Cited by 148Inhalation and Respiratory Drug DeliveryNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

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Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

Willis, Lauren, Hayes, Don, Mansour, Heidi M.·2012·Lung

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Abstract

Therapeutic liposomal powders (i.e., lipospheres and proliposomes) for dry powder inhalation aerosol delivery, formulated with phospholipids similar to endogenous lung surfactant, offer unique opportunities in pulmonary nanomedicine while offering controlled release and enhanced stability. Many pulmonary diseases such as lung cancer, tuberculosis (TB), cystic fibrosis (CF), bacterial and fungal lung infections, asthma, and chronic obstructive pulmonary disease (COPD) could greatly benefit from this type of pulmonary nanomedicine approach that can be delivered in a targeted manner by dry powder inhalers (DPIs). These delivery systems may require smaller doses for efficacy, exhibit reduced toxicity, fewer side effects, controlled drug release over a prolonged time period, and increased formulation stability as inhaled powders. This state-of-the-art review presents these novel aspects in depth.

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Authors: Willis, L., Hayes, D., & Mansour, H. M.
Affiliations: University of Kentucky (US)
Nationwide Children's Hospital (US)
Corresponding author: Mansour, Heidi M.
ORCID: Hayes, Don
Mansour, Heidi M.
Venue: Lung
Publisher: Springer Science and Business Media LLC
Published: 2012-01-25
Volume: 190
Issue: 3
Pages: 251-262
ISSN: 0341-2040 (ISSN-L)
1432-1750
DOI: 10.1007/s00408-011-9360-x
OpenAlex: W2081617033
Cited by: 148
References: 117
Citations by year: 2026: 8 · 2025: 10 · 2024: 10 · 2023: 12 · 2022: 11 · 2021: 7 · 2020: 14 · 2019: 8 · 2018: 8 · 2017: 9 · 2016: 8 · 2015: 8 · 2014: 22 · 2013: 11 · 2012: 2
FWCI: 2.32
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Lung (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: lipospheres, proliposomes, dry powder inhaler, phospholipids, pulmonary surfactant, controlled drug release, formulation stability, lung disease, lung cancer, tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, asthma, pulmonary infection
MeSH terms: Administration, Inhalation, Aerosols, Pharmaceutical Preparations, Humans, Liposomes, Lung, Lung Diseases, Powders, Nanocapsules

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Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

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