Interpersonal Psychotherapy for Mental Health Problems: A Comprehensive Meta-Analysis
Open accessAbstract
OBJECTIVE: Interpersonal psychotherapy (IPT) has been developed for the treatment of depression but has been examined for several other mental disorders. A comprehensive meta-analysis of all randomized trials examining the effects of IPT for all mental health problems was conducted. METHOD: Searches in PubMed, PsycInfo, Embase, and Cochrane were conducted to identify all trials examining IPT for any mental health problem. RESULTS: Ninety studies with 11,434 participants were included. IPT for acute-phase depression had moderate-to-large effects compared with control groups (g=0.60; 95% CI=0.45-0.75). No significant difference was found with other therapies (differential g=0.06) and pharmacotherapy (g=-0.13). Combined treatment was more effective than IPT alone (g=0.24). IPT in subthreshold depression significantly prevented the onset of major depression, and maintenance IPT significantly reduced relapse. IPT had significant effects on eating disorders, but the effects are probably slightly smaller than those of cognitive-behavioral therapy (CBT) in the acute phase of treatment. In anxiety disorders, IPT had large effects compared with control groups, and there is no evidence that IPT was less effective than CBT. There was risk of bias as defined by the Cochrane Collaboration in the majority of studies. There was little indication that the presence of bias influenced outcome. CONCLUSIONS: IPT is effective in the acute treatment of depression and may be effective in the prevention of new depressive disorders and in preventing relapse. IPT may also be effective in the treatment of eating disorders and anxiety disorders and has shown promising effects in some other mental health disorders.
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Evidence-based interventions for depression include CBT, BA, interpersonal therapy, and problem-solving therapy.
“Thus, we have evidence-based interventions for depression, including cognitive behavior therapy (CBT) [5, 6] and behavioral activation (BA) [7, 8], as well as interpersonal [3, 9] or problem-solving therapy [10].”
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- Authors
- Cuijpers, P., Donker, T., Weissman, M. M., Ravitz, P., & Cristea, I. A.
- Affiliations
- Leuphana University of Lüneburg (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2016-07-01
- Volume
- 173
- Issue
- 7
- Pages
- 680-687
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2322988647
- Cited by
- 283
- References
- 43
- Citations by year
- 2026: 22 · 2025: 26 · 2024: 35 · 2023: 25 · 2022: 30 · 2021: 22 · 2020: 24 · 2019: 35 · 2018: 31 · 2017: 29 · 2016: 4
- FWCI
- 43.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Multilingual Matters (Channel View Publications) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Columbia Academic Commons (Columbia University)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Keywords
- interpersonal psychotherapy, depression, subthreshold depression, depression prevention, relapse prevention, eating disorders, anxiety disorders, cognitive behavioral therapy comparison, drug therapy comparison, combined psychotherapy and pharmacotherapy, treatment effectiveness
- MeSH terms
- Acute Disease, Antidepressive Agents, Anxiety Disorders, Feeding and Eating Disorders, Mental Disorders, Combined Modality Therapy, Major Depressive Disorder, Depressive Disorder, Humans, Psychotherapy, Cognitive Behavioral Therapy, Bias, Randomized Controlled Trials as Topic
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