuroscience & Biobehavioral Reviews
- Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesisLi, Hongmei, Liu, Chia-Chen, Zheng, Hui, Huang, Timothy Y. · 2018 · Translational Neurodegeneration
- Alzheimer’s disease pathology: pathways between central norepinephrine activity, memory, and neuropsychiatric symptomsHeidi I.L. Jacobs, Joost M. Riphagen, Inez H.G.B. Ramakers, Frans R.J. Verhey · 2019 · Molecular Psychiatry
- Pathological Changes of Tau Related to Alzheimer’s DiseaseDandan Chu, Fei Liu · 2018 · ACS Chemical Neuroscience
- Characteristics of Tau and Its Ligands in PET ImagingRyuichi Harada, Nobuyuki Okamura, Shozo Furumoto, Tetsuro Tago, Kazuhiko Yanai, Hiroyuki Arai, Yukitsuka Kudo · 2016 · Biomolecules
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- Immunotherapy for Alzheimer's diseaseThomas Wısnıewskı, Fernando Goñi · 2014 · Biochemical Pharmacology
- Structural MR Imaging in the Diagnosis of Alzheimer's Disease and Other Neurodegenerative Dementia: Current Imaging Approach and Future PerspectivesMina Park, Won‐Jin Moon · 2016 · Korean Journal of Radiology
- Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD miceDai, Chun-ling, Hu, Wen, Tung, Yunn Chyn, Liu, Fei, Gong, Cheng-Xin, Iqbal, Khalid · 2018 · Alzheimer's Research & Therapy
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- Are cases with tau pathology occurring in the absence of Aβ deposits part of the AD-related pathological process?Heiko Braak, Kelly Del Tredici · 2014 · Acta Neuropathologica
- Multimodal Brain Imaging Reveals Structural Differences in Alzheimer’s Disease Polygenic Risk Carriers: A Study in Healthy Young AdultsSonya F. Foley, Katherine E. Tansey, Xavier Caseras, Thomas Matthew Lancaster, Tobias Bracht, Greg D. Parker, Jérémy Hall, Julie H. Williams, David E.J. Linden · 2016 · Biological Psychiatry
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- Microglial activation occurs late during preclinical Alzheimer's diseaseStreit, Wolfgang J., Braak, Heiko, Del Tredici, Kelly, Leyh, Judith, Lier, Julia, Khoshbouei, Habibeh, Eisenlöffel, Christian, Müller, Wolf, Bechmann, Ingo · 2018 · Glia
- Quadruple abnormal protein aggregates in brainstem pathology and exogenous metal-rich magnetic nanoparticles (and engineered Ti-rich nanorods). The substantia nigrae is a very early target in young urbanites and the gastrointestinal tract a key brainstem portalLilian Calderón‐Garcidueñas, Angélica González-Maciel, Rafael Reynoso-Robles, Jessica Hammond, Randy Joseph Kulesza, Ingolf Lachmann, Ricardo Torres‐Jardón, Partha S. Mukherjee, Barbara A. Maher · 2020 · Environmental Research
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- Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air PollutionLilian Calderón‐Garcidueñas, Antonieta Mora-Tiscareño, Maricela Franco-Lira, Hongtu Zhu B, Zhaohua Lu, Edelmira Solorio, Ricardo Torres‐Jardón, Amedeo D’Angiulli · 2015 · Journal of Alzheimer s Disease
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- Air pollution and detrimental effects on children’s brain. The need for a multidisciplinary approach to the issue complexity and challengesLilian Calderón‐Garcidueñas, Ricardo Torres‐Jardón, Randy Joseph Kulesza, Subin Park, Amedeo Dâ€TMAngiulli · 2014 · Frontiers in Human Neuroscience
- Trimeric Tau Is Toxic to Human Neuronal Cells at Low Nanomolar ConcentrationsTian, Huilai, Davidowitz, Eliot, Lopez, Patricia, Emadi, Sharareh, Moe, James, Sierks, Michael · 2013 · International Journal of Cell Biology
- Structural networks in Alzheimer's diseaseAndrew Reid, Alan Charles Evans · 2013 · European Neuropsychopharmacology
- Bidirectional links between Alzheimer's disease and Niemann–Pick type C diseaseMartina Malnar, Silva Katusic Hecimovic, Niklas Mattsson, Henrik Zetterberg · 2014 · Neurobiology of Disease
- Bacillus Calmette-Guérin (BCG) therapy lowers the incidence of Alzheimer’s disease in bladder cancer patientsOfer Nathan Gofrit, Benjamin Klein, Irun R. Cohen, Tamir Ben‐Hur, Charles L. Greenblatt, Hervé Bercovier · 2019 · PLoS ONE
- Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads AheadNovak, Petr, Kontsekova, Eva, Zilka, Norbert, Novak, Michal · 2018 · Frontiers in Neuroscience
- The central role of tau in Alzheimer’s disease: From neurofibrillary tangle maturation to the induction of cell deathDietmar Rudolf Thal, Sandra O. Tomé · 2022 · Brain Research Bulletin
- Alzheimer disease starts in childhood in polluted Metropolitan Mexico City. A major health crisis in progressLilian Calderón‐Garcidueñas, Ricardo Torres‐Jardón, Randy Joseph Kulesza, Yusra Mansour, Luis Oscar González‐González, Angélica González-Maciel, Rafael Reynoso-Robles, Partha S. Mukherjee · 2020 · Environmental Research
- Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer’s diseaseSaul, Anika, Sprenger, Frederik, Bayer, Thomas A., Wirths, Oliver · 2013 · Neurobiology of Aging
- Tauopathies: Deciphering Disease Mechanisms to Develop Effective TherapiesM. Catarina Silva, Stephen J. Haggarty · 2020 · International Journal of Molecular Sciences
- Pharmacogenomics of Alzheimer’s Disease: Novel Therapeutic Strategies for Drug DevelopmentRamón Cacabelos, Pablo Cacabelos, Clara Torrellas, Iván Tellado, Juan C. Carril · 2014 · Methods in molecular biology
- Recent Progress in Alzheimer’s Disease Research, Part 1: PathologyFrancis T. Hane, Brenda Yasie Lee, Zoya Leonenko · 2017 · Journal of Alzheimer s Disease
- Tau prion-like propagation: state of the art and current challengesDujardin, Simon, Hyman, Bradley T. · 2019 · Advances in Experimental Medicine and Biology
- Neuropathological assessment of the Alzheimer spectrumK. A. Jellinger · 2020 · Journal of Neural Transmission
- The Evolving Dialogue of Microglia and Neurons in Alzheimer’s Disease: Microglia as Necessary Transducers of PathologySimon, E., Obst, J., Gomez-Nicola, D. · 2019 · Neuroscience
- Measurement of Tau Filament Fragmentation Provides Insights into Prion-like SpreadingFranziska Kundel, Liu Hong, Benjamin Falcon, William A. McEwan, Thomas C. T. Michaels, Georg Meisl, Noemí Esteras, Andrey Y. Abramov, Tuomas P. J. Knowles, Michel Goedert et al. · 2018 · ACS Chemical Neuroscience