Course of mental health and mother–infant bonding in hospitalized women with threatened preterm birth
Open accessAbstract
Purpose Pregnancy complications (PC) with signs of threatened preterm birth are often associated with lengthy hospital stays, which have been shown to be accompanied by anxiety, depressive symptoms, and increased stress level. It remains unclear, whether the perinatal course of mental health of these women differs from women without PC and whether there may be differences in the postpartum mother-infant bonding.Methods In a naturalistic longitudinal study with two measurements (24-36th weeks of gestation and 6 weeks postpartum), we investigated depression (EPDS), anxiety (STAI-T), stress (PSS), and postpartum mother-infant bonding (PBQ) in women with threatened preterm birth (N = 75) and women without PC (N = 70). For data evaluation, we used means of frequency analysis, analysis of variance with repeated measurements, and t-tests for independent samples.Results The patient group showed significantly higher rates of depression, anxiety, and stress during inpatient treatment in pregnancy, as well as 6 weeks postpartum compared to the control group. While depression and anxiety decreased over time in both groups, stress remained at the same level 6 weeks postpartum as in pregnancy. We found no significant differences in mother-infant bonding between the two groups at all considered PBQ scales.Conclusion It is recommended to pay attention to the psychological burden of all obstetric patients as a routine to capture a psychosomatic treatment indication. A general bonding problem in women with threatened preterm birth was not found. Nevertheless, increased maternal stress, anxiety, and depressiveness levels during pregnancy may have a negative impact on the development of the fetus.
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The depression outcome meta-analysis included 17 studies of 1,998 women.
“Seventeen studies of 1,998 women were included in the meta-analysis of depression outcome42–58 (Table 1) and 7 studies of 851 women included in the anxiety outcome42,43,45–47,58,59 (Table 2).”
From Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications (2021) · cites this paper as [43]
Selection bias was possible in 7 studies that did not report participation rate and in 1 study with less than 50% participation.
“Selection bias was possible in 7 studies43,49,51,52,55–57 which did not report the participation rate of eligible subjects and one study44 which reported < 50% participation rate.”
From Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications (2021) · cites this paper as [43]
Sample size calculations with power justifications were not reported by 13 included studies.
“Although sample size calculations with power justifications were not reported by 13 investigators42–47,50,51,53–56,58 for their various primary outcomes, this does not diminish the validity of the reported prevalence of included studies.”
From Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications (2021) · cites this paper as [43]
The anxiety outcome meta-analysis included 7 studies of 851 women.
“Seventeen studies of 1,998 women were included in the meta-analysis of depression outcome42–58 (Table 1) and 7 studies of 851 women included in the anxiety outcome42,43,45–47,58,59 (Table 2).”
From Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications (2021) · cites this paper as [43]
Study quality assessment showed 4 studies in the top quartile, 13 in the third quartile, and 1 in the second quartile.
“Study quality assessment using the NIH quality assessment tool demonstrated 4 studies42,43,46,49 in the top quartile (rating ≥ 75%), 13 studies45,47,48,50–59 in the third quartile (with rating ≥ 50–74%), and a single study44 in the second quartile (rating < 50%) (Table 2).”
From Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications (2021) · cites this paper as [43]
Hospitalized antepartum patients are at increased risk for postpartum depression (PPD).
“Available data suggest that hospitalized antepartum patients are at increased risk for postpartum depression (PPD) [28, 29]”
From Factors associated with postpartum depression symptoms following antepartum hospitalization (2026) · cites this paper as [29]
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Prevalence of Depression or Anxiety During Antepartum Hospitalizations for Obstetric Complications
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Factors associated with postpartum depression symptoms following antepartum hospitalization
Goulding, A. N., Palacios, D., Aras, S., Chen, H., Pasupuleti, S., Toscano, M., Cirino, N., Christie, I. C., Liu, Z., Miller, E. S., et al. (2026) · Pregnancy · doi:10.1002/pmf2.70319
- Authors
- Hanko, C., Bittner, A., Junge-Hoffmeister, J., Mogwitz, S., Nitzsche, K., & Weidner, K.
- Affiliations
- University Hospital Carl Gustav Carus (DE)
- Corresponding author
- Hanko, Cornelia
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2019-12-11
- Volume
- 301
- Issue
- 1
- Pages
- 119-128
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- OpenAlex
- W2994653764
- Cited by
- 21
- References
- 68
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Health Sciences › Medicine › Obstetrics and Gynecology › Maternal and Perinatal Health Interventions
- Keywords
- threatened preterm labor, maternal mental health, mother-infant bonding, depression, anxiety, psychological stress, pregnancy complications, postpartum period, hospitalized pregnant women, psychosomatic treatment
- MeSH terms
- Adult, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Mental Health, Mother-Child Relations, Mothers, Pregnancy, Pregnancy Complications, Surveys and Questionnaires, Premature Birth
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