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Alzheimer’s disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation
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“In both AD and primary tauopathies, the accumulation of pathological forms of tau is closely linked with brain atrophy, neuronal and synaptic loss, and cognitive and functional decline linked to the location of these changes (Bejanin et al., 2017; La Joie et al., 2020; Petersen et al., 2019).”
From Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia (2021) · cites this paper as Petersen et al., 2019
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Self-citationNeuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
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Age, Neuropathology, and Dementia
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“We included ninety-four participants with a primary neuropathologic diagnosis of AD neuropathological change based on consensus criteria with varying levels of severity, and with or without argyrophilic grain disease (AGD) and age-related tau astrogliopathy [16].”
MethodDevelopment of methodology for conducting clinical trials in frontotemporal lobar degeneration
Knopman, D. S., Kramer, J. H., Boeve, B. F., Caselli, R. J., Graff-Radford, N. R., Mendez, M. F., Miller, B. L., & Mercaldo, N. (2008) · Brain · doi:10.1093/brain/awn234 · Cited by 442
Self-citationClinical, imaging, and pathological heterogeneity of the Alzheimer's disease syndrome
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Self-citation
Metadata
- Authors
- Petersen, C., Nolan, A. L., de Paula França Resende, E., Miller, Z., Ehrenberg, A. J., Gorno-Tempini, M. L., Rosen, H. J., Kramer, J. H., Spina, S., Rabinovici, G. D., Miller, B. L., Seeley, W. W., Heinsen, H., & Grinberg, L. T.
- Venue
- Acta Neuropathologica
- Published
- 2019-06-27
- Volume
- 138
- Issue
- 4
- Pages
- 597-612
- ISSN
- 0001-6322
- 1432-0533
- PMC
- PMC7012374
- Cited by
- 113
- References
- 14
- Language
- en
- Funders
- National Institutes of Health (K24AG053435, K24DC015544A, R01NS5091)
- University of California, San Francisco (P50AG023501, P01AG019724)
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