Cited by 348Psychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

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A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders

de Mello, M. Feijo, de Jesus Mari, J., Bacaltchuk, J., Verdeli, H., Neugebauer, R.·2005·European Archives of Psychiatry and Clinical Neuroscience

DOI 10.1007/s00406-004-0542-x

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Abstract

Objective Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach.Methods Studies of randomized clinical trials of IPT efficacy were located by searching all available data bases from 1974 to 2002. The searches employed the following MeSH categories: Depression/ Depressive Disorder; Interpersonal therapy; Outcome/Adverse Effects/Efficacy; in the identified studies. The efficacy outcomes were: remission; clinical improvement; the difference in depressive symptoms between the two arms of the trial at endpoint, and no recurrence. Drop out rates were used as an index of treatment acceptability.Results Thirteen studies fulfilled inclusion criteria and four meta-analyses were performed. IPT was superior in efficacy to placebo in nine studies (Weight Mean Difference (WMD) - 3.57 [-5.9, -1.16]). The combination of IPT and medication did not show an adjunctive effect compared to medication alone for acute treatment (RR 0.78 [0.30, 2.04]), for maintenance treatment (RR 1.01 [0.81, 1.25]), or for prophylactic treatment (RR 0.70 [0.30, 1.65]). IPT was significantly better than CBT (WMD -2.16 [-4.16,-0.15]).Conclusion The efficacy of IPT proved to be superior to placebo, similar to medication and did not increase when combined with medication. Overall, IPT was more efficacious than CBT. Current evidence indicates that IPT is an efficacious psychotherapy for DSD and may be superior to some other manualized psychotherapies.

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Authors: de Mello, M. F., de Jesus Mari, J., Bacaltchuk, J., Verdeli, H., & Neugebauer, R.
Affiliations: Universidade Federal de São Paulo (BR)
Columbia University (US)
New York State Psychiatric Institute (US)
ORCID: Verdeli, H.
Venue: European Archives of Psychiatry and Clinical Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-11-12
Volume: 255
Issue: 2
Pages: 75-82
ISSN: 0003-9373 (ISSN-L)
0940-1334
1433-8491
DOI: 10.1007/s00406-004-0542-x
OpenAlex: W2038051420
Cited by: 346
References: 49
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 36 · 2012: 17
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders: Medical Center, University of Pittsburgh
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: interpersonal psychotherapy, depressive disorders, major depressive disorder, psychotherapy efficacy, placebo comparison, cognitive behavioral therapy, antidepressant combination therapy, maintenance therapy, prophylaxis, remission, treatment discontinuation, treatment acceptability
MeSH terms: Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Humans, Interpersonal Relations, Patient Acceptance of Health Care, Psychiatric Status Rating Scales, Psychotherapy

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A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders

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