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A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders
Abstract
Objective Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach.Methods Studies of randomized clinical trials of IPT efficacy were located by searching all available data bases from 1974 to 2002. The searches employed the following MeSH categories: Depression/ Depressive Disorder; Interpersonal therapy; Outcome/Adverse Effects/Efficacy; in the identified studies. The efficacy outcomes were: remission; clinical improvement; the difference in depressive symptoms between the two arms of the trial at endpoint, and no recurrence. Drop out rates were used as an index of treatment acceptability.Results Thirteen studies fulfilled inclusion criteria and four meta-analyses were performed. IPT was superior in efficacy to placebo in nine studies (Weight Mean Difference (WMD) - 3.57 [-5.9, -1.16]). The combination of IPT and medication did not show an adjunctive effect compared to medication alone for acute treatment (RR 0.78 [0.30, 2.04]), for maintenance treatment (RR 1.01 [0.81, 1.25]), or for prophylactic treatment (RR 0.70 [0.30, 1.65]). IPT was significantly better than CBT (WMD -2.16 [-4.16,-0.15]).Conclusion The efficacy of IPT proved to be superior to placebo, similar to medication and did not increase when combined with medication. Overall, IPT was more efficacious than CBT. Current evidence indicates that IPT is an efficacious psychotherapy for DSD and may be superior to some other manualized psychotherapies.
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“IPT is considered a leading psychotherapeutic treatment for depression (Cuijpers, van Straten, Andersson, & van Oppen, 2008; de Mello, de Jesus Mari, Bacaltchuk, Verdeli, & Neugebauer, 2005; Schramm et al., 2008).”
From Sudanese Refugees in Cairo, Egypt: A Randomized Controlled Trial of Interpersonal Psychotherapy for Trauma, Depression and Interpersonal Violence: (517292011-807) (2009) · cites this paper as de Mello, de Jesus Mari, Bacaltchuk, Verdeli, & Neugebauer, 2005
In the citing paper
“the published data available prior to this study indicated a reduction of symptoms with application of IPT and no reports of adverse effects (Bass et al., 2006; Bleiberg & Markowitz, 2005; de Mello et al., 2005; Krupnick et al., 2008; Verdeli et al., 2008).”
From Sudanese Refugees in Cairo, Egypt: A Randomized Controlled Trial of Interpersonal Psychotherapy for Trauma, Depression and Interpersonal Violence: (517292011-807) (2009) · cites this paper as de Mello et al., 2005
In the citing paper
“The success of IPT with depression symptoms is consistent with previous studies, including those with refugee populations (Bass et al., 2006; de Mello et al., 2005).”
From Sudanese Refugees in Cairo, Egypt: A Randomized Controlled Trial of Interpersonal Psychotherapy for Trauma, Depression and Interpersonal Violence: (517292011-807) (2009) · cites this paper as de Mello et al., 2005
In the citing paper
“as an efficacious way of improving symptoms of depression [40].”
From Apps with maps-anxiety and depression mobile apps with evidence-based frameworks: Systematic search of major app stores (2020) · cites this paper as [40]
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Metadata
- Authors
- de Mello, M. F., de Jesus Mari, J., Bacaltchuk, J., Verdeli, H., & Neugebauer, R.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Columbia University (US)
- New York State Psychiatric Institute (US)
- ORCID
- Verdeli, H.
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2004-11-12
- Volume
- 255
- Issue
- 2
- Pages
- 75-82
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W2038051420
- Cited by
- 346
- References
- 49
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 36 · 2012: 17
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Medical Center, University of Pittsburgh
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- interpersonal psychotherapy, depressive disorders, major depressive disorder, psychotherapy efficacy, placebo comparison, cognitive behavioral therapy, antidepressant combination therapy, maintenance therapy, prophylaxis, remission, treatment discontinuation, treatment acceptability
- MeSH terms
- Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Humans, Interpersonal Relations, Patient Acceptance of Health Care, Psychiatric Status Rating Scales, Psychotherapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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