Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies

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A Preliminary Report on Brain-Derived Extracellular Vesicle as Novel Blood Biomarkers for Sport-Related Concussions

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Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder

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Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia

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Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors

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Minocycline, a microglial inhibitor, reduces ‘honey trap’ risk in human economic exchange

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CD38: An Immunomodulatory Molecule in Inflammation and Autoimmunity

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<i>Hikikomori</i>  : Multidimensional understanding, assessment, and future international perspectives

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Lactic Acid-Producing Probiotic Saccharomyces cerevisiae Attenuates Ulcerative Colitis via Suppressing Macrophage Pyroptosis and Modulating Gut Microbiota

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A brain-centric model of suicidal behavior

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Paracetamol – An old drug with new mechanisms of action

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Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

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Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations

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Pathogenesis and virulence of flavivirus infections

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Depression and suicidality: A link to premature T helper cell aging and increased Th17 cells

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Are Kynurenines Accomplices or Principal Villains in Dementia? Maintenance of Kynurenine Metabolism

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Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics

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Evolution of drug-eluting biomedical implants for sustained drug delivery

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Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

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The emerging tale of microglia in psychiatric disorders

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Organoids and organ chips in ophthalmology

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An update on potential links between type 2 diabetes mellitus and Alzheimer’s disease

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Direct Neuronal Differentiation of Neural Stem Cells for Spinal Cord Injury Repair

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Understanding the Signaling Pathways Related to the Mechanism and Treatment of Diabetic Peripheral Neuropathy

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Functional and molecular characterization of a non-human primate model of autism spectrum disorder shows similarity with the human disease

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Meteorological Variables and Suicidal Behavior: Air Pollution and Apparent Temperature Are Associated With High-Lethality Suicide Attempts and Male Gender

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Low Immunogenicity and Immunosuppressive Properties of Human ESC- and iPSC-Derived Retinas

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Communication and social interaction in the cannabinoid‐type 1 receptor null mouse: Implications for autism spectrum disorder

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Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures

Rátkai, A., Tárnok, K., Aouad, H. E., Micska, B., Schlett, K., & Szücs, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-82775-3 · Cited by 38 · see citing works

Biased agonism at adenosine receptors

McNeill, S. M., Baltos, J., White, P. J., & May, L. T. (2021) · Cellular Signalling · doi:10.1016/j.cellsig.2021.109954 · Cited by 42 · see citing works

Suicide Has Many Faces, So Does Ketamine: a Narrative Review on Ketamine’s Antisuicidal Actions

Lengvenytė, A., Olié, É., & Courtet, P. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1108-y · Cited by 40 · see citing works

Two‐pore channels regulate Tat endolysosome escape and Tat‐mediated HIV‐1 LTR transactivation

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Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models

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Chemokine alterations in the postmortem brains of suicide completers

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Regulation of cell growth, survival and migration by ceramide 1-phosphate - implications in lung cancer progression and inflammation

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Muscone Ameliorates LPS-Induced Depressive-Like Behaviors and Inhibits Neuroinflammation in Prefrontal Cortex of Mice

He, M., Shi, Z., Qin, M., Sha, N., Li, Y., Liao, D., Lin, F., Shu, B., Sun, Y., Yuan, T., et al. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500287 · Cited by 39 · see citing works

Microglial heterogeneity in chronic pain

Sideris-Lampretsas, G., & Malcangio, M. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.06.005 · Cited by 37 · see citing works

Identification of the protective effect of Polygonatum sibiricum polysaccharide on d -galactose-induced brain ageing in mice by the systematic characterization of a circular RNA-associated ceRNA network

Zhang, Z., Yang, B., Huang, J., Li, W., Yi, P., Yi, M., & Peng, W. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1893347 · Cited by 37 · see citing works

The Involvement of the Posterior Cerebellum in Reconstructing and Predicting Social Action Sequences

Overwalle, F. V., Pu, M., Ma, Q., Li, M., Haihambo, N. P., Baetens, K., Deroost, N., Baeken, C., & Heleven, E. (2021) · The Cerebellum · doi:10.1007/s12311-021-01333-9 · Cited by 36 · see citing works

Suicide in bipolar disorder patients is associated with hippocampal microglia activation and reduction of lymphocytes-activation gene 3 (LAG3) microglial checkpoint expression

Naggan, L., Robinson, E., Dinur, E., Goldenberg, H., Kozela, E., & Yirmiya, R. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.02.021 · Cited by 35 · see citing works

Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis

Klingl, Y. E., Pakravan, D., & Bosch, L. V. D. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15217 · Cited by 32 · see citing works

Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons

Schwartzentruber, A., Boschian, C., Lopes, F. M., Myszczynska, M. A., New, E. J., Beyrath, J., Smeitink, J. A. M., Ferraiuolo, L., & Mortiboys, H. (2020) · Scientific Reports · doi:10.1038/s41598-020-72345-4 · Cited by 35 · see citing works

Hyper/neuroinflammation in COVID-19 and suicide etiopathogenesis: Hypothesis for a nefarious collision?

Costanza, A., Amerio, A., Aguglia, A., Serafini, G., Amore, M., Hasler, R., Ambrosetti, J., Bondolfi, G., Sampogna, G., Berardelli, I., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104606 · Cited by 35 · see citing works

The prefrontal cortex as a target for atypical antipsychotics in schizophrenia, lessons of neurodevelopmental animal models

Tendilla‐Beltrán, H., Sanchez-Islas, N. D. C., Marina-Ramos, M., Leza, J. C., & Flores, G. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101967 · Cited by 34 · see citing works

Increased immune cell and altered microglia and neurogenesis transcripts in an Australian schizophrenia subgroup with elevated inflammation

North, H. F., Weissleder, C., Fullerton, J. M., Webster, M. J., & Weickert, C. S. (2022) · Schizophrenia Research · doi:10.1016/j.schres.2022.08.025 · Cited by 34 · see citing works

Early-Onset Dementia in War Veterans: Brain Polypathology and Clinicopathologic Complexity

Iacono, D., Lee, P. J., Edlow, B. L., Gray, N., Fischl, B. R., Kenney, K., Lew, H. L., Lozanoff, S., Liacouras, P. C., Lichtenberger, J. P., et al. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlz122 · Cited by 32 · see citing works

NIR Laser Photobiomodulation Induces Neuroprotection in an In Vitro Model of Cerebral Hypoxia/Ischemia

Gerace, E., Cialdai, F., Sereni, E., Lana, D., Nosi, D., Giovannini, M. G., Monici, M., & Mannaioni, G. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02496-6 · Cited by 32 · see citing works

Relating neurosteroid modulation of inhibitory neurotransmission to behaviour

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HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer’s disease pathology

Tanaka, H., Kondo, K., Fujita, K., Homma, H., Tagawa, K., Jin, X., Jin, M., Yoshioka, Y., Takayama, S., Masuda, H., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02671-4 · Cited by 31 · see citing works

Roles of Microglia in Neurodegenerative Diseases

Nakaso, K. (2024) · Yonago acta medica · doi:10.33160/yam.2024.02.001 · Cited by 30 · see citing works

Sex and region-specific effects of variable stress on microglia morphology

Tsyglakova, M., Huskey, A., Hurst, E. H., Telep, N. M., Wilding, M. C., Babington, M. E., Rainville, J. R., & Hodes, G. E. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100378 · Cited by 30 · see citing works

Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling

Fakhfouri, G., Mijailović, N. R., & Rahimian, R. (2024) · Cells · doi:10.3390/cells13020177 · Cited by 30 · see citing works

Exploring the Role of P2X Receptors in Alzheimer’s Disease

Godoy, P. A., Ramírez-Molina, O., & Fuentealba, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01330 · Cited by 29 · see citing works

Protocol for mouse adult neural stem cell isolation and culture

Ahmed, A. K. M. A., Isaksen, T. J., & Yamashita, T. (2021) · STAR Protocols · doi:10.1016/j.xpro.2021.100522 · Cited by 29 · see citing works

Mutant Huntingtin affects toll-like receptor 4 intracellular trafficking and cytokine production in mast cells

Pérez‐Rodríguez, M. J., Ibarra-Sánchez, A., Román-Figueroa, A., Pérez‐Severiano, F., & González‐Espinosa, C. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01758-9 · Cited by 28 · see citing works

The longevity-associated variant of BPIFB4 improves a CXCR4-mediated striatum–microglia crosstalk preventing disease progression in a mouse model of Huntington’s disease

Pardo, A. D., Ciaglia, E., Cattaneo, M., Maciag, A. E., Montella, F., Lopardo, V., Ferrario, A., Villa, F., Madonna, M., Amico, E., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02754-w · Cited by 28 · see citing works

6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling

Chen, W.-F., Shih, Y., Liu, H.-C., Cheng, C., Chang, C., Chen, C., Lin, I.-P., Lin, M.-Y., & Lee, C. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154025 · Cited by 27 · see citing works

Systemic HDAC3 inhibition ameliorates impairments in synaptic plasticity caused by simulated galactic cosmic radiation exposure in male mice

Keiser, A. A., Kramár, E. A., Dong, T. N., Shanur, S., Pirodan, M., Ru, N., Acharya, M. M., Baulch, J. E., Limoli, C. L., & Wood, M. A. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107367 · Cited by 24 · see citing works

Super-resolution imaging reveals extrastriatal synaptic dysfunction in presymptomatic Huntington disease mice

Ravalia, A. S., Lau, J., Barron, J. C., Purchase, S. L. M., Southwell, A. L., Hayden, M. R., Nafar, F., & Parsons, M. P. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105293 · Cited by 25 · see citing works

The Missing Piece? A Case for Microglia’s Prominent Role in the Therapeutic Action of Anesthetics, Ketamine, and Psychedelics

VanderZwaag, J., Halvorson, T., Dolhan, K., Šimončičová, E., Ben‐Azu, B., & Tremblay, M. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03772-0 · Cited by 26 · see citing works

Metabolomic markers of antepartum depression and suicidal ideation

Mitro, S. D., Larrabure-Torrealva, G. T., Sánchez, S. E., Molsberry, S. A., Williams, M. A., Clish, C. B., & Gelaye, B. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.061 · Cited by 25 · see citing works

Muscarinic receptors modulate Nerve Growth Factor production in rat Schwann-like adipose-derived stem cells and in Schwann cells

Piovesana, R., Faroni, A., Taggi, M., Matera, A., Soligo, M., Canipari, R., Manni, L., Reid, A. J., & Tata, A. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63645-w · Cited by 25 · see citing works

Phenol glycosides extract of Fructus Ligustri Lucidi attenuated depressive‐like behaviors by suppressing neuroinflammation in hypothalamus of mice

Feng, R., He, M., Li, Q., Liang, X., Tang, D., Zhang, J., Liu, S., Lin, F., & Zhang, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6777 · Cited by 25 · see citing works

Effects of endogenous inflammation signals elicited by nerve growth factor, interferon-γ, and interleukin-4 on peripheral nerve regeneration

Liao, C.-F., Chen, C.-C., Lu, Y.-W., Yao, C., Lin, J., Way, T., Yang, T.-Y., & Chen, Y.-S. (2019) · Journal of Biological Engineering · doi:10.1186/s13036-019-0216-x · Cited by 24 · see citing works

Intracellular Cl− dysregulation causing and caused by pathogenic neuronal activity

Akita, T., & Fukuda, A. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02375-4 · Cited by 23 · see citing works

Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells

Pislyagin, Е. А., Kozlovskiy, S., Menchinskaya, E. S., Chingizova, E. A., Николаевна, Л. Г., Gorpenchenko, T. Y., Sabutski, Y. E., Полоник, С. Г., & Aminin, D. L. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115975 · Cited by 23 · see citing works

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance

Ye, X., Wei, X., Liao, J., Chen, P., Li, X., Chen, Y., Yang, Y., Zhao, Q., Sun, H., Pan, L., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.617190 · Cited by 23 · see citing works

High-Fat Diet Consumption Induces Neurobehavioral Abnormalities and Neuronal Morphological Alterations Accompanied by Excessive Microglial Activation in the Medial Prefrontal Cortex in Adolescent Mice

Wang, C., Li, H., Chen, C., Yao, X., Yang, C., Yu, Z., Ren, J., Ming, Y., Huang, Y., Rong, Y., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119394 · Cited by 23 · see citing works

Low blue light hazard for tunable white light emitting diode with high color fidelity and circadian performances

Nie, J., Chen, Z., Jiao, F., Zhan, J., Chen, Y., Chen, Y., Pan, Z., Kang, X., Wang, Y., Wang, Q., et al. (2020) · Optics & Laser Technology · doi:10.1016/j.optlastec.2020.106709 · Cited by 23 · see citing works

Translational Research to Clarifythe Microglia Hypothesis of Depression and Suicide

加藤, 隆. (2019) · Kyushu University Institutional Repository (QIR) (Kyushu University) · doi:10.15017/2558874

Microglial Dysregulation and Suicidality: A Stress-Diathesis Perspective

Baharikhoob, P., & Kolla, N. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00781 · Cited by 37 · see citing works

The role of microglia in neuropsychiatric disorders and suicide

Brisch, R., Wojtylak, S., Saniotis, A., Steiner, J. H., Gos, T., Kumaratilake, J., Henneberg, M., & Wolf, R. J. (2021) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-021-01334-z · Cited by 71 · see citing works

Microglia as a Hub for Suicide Neuropathology: Future Investigation and Prevention Targets

de Andrade, E. G., Ibáñez, F. G., & Tremblay, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.839396 · Cited by 22 · see citing works

Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

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