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Cited by 52Endometriosis Research and TreatmentGynecological conditions and treatmentsDiagnosis and treatment of tuberculosis

Clinical management and immunohistochemical analysis of umbilical endometriosis

Mechsner, Sylvia, Bartley, Julia, Infanger, Manfred, Loddenkemper, Christoph, Herbel, Johanna, Ebert, Andreas D.·2009·Archives of Gynecology and Obstetrics
DOI 10.1007/s00404-008-0900-4
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Abstract

Purpose To established a strategy for diagnostic and therapeutic management of umbilical endometriosis and to determine the biological character.Methods Clinical examination, vaginal and abdominal ultrasound, magnetic resonance imaging of the abdominal wall and laparoscopy were performed on a 42-year-old woman with umbilical endometriosis. Surgery with umbilical reconstruction was performed by a new plastic surgery technique. Immunohistochemical analyses (against Ki 67, estrogen/progestogen receptor, CD10, smooth muscle actin, desmin, caldesmon, von Willebrandt factor, cyclooxygensae-2 and VEGF) were done to characterize the umbilical endometriotic lesion.Results The extension of the endometriotic lesion necessitated total removal of the umbilicus. Umbilical reconstruction was performed by a new plastic surgery technique. The lesion did express CD10, estrogen and progestogen receptors, and did show a moderate proliferation rate. Furthermore, signs of metaplastic processes such as smooth muscle metaplasia and angiogenesis were detected. The endometriotic lesion was positive not only for smooth muscle actin, caldesmon and desmin, but also for COX-2 and VEGF.Conclusion Based on a case report and a literature review, we discuss the diagnostic and therapeutic management of umbilical endometriosis at our endometriosis research center. Furthermore, our data suggest that the umbilical endometriotic lesion originated from reactivated multipotent cells.

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Crossref · 10.1007/s00404-008-0900-4

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  • Transabdominal ultrasonography can show umbilical endometriosis lesions as low echoic lesions, while CT and MRI are more useful to preoperatively determine the size and extent of lesions.

    “While transabdominal ultrasonography can show lesions as low echoic lesions, CT and MRI are more useful to preoperatively determine the size and extent of lesions.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [49]

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Authors
Mechsner, S., Bartley, J., Infanger, M., Loddenkemper, C., Herbel, J., & Ebert, A. D.
Affiliations
  • Stiftung Charité (DE)
  • Vivantes Klinikum (DE)
Corresponding author
Mechsner, Sylvia
ORCID
Venue
Archives of Gynecology and Obstetrics
Publisher
Springer Science and Business Media LLC
Published
2008-12-31
Volume
280
Issue
2
Pages
235-242
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
DOI
10.1007/s00404-008-0900-4
OpenAlex
W2080519940
Cited by
52
References
19
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 3
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Surgery › Diagnosis and treatment of tuberculosis
Keywords
umbilical endometriosis, umbilical reconstruction, plastic surgery techniques, immunohistochemistry, CD10, estrogen receptor, progesterone receptor, Ki-67 proliferation index, angiogenesis, cyclooxygenase-2, vascular endothelial growth factor, abdominal wall imaging, laparoscopic surgery
MeSH terms
Adult, Endometriosis, Female, Humans, Immunohistochemistry, Middle Aged, Laparoscopy, Umbilicus

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