Phasic dysfunction of dopamine transmission in Tourette's syndrome evaluated with 99mTc TRODAT-1 imaging
Abstract
This study investigated the complex dysregulation of the dopaminergic neurotransmitter system in Tourette's syndrome (TS) patients challenged with methylphenidate (MPH). Eight drug-naïve male patients (aged 21-25 years) who met DSM-IV criteria for TS and had a mean disease severity of 25 on the Yale Global Tic Severity Scale were recruited. Brain (99m)TC TRODAT-1 dopamine transporter (DAT) single photon emission computed tomography (SPECT) was performed 5 days before, and 2 h after 10 mg of orally administered MPH. Eight age-matched healthy males served as controls. Repeated measures analysis of variance was used to measure differences in DAT-binding ratios before and after MPH challenge between the TS patients and controls. The DAT-binding ratios decreased significantly after MPH treatment in both groups. However, a significant interaction between group and MPH effects was found only in the right caudate, which was mainly due to a smaller decline of the DAT-binding ratio after MPH in the TS group than in the controls. Such a distinction was not found in the other striatal sub-regions in the two groups. No correlation, however, was observed between the tic severity score and DAT-binding ratio measured from the whole striatum or its sub-regions. The observed change in the DAT-binding ratio might indicate a functional abnormality of the dopaminergic system in the right caudate nucleus of TS patients. Future studies exploring dopamine transmission are thus needed to understand the pathophysiology of TS.
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SPECT investigations in TS have found higher DAT binding in the right caudate, the striatum, the putamen after amphetamine challenge, and the basal ganglia.
“Single-photon emission computed tomography investigations in TS have found higher DAT binding in the right caudate [635], the striatum [636-639], the putamen after amphetamine challenge [640], and the basal ganglia [641].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [635]
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- Authors
- Yeh, C.-B., Lee, C.-S., Ma, K.-H., Lee, M.-S., Chang, C.-J., & Huang, W.-S.
- Affiliations
- Tri-Service General Hospital (TW)
- Chi Mei Medical Center (TW)
- National Defense Medical Center (TW)
- Corresponding author
- Huang, Wen-Sheng
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2007-10
- Volume
- 156
- Issue
- 1
- Pages
- 75-82
- ISSN
- 0925-4927 (ISSN-L)
- OpenAlex
- W2064263607
- Cited by
- 41
- References
- 53
- Citations by year
- 2023: 1 · 2022: 2 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 8
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- Tourette syndrome, dopamine transporter, 99mTc-TRODAT-1, dopamine signaling, caudate nucleus, striatum, tic severity, dopamine transporter binding
- MeSH terms
- Adult, Central Nervous System Stimulants, Brain, Caudate Nucleus, Dopamine, Tourette Syndrome, Humans, Male, Methylphenidate, Putamen, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Radiopharmaceuticals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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