Polycystic ovary syndrome management: a review of the possible amazing role of berberine
Open accessAbstract
Purpose: The therapy of polycystic ovary syndrome (PCOS) is based on synthetic hormones associated with lifestyle changes, but these therapies cannot be taken continuously, especially by women who would like to become pregnant. Thus, nutraceutical compounds were investigated as possible agents for treatment of PCOS. Berberine is shown to be effective against insulin resistance and obesity, particularly against visceral adipose tissue (VAT). Because of these properties, researchers theorized that berberine could be effective in PCOS treatment. Methods: The aim of this narrative review was to assess the state of the art about the use of berberine in PCOS management. Results: This review included 5 eligible studies. Despite the number of studies considered being low, the number of women studied is high (1078) and the results are interesting. Two authors find out that berberine induced a redistribution of adipose tissue, reducing VAT in the absence of weight loss and improved insulin sensitivity, quite like metformin. One author demonstrated that berberine improved the lipid pattern. Moreover, three authors demonstrated that berberine improved insulin resistance in theca cells with an improvement of the ovulation rate per cycle, so berberine is also effective on fertility and live birth rates. Conclusions: Finally, berberine is safe to use in premenopausal women who want to get pregnant and showed few side effects in all the cited studies. In conclusion, the use of berberine for PCOS is safe and promising, even if more studies are needed to create a consensus about the dosage of berberine useful for long-term therapy.
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CoQ10 supplementation has been effective in enhancing insulin sensitivity and lowering indicators of inflammation in PCOS.
“It has been effective in enhancing insulin sensitivity and lowering indicators of inflammation. Thus, PCOS management can benefit from the intervention [194].”
From Nutritional and herbal interventions for polycystic ovary syndrome (PCOS): a comprehensive review of dietary approaches, macronutrient impact, and herbal medicine in management (2025) · cites this paper as [194]
The Results section reports improved insulin resistance and reduced C-reactive protein with berberine in women with PCOS, not with CoQ10. Searches for CoQ10, coenzyme Q10, ubiquinone, and ubiquinol found no passage addressing whether CoQ10 has these effects; the berberine findings neither establish nor contradict the CoQ10 claim. No page numbers are available in our copy. (LLM, conf=0.78)
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- Authors
- Rondanelli, M., Infantino, V., Riva, A., Petrangolini, G., Faliva, M. A., Peroni, G., Naso, M., Nichetti, M., Spadaccini, D., Gasparri, C., & Perna, S.
- Affiliations
- University of Pavia (IT)
- University of Bari Aldo Moro (IT)
- Indena (Italy) (IT)
- University of Bahrain (BH)
- Corresponding author
- Infantino, Vittoria
- ORCID
- Venue
- Archives of Gynecology and Obstetrics
- Published
- 2020-01
- Volume
- 301
- Issue
- 1
- Pages
- 53-60
- ISSN
- 0003-9128 (ISSN-L)
- 0932-0067
- 1432-0711
- PMC
- PMC7028834
- OpenAlex
- W3006151061
- Cited by
- 46
- References
- 29
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 12 · 2020: 3
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Archives of Gynecology and Obstetrics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Pharmacology › Berberine and alkaloids research
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Keywords
- polycystic ovary syndrome, berberine, nutraceuticals, insulin resistance, visceral adipose tissue, obesity, theca cells, ovulation rate, fertility, live birth rate, lipid profile, metformin, premenopausal women
- MeSH terms
- Adult, Berberine, Female, Humans, Polycystic Ovary Syndrome, Pregnancy
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