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Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes

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Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer’s disease models

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The pathophysiology of neurodegenerative disease: Disturbing the balance between phase separation and irreversible aggregation

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Nuclear Transport Deficits in Tau-Related Neurodegenerative Diseases

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DrosophilaTau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis

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What’s in a Gene? The Outstanding Diversity of MAPT

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CPEB and translational control by cytoplasmic polyadenylation: impact on synaptic plasticity, learning, and memory

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Protein synthesis inhibition and loss of homeostatic functions in astrocytes from an Alzheimer’s disease mouse model: a role for ER-mitochondria interaction

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation

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APOE4 Affects Basal and NMDAR-Mediated Protein Synthesis in Neurons by Perturbing Calcium Homeostasis

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Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy

Brody, A. H., Nies, S. H., Guan, F., Smith, L. M., Mukherjee, B., Salazar, S. A., Lee, S., Lam, T. K. T., & Strittmatter, S. M. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00526-y · Cited by 33 · see citing works

Tau protein- induced sequestration of the eukaryotic ribosome: Implications in neurodegenerative disease

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Pathologic tau conformer ensembles induce dynamic, liquid-liquid phase separation events at the nuclear envelope

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Overexpressing eukaryotic elongation factor 1 alpha (eEF1A) proteins to promote corticospinal axon repair after injury

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The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review

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Acute inhibition of the CNS-specific kinase TTBK1 significantly lowers tau phosphorylation at several disease relevant sites

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Differential Expression of mRNAs in Peripheral Blood Related to Prodrome and Progression of Alzheimer’s Disease

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De novo proteomic methods for examining the molecular mechanisms underpinning long-term memory

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Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer’s Disease

Guo, Q., Dammer, E. B., Zhou, M., Kundinger, S. R., Gearing, M., Lah, J. J., Levey, A. I., Shulman, J. M., & Seyfried, N. T. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.623659 · Cited by 23 · see citing works

Mechanisms of Regulation and Diverse Activities of Tau-Tubulin Kinase (TTBK) Isoforms

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Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors

Amaral, B., Capacci, A., Anderson, T., Tezer, C., Bajrami, B., Lulla, M., Lucas, B., Chodaparambil, J. V., Marcotte, D., Kumar, P. R., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00476 · Cited by 22 · see citing works

Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration

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Contribution of Energy Dysfunction to Impaired Protein Translation in Neurodegenerative Diseases

Liu, Y., & Chern, Y. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.668500 · Cited by 19 · see citing works

Simple model systems reveal conserved mechanisms of Alzheimer’s disease and related tauopathies

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Donor-Specific Transcriptomic Analysis of Alzheimer's Disease-Associated Hypometabolism Highlights a Unique Donor, Ribosomal Proteins and Microglia

Patel, S., Howard, D., Man, A., Schwartz, D. H., Jee, J., Felsky, D., Pausová, Z., Paus, T., & French, L. (2020) · eNeuro · doi:10.1523/eneuro.0255-20.2020 · Cited by 16 · see citing works

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

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Cytoplasmic Expression of the ALS/FTD-Related Protein TDP-43 Decreases Global Translation Both in vitro and in vivo

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Prion-Like Propagation Mechanisms in Tauopathies and Traumatic Brain Injury: Challenges and Prospects

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Tau, RNA, and RNA-Binding Proteins: Complex Interactions in Health and Neurodegenerative Diseases

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Experimental upregulation of developmentally downregulated ribosomal protein large subunits 7 and 7A promotes axon regeneration after injury in vivo

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β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer’s disease

Jiang, L., Roberts, R., Wong, M., Zhang, L., Webber, C. J., Libera, J., Wang, Z., Kilci, A., Jenkins, M., Ortiz, A. R., et al. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1372297 · Cited by 15 · see citing works

Co-expression network analysis of human tau-transgenic mice reveals protein modules associated with tau-induced pathologies

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Pathogenic tau induces an adaptive elevation in mRNA translation rate at early stages of disease

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Posttranscriptional regulation of neurofilament proteins and tau in health and disease

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Tau mRNA Metabolism in Neurodegenerative Diseases: A Tangle Journey

da Costa, P. J., Hamdane, M., Buée, L., & Martin, F. (2022) · Biomedicines · doi:10.3390/biomedicines10020241 · Cited by 14 · see citing works

Whole genome methylation and transcriptome analyses to identify risk for cerebral palsy (CP) in extremely low gestational age neonates (ELGAN)

Massaro, A. N., Bammler, T. K., MacDonald, J. W., Perez, K., Comstock, B. A., & Juul, S. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-84214-9 · Cited by 14 · see citing works

Proteomic Techniques to Examine Neuronal Translational Dynamics

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Effects of altered tau expression on dentate granule cell excitability in mice

Cloyd, R., Koren, J., Abisambra, J. F., & Smith, B. N. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113766 · Cited by 14 · see citing works

Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy

Koren, S. A., Hamm, M. J., Cloyd, R., Fontaine, S. N., Chishti, E. A., Lanzillotta, C., Rodriguez-Rivera, J., Ingram, A., Bell, M. C., Escobar, S. M. G., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031186 · Cited by 13 · see citing works

Altered Brain Arginine Metabolism and Polyamine System in a P301S Tauopathy Mouse Model: A Time-Course Study

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TauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability

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Temporal Cortex Microarray Analysis Revealed Impaired Ribosomal Biogenesis and Hyperactivity of the Glutamatergic System: An Early Signature of Asymptomatic Alzheimer's Disease

Kumari, A., Rahaman, A., Zeng, X., Farooq, M. A., Huang, Y., Yao, R., Ali, M., Ishrat, R., & Ali, R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.966877 · Cited by 11 · see citing works

ZCCHC17 Modulates Neuronal RNA Splicing and Supports Cognitive Resilience in Alzheimer's Disease

Bartosch, A. M. W., Youth, E. H. H., Hansen, S., Wu, Y., Buchanan, H. M., Kaufman, M. E., Xiao, H., Koo, S. Y., Ashok, A., Sivakumar, S., et al. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2324-22.2023 · Cited by 10 · see citing works

Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference

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Ribosomal proteins are blood biomarkers and associated with CD4+ T cell activation in Alzheimer's disease: a study based on machine learning strategies and scRNA-Seq data validation.

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Long‐read sequencing reveals genomic and epigenomic variation in the dark genome of human Alzheimer's disease

Ramirez, P., Sun, W., Dehkordi, S. K., Zare, H., Pascarella, G., Carninci, P., Fongang, B., Bieniek, K. F., & Frost, B. E. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70852 · Cited by 9 · see citing works

Effect of age on the vascular proteome in middle cerebral arteries and mesenteric resistance arteries in mice

Rabaglino, M. B., Wakabayashi, M., Pearson, J. T., & Jensen, L. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111594 · Cited by 9 · see citing works

BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons

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Comparative proteomic analysis provides insight into the key proteins as potential targets underlying the effect of malachite green against Ichthyophthirius multifiliis

Qu, S., Song, C., Tan, X., Wang, G., & Ling, F. (2021) · Journal of Fish Diseases · doi:10.1111/jfd.13346 · Cited by 8 · see citing works

Investigation of early molecular alterations in tauopathy with generative adversarial networks

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To aggregate or not to aggregate – Is it a matter of the ribosome?

Iben, S. (2023) · BioEssays · doi:10.1002/bies.202200230 · Cited by 7 · see citing works

Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response

Zubčić, K., Franić, D., Pravica, M., Hof, P. R., Šimić, G., & Boban, M. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14304 · Cited by 5 · see citing works

Selective neuronal vulnerability to deficits in RNA processing

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Transcriptome and Translatome Regulation of Pathogenesis in Alzheimer’s Disease Model Mice

Eastman, G., Sharlow, E. R., Lazo, J. S., Bloom, G. S., & Sotelo-Silveira, J. R. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215357 · Cited by 7 · see citing works

Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia

Amabebe, E., Huang, Z., Jash, S., Krishnan, B., Cheng, S., Nakashima, A., Li, Y., Li, Z., Wang, R., Menon, R., et al. (2024) · Biomedicines · doi:10.3390/biomedicines13010029 · Cited by 5 · see citing works

Cell‐specific protein expression in Alzheimer's disease prefrontal cortex

Gholampour, M., Basu, M. K., Swerdlow, R. H., Zhuo, X., & Haeri, M. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70339 · Cited by 5 · see citing works

Comparison of proteome alterations during aging in the temporal lobe of humans and rhesus macaques

Wang, X., Chen, K., Pan, M., Ge, W., & He, Z. (2020) · Experimental Brain Research · doi:10.1007/s00221-020-05855-2 · Cited by 5 · see citing works

Proteomic Assessment of C57BL/6 Hippocampi after Non-Selective Pharmacological Inhibition of Nitric Oxide Synthase Activity: Implications of Seizure-like Neuronal Hyperexcitability Followed by Tauopathy

Hendrickx, J. O., Adams, C., Sieben, A., Laukens, K., Dam, D. V., & Meyer, G. R. Y. D. (2022) · Biomedicines · doi:10.3390/biomedicines10081772 · Cited by 5 · see citing works

Tyrosine and Phenylalanine Activate Neuronal DNA Repair but Exhibit Opposing Effects on Global Transcription and Adult Female Mice Are Resilient to TyrRS / YARS1 Depletion

Jhanji, M., Bhan, A., Arrowood, C. A., Yakout, D. W., Shroff, A., McManus, D., Gifford, H., Vacharasin, J. M., Lizarraga, S. B., Nazarko, T. Y., et al. (2025) · IUBMB Life · doi:10.1002/iub.70030 · Cited by 4 · see citing works

Compilation of all known protein changes in the human Alzheimer’s disease brainPreprint

Askenazi, M., Kavanagh, T., Pires, G., Ueberheide, B. M., Wısnıewskı, T., & Drummond, E. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.13.536828 · Cited by 4 · see citing works

Translated retained intron 11 sequence confers pathological properties to Tau in Alzheimer’s disease

Tan, Y.-Y., Leow, C., Choo, C., Tan, J., & Ong, C. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102872 · Cited by 3 · see citing works

Neurons with granulovacuolar degeneration bodies are resilient to tau-induced protein synthesis impairment

Smits, J. F. M., Ligthart, T., Jorge‐Oliva, M., Middelhoff, S., Schipper, F., Pita-Illobre, D., Li, K. W., & Scheper, W. (2026) · Science Advances · doi:10.1126/sciadv.aea8940 · Cited by 3 · see citing works

Mapping the spatiotemporal dynamics of de novo protein synthesis during long-term memory formationPreprint

Evans, H. T., Adler, D. I., Sellés, M. C., Kalavai, S. V., Yu, A., Wu, V., Denil, E., Golhan, E. N., Polavarapu, A., Balamoti, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.17.649250 · Cited by 3 · see citing works

Distinct neuroprotective and anti-inflammatory effects of Kampo formulas ninjinyoeito and juzentaihoto in depression-like SAMP8 mice

Maruko, A., Ito, N., Oshima, K., Nishi, A., Kobayashi, Y., & Okada, N. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1600176 · Cited by 2 · see citing works

Multi-omics integration and machine learning reveal biomarker networks and therapeutic targets in Alzheimer's disease

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Structural evidence that RNA contributes to polymorphism of tau amyloid fibrils

Abskharon, R. N. N., Jiang, Y. X., Sawaya, M. R., Ge, P., Zhang, J., Boyer, D. R., Dolinsky, J. L., Pi, J., Cascio, D., Guo, F., et al. (2026) · iScience · doi:10.1016/j.isci.2026.115501 · Cited by 2 · see citing works

Transcriptional-profile changes in the medial geniculate body after noise-induced tinnitus

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Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

Panneerselvam, K., Tiwari, K. K., Licata, L., Panni, S., Ricard‐Blum, S., Balu, S., Huget, S., Reyes, J. J. M., Ragueneau, E., Perfetto, L., et al. (2025) · PROTEOMICS · doi:10.1002/pmic.70018 · Cited by 1 · see citing works

Mutant Tau (P301L) Enhances Global Protein Translation in Differentiated SH-SY5Y Cells by Upregulating mTOR Signalling

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Ribosome impairment, tau alternative splicing, and stress granules: a convergent axis of neuronal vulnerability driving Alzheimer's disease

Masi, M., Oliviero, C., Govoni, S. M., Wolozin, B. L., Racchi, M., & Buoso, E. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179033 · Cited by 1 · see citing works

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

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Neuronetworks: Analysis of brain pathology in Mucopolysaccharidoses – A systems biology approach

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Broad kinase inhibition mitigates early neuronal dysfunction and cognitive deficits in tauopathyPreprint

Koren, S. A., Hamm, M. J., Cloyd, R., Fontaine, S. N., Chishti, E. A., Lanzillotta, C., Rodriguez-Rivera, J., Ingram, A., Bell, M. C., Escobar, S. M. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.31.229583 · Cited by 1 · see citing works

Susceptibility to gingipains and transcriptomic response to P. gingivalis highlights the ribosome, hypothalamus, and cholinergic neuronsPreprint

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Modified tau leads to neuronal and global ribosome dysfunction in C. elegans model of tauopathyPreprint

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Elevation of the mechanically-sensitive protein emerin links nuclear mechanotransduction to tau-induced cytoskeletal remodeling in neuronsPreprint

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Pathological Tau as a Cause, and Consequence, of Cellular Dysfunction

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A Complex Containing HNRNPA2B1 and N 6 -methyladenosine Modified Transcripts Mediates Actions of Toxic Tau OligomersPreprint

Jiang, L., Lin, W., Zhang, C., Verma, M., Kwan, J., van Vliet, E., Ash, P. E. A., Cruz, A. L., Boudeau, S., Maziuk, B. F., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.12.03.409334

A Complex Containing HNRNPA2B1 and N 6-Methyladenosine Modified Transcripts Mediates Actions of Toxic Tau OligomersPreprint

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THE ROLE OF MICROTUBULE-ASSOCIATED PROTEIN TAU IN NEURONAL EXCITABILITY AND EPILEPTOGENESIS

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