Cited by 282Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatment

Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment

Dresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H.F., Hahn, K., Tatsch, K.·2000·European Journal of Nuclear Medicine

Abstract

Involvement of the dopaminergic system has been suggested in patients suffering from attention deficit hyperactivity disorder (ADHD) since the symptoms can be successfully treated with methylphenidate, a potent blocker of the dopamine transporter (DAT). This study reports the findings on the status of the DAT in adults with ADHD before and after commencement of treatment with methylphenidate, as measured using [99mTc]TRODAT-1. Seventeen patients (seven males, ten females, aged 21-64 years, mean 38 years) were examined before and after the initiation of methylphenidate treatment (3x5 mg/day). All subjects were injected with 800 MBq [99mTc]TRODAT-1 and imaged 3 h p.i. Single-photon emission tomography (SPET) scans were acquired using a triple-headed gamma camera. For semiquantitative evaluation of the DAT, transverse slices corrected for attenuation were used to calculate specific binding in the striatum, with the cerebellum used as background [(STR-BKG)/BKG]. Data were compared with an age-matched control group. It was found that untreated patients presented with a significantly increased specific binding of [99mTc]TRODAT-1 to the DAT as compared with normal controls [(STR-BKG)/BKG: 1.43+/-0.18 vs 1.22+/-0.06, P<0.001]. Under treatment with methylphenidate, specific binding decreased significantly in all patients [(STR-BKG)/BKG: 1.00+/-0.14, P<0.001]. Our findings suggest that the number of DAT binding sites is higher in drug-naive patients suffering from ADHD than in normal c…

Integrity signals

Registry

Crossref · 10.1007/s002590000330

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Dresel, S., Krause, J., Krause, K.-H., LaFougere, C., Brinkbäumer, K., Kung, H. F., Hahn, K., & Tatsch, K.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • University of Pennsylvania (US)
Corresponding author
Dresel, S.
Venue
European Journal of Nuclear Medicine
Published
2000-08-09
Volume
27
Issue
10
Pages
1518-1524
ISSN
  • 1619-7070 (ISSN-L)
  • 0340-6997
  • 1619-7089
OpenAlex
W2047018372
Cited by
278
References
38
Citations by year
2026: 2 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 7 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 6 · 2015: 4 · 2014: 13 · 2013: 7 · 2012: 12
FWCI
10.12
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Nuclear Medicine and Molecular Imaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
attention deficit hyperactivity disorder, dopamine transporter, 99mTc-TRODAT-1, methylphenidate, dopaminergic system, striatum, adult ADHD, treatment response, SPECT imaging
MeSH terms
Adult, Attention Deficit Disorder with Hyperactivity, Brain, Carrier Proteins, Caudate Nucleus, Corpus Striatum, Dopamine, Female, Humans, Male, Membrane Glycoproteins, Methylphenidate, Middle Aged, Nerve Tissue Proteins, Putamen, Tropanes, Organotechnetium Compounds, Tomography, Emission-Computed, Single-Photon, Dopamine Uptake Inhibitors, Radiopharmaceuticals, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review