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Cited by 6Pregnancy and preeclampsia studiesMaternal and fetal healthcareBirth, Development, and Health

Placental abruption and long-term cardiovascular morbidity of the offspring

Berkman, Liron, Wainstock, Tamar, Sheiner, Eyal, Landau, Daniella, Pariente, Gali·2019·Archives of Gynecology and Obstetrics
DOI 10.1007/s00404-018-4974-3
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Abstract

Objective While placental abruption is often associated with short-term adverse pregnancy outcomes, we sought to assess whether placental abruption increases the risk for long-term cardiovascular morbidity of the offspring.Methods To study the long-term cardiovascular hospitalizations of offspring of patients with and without placental abruption, cardiovascular morbidity was assessed up to the age of 18 years according to a predefined set of ICD-9 codes associated with hospitalization of the offspring. Our data consist of deliveries which occurred between the years 1991 and 2014 in a tertiary medical center. Pregnancies following fertility treatments, multifetal pregnancies, and pregnancies with offspring with congenital anomalies, lack of prenatal care, and perinatal mortality were excluded from the study. We used Kaplan-Meier curve to compare cumulative morbidity incidence and Cox proportional hazards model to control for confounder.Results During the study period, we examined 217,910 deliveries, out of which 0.46% (n = 1003) were effected by placental abruption. Compared to normal birth children, children born to mothers with placental abruption did not show a significantly higher cumulative incidence of long-term cardiovascular morbidity (1.0% vs. 0.6%; p = 0.127). Placental abruption was not noted as an independent risk factor for long-term cardiovascular morbidity of offspring in the Cox regression analysis, which adjusted for confounders.Conclusion Our study does not support the association between placental abruption and risk for long-term cardiovascular morbidity of the offspring.

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Crossref · 10.1007/s00404-018-4974-3

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  • A large cohort study of 217,910 deliveries with 1003 cases of abruption reported no increased risk of non-fatal cardiovascular disease in the offspring (hazard ratio 1.12, 95% CI 0.60-2.11).

    “A large cohort study of 217,910 deliveries with 1003 cases of abruption reported no increased risk of non-fatal CVD in the offspring (hazard ratio 1.12, 95% CI 0.60–2.11) (122).”

    From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [122]

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Authors
Berkman, L., Wainstock, T., Sheiner, E., Landau, D., & Pariente, G.
Affiliations
Ben-Gurion University of the Negev (IL)
Corresponding author
Sheiner, Eyal
ORCID
Venue
Archives of Gynecology and Obstetrics
Publisher
Springer Science and Business Media LLC
Published
2018-11-26
Volume
299
Issue
2
Pages
393-401
ISSN
  • 0003-9128 (ISSN-L)
  • 0932-0067
  • 1432-0711
DOI
10.1007/s00404-018-4974-3
OpenAlex
W2902649553
Cited by
6
References
35
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Archives of Gynecology and Obstetrics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
placental abruption, cardiovascular morbidity, offspring, long-term outcomes, pediatric hospitalization, pregnancy complications, risk factors
MeSH terms
Abruptio Placentae, Adult, Cardiovascular Diseases, Child, Child, Preschool, Female, Humans, Infant, Male, Morbidity, Pregnancy, Pregnancy Outcome, Risk Factors, Incidence, Premature Birth

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