Influence of striatal dopamine transporter availability on the response to methylphenidate in adult patients with ADHD
Abstract
In this study, we investigated whether availability of striatal dopamine transporter (DAT) may have an influence on the response of adult patients with attention deficit hyperactivity disorder (ADHD) on methylphenidate (MPH). In 18 non-smoking and non-medicated adult patients with ADHD, availability of DAT was measured with [(99m)Tc] TRODAT-1 SPECT. Then, the patients received methylphenidate (MPH), individually titrated up to 60 mg per day. Ten weeks later, clinical improvement was rated by Clinical Global Impressions scale. In all, 6 patients were classified as non-responders, and 12 responded to MPH. From the non-responders, 5 presented with a DAT availability below that of normal controls of the same age, whereas in the group of responders all patients had elevated DAT availability. There was a significant negative correlation between values for global clinical improvement and striatal DAT availability. In conclusion, ADHD patients with low DAT availability seem not to respond to therapy with MPH.
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Significant correlations exist between global clinical improvement in ADHD symptoms following methylphenidate treatment and striatal dopamine transporter availability.
“Furthermore, studies have shown significant correlations between global clinical improvement in ADHD symptoms following MPH treatment and striatal DAT availability (213, 214), and the MPH-induced increases in DA availability in the ventral striatum are associated with improved ADHD symptomology in adults with ADHD (215).”
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“Additionally, Krause et al (2005) investigated whether availability of striatal DAT may have an infl uence on the response of adult ADHD patients to methylphenidate, as measured with SPECT scans.”
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- Authors
- Krause, J., la Fougere, C., Krause, K.-H., Ackenheil, M., & Dresel, S. H.
- Affiliations
- Medprevent Ottobrunn (DE)
- Ludwig-Maximilians-Universität München (DE)
- Corresponding author
- Krause, J.
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2005-08-17
- Volume
- 255
- Issue
- 6
- Pages
- 428-431
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- OpenAlex
- W1989984708
- Cited by
- 84
- References
- 5
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 5 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 3.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- attention deficit hyperactivity disorder, adult ADHD, methylphenidate, dopamine transporter availability, striatum, treatment response, non-responders, dopamine transporter imaging
- MeSH terms
- Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Female, Humans, Male, Methylphenidate, Middle Aged, Psychiatric Status Rating Scales, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Neostriatum, Dopamine Uptake Inhibitors, Radiopharmaceuticals, Dopamine Plasma Membrane Transport Proteins
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