Clinicopathological correlations in corticobasal degeneration
Open accessAbstract
OBJECTIVE: To characterize cognitive and behavioral features, physical findings, and brain atrophy patterns in pathology-proven corticobasal degeneration (CBD) and corticobasal syndrome (CBS) with known histopathology. METHODS: We reviewed clinical and magnetic resonance imaging data in all patients evaluated at our center with either an autopsy diagnosis of CBD (n = 18) or clinical CBS at first presentation with known histopathology (n = 40). Atrophy patterns were compared using voxel-based morphometry. RESULTS: CBD was associated with 4 clinical syndromes: progressive nonfluent aphasia (n = 5), behavioral variant frontotemporal dementia (n = 5), executive-motor (n = 7), and posterior cortical atrophy (n = 1). Behavioral or cognitive problems were the initial symptoms in 15 of 18 patients; less than half exhibited early motor findings. Compared to controls, CBD patients showed atrophy in dorsal prefrontal and perirolandic cortex, striatum, and brainstem (p < 0.001 uncorrected). The most common pathologic substrates for clinical CBS were CBD (35%), Alzheimer disease (AD, 23%), progressive supranuclear palsy (13%), and frontotemporal lobar degeneration (FTLD) with TDP inclusions (13%). CBS was associated with perirolandic atrophy irrespective of underlying pathology. In CBS due to FTLD (tau or TDP), atrophy extended into prefrontal cortex, striatum, and brainstem, whereas in CBS due to AD, atrophy extended into temporoparietal cortex and precuneus (p < 0.001 uncorrected). INTERPRETATION: Frontal lobe involvement is characteristic of CBD, and in many patients frontal, not parietal or basal ganglia, symptoms dominate early stage disease. CBS is driven by medial perirolandic dysfunction, but this anatomy is not specific to a single underlying histopathology. Antemortem prediction of CBD will remain challenging until clinical features of CBD are redefined, and sensitive, specific biomarkers are identified.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A corticobasal syndrome is more often due to AD pathology than corticobasal degeneration or other disorders.
“On the other hand, a corticobasal syndrome (asymmetric parkinsonism with limb dystonia, apraxia, and cortical sensory loss) is more often due to AD pathology than corticobasal degeneration or other disorders [31].”
From Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road (2017) · cites this paper as [31]
The Abstract (Results) reports that CBD was the most common pathological cause of clinical corticobasal syndrome (35%), followed by AD (23%). The Results (Subjects: Histopathology) likewise lists 14 CBD cases versus 9 AD cases, contrary to the claim that AD was more common. (LLM, conf=0.94)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIn behavioural or dysexecutive variants, corticobasal syndrome, and semantic or non-fluent variants of primary progressive aphasia, positive Alzheimer's disease biomarkers are particularly ambiguous and can be considered either as Alzheimer's disease copathology or atypical forms of Alzheimer's disease.
“This biomarker positivity is particularly ambiguous in the case of behavioural or dysexecutive variants, corticobasal syndrome, and semantic or non-fluent variants of primary progressive aphasia, in which the presence of positive Alzheimer’s disease biomarkers can be considered either as Alzheimer’s disease copathology or atypical forms of Alzheimer’s disease94,96,98,99 (appendix p 2).”
From Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group (2021) · cites this paper as [98]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · see citing works
Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
Neary, D., Snowden, J. S., Gustafson, L., Passant, U., Stuss, D., Black, S., Freedman, M., Kertesz, A., Robert, P. H., Albert, M., et al. (1998) · Neurology · doi:10.1212/wnl.51.6.1546 · Cited by 5,047 · see citing works
Self-citationAssociation of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works
Self-citationNeurodegenerative Diseases Target Large-Scale Human Brain Networks
Seeley, W. W., Crawford, R. K., Zhou, J., Miller, B. L., & Greicius, M. D. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.024 · Cited by 2,350 · see citing works
Self-citationCognition and anatomy in three variants of primary progressive aphasia
Gorno‐Tempini, M. L., Dronkers, N. F., Rankin, K. P., Ogar, J. M., Phengrasamy, L., Rosen, H. J., Johnson, J. K., Weiner, M. W., & Miller, B. L. (2004) · Annals of Neurology · doi:10.1002/ana.10825 · Cited by 1,608 · see citing works
Self-citationHYMAN, B. T., & TROJANOWSKI, J. Q. (1997) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199710000-00002 · Cited by 1,542 · see citing works
Self-citationMackenzie, I. R. A., Neumann, M., Bigio, E. H., Cairns, N. J., Alafuzoff, I., Kril, J., Kovacs, G. G., Ghetti, B., Halliday, G., Holm, I. E., et al. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0612-2 · Cited by 1,012 · see citing works
Self-citationClinicopathological and imaging correlates of progressive aphasia and apraxia of speech
Josephs, K. A. (2006) · Brain · doi:10.1093/brain/awl078 · Cited by 679 · see citing works
Corticodentatonigral Degeneration With Neuronal Achromasia
Rebeiz, J. J., Kolodny, E. H., & Richardson, E. P. (1968) · Archives of Neurology · doi:10.1001/archneur.1968.00470310034003 · Cited by 627 · see citing works
The evolution and pathology of frontotemporal dementia
Kertesz, A., McMonagle, P., Blair, M., Davidson, W., & Munoz, D. G. (2005) · Brain · doi:10.1093/brain/awh598 · Cited by 609 · see citing works
Focal cortical presentations of Alzheimer's disease
Alladi, S., Xuereb, J., Bak, T., Nestor, P., Knibb, J., Patterson, K., & Hodges, J. R. (2007) · Brain · doi:10.1093/brain/awm213 · Cited by 581 · see citing works
Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration
Gass, J. M., Cannon, A. D., Mackenzie, I. R., Boeve, B. F., Baker, M. C., Adamson, J. L., Crook, R., Melquist, S., Kuntz, K., Petersen, R. C., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl241 · Cited by 574 · see citing works
Cortical‐basal ganglionic degeneration
Riley, D. E., Lang, A. E., Lewis, A., Resch, L., Ashby, P., Hornykiewicz, O., & Black, S. E. (1990) · Neurology · doi:10.1212/wnl.40.8.1203 · Cited by 570 · see citing works
Boeve, B. F., Lang, A. E., & Litvan, I. (2003) · Annals of Neurology · doi:10.1002/ana.10570 · Cited by 526 · see citing works
Kramer, J. H., Jurik, J., Sha, S. J., Rankin, K., Rosen, H. J., Johnson, J. K., & Miller, B. L. (2003) · Cognitive and Behavioral Neurology · doi:10.1097/00146965-200312000-00002 · Cited by 504 · see citing works
Self-citationClark, L. N., Poorkaj, P., Wszolek, Z., Geschwind, D., Nasreddine, Z. S., Miller, B. L., Li, D., Payami, H., Awert, F., Markopoulou, K., et al. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.22.13103 · Cited by 488 · see citing works
Self-citationAβ amyloid and glucose metabolism in three variants of primary progressive aphasia
Rabinovici, G. D., Jagust, W. J., Furst, A. J., Ogar, J. M., Racine, C. A., Mormino, E. C., O'Neil, J. P., Lal, R. A., Dronkers, N. F., Miller, B. L., et al. (2008) · Annals of Neurology · doi:10.1002/ana.21451 · Cited by 477 · see citing works
Self-citationClinicopathologic analysis of frontotemporal and corticobasal degenerations and PSP
Josephs, K. A., Petersen, R. C., Knopman, D. S., Boeve, B. F., Whitwell, J. L., Duffy, J. R., Parisi, J. E., & Dickson, D. W. (2006) · Neurology · doi:10.1212/01.wnl.0000191307.69661.c3 · Cited by 455 · see citing works
Pathologic heterogeneity in clinically diagnosed corticobasal degeneration
Boeve, B. F., Maraganore, D. M., Parisi, J. E., Ahlskog, J. E., Graff-Radford, N., Caselli, R. J., Dickson, D. W., Kokmen, E., & Petersen, R. C. (1999) · Neurology · doi:10.1212/wnl.53.4.795 · Cited by 417 · see citing works
Does corticobasal degeneration exist? A clinicopathological re-evaluation
Ling, H., O'Sullivan, S. S., Holton, J. L., Revesz, T., Massey, L. A., Williams, D. R., Paviour, D. C., & Lees, A. J. (2010) · Brain · doi:10.1093/brain/awq123 · Cited by 394 · see citing works
Accuracy of the Clinical Diagnosis of Corticobasal Degeneration
Litvan, I., Agid, Y., Goetz, C. G., Jankovic, J. J., Wenning, G. K., Brandel, J., Lai, E. C., Verny, M., Chaudhuri, К. R., McKee, A. C., et al. (1997) · Neurology · doi:10.1212/wnl.48.1.119 · Cited by 377 · see citing works
Constantinidis, J., Richard, J., & Tissot, R. (2008) · European Neurology · doi:10.1159/000114320 · Cited by 352 · see citing works
Progressive posterior cortical dysfunction
Renner, J. A., Burns, J. M., Hou, C. E., McKeel, D. W., Storandt, M., & Morris, J. C. (2004) · Neurology · doi:10.1212/01.wnl.0000140290.80962.bf · Cited by 311 · see citing works
The corticobasal degeneration syndrome overlaps progressive aphasia and frontotemporal dementia
KERTESZ, A. E., Martínez‐Lage, P., Davidson, W., & Muñoz, D. G. (2000) · Neurology · doi:10.1212/wnl.55.9.1368 · Cited by 304 · see citing works
The cognitive profile of posterior cortical atrophy
McMonagle, P., Deering, F., Berliner, Y., & KERTESZ, A. E. (2006) · Neurology · doi:10.1212/01.wnl.0000196477.78548.db · Cited by 263 · see citing works
Clinical syndromes associated with posterior atrophy
Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S. J., Rabinovici, G. D., Miller, B. L., & Gorno‐Tempini, M. L. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c0d427 · Cited by 252 · see citing works
Self-citationImaging correlates of pathology in corticobasal syndrome
Whitwell, J. L., Jack, C. R., Boeve, B. F., Parisi, J. E., Ahlskog, J. E., Drubach, D. A., Senjem, M. L., Knopman, D. S., Petersen, R. C., Dickson, D. W., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181feb2e8 · Cited by 241 · see citing works
Voxel-based morphometry in autopsy proven PSP and CBD
Josephs, K. A., Whitwell, J. L., Dickson, D. W., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., & Jack, C. R. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.019 · Cited by 234 · see citing works
Cognitive and motor assessment in autopsy-proven corticobasal degeneration
Murray, R., Neumann, M., Forman, M. S., Farmer, J. M., Massimo, L. M., Rice, A., Miller, B. L., Johnson, J. K., Clark, C. M., Hurtig, H. I., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000259519.78480.c3 · Cited by 218 · see citing works
Self-citationDementia as the most common presentation of cortical-basal ganglionic degeneration
Grimes, D. A., Lang, A. E., & Bergeron, C. (1999) · Neurology · doi:10.1212/wnl.53.9.1969 · Cited by 218 · see citing works
Josephs, K. A., & Dickson, D. W. (2003) · Movement Disorders · doi:10.1002/mds.10488 · Cited by 163 · see citing works
Corticobasal degeneration: etiopathological significance of the cytoskeletal alterations
Wakabayashi, K., Oyanagi, K., Makifuchi, T., Ikuta, F., Homma, A., Homma, Y., Horikawa, Y., & Tokiguchi, S. (1994) · Acta Neuropathologica · doi:10.1007/bf00293314 · Cited by 157 · see citing works
Primary progressive aphasia: Diagnosis, varieties, evolution
KERTESZ, A. E., Davidson, W., MCCABE, P., TAKAGI, K., & Muñoz, D. G. (2003) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617703950041 · Cited by 156 · see citing works
Hyperphosphorylated tau proteins differentiate corticobasal degeneration and Pick's disease
Buée‐Scherrer, V., Hof, P. R., Buée, L., Leveugle, B., Vermersch, P., Perl, D. P., Olanow, C. W., & Delacourte, A. (1996) · Acta Neuropathologica · doi:10.1007/s004010050436 · Cited by 144 · see citing works
Is the pathology of corticobasal syndrome predictable in life?
Shelley, B. P., Hodges, J. R., Kipps, C., Xuereb, J. H., & Bak, T. H. (2009) · Movement Disorders · doi:10.1002/mds.22558 · Cited by 139 · see citing works
Temporoparietal atrophy: a marker of AD pathology independent of clinical diagnosis
Whitwell, J., Clifford, R., Przybelski, S., Parisi, J., Senjem, M., Boeve, B., Knopman, D., Petersen, R., Dickson, D., & Josephs, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.10.012 · Cited by 131 · see citing works
Alzheimer's disease and corticobasal degeneration presenting as corticobasal syndrome
Hu, W. T., Rippon, G. W., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., & Josephs, K. A. (2009) · Movement Disorders · doi:10.1002/mds.22574 · Cited by 126 · see citing works
Gröschel, K., Hauser, T.-K., Luft, A., Patronas, N., Dichgans, J., Litvan, I., & Schulz, J. B. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.070 · Cited by 125 · see citing works
The many faces of corticobasal degeneration
Wadia, P. M., & Lang, A. E. (2007) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(08)70027-0 · Cited by 114 · see citing works
Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy
KERTESZ, A. E., & McMonagle, P. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.08.036 · Cited by 110 · see citing works
Imaging of corticobasal degeneration syndrome
Koyama, M., Yagishita, A., Nakata, Y., et al. (2007) · Neuroradiology · doi:10.1007/s00234-007-0265-6 · Cited by 89 · see citing works
Anatomical differences between CBS‐corticobasal degeneration and CBS‐Alzheimer's disease
Josephs, K. A., Whitwell, J. L., Boeve, B. F., Knopman, D. S., Petersen, R. C., Hu, W. T., Parisi, J. E., Dickson, D. W., & Jack, C. R. (2010) · Movement Disorders · doi:10.1002/mds.23062 · Cited by 85 · see citing works
Arima, K., Uesugi, H., Fujita, I., et al. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90072-8 · Cited by 63 · see citing works
Symmetric corticobasal degeneration (S-CBD)
Hassan, A., Whitwell, J. L., Boeve, B. F., Jack, C. R., Parisi, J. E., Dickson, D. W., & Josephs, K. A. (2009) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2009.11.013 · Cited by 61 · see citing works
Neuropsychiatric Features in 36 Pathologically Confirmed Cases of Corticobasal Degeneration
Geda, Y. E., Boeve, B. F., Negash, S., Graff‐Radford, N. R., Knopman, D. S., Parisi, J. E., Dickson, D. W., & Petersen, R. C. (2007) · Journal of Neuropsychiatry · doi:10.1176/jnp.2007.19.1.77 · Cited by 49 · see citing works
Gibb, W., Luthert, P., & Marsden, C. (1989) · Brain : a journal of neurology · doi:10.1093/brain/112.5.1171 · Cited by 39 · see citing works
VanVoorst, W. A., Greenaway, M. C., Boeve, B. F., Ivnik, R. J., Parisi, J. E., Ahlskog, J. E., Knopman, D. S., Dickson, D. W., Petersen, R. C., Smith, G. E., et al. (2007) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2007.09.006 · Cited by 34 · see citing works
Ukmar, M., Moretti, R., Torre, P., et al. (2003) · Neuroradiology · doi:10.1007/s00234-003-1058-1 · Cited by 22 · see citing works
[Limits & current concept of Pick's disease; its differential diagnosis].
Delay, J., Brion, S., & Escourolle, R. (1957) · PubMed · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Criteria for the diagnosis of corticobasal degeneration
Armstrong, M. J., Litvan, I., Lang, A. E., Bak, T. H., Bhatia, K. P., Borroni, B., Boxer, A. L., Dickson, D. W., Grossman, M., Hallett, M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f0fd1 · Cited by 1,904 · see citing works
Self-citationClinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group
Dubois, B., Villain, N., Frisoni, G. B., Rabinovici, G. D., Sabbagh, M., Cappa, S., Bejanin, A., Bombois, S., Epelbaum, S., Teichmann, M., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00066-1 · Cited by 1,051 · see citing works
“Other phenotypes, including the behavioural/dysexecutive variant 70,71 , the cortico-basal variant 72,73 , and the other variants of primary progressive aphasia 69,74 (Supplementary Figure 1), are less commonly related to AD pathology (uncommon AD phenotypes).”
BackgroundSelf-citationAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators, Thijssen, E. H., La Joie, R., Wolf, A., Strom, A., Wang, P., Iaccarino, L., Bourakova, V., Cobigo, Y., Heuer, H., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0762-2 · Cited by 761 · see citing works
Self-citationBridel, C., van Wieringen, W. N., Zetterberg, H., Tijms, B. M., Teunissen, C. E., and the NFL Group, Alvarez-Cermeño, J. C., Andreasson, U., Axelsson, M., Bäckström, D. C., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.1534 · Cited by 764 · see citing works
Self-citationPredicting Regional Neurodegeneration from the Healthy Brain Functional Connectome
Zhou, J., Gennatas, E. D., Kramer, J. H., Miller, B. L., & Seeley, W. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.004 · Cited by 706 · see citing works
Self-citationNew insights into atypical Alzheimer's disease in the era of biomarkers
Graff-Radford, J., Yong, K. X. X., Apostolova, L. G., Bouwman, F. H., Carrillo, M., Dickerson, B. C., Rabinovici, G. D., Schott, J. M., Jones, D. T., & Murray, M. E. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30440-3 · Cited by 706 · see citing works
Self-citationPrevalence of Amyloid PET Positivity in Dementia Syndromes: A Meta-analysis
Ossenkoppele, R., Jansen, W. J., Rabinovici, G. D., Knol, D. L., van der Flier, W. M., van Berckel, B. N. M., Scheltens, P., Visser, P. J., Verfaillie, S. C. J., Zwan, M. D., et al. (2015) · JAMA · doi:10.1001/jama.2015.4669 · Cited by 677 · see citing works
Self-citationConsensus classification of posterior cortical atrophy
Crutch, S. J., Schott, J. M., Rabinovici, G. D., Murray, M., Snowden, J. S., van der Flier, W. M., Dickerson, B. C., Vandenberghe, R., Ahmed, S., Bak, T. H., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.01.014 · Cited by 665 · see citing works
Self-citationThijssen, E. H., La Joie, R., Strom, A., Fonseca, C., Iaccarino, L., Wolf, A., Spina, S., Allen, I. E., Cobigo, Y., Heuer, H., et al. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00214-3 · Cited by 607 · see citing works
Self-citationEpileptic activity in Alzheimer’s disease: Causes and clinical relevance
Vossel, K. A., Tartaglia, M. C., Nygaard, H. B., Zeman, A. Z., & Miller, B. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30044-3 · Cited by 590 · see citing works
Self-citationOssenkoppele, R., Pijnenburg, Y. A. L., Perry, D. C., Cohn-Sheehy, B. I., Scheltens, N. M. E., Vogel, J. W., Kramer, J. H., van der Vlies, A. E., Joie, R. L., Rosen, H. J., et al. (2015) · Brain · doi:10.1093/brain/awv191 · Cited by 548 · see citing works
Self-citationClinicopathological correlations in behavioural variant frontotemporal dementia
Perry, D. C., Brown, J. A., Possin, K. L., Datta, S., Trujillo, A., Radke, A., Karydas, A., Kornak, J., Sias, A. C., Rabinovici, G. D., et al. (2017) · Brain · doi:10.1093/brain/awx254 · Cited by 309 · see citing works
Self-citationScherling, C. S., Hall, T., Berisha, F., Klepac, K., Karydas, A., Coppola, G., Kramer, J. H., Rabinovici, G., Ahlijanian, M., Miller, B. L., et al. (2014) · Annals of Neurology · doi:10.1002/ana.24052 · Cited by 249 · see citing works
Self-citationFrontotemporal lobar degeneration
Grossman, M., Seeley, W. W., Boxer, A. L., Hillis, A. E., Knopman, D. S., Ljubenov, P. A., Miller, B., Piguet, O., Rademakers, R., Whitwell, J. L., et al. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00447-0 · Cited by 178 · see citing works
Self-citationBeagle, A. J., Darwish, S. M., Ranasinghe, K. G., La, A. L., Karageorgiou, E., & Vossel, K. A. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-170031 · Cited by 173 · see citing works
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes
Tsai, R. M., Bejanin, A., Lesman-Segev, O., LaJoie, R., Visani, A., Bourakova, V., O’Neil, J. P., Janabi, M., Baker, S., Lee, S. E., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0470-7 · Cited by 164 · see citing works
Self-citationRedefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes
Murley, A. G., Coyle-Gilchrist, I., Rouse, M. A., Jones, P. S., Li, W., Wiggins, J., Lansdall, C., Rodríguez, P. V., Wilcox, A., Tsvetanov, K. A., et al. (2020) · Brain · doi:10.1093/brain/awaa097 · Cited by 162 · see citing works
Mandelli, M. L., Vilaplana, E., Brown, J. A., Hubbard, H. I., Binney, R. J., Attygalle, S., Santos-Santos, M. A., Miller, Z. A., Pakvasa, M., Henry, M. L., et al. (2016) · Brain · doi:10.1093/brain/aww195 · Cited by 139 · see citing works
Self-citationAn algorithmic approach to structural imaging in dementia
Harper, L., Barkhof, F., Scheltens, P., Schott, J. M., & Fox, N. C. (2014) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306285 · Cited by 137 · see citing works
Alzheimer's disease including focal presentations
Villain, N., & Dubois, B. (2019) · Seminars in Neurology · doi:10.1055/s-0039-1681041 · Cited by 113 · see citing works
Preferential degradation of cognitive networks differentiates Alzheimer’s disease from ageing
Chhatwal, J. P., Schultz, A. P., Johnson, K. A., Hedden, T., Jaimes, S., Benzinger, T. L. S., Jack, C., Ances, B. M., Ringman, J. M., Marcus, D. S., et al. (2018) · Brain · doi:10.1093/brain/awy053 · Cited by 101 · see citing works
Irwin, D. J., Trojanowski, J. Q., & Grossman, M. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00006 · Cited by 96 · see citing works
Self-citationStaffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91 · see citing works
Self-citationUse of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium
Miyagawa, T., Brushaber, D., Syrjanen, J., Kremers, W., Fields, J., Forsberg, L. K., Heuer, H. W., Knopman, D., Kornak, J., Boxer, A., et al. (2020) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.05.013 · Cited by 92 · see citing works
Self-citationChételat, G., Ossenkoppele, R., Villemagne, V. L., Perrotin, A., Landeau, B., Mézenge, F., Jagust, W. J., Dore, V., Miller, B. L., Egret, S., et al. (2016) · Brain · doi:10.1093/brain/aww159 · Cited by 80 · see citing works
Self-citationNeocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease
Phillips, J. S., Da Re, F., Dratch, L., Xie, S. X., Irwin, D. J., McMillan, C. T., Vaishnavi, S. N., Ferrarese, C., Lee, E. B., Shaw, L. M., et al. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.11.008 · Cited by 74 · see citing works
Self-citationUnderstanding the cause of sporadic Alzheimer’s disease
Zetterberg, H., & Mattsson, N. (2014) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.2014.915740 · Cited by 73 · see citing works
Tau-induced pathology in epilepsy and dementia: notions from patients and animal models.
Sánchez, M., García-Cabrero, A., Sánchez-Elexpuru, G., Burgos, D., & Serratosa, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041092 · Cited by 68 · see citing works
García, A. M., Welch, A. E., Mandelli, M. L., Henry, M. L., Lukic, S., Torres Prioris, M. J., Deleon, J., Ratnasiri, B. M., Lorca-Puls, D. L., Miller, B. L., et al. (2022) · Neurology · doi:10.1212/wnl.0000000000200750 · Cited by 47 · see citing works
Self-citationBharti, K., Bologna, M., Upadhyay, N., Piattella, M. C., Suppa, A., Petsas, N., Giannì, C., Tona, F., Berardelli, A., & Pantano, P. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00248 · Cited by 44 · see citing works
Diagnosing the frontal variant of Alzheimer’s disease: a clinician’s yellow brick road
Sawyer, R. P., Rodriguez-Porcel, F., Hagen, M., Shatz, R., & Espay, A. J. (2017) · Journal of Clinical Movement Disorders · doi:10.1186/s40734-017-0052-4 · Cited by 40 · see citing works
“On the other hand, a corticobasal syndrome (asymmetric parkinsonism with limb dystonia, apraxia, and cortical sensory loss) is more often due to AD pathology than corticobasal degeneration or other disorders [31].”
BackgroundAtypical Alzheimer Disease Variants
Polsinelli, A. J., & Apostolova, L. G. (2022) · Continuum · doi:10.1212/con.0000000000001082 · Cited by 39 · see citing works
Kim, E.-J., Vatsavayai, S., & Seeley, W. W. (2016) · The Behavioral Neurology of Dementia · doi:10.1017/9781139924771.008 · Cited by 7 · see citing works
Self-citation
- Authors
- Lee, S. E., Rabinovici, G. D., Mayo, M. C., Wilson, S. M., Seeley, W. W., DeArmond, S. J., Huang, E. J., Trojanowski, J. Q., Growdon, M. E., Jang, J. Y., Sidhu, M., See, T. M., Karydas, A. M., Gorno‐Tempini, M., Boxer, A. L., Weiner, M. W., Geschwind, M. D., Rankin, K. P., & Miller, B. L.
- Affiliations
- University of California, San Francisco (US)
- University of Arizona (US)
- University of Pennsylvania (US)
- Corresponding author
- Lee, Suzee E.
- ORCID
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 2011-08
- Volume
- 70
- Issue
- 2
- Pages
- 327-340
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- PMC
- PMC3154081
- OpenAlex
- W1996314668
- Cited by
- 434
- References
- 52
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 23 · 2023: 22 · 2022: 30 · 2021: 34 · 2020: 35 · 2019: 39 · 2018: 29 · 2017: 34 · 2016: 34 · 2015: 29 · 2014: 32 · 2013: 23 · 2012: 21
- FWCI
- 17.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Neurology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion)
- Funders
- National Institutes of Health (K26OD010927)
- National Institute on Aging (K23AG021989, AG-19724, P30AG010124, P01AG017586, AG17586, AG-10124, AG023501, R01AG031189, R01AG031278, K23AG031861, R01AG038791, P01AG019724, T32AG023481, P50AG023501)
- National Institute on Deafness and Other Communication Disorders (R03DC010878)
- National Institute of Neurological Disorders and Stroke (R01NS050915)
- National Center for Research Resources (UL1RR024131, K26RR024858, P41RR023953)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- corticobasal degeneration, corticobasal syndrome, clinicopathological correlation, brain atrophy patterns, frontal lobe involvement, progressive nonfluent aphasia, behavioral variant frontotemporal dementia, posterior cortical atrophy, Alzheimer's disease, progressive supranuclear palsy, frontotemporal lobar degeneration, voxel-based morphometry, differential diagnosis
- MeSH terms
- Aged, Aged, 80 and over, Autopsy, Basal Ganglia, Cerebral Cortex, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Syndrome, Neurodegenerative Diseases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
