CoChat
Sign Up
Cited by 149

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Cell-to-Cell Transmission of Tau and α-Synuclein

Uemura, Norihito, Uemura, Maiko T., Luk, Kelvin C., Lee, Virginia M.-Y., Trojanowski, John Q.·2020·Trends in Molecular Medicine
DOI 10.1016/j.molmed.2020.03.012PMC PMC7529725
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.molmed.2020.03.012

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 45 references

Research works printed but not linked: 99

  1. Thal, 2002, Phases of A beta-deposition in the human brain and its relevance for the development of AD, Neurology, 58, 1791, 10.1212/WNL.58.12.1791 · DOI · Paper page
  2. Uchihara, 2003, Pick body disease and Pick syndrome, Neuropathology, 23, 318, 10.1046/j.1440-1789.2003.00523.x · DOI
  3. Komori, 1999, Tau-positive glial inclusions in progressive supranuclear palsy, corticobasal degeneration and Pick's disease, Brain Pathol., 9, 663, 10.1111/j.1750-3639.1999.tb00549.x · DOI
  4. Dickson, 1999, Neuropathologic differentiation of progressive supranuclear palsy and corticobasal degeneration, J. Neurol., 246, II6, 10.1007/BF03161076 · DOI
  5. Lashley, 2015, Review: an update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations, Neuropathol. Appl. Neurobiol., 41, 858, 10.1111/nan.12250 · DOI
  6. Kovacs, 2017, Evaluating the patterns of aging-related tau astrogliopathy unravels novel insights Into brain aging and neurodegenerative diseases, J. Neuropathol. Exp. Neurol., 76, 270, 10.1093/jnen/nlx007 · DOI · Paper page
  7. Dickson, 2009, Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria, Lancet Neurol., 8, 1150, 10.1016/S1474-4422(09)70238-8 · DOI · Paper page
  8. Braak, 2003, Staging of brain pathology related to sporadic Parkinson's disease, Neurobiol. Aging, 24, 197, 10.1016/S0197-4580(02)00065-9 · DOI · Paper page
  9. Irwin, 2012, Neuropathologic substrates of Parkinson disease dementia, Ann. Neurol., 72, 587, 10.1002/ana.23659 · DOI · Paper page
  10. Lippa, 2007, DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers, Neurology, 68, 812, 10.1212/01.wnl.0000256715.13907.d3 · DOI · Paper page
  11. Jellinger, 2018, Are dementia with Lewy bodies and Parkinson's disease dementia the same disease?, BMC Med., 16, 34, 10.1186/s12916-018-1016-8 · DOI
  12. Krismer, 2017, Multiple system atrophy: insights into a rare and debilitating movement disorder, Nat. Rev. Neurol., 13, 232, 10.1038/nrneurol.2017.26 · DOI
  13. Trojanowski, 2007, Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy, Neuropathol. Appl. Neurobiol., 33, 615, 10.1111/j.1365-2990.2007.00907.x · DOI · Paper page
  14. Braak, 2006, Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology, Neurosci. Lett., 396, 67, 10.1016/j.neulet.2005.11.012 · DOI · Paper page
  15. Killinger, 2018, The vermiform appendix impacts the risk of developing Parkinson's disease, Sci. Transl. Med., 10, 10.1126/scitranslmed.aar5280 · DOI
  16. Lu, 2019, Lack of association between appendectomy and Parkinson's disease: a systematic review and meta-analysis, Aging Clin. Exp. Res.
  17. Luk, 2009, Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells, Proc. Natl. Acad. Sci. U. S. A., 106, 20051, 10.1073/pnas.0908005106 · DOI · Paper page
  18. Volpicelli-Daley, 2011, Exogenous alpha-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death, Neuron, 72, 57, 10.1016/j.neuron.2011.08.033 · DOI · Paper page
  19. Desplats, 2009, Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein, Proc. Natl. Acad. Sci. U. S. A., 106, 13010, 10.1073/pnas.0903691106 · DOI · Paper page
  20. Liu, 2012, Trans-synaptic spread of tau pathology in vivo, PLoS One, 7
  21. Luk, 2012, Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice, Science, 338, 949, 10.1126/science.1227157 · DOI · Paper page
  22. Luk, 2012, Intracerebral inoculation of pathological alpha-synuclein initiates a rapidly progressive neurodegenerative alpha-synucleinopathy in mice, J. Exp. Med., 209, 975, 10.1084/jem.20112457 · DOI
  23. Masuda-Suzukake, 2013, Prion-like spreading of pathological alpha-synuclein in brain, Brain, 136, 1128, 10.1093/brain/awt037 · DOI · Paper page
  24. Clavaguera, 2013, Brain homogenates from human tauopathies induce tau inclusions in mouse brain, Proc. Natl. Acad. Sci. U. S. A., 110, 9535, 10.1073/pnas.1301175110 · DOI
  25. Narasimhan, 2017, Pathological tau strains from human brains recapitulate the diversity of tauopathies in nontransgenic mouse brain, J. Neurosci., 37, 11406, 10.1523/JNEUROSCI.1230-17.2017 · DOI · Paper page
  26. He, 2020, Transmission of tauopathy strains is independent of their isoform composition, Nat. Commun., 11, 7, 10.1038/s41467-019-13787-x · DOI
  27. Guo, 2013, Distinct alpha-synuclein strains differentially promote tau inclusions in neurons, Cell, 154, 103, 10.1016/j.cell.2013.05.057 · DOI · Paper page
  28. Prusiner, 2015, Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism, Proc. Natl. Acad. Sci. U. S. A., 112, E5308, 10.1073/pnas.1514475112 · DOI
  29. Peng, 2018, Cellular milieu imparts distinct pathological alpha-synuclein strains in alpha-synucleinopathies, Nature, 557, 558, 10.1038/s41586-018-0104-4 · DOI · Paper page
  30. Uemura, 2019, Slow progressive accumulation of oligodendroglial alpha-synuclein (alpha-syn) pathology in synthetic alpha-syn fibril-induced mouse models of synucleinopathy, J. Neuropathol. Exp. Neurol., 78, 877, 10.1093/jnen/nlz070 · DOI
  31. Lau, 2020, alpha-Synuclein strains target distinct brain regions and cell types, Nat. Neurosci., 23, 21, 10.1038/s41593-019-0541-x · DOI
  32. Falcon, 2019, Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules, Nature, 568, 420, 10.1038/s41586-019-1026-5 · DOI
  33. Falcon, 2018, Structures of filaments from Pick's disease reveal a novel tau protein fold, Nature, 561, 137, 10.1038/s41586-018-0454-y · DOI
  34. Arakhamia, 2020, Posttranslational modifications mediate the structural diversity of tauopathy strains, Cell, 180, 633, 10.1016/j.cell.2020.01.027 · DOI
  35. Zhang, 2020, Novel tau filament fold in corticobasal degeneration, Nature, 580, 283, 10.1038/s41586-020-2043-0 · DOI
  36. Shahnawaz, 2020, Discriminating alpha-synuclein strains in Parkinson's disease and multiple system atrophy, Nature, 578, 273, 10.1038/s41586-020-1984-7 · DOI · Paper page
  37. Marklund, 2009, Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury, J. Neurosurg., 110, 1227, 10.3171/2008.9.JNS08584 · DOI
  38. Yamada, 2011, In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice, J. Neurosci., 31, 13110, 10.1523/JNEUROSCI.2569-11.2011 · DOI · Paper page
  39. Asai, 2015, Depletion of microglia and inhibition of exosome synthesis halt tau propagation, Nat. Neurosci., 18, 1584, 10.1038/nn.4132 · DOI · Paper page
  40. Stuendl, 2016, Induction of alpha-synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies, Brain, 139, 481, 10.1093/brain/awv346 · DOI · Paper page
  41. Katsinelos, 2018, Unconventional secretion mediates the trans-cellular spreading of tau, Cell Rep., 23, 2039, 10.1016/j.celrep.2018.04.056 · DOI
  42. Lee, 2008, Assembly-dependent endocytosis and clearance of extracellular alpha-synuclein, Int. J. Biochem. Cell Biol., 40, 1835, 10.1016/j.biocel.2008.01.017 · DOI · Paper page
  43. Mao, 2016, Pathological alpha-synuclein transmission initiated by binding lymphocyte-activation gene 3, Science, 353, 10.1126/science.aah3374 · DOI · Paper page
  44. Gibbons, 2017, GFP-mutant human tau transgenic mice develop tauopathy following CNS injections of Alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils, J. Neurosci., 37, 11485, 10.1523/JNEUROSCI.2393-17.2017 · DOI · Paper page
  45. Karpowicz, 2017, Selective imaging of internalized proteopathic alpha-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies, J. Biol. Chem., 292, 13482, 10.1074/jbc.M117.780296 · DOI
  46. Flavin, 2017, Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins, Acta Neuropathol., 134, 629, 10.1007/s00401-017-1722-x · DOI
  47. Polanco, 2018, Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons, Acta Neuropathol. Commun., 6, 10, 10.1186/s40478-018-0514-4 · DOI
  48. Tardivel, 2016, Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological tau protein assemblies, Acta Neuropathol. Commun., 4, 117, 10.1186/s40478-016-0386-4 · DOI · Paper page
  49. Abounit, 2016, Tunneling nanotubes spread fibrillar alpha-synuclein by intercellular trafficking of lysosomes, EMBO J., 35, 2120, 10.15252/embj.201593411 · DOI · Paper page
  50. Pooler, 2013, Physiological release of endogenous tau is stimulated by neuronal activity, EMBO Rep., 14, 389, 10.1038/embor.2013.15 · DOI · Paper page
  51. Yamada, 2014, Neuronal activity regulates extracellular tau in vivo, J. Exp. Med., 211, 387, 10.1084/jem.20131685 · DOI
  52. Wu, 2016, Neuronal activity enhances tau propagation and tau pathology in vivo, Nat. Neurosci., 19, 1085, 10.1038/nn.4328 · DOI · Paper page
  53. Busche, 2008, Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease, Science, 321, 1686, 10.1126/science.1162844 · DOI · Paper page
  54. Martini-Stoica, 2018, TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading, J. Exp. Med., 215, 2355, 10.1084/jem.20172158 · DOI · Paper page
  55. Loria, 2017, alpha-Synuclein transfer between neurons and astrocytes indicates that astrocytes play a role in degradation rather than in spreading, Acta Neuropathol., 134, 789, 10.1007/s00401-017-1746-2 · DOI
  56. Venezia, 2017, Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal alpha-synucleinopathy, Mol. Neurodegener., 12, 52, 10.1186/s13024-017-0195-7 · DOI
  57. Narasimhan, 2020, Human tau pathology transmits glial tau aggregates in the absence of neuronal tau, J. Exp. Med., 217, 10.1084/jem.20190783 · DOI
  58. Tran, 2014, Alpha-synuclein immunotherapy blocks uptake and templated propagation of misfolded alpha-synuclein and neurodegeneration, Cell Rep., 7, 2054, 10.1016/j.celrep.2014.05.033 · DOI
  59. Games, 2014, Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models, J. Neurosci., 34, 9441, 10.1523/JNEUROSCI.5314-13.2014 · DOI
  60. Boutajangout, 2010, Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model, J. Neurosci., 30, 16559, 10.1523/JNEUROSCI.4363-10.2010 · DOI · Paper page
  61. Yanamandra, 2013, Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo, Neuron, 80, 402, 10.1016/j.neuron.2013.07.046 · DOI · Paper page
  62. Dai, 2018, Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated tau-induced pathology in 3 x Tg-AD mice, Alzheimers Res. Ther., 10, 13, 10.1186/s13195-018-0341-7 · DOI · Paper page
  63. Mandler, 2014, Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials, Acta Neuropathol., 127, 861, 10.1007/s00401-014-1256-4 · DOI
  64. Henderson, 2019, Characterization of novel conformation-selective alpha-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease, Neurobiol. Dis., 136, 104712, 10.1016/j.nbd.2019.104712 · DOI
  65. Cummings, 2019, Anti-tau trials for Alzheimer's disease: a report from the EU/US/CTAD task force, J. Prev. Alzheimers Dis., 6, 157, 10.14283/jpad.2019.14 · DOI
  66. Zella, 2019, Emerging immunotherapies for Parkinson disease, Neurol. Ther., 8, 29, 10.1007/s40120-018-0122-z · DOI · Paper page
  67. Stopschinski, 2020, A synthetic heparinoid blocks tau aggregate cell uptake and amplification, J. Biol. Chem., 295, 2974, 10.1074/jbc.RA119.010353 · DOI
  68. Konno, 2012, Suppression of dynamin GTPase decreases alpha-synuclein uptake by neuronal and oligodendroglial cells: a potent therapeutic target for synucleinopathy, Mol. Neurodegener., 7, 38, 10.1186/1750-1326-7-38 · DOI
  69. Luna, 2018, Differential alpha-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity, Acta Neuropathol., 135, 855, 10.1007/s00401-018-1829-8 · DOI
  70. Uehara, 2019, Amido-bridged nucleic acid (AmNA)-modified antisense oligonucleotides targeting alpha-synuclein as a novel therapy for Parkinson's disease, Sci. Rep., 9, 7567, 10.1038/s41598-019-43772-9 · DOI
  71. Llorens-Martin, 2012, Tau isoform with three microtubule binding domains is a marker of new axons generated from the subgranular zone in the hippocampal dentate gyrus: implications for Alzheimer's disease, J. Alzheimers Dis., 29, 921, 10.3233/JAD-2012-112057 · DOI
  72. Monroy, 2018, Competition between microtubule-associated proteins directs motor transport, Nat. Commun., 9, 1487, 10.1038/s41467-018-03909-2 · DOI · Paper page
  73. Burre, 2014, alpha-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation, Proc. Natl. Acad. Sci. U. S. A., 111, E4274, 10.1073/pnas.1416598111 · DOI
  74. DeWitt, 2013, alpha-Synuclein can inhibit SNARE-mediated vesicle fusion through direct interactions with lipid bilayers, Biochemistry, 52, 2385, 10.1021/bi4002369 · DOI
  75. Sun, 2019, Functional cooperation of alpha-synuclein and VAMP2 in synaptic vesicle recycling, Proc. Natl. Acad. Sci. U. S. A., 116, 11113, 10.1073/pnas.1903049116 · DOI
  76. Wille, 1992, Alzheimer-like paired helical filaments and antiparallel dimers formed from microtubule-associated protein tau in vitro, J. Cell Biol., 118, 573, 10.1083/jcb.118.3.573 · DOI
  77. Conway, 1998, Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease, Nat. Med., 4, 1318, 10.1038/3311 · DOI
  78. Nuber, 2018, Abrogating native alpha-synuclein tetramers in mice causes a L-DOPA-responsive motor syndrome closely resembling Parkinson's disease, Neuron, 100, 75, 10.1016/j.neuron.2018.09.014 · DOI
  79. Ittner, 2010, Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models, Cell, 142, 387, 10.1016/j.cell.2010.06.036 · DOI · Paper page
  80. Winner, 2011, In vivo demonstration that alpha-synuclein oligomers are toxic, Proc. Natl. Acad. Sci. U. S. A., 108, 4194, 10.1073/pnas.1100976108 · DOI · Paper page
  81. Osterberg, 2015, Progressive aggregation of alpha-synuclein and selective degeneration of Lewy inclusion-bearing neurons in a mouse model of Parkinsonism, Cell Rep., 10, 1252, 10.1016/j.celrep.2015.01.060 · DOI
  82. Wang, 2016, Tau in physiology and pathology, Nat. Rev. Neurosci., 17, 5, 10.1038/nrn.2015.1 · DOI · Paper page
  83. Wong, 2017, alpha-Synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies, Nat. Med., 23, 1, 10.1038/nm.4269 · DOI · Paper page
  84. Mirbaha, 2018, Inert and seed-competent tau monomers suggest structural origins of aggregation, eLife, 7, 10.7554/eLife.36584 · DOI
  85. Sharma, 2018, Tau monomer encodes strains, eLife, 7, 10.7554/eLife.37813 · DOI
  86. Pieri, 2016, Structural and functional properties of prefibrillar alpha-synuclein oligomers, Sci. Rep., 6, 24526, 10.1038/srep24526 · DOI
  87. Evans, 2018, Extracellular monomeric and aggregated tau efficiently enter human neurons through overlapping but distinct pathways, Cell Rep., 22, 3612, 10.1016/j.celrep.2018.03.021 · DOI
  88. Bassil, 2020, Amyloid-beta (Aβ) plaques promote seeding and spreading of alpha-synuclein and tau in a mouse model of Lewy body disorders with Aβ pathology, Neuron, 105, 260, 10.1016/j.neuron.2019.10.010 · DOI
  89. Zanier, 2018, Induction of a transmissible tau pathology by traumatic brain injury, Brain, 141, 2685
  90. Rey, 2016, Widespread transneuronal propagation of alpha-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease, J. Exp. Med., 213, 1759, 10.1084/jem.20160368 · DOI
  91. Manfredsson, 2018, Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology, Neurobiol. Dis., 112, 106, 10.1016/j.nbd.2018.01.008 · DOI · Paper page
  92. Kim, 2019, Transneuronal propagation of pathologic alpha-synuclein from the gut to the brain models Parkinson's disease, Neuron, 103, 627, 10.1016/j.neuron.2019.05.035 · DOI · Paper page
  93. Uemura, 2020, Limited spread of pathology within the brainstem of alpha-synuclein BAC transgenic mice inoculated with preformed fibrils into the gastrointestinal tract, Neurosci. Lett., 716, 134651, 10.1016/j.neulet.2019.134651 · DOI
  94. Braak, 2016, Potential pathways of abnormal tau and alpha-synuclein dissemination in sporadic Alzheimer's and Parkinson's diseases, Cold Spring Harb. Perspect. Biol., 8, a023630, 10.1101/cshperspect.a023630 · DOI
  95. Ahmed, 2014, A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity, Acta Neuropathol., 127, 667, 10.1007/s00401-014-1254-6 · DOI
  96. Franzmeier, 2020, Functional brain architecture is associated with the rate of tau accumulation in Alzheimer's disease, Nat. Commun., 11, 347, 10.1038/s41467-019-14159-1 · DOI
  97. Mason, 2016, Transmission of alpha-synucleinopathy from olfactory structures deep into the temporal lobe, Mol. Neurodegener., 11, 49, 10.1186/s13024-016-0113-4 · DOI
  98. Taguchi, 2014, Differential expression of alpha-synuclein in hippocampal neurons, PLoS One, 9, 10.1371/journal.pone.0089327 · DOI
  99. Mezias, 2020, Neural connectivity predicts spreading of alpha-synuclein pathology in fibril-injected mouse models: involvement of retrograde and anterograde axonal propagation, Neurobiol. Dis., 134, 104623, 10.1016/j.nbd.2019.104623 · DOI

Cited by

Sorted by citations

See all 149

Metadata

Authors
Uemura, N., Uemura, M. T., Luk, K. C., Lee, V. M.-Y., & Trojanowski, J. Q.
Venue
Trends in Molecular Medicine
Publisher
Elsevier BV
Published
2020-10
Volume
26
Issue
10
Pages
936-952
ISSN
1471-4914
DOI
10.1016/j.molmed.2020.03.012
PMC
PMC7529725
Cited by
149
References
45
Language
en
Licence
Funders
National Institutes of Health

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Cell-to-Cell Transmission of Tau and α-Synuclein. https://app.cochat.ai/papers/10.1016/j.molmed.2020.03.012
The paper
Uemura, N., Uemura, M. T., Luk, K. C., Lee, V. M.-Y., & Trojanowski, J. Q. (2020). Cell-to-Cell Transmission of Tau and α-Synuclein. Trends in Molecular Medicine. https://doi.org/10.1016/j.molmed.2020.03.012