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Cited by 42Endometriosis Research and TreatmentGynecological conditions and treatmentsEndometrial and Cervical Cancer Treatments

A National Survey of Umbilical Endometriosis in Japan

Hirata, Tetsuya, Koga, Kaori, Kitade, Mari, Fukuda, Shinya, Neriishi, Kazuaki, Taniguchi, Fuminori, Honda, Ritsuo, Takazawa, Naoko +13 more·2020·Journal of Minimally Invasive Gynecology
DOI 10.1016/j.jmig.2019.02.021
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Abstract

STUDY OBJECTIVE To identify the clinical presentation, diagnostic evaluation, operative or medical management, and postoperative recurrence of umbilical endometriosis. DESIGN A retrospective national survey. SETTING Obstetrics and Gynecology and Plastic Surgery Departments at a teaching hospital in Japan. PATIENTS Patients with umbilical endometriosis or malignant transformation. INTERVENTIONS A national survey was conducted to identify and evaluate cases of umbilical endometriosis or malignant transformation documented between 2006 and 2016. MEASUREMENTS AND MAIN RESULTS The following were evaluated for each patient: age at diagnosis, body mass index, medical history, presence of extragenital endometriosis, surgical history, symptoms, imaging modalities, surgical therapy, hormonal therapy, follow-up period, postoperative recurrence, and time to recurrence. Ninety-six patients were identified with pathologically diagnosed benign umbilical endometriosis. The patients frequently had swelling (86.5%), pain (81.3%), or bleeding (44.8%) in the umbilicus. Sensitivity was 87.1% for physical examination, 76.5% for transabdominal ultrasonography, 75.6% for computed tomography, and 81.8% for magnetic resonance imaging. The cumulative recurrence rate was 1.34% at 6 months, 6.35% at 12 months, and 6.35% at 60 months after surgery. Importantly, there was no recurrence after wide resection including of the peritoneum (0 of 37 cases). The efficacy of dienogest (an oral progestin), gonadotropin-releasing hormone agonists, and oral contraceptives was 91.7%, 81.8%, and 57.1%, respectively. Finally, 2 cases of malignant transformation were identified. CONCLUSION There was a low recurrence rate following surgery, and hormonal treatment is an option, although the current findings suggest surgical therapy as the first choice of treatment for umbilical endometriosis.

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Crossref · 10.1016/j.jmig.2019.02.021

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  • Many patients with umbilical endometriosis are diagnosed by physical examination and imaging modalities.

    “Many patients with umbilical endometriosis are diagnosed by physical examination and imaging modalities.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [44]

  • Symptoms of swelling, pain, or bleeding at umbilical endometriosis lesions were present in 86.5%-90.9%, 80.5%-81.3%, or 44.8%-49.2% of cases, respectively.

    “Symptoms of swelling, pain, or bleeding at the lesions were present in 86.5%‐90.9%, 80.5%‐81.3%, or 44.8%‐49.2% of cases, respectively.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [44]

  • In a survey of 96 patients pathologically diagnosed with umbilical endometriosis, 66.7% had no history of prior surgery.

    “In a survey of 96 patients pathologically diagnosed with umbilical endometriosis, 66.7% had no history of prior surgery.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [44]

  • Among umbilical endometriosis, primary umbilical endometriosis is more frequent.

    “Among umbilical endometriosis, primary umbilical endometriosis is more frequent.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [44]

  • No postoperative recurrence was reported in cases of radical surgery resected to the peritoneum for umbilical endometriosis.

    “In particular, no postoperative recurrence was reported in cases of radical surgery resected to the peritoneum.”

    From Extra-pelvic endometriosis: a review. (2020) · cites this paper as [44]

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Authors
Hirata, T., Koga, K., Kitade, M., Fukuda, S., Neriishi, K., Taniguchi, F., Honda, R., Takazawa, N., Tanaka, T., Kurihara, M., Nakajima, J., Horie, S., Nakai, H., Enomoto, T., Mandai, M., Narahara, H., Kitawaki, J., Harada, T., Katabuchi, H., Yoshimura, K., & Osuga, Y.
Affiliations
  • Tottori University (JP)
  • Kumamoto University (JP)
  • Juntendo University (JP)
  • Nissan Tamagawa Hospital (JP)
  • The University of Tokyo (JP)
  • Kindai University (JP)
  • Niigata University (JP)
  • Kyoto University (JP)
  • Oita University (JP)
  • Kyoto Prefectural University (JP)
  • Jichi Medical University (JP)
Corresponding author
Hirata, Tetsuya
ORCID
Venue
Journal of Minimally Invasive Gynecology
Publisher
Elsevier BV
Published
2020-01
Volume
27
Issue
1
Pages
80-87
ISSN
1553-4650 (ISSN-L)
DOI
10.1016/j.jmig.2019.02.021
OpenAlex
W2932205255
Semantic Scholar
3a485f8d1e7a41e65f2c05cf1aa77bb7d5aa1eaa
Cited by
40
References
30
Citations by year
2026: 1 · 2025: 9 · 2024: 11 · 2023: 5 · 2022: 8 · 2021: 2 · 2020: 4
FWCI
3.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Minimally Invasive Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Ministry of Education, Culture, Sports, Science and Technology
  • Japan Agency for Medical Research and Development
  • Ministry of Health, Labour and Welfare
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
  • Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
Keywords
umbilical endometriosis, postoperative recurrence, surgical management, wide resection, hormone therapy, dienogest, GnRH agonist, oral contraceptives, malignant transformation, diagnostic imaging, clinical features, Japan
MeSH terms
Adult, Endometriosis, Female, Humans, Japan, Middle Aged, Muscular Diseases, Postoperative Period, Surveys and Questionnaires, Recurrence, Retrospective Studies, Umbilicus, Treatment Outcome

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