Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment
Abstract
Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [99mTc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21-64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3x5 mg/day). All subjects were injected with 800 MBq [99mTc]TRODAT-1 and imaged 3 h p.i. Single-photon emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semiquantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background [(STR-BKG)/BKG]. Data were compared with an age-matched control group. It was found that untreated patients presented with a significantly increased specific binding of [99mTc]TRODAT-1 to the DAT as compared with normal controls [(STR-BKG)/BKG: 1.43+/-0.18 vs 1.22+/-0.06, P<0.001]. Under treatment with methylphenidate, specific binding decreased significantly in all patients [(STR-BKG)/BKG: 1.00+/-0.14, P<0.001]. Our findings suggest that the number of DAT binding sites is higher in drug-naive patients suffering from ADHD than in normal c…
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Two SPECT studies and one PET study showed that adults with ADHD had higher dopamine transporter concentrations than adults without ADHD, and the SPECT studies reported that methylphenidate reduced DAT availability in adults with ADHD.
“Two SPECT studies and 1 PET study showed that adults with ADHD had higher DAT concentrations than adults without ADHD (210-212), with the SPECT studies further reporting that MPH reduced DAT availability in adults with ADHD (210, 211).”
Cites
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.6.885 · Cited by 1,421 · see citing works
LEVY, F., HAY, D. A., McSTEPHEN, M., WOOD, C., & WALDMAN, I. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199706000-00009 · Cited by 956 · see citing works
Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1325 · Cited by 885 · see citing works
Vaidya, C. J., Austin, G., Kirkorian, G., Ridlehuber, H. W., Desmond, J. E., Glover, G. H., & Gabrieli, J. D. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14494 · Cited by 845 · see citing works
Dopamine transporter density in patients with attention deficit hyperactivity disorder
Dougherty, D. D., Bonab, A. A., Spencer, T. J., Rauch, S. L., Madras, B. K., & Fischman, A. J. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04030-1 · Cited by 684 · see citing works
Brain Morphology in Developmental Dyslexia and Attention Deficit Disorder/Hyperactivity
Hynd, G. W., Semrud‐Clikeman, M., Lorys, A. R., Novey, E. S., & Eliopulos, D. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530080107018 · Cited by 612 · see citing works
Striatal Dysfunction in Attention Deficit and Hyperkinetic Disorder
LOU, H. C., Henriksen, L., Bruhn, P. J., Borner, H., & Nielsen, J. B. (1989) · Archives of Neurology · doi:10.1001/archneur.1989.00520370050018 · Cited by 543 · see citing works
Hyperactivity and conduct problems as risk factors for adolescent development.
Taylor, E., Chadwick, O., Heptinstall, E., & Danckaerts, M. (1996) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199609000-00019 · Cited by 484 · see citing works
Gill, M., Daly, G., Heron, S., Hawi, Z., & Fitzgerald, M. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000290 · Cited by 482 · see citing works
Catecholamines in Attention-Deficit Hyperactivity Disorder: Current Perspectives
Pliszka, S. R., McCracken, J. T., & Maas, J. W. (1996) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199603000-00006 · Cited by 440 · see citing works
Quantitative morphology of the corpus callosum in attention deficit hyperactivity disorder
Giedd, J. N., Castellanos, F. X., Casey, B. J., Kozuch, P. L., King, A. C., Hamburger, S. D., & Rapoport, J. L. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.5.665 · Cited by 422 · see citing works
Daly, G., Hawi, Z., Fitzgerald, M., & Gill, M. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000510 · Cited by 414 · see citing works
Brain Metabolism in Teenagers With Attention-Deficit Hyperactivity Disorder
Zametkin, A. J. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820170011002 · Cited by 341 · see citing works
Ernst, M., Zametkin, A. J., Matochik, J. A., Jons, P. H., & Cohen, R. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-15-05901.1998 · Cited by 320 · see citing works
Imaging dopamine transmission in schizophrenia. A review and meta-analysis.
Laruelle, M. (1998) · PubMed · Cited by 280 · see citing works
Ernst, M., Zametkin, A. J., Matochik, J. A., Pascualvaca, D., Jons, P. H., & Cohen, R. M. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1209 · Cited by 256 · see citing works
Imaging of dopamine transporters in humans with technetium-99m TRODAT 1
Kung, H. F., Kim, H. J., Kung, M., Meegalla, S. K., Plöessl, K., & Lee, H. (1996) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf01254479 · Cited by 225 · see citing works
Self-citationMozley, P. D., Schneider, J. S., Acton, P. D., Plößl, K., Stern, M. B., Siderowf, A. D., Leopold, N. A., Li, P. Y., Alavi, A. A., & Kung, H. F. (2000) · PubMed · Cited by 174 · see citing works
Self-citationImaging of dopamine transporters with iodine-123-beta-CIT and SPECT in Parkinson's disease.
Asenbaum, S., Brücke, T., Pirker, W., Podreka, I., Angelberger, P., Wenger, S., Wöber, C., Müller, F. M., & Deecke, L. (1997) · PubMed · Cited by 163 · see citing works
SPECT Brain Imaging Abnormalities in Attention Deficit Hyperactivity Disorder
SIEG, K. G., Gaffney, G., Preston, D. F., & Hellings, J. A. (1995) · Clinical Nuclear Medicine · doi:10.1097/00003072-199501000-00014 · Cited by 163 · see citing works
[ 99m Tc]TRODAT-1: a novel technetium-99m complex as a dopamine transporter imaging agent
Kung, M., Stevenson, D. A., Pl�ssl, K., Meegalla, S. K., Beckwith, A. W., Essman, W. D., Mu, M., Lucki, I., & Kung, H. F. (1997) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00881808 · Cited by 162 · see citing works
Self-citationThapar, A., Amaia Hervas, G., & McGuffin, P. (1995) · Behavior Genetics · doi:10.1007/bf02327577 · Cited by 151 · see citing works
Tatsch, K., Schwarz, J., Mozley, P. D., Linke, R., Pogarell, O. M., Oertel, W. H., Fieber, R. S., Hahn, K. M., & Kung, H. F. (1997) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/bf00881814 · Cited by 140 · see citing works
Self-citationHigh-resolution brain SPECT imaging in ADHD.
Amen, D., & Carmichael, B. D. (1997) · Annals of Clinical Psychiatry · doi:10.1023/a:1026201218296 · Cited by 128 · see citing works
Sunohara, G. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00023-8 · Cited by 124 · see citing works
Effects of age on dopamine transporters in healthy humans.
Mozley, P. D., Acton, P. D., Barraclough, E. D., Plößl, K., Gur, R. C., Alavi, A. A., Mathur, A., Saffer, J. R., & Kung, H. F. (1999) · PubMed · Cited by 116 · see citing works
Self-citationResponse to methylphenidate in boys with attention-deficit hyperactivity disorder
Zeiner, P., Bryhn, G., Bjercke, C., Truyen, K., & Strand, G. (1999) · Acta Paediatrica · doi:10.1111/j.1651-2227.1999.tb01100.x · Cited by 87 · see citing works
Mozley, P. D., Stubbs, J. B., Plößl, K., Dresel, S. H. J., Barraclough, E. D., Alavi, A. A., Araujo, L. I., & Kung, H. F. (1998) · PubMed · Cited by 86 · see citing works
Self-citationShaya, E. K., Scheffel, U., Dannals, R. F., Ricaurte, G. A., Carroll, F. I., Wagner, H. N., Kuhar, M. J., & Wong, D. F. (1992) · Synapse · doi:10.1002/syn.890100210 · Cited by 85 · see citing works
Dresel, S. H. J., Kung, M., Plöessl, K., Meegalla, S. K., & Kung, H. F. (1997) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050191 · Cited by 84 · see citing works
Self-citationGarland, E. J. (1998) · Journal of Psychopharmacology · doi:10.1177/026988119801200410 · Cited by 77 · see citing works
IPT: A novel iodinated ligand for the CNS dopamine transporter
Kung, M., Essman, W. D., Frederick, D., Meegalla, S. K., Goodman, M. M., Mu, M., Lucki, I., & Kung, H. F. (1995) · Synapse · doi:10.1002/syn.890200405 · Cited by 72 · see citing works
Self-citationMonique Ernst, D., Zametkin, A. J., Matochik, J. A., Liebenauer, L. L., FITZGERALD, G. A., & Cohen, R. M. (1994) · PubMed · Cited by 49 · see citing works
Rinne, J. O., Kuikka, J. T., Bergström, K., & Rinne, U. K. (1995) · Parkinsonism & Related Disorders · doi:10.1016/1353-8020(95)00012-u · Cited by 48 · see citing works
Simultaneous SPECT studies of pre- and postsynaptic dopamine binding sites in baboons.
Dresel, S. H. J., Kung, M., Huang, X., Plößl, K., Hou, C., Meegalla, S. K., Patselas, G., Mu, M., Saffer, J. R., & Kung, H. F. (1999) · PubMed · Cited by 46 · see citing works
Self-citationBehaviour After Neostriatal Lesions in Animals
Iversen, S. D. (1979) · Elsevier eBooks · doi:10.1016/b978-0-08-023174-7.50017-5 · Cited by 37 · see citing works
The Epidemiology of childhood hyperactivity
Taylor, E. A. (1991) · Medical Entomology and Zoology · Cited by 33 · see citing works
Development of PET/SPECT Ligands for the Serotonin Transporter
Scheffel, U., Dannals, R. F., Suehiro, M., Ricaurte, G. A., Carroll, F. I., Kuhar, M. J., & Wagner, H. N. (1994) · PsycEXTRA Dataset · doi:10.1037/e495902006-009 · Cited by 21 · see citing works
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Attention-deficit hyperactivity disorder
Biederman, J., & Faraone, S. V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66915-2 · Cited by 1,463 · see citing works
Bymaster, F. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00346-9 · Cited by 1,123 · see citing works
Insights into the neural basis of response inhibition from cognitive and clinical neuroscience
Chambers, C. D., Garavan, H., & Bellgrove, M. A. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.08.016 · Cited by 938 · see citing works
del Campo, N., Chamberlain, S. R., Sahakian, B. J., & Robbins, T. W. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.02.036 · Cited by 685 · see citing works
Faraone, S. V. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.001 · Cited by 631 · see citing works
DIAMOND, A. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050388 · Cited by 428 · see citing works
The Dopamine Transporter and Attention-Deficit/Hyperactivity Disorder
Madras, B. K., Miller, G. M., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.011 · Cited by 393 · see citing works
Smaller prefrontal and premotor volumes in boys with attention-deficit/hyperactivity disorder
Mostofsky, S. H., Cooper, K. L., Kates, W. R., Denckla, M. B., & Kaufmann, W. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01412-9 · Cited by 379 · see citing works
Mill, J., Asherson, P., Browes, C., D'Souza, U., & Craig, I. (2002) · American Journal of Medical Genetics · doi:10.1002/ajmg.b.10948 · Cited by 341 · see citing works
Assessing the molecular genetics of attention networks
Fossella, J., Sommer, T., Fan, J., Wu, Y., Swanson, J. M., Pfaff, D. W., & Posner, M. I. (2002) · BMC Neuroscience · doi:10.1186/1471-2202-3-14 · Cited by 339 · see citing works
Brookes, K., Mill, J., Guindalini, C., Curran, S., Xu, X.-H., Knight, J., Chen, C.-K., Huang, Y.-S., Sethna, V., Taylor, E., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.74 · Cited by 315 · see citing works
Smith, A. B., Taylor, E., Brammer, M., Toone, B., & Rubia, K. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.6.1044 · Cited by 300 · see citing works
Wilens, T. E. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e318173312f · Cited by 269 · see citing works
Nutt, D. J., Fone, K., Asherson, P., Bramble, D., Hill, P., Matthews, K., Morris, K. A., Santosh, P., Sonuga-Barke, E., Taylor, E., et al. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073219 · Cited by 259 · see citing works
Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene.
van Dyck, C. H., Malison, R. T., Jacobsen, L. K., Seibyl, J. P., Staley, J. K., Laruelle, M. A., Baldwin, R. M., Innis, R. B., & Gelernter, J. E. (2005) · PubMed · Cited by 258 · see citing works
Animal models of attention-deficit hyperactivity disorder.
Davids, E., Zhang, K., Tarazi, F. I., & Baldessarini, R. J. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00274-6 · Cited by 250 · see citing works
Lévesque, J., Beauregard, M., & Mensour, B. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.10.100 · Cited by 250 · see citing works
Brain dopamine transporter levels in treatment and drug naive adults with ADHD
Volkow, N. D., Wang, G.-J., Newcorn, J., Fowler, J. S., Telang, F., Solanto, M. V., Logan, J., Wong, C., Ma, Y., Swanson, J. M., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.014 · Cited by 249 · see citing works
Jucaite, A., Fernell, E., Halldin, C., Forssberg, H., & Farde, L. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.009 · Cited by 236 · see citing works
The genetics of attention deficit hyperactivity disorder
Thapar, A., O’Donovan, M. C., & Owen, M. J. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi263 · Cited by 235 · see citing works
Miller, G. M., & Madras, B. K. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000921 · Cited by 230 · see citing works
Bellgrove, M. A., Hawi, Z., Kirley, A., Gill, M., & Robertson, I. H. (2005) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2005.03.011 · Cited by 218 · see citing works
Bush, G., Spencer, T. J., Holmes, J., Shin, L. M., Valera, E. M., Seidman, L. J., Makris, N., Surman, C., Aleardi, M., Mick, E., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.16 · Cited by 201 · see citing works
Dopamine and alcoholism: neurobiological basis of ethanol abuse.
Tupala, E., & Tiihonen, J. (2004) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.06.022 · Cited by 209 · see citing works
McClernon, F. J., & Kollins, S. H. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.016 · Cited by 188 · see citing works
Cheon, K.-A. A., Ryu, Y. H., Kim, Y.-K., Namkoong, K., Kim, C., & Lee, J. E. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-1047-3 · Cited by 187 · see citing works
Spencer, T. J., Biederman, J., Madras, B. K., Faraone, S. V., Dougherty, D. D., Bonab, A. A., & Fischman, A. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.036 · Cited by 185 · see citing works
The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder
Krause, K.-H., Dresel, S. H. J., Krause, J., la Fougère, C. J., & Ackenheil, M. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.012 · Cited by 181 · see citing works
Self-citationYang, B., Chan, R., Jing, J., Li, T., Sham, P., & Chen, R. Y. L. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30453 · Cited by 184 · see citing works
Beauregard, M., & Lévesque, J. (2006) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-006-9001-y · Cited by 153 · see citing works
ERPs correlates of EEG relative beta training in ADHD children
Kropotov, J. D., Grin-Yatsenko, V. A., Ponomarev, V. A., Chutko, L. S., Yakovenko, E. A., & Is, N. (2004) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2004.05.011 · Cited by 152 · see citing works
The genetics of attention deficit hyperactivity disorder
Waldman, I. D., & Gizer, I. R. (2006) · Clinical Psychology Review · doi:10.1016/j.cpr.2006.01.007 · Cited by 149 · see citing works
Kirley, A., Lowe, N., Hawi, Z., Mullins, C., Daly, G., Waldman, I. D., McCarron, M., O'Donnell, D., Fitzgerald, M., & Gill, M. (2003) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20071 · Cited by 151 · see citing works
Zhu, J., & Reith, M. (2008) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152708786927877 · Cited by 140 · see citing works
Hahn, M. K., & Blakely, R. (2002) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500106 · Cited by 142 · see citing works
Unaltered Dopamine Transporter Availability in Adult Attention Deficit Hyperactivity Disorder
van Dyck, C. H., Quinlan, D. M., Cretella, L. M., Staley, J. K., Malison, R. T., Baldwin, R. M., Seibyl, J. P., & Innis, R. B. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.2.309 · Cited by 139 · see citing works
Rosa-Neto, P., Lou, H. C., Cumming, P., Pryds, O., Karrebaek, H., Lunding, J., & Gjedde, A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.031 · Cited by 135 · see citing works
Attention-deficit/hyperactivity disorder and the dopaminergic hypotheses
Genro, J. P., Kieling, C., Rohde, L. A., & Hutz, M. H. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.17 · Cited by 133 · see citing works
Consequences of Variations in Genes that affect Dopamine in Prefrontal Cortex
Diamond, A. D. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm082 · Cited by 128 · see citing works
Hünnerkopf, R., Strobel, A., Gutknecht, L., Brocke, B., & Lesch, K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301383 · Cited by 129 · see citing works
Nikolaus, S., Antke, C., & Müller, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.009 · Cited by 125 · see citing works
The Functional Impact of SLC6 Transporter Genetic Variation
Hahn, M. K., & Blakely, R. (2006) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105242 · Cited by 124 · see citing works
Attention?Deficit Hyperactivity Disorder in the post?genomic era
Asherson, P. J. (2004) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-004-1006-6 · Cited by 124 · see citing works
Dalsgaard, S., Kvist, A. P., Leckman, J. F., Nielsen, H. S., & Simonsen, M. (2014) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0020 · Cited by 121 · see citing works
Mazei‐Robison, M. S., Couch, R. S., Shelton, R. C., Stein, M. A., & Blakely, R. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.08.003 · Cited by 115 · see citing works
Masuo, Y., Morita, M., Oka, S., & Ishido, M. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.05.010 · Cited by 119 · see citing works
The dopamine transporter: role in neurotoxicity and human disease
Bannon, M. J. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.08.013 · Cited by 116 · see citing works
Schulz, K. P., Fan, J., Bédard, A.-C. V., Clerkin, S. M., Ivanov, I., Tang, C. Y., Halperin, J. M., & Newcorn, J. H. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.2053 · Cited by 114 · see citing works
Kollins, S. H. (2003) · PubMed · Cited by 111 · see citing works
SPECT and PET of the dopamine transporter in attention-deficit/hyperactivity disorder
Krause, J. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.4.611 · Cited by 110 · see citing works
Self-citationGagnon, B., Low, G., & Schreier, G. (2005) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0516 · Cited by 109 · see citing works
Russell, V. A. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.010 · Cited by 107 · see citing works
ADHD and Conduct Disorder: An MRI Study in a Community Sample
Bussing, R., Grudnik, J. L., Mason, D. M., Wasiak, M., & Leonard, C. M. (2002) · The World Journal of Biological Psychiatry · doi:10.3109/15622970209150624 · Cited by 106 · see citing works
Advances in Development of Dopaminergic Aporphinoids
Zhang, A., Zhang, Y., Branfman, A. R., Baldessarini, R. J., & Neumeyer, J. L. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm060959i · Cited by 106 · see citing works
Advances in genetic findings on attention deficit hyperactivity disorder
Thapar, A., Langley, K., Owen, M. J., & O’Donovan, M. C. (2007) · Psychological Medicine · doi:10.1017/s0033291707000773 · Cited by 106 · see citing works
Brain function and structure in adults with attention-deficit/hyperactivity disorder
Seidman, L. J., Valera, E. M., & Bush, G. (2004) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2004.01.002 · Cited by 106 · see citing works
Sobel, L. J., Bansal, R., Maia, T. V., Sanchez, J., Mazzone, L., Durkin, K., Liu, J., Hao, X., Ivanov, I., Miller, A., et al. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09091259 · Cited by 105 · see citing works
Smoking Behaviour and Mental Health Disorders—Mutual Influences and Implications for Therapy
Minichino, A., Bersani, F. S., Calò, W. K., Spagnoli, F., Francesconi, M., Vicinanza, R., Chiaie, R. D., & Biondi, M. (2013) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph10104790 · Cited by 104 · see citing works
Altered midbrain dopaminergic neurotransmission during development in an animal model of ADHD
Leo, D., Sorrentino, E., Volpicelli, F., Eyman, M., Greco, D., Viggiano, D., di Porzio, U., & Perrone-Capano, C. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.08.009 · Cited by 103 · see citing works
MacDonald, H. J., Kleppe, R., Szigetvari, P. D., & Haavik, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1492126 · Cited by 114 · see citing works
Attention deficit hyperactivity disorder and borderline personality disorder
Davids, E., & Gastpar, M. (2005) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2005.04.033 · Cited by 98 · see citing works
Biological and social influences on cognitive control processes dependent on prefrontal cortex
Diamond, A. D. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53884-0.00032-4 · Cited by 96 · see citing works
Monastra, V. J. (2005) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2004.07.004 · Cited by 96 · see citing works
The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)
Madras, B. K., Miller, G. M., & Fischman, A. J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00439-9 · Cited by 97 · see citing works
Zhang, K. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00262-7 · Cited by 94 · see citing works
Brookes, K. J., Neale, B. M., Sugden, K., Khan, N., Asherson, P. J., & D’Souza, U. M. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30572 · Cited by 94 · see citing works
Bellgrove, M. A., Hawi, Z., Kirley, A., Fitzgerald, M., Gill, M., & Robertson, I. H. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300839 · Cited by 93 · see citing works
Transient expression analysis of allelic variants of a VNTR in the dopamine transporter gene (DAT1)
Mill, J. S., Asherson, P. J., Craig, I., & D’Souza, U. M. (2005) · BMC Genetics · doi:10.1186/1471-2156-6-3 · Cited by 91 · see citing works
Krause, K.-H., Dresel, S. H., Krause, J., Kung, H. F., Tatsch, K., & Ackenheil, M. (2002) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145702002821 · Cited by 88 · see citing works
Self-citationRecent Advances in Imaging of Dopaminergic Neurons for Evaluation of Neuropsychiatric Disorders
Shen, L., Liao, M.-H., & Tseng, Y.-C. (2012) · BioMed Research International · doi:10.1155/2012/259349 · Cited by 86 · see citing works
Krause, J., la Fougere, C., Krause, K.-H., Ackenheil, M., & Dresel, S. H. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0602-x · Cited by 84 · see citing works
Self-citationAlpha-synuclein modulates dopamine neurotransmission
Butler, B., Sambo, D. O., & Khoshbouei, H. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.06.001 · Cited by 71 · see citing works
Kim, C.-H., Koo, M.-S., Cheon, K.-A., Ryu, Y.-H., Lee, J.-D., & Lee, H.-S. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-003-1245-7 · Cited by 82 · see citing works
Molecular Genetics of Attention
Bellgrove, M. A., & Mattingley, J. B. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1417.013 · Cited by 81 · see citing works
Association and linkage of allelic variants of the dopamine transporter gene in ADHD
Friedel, S., Saar, K., Sauer, S., Dempfle, A., Walitza, S., Renner, T., Romanos, M., Freitag, C. M., Seitz, C., Pálmason, H., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001986 · Cited by 80 · see citing works
Gonon, F., Konsman, J. P., Cohen, D., & Boraud, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044275 · Cited by 77 · see citing works
Roessner, V., Sagvolden, T., DasBanerjee, T., Middleton, F. A., Faraone, S. V., Walaas, S. I., Becker, A., Rothenberger, A., & Bock, N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.02.073 · Cited by 76 · see citing works
Multivariate Analysis of Dopaminergic Gene Variants as Risk Factors of Heroin Dependence
Vereczkei, A., Demetrovics, Z., Székely, A., Sárközy, P., Antal, P., Szilágyi, Á., Sasvári‐Székely, M., & Barta, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066592 · Cited by 75 · see citing works
Differential Pharmacokinetics and Pharmacodynamics of Methylphenidate Enantiomers
Markowitz, J. S., & Patrick, K. S. (2008) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e3181733560 · Cited by 74 · see citing works
Neurobehavioural deficits associated with apoptotic neurodegeneration and vulnerability for ADHD
Fredriksson, A., & Archer, T. (2004) · Neurotoxicity Research · doi:10.1007/bf03033280 · Cited by 71 · see citing works
Causal Factors of Increased Smoking in ADHD: A Systematic Review
van Amsterdam, J., van der Velde, B., Schulte, M., & van den Brink, W. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2017.1334066 · Cited by 63 · see citing works
Dopamine transporter change in drug-naıve schizophrenia: an imaging study with 99mTc-TRODAT-1
Hsiao, M., Lin, K., Liu, C.-Y., Tzen, K., & Yen, T. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00006-9 · Cited by 68 · see citing works
Dopamine transporter imaging in adult patients with attention-deficit/hyperactivity disorder
Hesse, S., Ballaschke, O., Barthel, H., & Sabri, O. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.01.002 · Cited by 69 · see citing works
Jučaitė, A., Odano, I., Olsson, H., Pauli, S., Halldin, C., & Farde, L. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-0027-9 · Cited by 67 · see citing works
Radiopharmaceuticals for single-photon emission computed tomography brain imaging
Kung, H. F., Kung, M., & Choi, S. (2003) · Seminars in Nuclear Medicine · doi:10.1053/snuc.2003.127296 · Cited by 66 · see citing works
Self-citationLenz, D., Krauel, K., Schadow, J., Baving, L., Düzel, E., & Herrmann, C. S. (2008) · Brain Research · doi:10.1016/j.brainres.2008.06.023 · Cited by 65 · see citing works
Kambeitz, J., Romanos, M., & Ettinger, U. (2014) · The Pharmacogenomics Journal · doi:10.1038/tpj.2013.9 · Cited by 64 · see citing works
Classics in Chemical Neuroscience: Methylphenidate
Wenthur, C. J. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00199 · Cited by 65 · see citing works
Polymorphisms of the Dopamine Transporter Gene
Roman, T., Rohde, L. A., & Hutz, M. H. (2004) · American Journal of PharmacoGenomics · doi:10.2165/00129785-200404020-00003 · Cited by 63 · see citing works
Johnson, K. A., Barry, E., Bellgrove, M. A., Cox, M., Kelly, S. P., Dáibhis, A., Daly, M., Keavey, M., Watchorn, A., Fitzgerald, M., et al. (2008) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2008.01.002 · Cited by 62 · see citing works
Vanicek, T., Spies, M., Rami-Mark, C., Savli, M., Höflich, A., Kranz, G. S., Hahn, A., Kutzelnigg, A., Traub-Weidinger, T., Mitterhauser, M., et al. (2014) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2014.1226 · Cited by 61 · see citing works
Forssberg, H., Fernell, E., Waters, N., Waters, N., & Tedroff, J. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-40 · Cited by 61 · see citing works
Attention Deficit Hyperactivity Disorder
Kuntsi, J., McLoughlin, G., & Asherson, P. J. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:4:461 · Cited by 61 · see citing works
Positron emission tomography neuroimaging for a better understanding of the biology of ADHD
Zimmer, L. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.08.001 · Cited by 60 · see citing works
Langleben, D. D., Austin, G., Krikorian, G., Ridlehuber, H. W., Goris, M. L., & Strausś, H. W. (2001) · Nuclear Medicine Communications · doi:10.1097/00006231-200112000-00009 · Cited by 60 · see citing works
The dopamine transporter haplotype and reward-related striatal responses in adult ADHD
Hoogman, M., Onnink, A. M. H., Cools, R., Aarts, E., Kan, C. C., Vásquez, A. A., Buitelaar, J. K., & Franke, B. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.05.011 · Cited by 59 · see citing works
Langleben, D. D., Acton, P. D., Austin, G., Elman, I., Krikorian, G., Monterosso, J. R., Portnoy, O., Ridlehuber, H. W., & Strausś, H. W. (2002) · PubMed · Cited by 60 · see citing works
Larisch, R., Sitte, W., Antke, C., Nikolaus, S., Franz, M., Tress, W., & M??ller, H.-W. (2006) · Nuclear Medicine Communications · doi:10.1097/00006231-200603000-00010 · Cited by 58 · see citing works
la Fougère, C., Krause, J., Krause, K.-H., Josef Gildehaus, F., Hacker, M., Koch, W., Hahn, K., Tatsch, K., & Dresel, S. (2006) · Nuclear Medicine Communications · doi:10.1097/01.mnm.0000230077.48480.68 · Cited by 57 · see citing works
Self-citationKim, C. H., Cheon, K.-A. A., Koo, M.-H., Ryu, Y. H., Lee, J. D., Chang, J. W., & Lee, H. S. (2007) · Neuropsychobiology · doi:10.1159/000106474 · Cited by 57 · see citing works
- Authors
- Dresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H. F., Hahn, K., & Tatsch, K.
- Affiliations
- Ludwig-Maximilians-Universität München (DE)
- University of Pennsylvania (US)
- Corresponding author
- Dresel, S.
- ORCID
- Venue
- European Journal of Nuclear Medicine
- Published
- 2000-08-09
- Volume
- 27
- Issue
- 10
- Pages
- 1518-1524
- ISSN
- 1619-7070 (ISSN-L)
- 0340-6997
- 1619-7089
- OpenAlex
- W2047018372
- Cited by
- 278
- References
- 38
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 13 · 2013: 7 · 2012: 12
- FWCI
- 10.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- attention deficit hyperactivity disorder, dopamine transporter, 99mTc-TRODAT-1, methylphenidate, dopaminergic system, striatum, adult ADHD, treatment response, SPECT imaging
- MeSH terms
- Adult, Attention Deficit Disorder with Hyperactivity, Brain, Carrier Proteins, Caudate Nucleus, Corpus Striatum, Dopamine, Female, Humans, Male, Membrane Glycoproteins, Methylphenidate, Middle Aged, Nerve Tissue Proteins, Putamen, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Dopamine Uptake Inhibitors, Radiopharmaceuticals, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
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