Cited by 348Psychotherapy Techniques and ApplicationsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major Depression

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A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders

de Mello, M. Feijo, de Jesus Mari, J., Bacaltchuk, J., Verdeli, H., Neugebauer, R.·2005·European Archives of Psychiatry and Clinical Neuroscience

DOI 10.1007/s00406-004-0542-x

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Abstract

Objective Interpersonal psychotherapy (IPT) is a time-limited psychotherapy for major depression. The aim of this study is to summarize findings from controlled trials of the efficacy of IPT in the treatment of depressive spectrum disorders (DSD) using a meta-analytic approach.Methods Studies of randomized clinical trials of IPT efficacy were located by searching all available data bases from 1974 to 2002. The searches employed the following MeSH categories: Depression/ Depressive Disorder; Interpersonal therapy; Outcome/Adverse Effects/Efficacy; in the identified studies. The efficacy outcomes were: remission; clinical improvement; the difference in depressive symptoms between the two arms of the trial at endpoint, and no recurrence. Drop out rates were used as an index of treatment acceptability.Results Thirteen studies fulfilled inclusion criteria and four meta-analyses were performed. IPT was superior in efficacy to placebo in nine studies (Weight Mean Difference (WMD) - 3.57 [-5.9, -1.16]). The combination of IPT and medication did not show an adjunctive effect compared to medication alone for acute treatment (RR 0.78 [0.30, 2.04]), for maintenance treatment (RR 1.01 [0.81, 1.25]), or for prophylactic treatment (RR 0.70 [0.30, 1.65]). IPT was significantly better than CBT (WMD -2.16 [-4.16,-0.15]).Conclusion The efficacy of IPT proved to be superior to placebo, similar to medication and did not increase when combined with medication. Overall, IPT was more efficacious than CBT. Current evidence indicates that IPT is an efficacious psychotherapy for DSD and may be superior to some other manualized psychotherapies.

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“These included (1) psychotherapy (eg, cognitive behavioral therapy [22], interpersonal therapy [23], problem-solving therapy [24], supportive therapy [25]), (2) psychoeducation [26], and (3) exercise/physical activity [27] which showed results on par with a pharmacological treatment.”
Background
Adaptation of interpersonal psychotherapy to borderline personality disorder: a comparison of combined therapy and single pharmacotherapy
Bellino, S., Rinaldi, C., & Bogetto, F. (2010) · The Canadian Journal of Psychiatry · doi:10.1177/070674371005500203 · Cited by 64
The effects of reminiscence therapy on depressive symptoms of Chinese elderly: study protocol of a randomized controlled trial
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APPLYING NEPALI ETHNOPSYCHOLOGY TO PSYCHOTHERAPY FOR THE TREATMENT OF MENTAL ILLNESS AND PREVENTION OF SUICIDE AMONG BHUTANESE REFUGEES
Kohrt, B. A., Maharjan, S. M., Timsina, D., & Griffith, J. L. (2012) · Annals of Anthropological Practice · doi:10.1111/j.2153-9588.2012.01094.x · Cited by 46
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Interpersonal psychotherapy for depression? The need to define its ecological niche
Parker, G. B., Parker, I., Brotchie, H., & Stuart, S. P. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.019 · Cited by 44
“A meta-analysis by de Mello et al. (2005) considered a refined set of 13 studies, with the criterion diagnosis being major depression in eight, neurotic depression in one, dysthymia in two, major depression/ dysthymia/double depression in one, and ‘mood disorder’ in the remaining study.”
Method
Optimizing the management of depression: primary care experience
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Patient-reported outcomes before and after treatment of major depressive disorder
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Interpersonal psychotherapy for depressed older adults
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Comparing Bona Fide Psychotherapies of Depression in Adults with Two Meta-Analytical Approaches
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“Cast into numbers-needed-to-treat (NNT; using [37]), the NNT was 9 (95% confidence interval = [6,36]) in these studies for one extra patient to achieve a clinically significant change when treated with another treatment compared to supportive therapy.”
BackgroundMethod
Masked facial affect priming is associated with therapy response in clinical depression
Dannlowski, U., Kersting, A., Donges, U., Lalee-Mentzel, J., Arolt, V., & Suslow, T. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0628-0 · Cited by 45
Treatment of Depressive Disorders
Bschor, T., & Adli, M. (2008) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2008.0782 · Cited by 16
Systematic Review of the Effects of Religion-Accommodative Psychotherapy for Depression and Anxiety
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“Psychotherapy is an effective method of treating anxiety and depression for many individuals (de Maat et al. 2007; Otto et al. 2004) but reviews indicate that only about 50% of those treated show clinically significant reductions in symptoms (e.g., Westen and Morrison 2001), and there is a significant attrition rate (…”
Method
Psychotherapie der Depression
Hautzinger, M. (2008) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-008-0510-0 · Cited by 44
Psychological therapies for preventing seasonal affective disorder
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Interpersonal psychotherapy versus treatment as usual for PTSD and depression among Sichuan earthquake survivors: a randomized clinical trial
Jiang, R. F., Tong, H. Q., Delucchi, K., Neylan, T. C., Shi, Q., & Meffert, S. M. (2014) · Conflict and Health · doi:10.1186/1752-1505-8-14 · Cited by 41
“[12,13].”
Psychological Characteristics of Problem Gamblers with and without Mood Disorder
Lister, J. J., Milosevic, A., & Ledgerwood, D. M. (2015) · The Canadian Journal of Psychiatry · doi:10.1177/070674371506000806 · Cited by 39
Dropout from interpersonal psychotherapy for mental health disorders: A systematic review and meta-analysis
Linardon, J., Fitzsimmons‐Craft, E. E., Brennan, L., Barillaro, M., & Wilfley, D. E. (2018) · Psychotherapy Research · doi:10.1080/10503307.2018.1497215 · Cited by 46
“Based on two earlier and smaller meta-analyses of IPT (Cuijpers et al., 2008; de Mello et al., 2005), we predicted that there would be no differences in dropout rates between the conditions.”
Result
How Do Audiologists Respond to Emotional and Psychological Concerns Raised in the Audiology Setting? Three Case Vignettes
Bennett, R. J., Meyer, C., Ryan, B., & Eikelboom, R. H. (2020) · Ear and Hearing · doi:10.1097/aud.0000000000000887 · Cited by 39
Maternal Depression and Early Intervention
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Vollmann, M., Scharloo, M., Salewski, C., Dienst, A., Schonauer, K., & Renner, B. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.01.075 · Cited by 46
“With respect to implications for treatment, addressing interpersonal problems in psychotherapy has been found to be among the most effective treatments of depression ((uijpers et aL, 2008; de Mello et aI., 2005).”
Background
Shared Dysregulation of Homeostatic Brain-Body Pathways in Depression and Type 2 Diabetes
Hoogendoorn, C. J., Delgado, J. F. R., & Gonzalez, J. S. (2017) · Current Diabetes Reports · doi:10.1007/s11892-017-0923-y · Cited by 41
Working through the blues: A meta-analysis on Interpersonal Psychotherapy for depressed adolescents (IPT-A)
Mychailyszyn, M. P., & Elson, D. M. (2018) · Children and Youth Services Review · doi:10.1016/j.childyouth.2018.02.011 · Cited by 27
“The meta-analysis by de Mello et al. (2005) only included two studies exclusively sampling adolescents and lacked conclusions about IPT-A.”
BackgroundMethodResultInfluential
Pharmacologic management of adult depression.
Adams, S., Miller, K. E., & Zylstra, R. G. (2008) · PubMed · Cited by 35
Combined therapy of major depression with concomitant borderline personality disorder: comparison of interpersonal and cognitive psychotherapy
Bellino, S., Zizza, M., Rinaldi, C., & Bogetto, F. (2007) · The Canadian Journal of Psychiatry · doi:10.1177/070674370705201106 · Cited by 45
Psychotherapy Training for Residents: Reconciling Requirements With Evidence-Based, Competency-Focused Practice
Weerasekera, P., Manring, J., & Lynn, D. J. (2010) · Academic Psychiatry · doi:10.1176/appi.ap.34.1.5 · Cited by 35
“With respect to non-cognitive behavior based therapies, moderate to large effect sizes have been found for interpersonal therapy for depressed patients (32), with some evidence showing a differential response for patients with specific psychosocial stressors and “obsessional” personality traits (33) and fewer dropouts…”
Background
The effect of dancing interventions on depression symptoms, anxiety, and stress in adults without musculoskeletal disorders: An integrative review and meta-analysis
Salihu, D., Kwan, R. Y. C., & Wong, E. M. L. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101467 · Cited by 41
Promising eco-friendly biomaterials for future biomedicine: Cleaner production and applications of Nanocellulose
Rajasekharan, R., Philip, E., Madhavan, A., Arun, K. B., Binod, P., Pugazhendhi, A., Awasthi, M. K., Gnansounou, E., Pandey, A., & Sindhu, R. (2021) · Environmental Technology & Innovation · doi:10.1016/j.eti.2021.101855 · Cited by 37
“…such as blood vessel growth, breast prostheses, urethral catheters, adhesion, arti cial skin, articular cartilage repair, barrier, drug release systems, regeneration of dura-meter and gum, diagnostics and testing , etc (Torriani et al. 1990; Feijo et al. 2005; Negro et al. 2006; Bhat et al. 2018).”
Background
Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders.
Fuhr, K., Reitenbach, I., Kraemer, J., Hautzinger, M., & Meyer, T. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.01.021 · Cited by 25
Through a Glass Darkly: The Disutility of the DSM Nosology of Depressive Disorders
Parker, G. B. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605101403 · Cited by 33
Interventions in Chinese Undergraduate Students’ Mental Health: Systematic Review
Shan, Y., Ji, M., Xie, W., Li, R., Qian, X., Zhang, X., & Hao, T. (2022) · Interactive Journal of Medical Research · doi:10.2196/38249 · Cited by 42
“Several therapies have showed effects on par with those of pharmacological treatment [35], including psychotherapy [36], interpersonal therapy [37], problem-solving therapy [38], supportive therapy [39], psychoeducation [40], and exercise/physical activity [41].”
Background
PTSD, Depressive Symptoms, and Suicidal Ideation in African American Women: A Mediated Model
Carr, E. R., Woods, A. M., Vahabzadeh, A. B. N., Sutton, C., Wittenauer, J., & Kaslow, N. J. (2012) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-012-9316-1 · Cited by 32
Psychological intervention combined with direct electrical brain stimulation (PIN-CODES) for treating major depression: A pre-test, post-test, follow-up pilot study
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Pharmacotherapy, drug-drug interactions and potentially inappropriate medication in depressive disorders
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Rejection Sensitivity and College Student Depression: Findings and Implications for Counseling
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“The test-retest reliability in Downey and Feldman's (1996) initial study with undergraduates on the RSQ indicated a reliability coefficient of .”
Method
Emerging treatments for depression
Holtzheimer, P. E., & Nemeroff, C. B. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.17.2323 · Cited by 27
“3 Psychotherapy Cognitive-behavioural therapy (CBT) and interpersonal therapy (IPT) have demonstrated clear antidepressant efficacy in multiple controlled trials [19-21].”
Background
Depression and Prolonged Grief in the Wake of Disasters
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Authors: de Mello, M. F., de Jesus Mari, J., Bacaltchuk, J., Verdeli, H., & Neugebauer, R.
Affiliations: Universidade Federal de São Paulo (BR)
Columbia University (US)
New York State Psychiatric Institute (US)
ORCID: Verdeli, H.
Venue: European Archives of Psychiatry and Clinical Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2004-11-12
Volume: 255
Issue: 2
Pages: 75-82
ISSN: 0003-9373 (ISSN-L)
0940-1334
1433-8491
DOI: 10.1007/s00406-004-0542-x
OpenAlex: W2038051420
Cited by: 346
References: 49
Citations by year: 2026: 3 · 2025: 5 · 2024: 5 · 2023: 12 · 2022: 8 · 2021: 18 · 2020: 19 · 2019: 15 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 16 · 2014: 16 · 2013: 36 · 2012: 17
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
PubMed (publishedVersion)
UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders: Medical Center, University of Pittsburgh
Topics: Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: interpersonal psychotherapy, depressive disorders, major depressive disorder, psychotherapy efficacy, placebo comparison, cognitive behavioral therapy, antidepressant combination therapy, maintenance therapy, prophylaxis, remission, treatment discontinuation, treatment acceptability
MeSH terms: Antidepressive Agents, Combined Modality Therapy, Depressive Disorder, Humans, Interpersonal Relations, Patient Acceptance of Health Care, Psychiatric Status Rating Scales, Psychotherapy

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A systematic review of research findings on the efficacy of interpersonal therapy for depressive disorders

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