Clear cell adenocarcinoma arising from umbilical endometriosis
Abstract
Umbilical endometriosis is a very rare condition, and as far as we are aware, there have been no reported cases of its malignant transformation. Here, we report a case of clear cell adenocarcinoma arising from umbilical endometriosis in a 60‐year‐old woman who underwent hysterectomy for a uterine myoma at the age of 38, and who denied cyclic bleeding at the site of an umbilical cutaneous nodule correlating with menses until the age of 48. An umbilical tumor (3 cm diameter) was identified by magnetic resonance imaging and an abnormal accumulation was found only at the umbilical lesion by positron emission tomography examination. We observed endometriosis adjacent to the clear cell adenocarcinoma and transformation to carcinoma from endometriosis at the umbilical lesion histopathologically. Clear cell adenocarcinoma of the umbilicus was thought to have arisen from endometriosis; it expressed HER‐2 protein and showed strong mesothelial characteristics immunohistochemically.
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PET-CT was reported to be useful for the diagnosis of malignancy in umbilical endometriosis.
“As a preoperative imaging test, positron emission tomography (PET)‐CT was reported to be useful for the diagnosis of malignancy.”
From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [54]
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Extra-pelvic endometriosis: a review.
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- Authors
- Obata, K., Ikoma, N., Oomura, G., & Inoue, Y.
- Affiliations
- Kindai University (JP)
- ORCID
- Inoue, Yoshiki
- Venue
- Journal of Obstetrics and Gynaecology Research
- Publisher
- Wiley
- Published
- 2012-07-29
- Volume
- 39
- Issue
- 1
- Pages
- 455-461
- ISSN
- 1341-8076 (ISSN-L)
- 1447-0756
- OpenAlex
- W2156220155
- Cited by
- 40
- References
- 24
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 3 · 2022: 10 · 2021: 3 · 2020: 4 · 2019: 2 · 2017: 3 · 2016: 5 · 2014: 3 · 2013: 2
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of obstetrics and gynaecology research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Metastasis and carcinoma case studies
- Health Sciences › Medicine › Surgery › Urinary and Genital Oncology Studies
- Keywords
- clear cell adenocarcinoma, umbilical endometriosis, malignant transformation of endometriosis, HER2 expression, uterine fibroids, hysterectomy, positron emission tomography
- MeSH terms
- Abdominal Neoplasms, Cell Transformation, Neoplastic, Endometriosis, Female, Humans, Middle Aged, Umbilicus, Adenocarcinoma, Clear Cell
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