Microglia in the dorsal raphe nucleus plays a potential role in both suicide facilitation and prevention in affective disorders
Open accessAbstract
An involvement of the central serotonergic system has constantly been reported in the pathogenesis of suicide. The dorsal raphe nucleus (DRN) is the main source of serotonergic innervation of forebrain limbic structures disturbed in suicidal behaviour, in which an abnormal microglia reaction seems to play a role. In our present study, the density of microglia immunostained for the HLA-DR antigen was evaluated in the DRN. These analyses were carried out on paraffin-embedded brains from 24 suicidal and 21 non-suicidal patients; among them, 27 depressed (15 major depressive disorder and 12 bipolar disorder) and 18 schizophrenia (9 residual and 9 paranoid) patients and 22 matched controls without mental disorders. Only the non-suicidal depressed subgroup revealed significantly lower microglial reaction, i.e., a decreased density of HLA-DR positive microglia versus both depressed suicide victims and controls. The effect was not related to antidepressant or antipsychotic medication, as the former correlated positively with microglial density in non-suicidal depressed patients, and the latter had no effect. Moreover, the comparison of these results with previously published data from our workgroup in the same cohort (Krzyżanowska et al. in Psychiatry Res 241:43-46, 4) suggested a positive impact of microglia on ribosomal DNA transcription in DRN neurons in the non-suicidal depressed subgroup, but not in depressed suicidal cases. Therefore, the interaction between microglia and neurons in the DRN may be potentially involved in opposite ways regarding suicide facilitation and prevention in the tested subgroups of depressed patients.
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Activation of Gi-coupled pathways on pvMΦs via 5-HT1B receptors is a potential mechanism for the regulation of macrophage polarization and inflammatory responses by tonic 5-HT release within the DRN.
“Activation of Gi-coupled pathways on pvMΦs via 5-HT1B receptors is also a potential mechanism for the regulation of macrophage polarization and inflammatory responses by tonic 5-HT release within the DRN, which may be relevant to the increasing importance of neuroinflammatory pathways in the etiology of psychiatric disorders (Brisch et al., 2017; Howerton et al., 2014; Watkins et al., 2014).”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Brisch et al., 2017
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Enache, D., Pariante, C. M., & Mondelli, V. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2019.06.015 · Cited by 615 · see citing works
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Molecular and anatomical organization of the dorsal raphe nucleus
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Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies
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- Authors
- Brisch, R., Steiner, J., Mawrin, C., Krzyżanowska, M., Jankowski, Z., & Gos, T.
- Affiliations
- Gdańsk Medical University (PL)
- Otto-von-Guericke-Universität Magdeburg (DE)
- Corresponding author
- Gos, Tomasz
- Venue
- European Archives of Psychiatry and Clinical Neuroscience
- Published
- 2017-02-22
- Volume
- 267
- Issue
- 5
- Pages
- 403-415
- ISSN
- 0003-9373 (ISSN-L)
- 0940-1334
- 1433-8491
- PMC
- PMC5509773
- OpenAlex
- W2591521134
- Cited by
- 60
- References
- 75
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 12 · 2019: 13 · 2018: 2 · 2017: 2
- FWCI
- 10.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- European Archives of Psychiatry and Clinical Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Gdański Uniwersytet Medyczny
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- microglia, dorsal raphe nucleus, suicide, HLA-DR, major depressive disorder, bipolar disorder, schizophrenia, serotonergic system, microglial activation, antidepressants, ribosomal DNA transcription, microglia-neuron interaction, mood disorders
- MeSH terms
- Adult, Aged, Bipolar Disorder, Cell Count, Major Depressive Disorder, Depressive Disorder, Major, Female, HLA-DR Antigens, Humans, Male, Middle Aged, Schizophrenia, Schizophrenic Psychology, Suicide, Case-Control Studies, Microglia, Statistics, Nonparametric, Mood Disorders, Dorsal Raphe Nucleus
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