Pulmonary drug delivery systems for tuberculosis treatment
Abstract
Tuberculosis (TB) remains a major global health problem as it is the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). Conventional treatments fail either because of poor patient compliance to the drug regimen or due to the emergence of multidrug-resistant tuberculosis. The aim of this review is to give an update on the information available on tuberculosis, its pathogenesis and current antitubercular chemotherapies. Direct lung delivery of anti-TB drugs using pulmonary delivery systems is then reviewed since it appears as an interesting strategy to improve first and second line drugs. A particular focus is place on research performed on inhalable dry powder formulations of antitubercular drugs to target alveolar macrophages where the bacteria develop. Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release. Treatments of infected animals show a significant reduction of the number of viable bacteria as well as a decrease in tissue damage. These new formulations appear as interesting alternatives to deliver directly drugs to the lungs and favor efficient TB treatment.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Parenteral and pulmonary routes have higher bioavailability than the oral route because they bypass first-pass metabolism.
“On the other hand, the parenteral and pulmonary routes have higher bioavailability due to bypassing the first-pass metabolism.196”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [196]
Nanodrug delivery system reduces adverse systemic side effects and frequency of drug administration, leading to better patient compliance.
“Furthermore, the nanodrug delivery system reduces the adverse systemic side effects and frequency of drug administration, which eventually leads to better patient compliance.196,197”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [196]
Cites
Global tuberculosis report (2014)
Gabbasova, L. A., & Who, E. R. E. (2014) · Cited by 12,702 · see citing works
Aerosol Technology Properties, Behavior, and Measurement of Airborne Particles
Laucks, M. L. (2000) · Journal of Aerosol Science · doi:10.1016/s0021-8502(99)00571-6 · Cited by 3,426 · see citing works
Blumberg, H. M., Burman, W. J., Chaisson, R. E., Daley, C. L., Etkind, S. C., Friedman, L. N., Fujiwara, P., Grzemska, M., Hopewell, P. C., Iseman, M. D., et al. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.167.4.603 · Cited by 1,936 · see citing works
(2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.4.16141 · Cited by 1,524 · see citing works
Large Porous Particles for Pulmonary Drug Delivery
Edwards, D. A., Hanes, J. S., Caponetti, G., Hrkach, J. S., Ben-Jebria, A., Eskew, M. L., Mintzes, J. D., Deaver, D. R., Lotan, N., & Langer, R. (1997) · Science · doi:10.1126/science.276.5320.1868 · Cited by 1,176 · see citing works
Deposition of particles in the human respiratory tract in the size range 0.005–15 μm
Heyder, J., Gebhart, J., Rudolf, G., Schiller-Scotland, C. F., & STAHLHOFEN, W. (1986) · Journal of Aerosol Science · doi:10.1016/0021-8502(86)90035-2 · Cited by 1,030 · see citing works
Global Tuberculosis Control 2011, WHO Report 2011
Behera, D. (2012) · The Indian Journal of Medical Research · Cited by 1,022 · see citing works
Turner, P. V., Brabb, T., Pekow, C. A., & Vasbinder, M. A. (2011) · PubMed Central · Cited by 982 · see citing works
Tuberculosis: Pathogenesis, Protection and Control
(1996) · Nature Medicine · doi:10.1038/nm0296-244b · Cited by 977 · see citing works
Development of Nanoparticles for Antimicrobial Drug Delivery
Zhang, L., Pornpattananangkul, D., Hu, C.-M., & Huang, C.-W. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710790416290 · Cited by 890 · see citing works
Lung biology in health and disease
Horsmanheimo, M., & Fudenberg, H. H. (1977) · Clinical Immunology and Immunopathology · doi:10.1016/0090-1229(77)90040-x · Cited by 798 · see citing works
Treatment of Multidrug-Resistant Tuberculosis
Wood, A. J. J., & Iseman, M. D. (1993) · New England Journal of Medicine · doi:10.1056/nejm199309093291108 · Cited by 712 · see citing works
Nanoparticles for drug delivery to the lungs
Sung, J. C., Pulliam, B., & Edwards, D. A. (2007) · Trends in biotechnology · doi:10.1016/j.tibtech.2007.09.005 · Cited by 644 · see citing works
Trojan particles: Large porous carriers of nanoparticles for drug delivery
Tsapis, N., Bennett, D., Jackson, B., Weitz, D. A., & Edwards, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182233999 · Cited by 546 · see citing works
Self-citationChaisson, R. E., Schecter, G. F., Theuer, C. P., Rutherford, G. W., Echenberg, D. F., & Hopewell, P. C. (1987) · American Review of Respiratory Disease · doi:10.1164/ajrccm/136.3.570 · Cited by 453 · see citing works
New insights into the function of granulomas in human tuberculosis
Ulrichs, T., & Kaufmann, S. H. E. (2006) · Journal of Pathology · doi:10.1002/path.1906 · Cited by 421 · see citing works
Lippincott's Illustrated Reviews: Pharmacology
Whalen, K., Finkel, R. S., & Panavelil, T. A. (1991) · Cited by 415 · see citing works
Delivery strategies for sustained drug release in the lungs
Loira-Pastoriza, C., Todoroff, J., & Rita Vanbever, A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.017 · Cited by 395 · see citing works
Pandey, R. (2003) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkg477 · Cited by 389 · see citing works
Liposomes: A Review of Manufacturing Techniques and Targeting Strategies
Maherani, B., Arab‐Tehrany, E., Mozafari, M. R., Gaïani, C., & Linder, M. (2011) · Current Nanoscience · doi:10.2174/157341311795542453 · Cited by 369 · see citing works
Treatment of multidrug-resistant pulmonary tuberculosis with interferon-γ via aerosol
Condos, R., Rom, W. N., & Schluger, N. W. (1997) · The Lancet · doi:10.1016/s0140-6736(96)12273-x · Cited by 318 · see citing works
Pandey, R., & Khuller, G. K. (2005) · Tuberculosis · doi:10.1016/j.tube.2004.11.003 · Cited by 318 · see citing works
Formulation and Physical Characterization of Large Porous Particles for Inhalation
Rita Vanbever, A., Mintzes, J. D., Wang, J., Nice, J., Chen, D., Batycky, R., Langer, R., & Edwards, D. A. (1999) · Pharmaceutical Research · doi:10.1023/a:1018910200420 · Cited by 315 · see citing works
Inhalable alginate nanoparticles as antitubercular drug carriers against experimental tuberculosis
Zahoor, A., Sharma, S., & Khuller, G. K. (2005) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2005.07.012 · Cited by 314 · see citing works
Manual of clinical microbiology
Lennette, E. H. (1982) · Journal of Oral and Maxillofacial Surgery · doi:10.1016/0278-2391(82)90036-2 · Cited by 302 · see citing works
Bosquillon, C., Lombry, C., Véronique Préat, A., & Rita Vanbever, A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00362-x · Cited by 296 · see citing works
Tuberculosis in patients with the acquired immunodeficiency syndrome
Richard, R. (1987) · Medical Entomology and Zoology · Cited by 294 · see citing works
Kanchan, V., & Panda, A. K. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.015 · Cited by 283 · see citing works
Global Tuberculosis Control: WHO Report 2011
Williams, C. (2012) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1753-6405.2012.00928.x · Cited by 268 · see citing works
Design of liposomal aerosols for improved delivery of rifampicin to alveolar macrophages
Vyas, S. P., Kannan, M., Jain, S., Mishra, V. K., & Singh, P. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.08.017 · Cited by 262 · see citing works
Dry powder inhalers for pulmonary drug delivery
Frijlink, H. W., & de Boer, A. H. (2004) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.1.1.67 · Cited by 259 · see citing works
Sharma, A., Sharma, S., & Khuller, G. K. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh411 · Cited by 251 · see citing works
Sung, J. C., Padilla, D. J., Garcia‐Contreras, L., VerBerkmoes, J. L., Durbin, D., Peloquin, C. A., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9894-2 · Cited by 245 · see citing works
Nanotechnology and pulmonary delivery to overcome resistance in infectious diseases
Andrade, F., Rafael, D., Videira, M., Ferreira, D., Sosnik, A., & Sarmento, B. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.07.020 · Cited by 245 · see citing works
O’Hara, P. J., & Hickey, A. J. (2000) · Pharmaceutical Research · doi:10.1023/a:1007527204887 · Cited by 242 · see citing works
Pandey, R., Zahoor, A., Sharma, S., & Khuller, G. K. (2003) · Tuberculosis · doi:10.1016/j.tube.2003.07.001 · Cited by 220 · see citing works
Tuberculosis chemotherapy: current drug delivery approaches
du Toit, L. C., Pillay, V., & Danckwerts, M. P. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-118 · Cited by 213 · see citing works
Sharma, R., Saxena, D., Dwivedi, A. K., & Misra, A. (2001) · Pharmaceutical Research · doi:10.1023/a:1012296604685 · Cited by 201 · see citing works
Epidemiology of selected mycobacteria that infect humans and other animals
Ashford, D. A., Whitney, E. A. S., Raghunathan, P. L., & Cosivi, O. (2001) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.20.1.1266 · Cited by 191 · see citing works
Antitubercular inhaled therapy: opportunities, progress and challenges
Pandey, R., & Khuller, G. K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki027 · Cited by 188 · see citing works
Golden Holocaust: Origins of the Cigarette Catastrophe and the Case for Abolition
Daube, M. (2012) · Australian and New Zealand Journal of Public Health · doi:10.1111/j.1753-6405.2012.00927.x · Cited by 187 · see citing works
Ohashi, K., Kabasawa, T., Ozeki, T., & Okada, H. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.11.027 · Cited by 178 · see citing works
The rationale for recommending fixed-dose combination tablets for treatment of tuberculosis.
Blomberg, B., Spinaci, S., Fourie, B. P., & Laing, R. O. (2001) · Europe PMC (PubMed Central) · Cited by 176 · see citing works
Inhalable microparticles containing large payload of anti-tuberculosis drugs
Muttil, P., Kaur, J. P., Kumar, K., Yadav, A. B., Sharma, R., & Misra, A. (2007) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2007.06.006 · Cited by 173 · see citing works
Delivery of Biotherapeutics by Inhalation Aerosol
Niven, R. W. (1995) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v12.i2-3.20 · Cited by 164 · see citing works
Immunopathogenesis of Pulmonary Tuberculosis
Dannenberg, A. M. (1993) · Hospital Practice · doi:10.1080/21548331.1993.11442738 · Cited by 164 · see citing works
Suarez, S., O’Hara, P. J., Kazantseva, M., Newcomer, C. E., Hopfer, R. L., McMurray, D. N., & Hickey, A. J. (2001) · Pharmaceutical Research · doi:10.1023/a:1013094112861 · Cited by 159 · see citing works
Airways delivery of rifampicin microparticles for the treatment of tuberculosis
Suarez, S. (2001) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/48.3.431 · Cited by 156 · see citing works
Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery
Willis, L., Hayes, D., & Mansour, H. M. (2012) · Lung · doi:10.1007/s00408-011-9360-x · Cited by 148 · see citing works
Inhaled Drug Delivery for Tuberculosis Therapy
Muttil, P., Wang, C., & Hickey, A. J. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9957-4 · Cited by 145 · see citing works
Makino, K., Nakajima, T., Shikamura, M., Ito, F., Ando, S., Kochi, C., Inagawa, H., Soma, G., & Terada, H. (2004) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2004.03.018 · Cited by 145 · see citing works
Inhaled Large Porous Particles of Capreomycin for Treatment of Tuberculosis in a Guinea Pig Model
Garcia‐Contreras, L., Fiegel, J., Telko, M. J., Elbert, K. J., Hawi, A. A., Thomas, M., VerBerkmoes, J. L., Germishuizen, W. A., Fourie, P. B., Hickey, A. J., et al. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01164-06 · Cited by 139 · see citing works
Lienhardt, C., Vernon, A., & Raviglione, M. C. (2010) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328337580c · Cited by 137 · see citing works
Dry powder platform for pulmonary drug delivery
Daniher, D., & Zhu, J. (2008) · Particuology · doi:10.1016/j.partic.2008.04.004 · Cited by 133 · see citing works
Hirota, K., Hasegawa, T., Nakajima, T., Inagawa, H., Kohchi, C., Soma, G., Makino, K., & Terada, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.11.020 · Cited by 129 · see citing works
Deol, P., Khuller, G. K., & Joshi, K. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.6.1211 · Cited by 128 · see citing works
Isoniazid Proliposome Powders for Inhalation—Preparation, Characterization and Cell Culture Studies
Rojanarat, W., Changsan, N., Tawithong, E., Pinsuwan, S., Chan, H., & Srichana, T. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12074414 · Cited by 120 · see citing works
Respirable nanocarriers as a promising strategy for antitubercular drug delivery
Mehanna, M. M., Mohyeldin, S. M., & Elgindy, N. A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.038 · Cited by 119 · see citing works
Grosset, J. H. E., Singer, T. G., & Bishai, W. R. (2012) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.12.0277 · Cited by 118 · see citing works
Polymer Based Drug Delivery Systems for Mycobacterial Infections
Pandey, R., & Khuller, G. K. (2004) · Current Drug Delivery · doi:10.2174/1567201043334669 · Cited by 116 · see citing works
Barrow, E. L. W., Winchester, G. A., Staas, J. K., Quenelle, D. C., & Barrow, W. W. (1998) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.42.10.2682 · Cited by 113 · see citing works
Changsan, N., Chan, H., Separovic, F., & Srichana, T. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21441 · Cited by 108 · see citing works
Saari, M., Vidgren, M. T., Koskinen, M. O., Turjanmaa, V., & Nieminen, M. M. (1999) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00398-6 · Cited by 105 · see citing works
Canonico, A. E., Plitman, J. D., Conary, J. T., Meyrick, B. O., & Brigham, K. L. (1994) · Journal of Applied Physiology · doi:10.1152/jappl.1994.77.1.415 · Cited by 103 · see citing works
A novel dry powder inhalable formulation incorporating three first-line anti-tubercular antibiotics
Chan, J. G. Y., Chan, H., Prestidge, C. A., Denman, J. A., Young, P. M., & Traini, D. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.08.007 · Cited by 100 · see citing works
Recent advances in liposomal dry powder formulations: preparation and evaluation
Misra, A. R., Jinturkar, K., Patel, D. H., Lalani, J., & Chougule, M. B. (2009) · Expert Opinion on Drug Delivery · doi:10.1517/17425240802652309 · Cited by 99 · see citing works
Verma, R. K., Kaur, J. P., Kumar, K., Yadav, A. B., & Misra, A. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00153-08 · Cited by 96 · see citing works
Preparation and in Vivo Evaluation of a Dry Powder for Inhalation of Capreomycin
Fiegel, J., Garcia‐Contreras, L., Thomas, M., VerBerkmoes, J. L., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9381-6 · Cited by 95 · see citing works
Abu‐Dahab, R., Schäfer, U. F., & Lehr, C. (2001) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(01)00147-6 · Cited by 95 · see citing works
Sharma, R., Muttil, P., Yadav, A. B., Rath, S. K., Bajpai, V. K., Mani, U., & Misra, A. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl533 · Cited by 94 · see citing works
Acute Effects of Liposome Aerosol Inhalation on Pulmonary Function in Healthy Human Volunteers
Thomas, D. A., Myers, M. A., Wichert, B. M., Schreier, H., & Gonzalez‐Rothi, R. J. (1991) · CHEST Journal · doi:10.1378/chest.99.5.1268 · Cited by 83 · see citing works
Slow Release Formulations of Inhaled Rifampin
Coowanitwong, I., Arya, V., Kulvanich, P., & Hochhaus, G. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9044-5 · Cited by 79 · see citing works
Inhaled pyrazinamide proliposome for targeting alveolar macrophages
Rojanarat, W., Nakpheng, T., Thawithong, E., Yanyium, N., & Srichana, T. (2012) · Drug Delivery · doi:10.3109/10717544.2012.721144 · Cited by 79 · see citing works
Koh, W., Kwon, O. J., Suh, G. Y., Chung, M. P., Kim, H., Lee, N. Y., Kim, T., & Lee, K. S. (2004) · Journal of Korean Medical Science · doi:10.3346/jkms.2004.19.2.167 · Cited by 79 · see citing works
Incorporation of Antibiotics in Liposomes Designed for Tuberculosis Therapy by Inhalation
Justo, O. R., & Moraes, Â. M. (2003) · Drug Delivery · doi:10.1080/713840401 · Cited by 77 · see citing works
Dry Powder PA-824 Aerosols for Treatment of Tuberculosis in Guinea Pigs
Garcia‐Contreras, L., Sung, J. C., Muttil, P., Padilla, D., Telko, M., VerBerkmoes, J. L., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01471-09 · Cited by 76 · see citing works
Chimote, G., & Banerjee, R. (2010) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.31608 · Cited by 75 · see citing works
Cosgrove, B. D., Cheng, C., Pritchard, J. R., Stolz, D. B., Lauffenburger, D. A., & Griffith, L. G. (2008) · Hepatology · doi:10.1002/hep.22335 · Cited by 75 · see citing works
Wijagkanalan, W., Higuchi, Y., Kawakami, S., Teshima, M., Sasaki, H., & Hashida, M. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.050153 · Cited by 74 · see citing works
Direct lung delivery of para-aminosalicylic acid by aerosol particles
Tsapis, N., Bennett, D., O'Driscoll, K. M., Shea, K., Lipp, M., Fu, K., Clarke, R. W., Deaver, D. R., Yamins, D. L. K., Wright, J. E., et al. (2003) · Tuberculosis · doi:10.1016/j.tube.2003.08.016 · Cited by 72 · see citing works
Self-citationDry Powder Nitroimidazopyran Antibiotic PA-824 Aerosol for Inhalation
Sung, J. C., Garcia‐Contreras, L., VerBerkmoes, J. L., Peloquin, C. A., Elbert, K. J., Hickey, A. J., & Edwards, D. A. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01389-08 · Cited by 72 · see citing works
Understanding Tuberculosis - New Approaches to Fighting Against Drug Resistance
Cardona, P.-J. (2012) · InTech eBooks · doi:10.5772/2477 · Cited by 71 · see citing works
Powder properties and their influence on dry powder inhaler delivery of an antitubercular drug
Sethuraman, V. V., & Hickey, A. J. (2002) · AAPS PharmSciTech · doi:10.1208/pt030428 · Cited by 68 · see citing works
Levofloxacin-Proliposomes: Opportunities for Use in Lung Tuberculosis
Rojanarat, W., Nakpheng, T., Thawithong, E., Yanyium, N., & Srichana, T. (2012) · Pharmaceutics · doi:10.3390/pharmaceutics4030385 · Cited by 67 · see citing works
Did we reach the 2005 targets for tuberculosis control?
Dye, C. (2007) · Bulletin of the World Health Organization · doi:10.2471/blt.06.037580 · Cited by 66 · see citing works
Effects of Gender, AIDS, and Acetylator Status on Intrapulmonary Concentrations of Isoniazid
Conte, J. E., Golden, J. A., McQuitty, M., Kipps, J., Duncan, S., McKenna, E., & Zurlinden, E. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.8.2358-2364.2002 · Cited by 65 · see citing works
Sacks, L. V., Pendle, S., Orlovic, D., Andre, M., Popara, M., Moore, G. A., Thonell, L., & Hurwitz, S. (2001) · Clinical Infectious Diseases · doi:10.1086/317524 · Cited by 64 · see citing works
Yoshida, A., Matumoto, M., Hshizume, H., Oba, Y., Tomishige, T., Inagawa, H., Kohchi, C., Hino, M., Ito, F., Tomoda, K., et al. (2006) · Microbes and Infection · doi:10.1016/j.micinf.2006.06.004 · Cited by 63 · see citing works
Nebulization of liposome encapsulated antitubercular drugs in guinea pigs
Pandey, R., Sharma, S., & Khuller, G. K. (2004) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2004.04.004 · Cited by 63 · see citing works
Prabakaran, D. S., Singh, P., Jaganathan, K. S., & Vyas, S. P. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2003.11.013 · Cited by 62 · see citing works
Patomchaiviwat, V., Paeratakul, O., & Kulvanich, P. (2008) · AAPS PharmSciTech · doi:10.1208/s12249-008-9152-7 · Cited by 62 · see citing works
Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages
Zhou, H., Zhang, Y., Biggs, D. L., Manning, M. C., Randolph, T. W., Christians, U., Hybertson, B. M., & Ng, K. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.009 · Cited by 61 · see citing works
Agrawal, S., Singh, I., Kaur, K. J., Bhade, S. R., Kaul, C. L., & Panchagnula, R. (2004) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2004.02.019 · Cited by 61 · see citing works
Liposomal amikacin dry powder inhaler: Effect of fines on in vitro performance
Shah, S. P., & Misra, A. R. (2004) · AAPS PharmSciTech · doi:10.1208/pt050465 · Cited by 58 · see citing works
Iron enhances the antituberculous activity of pyrazinamide
Somoskövi, Á. (2004) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkh042 · Cited by 58 · see citing works
Sustained release of insulin from insoluble inhaled particles
Rita Vanbever, A., Jebria, A. B., Mintzes, J. D., Langer, R., & Edwards, D. A. (1999) · Drug Development Research · doi:10.1002/(sici)1098-2299(199912)48:4 · Cited by 56 · see citing works
Pulmonary Delivery of Inhalable Nanoparticles: Dry Powder Inhalers
Alhallak, K., Sarfraz, M., Azarmi, S., Roa, W., Finlay, W. H., & Löbenberg, R. (2011) · Therapeutic Delivery · doi:10.4155/tde.11.100 · Cited by 55 · see citing works
Liposomes for Drug Delivery to the Respiratory Tract
Taylor, K. M. G., & Fan, S. J. (1993) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049309038764 · Cited by 52 · see citing works
Pham, D.-D., Fattal, E., Ghermani, N., Guiblin, N., & Tsapis, N. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.04.016 · Cited by 51 · see citing works
Self-citationSchoubben, A., Blasi, P., Marenzoni, M. L., Barberini, L., Giovagnoli, S., Cirotto, C., & Ricci, M. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.11.005 · Cited by 48 · see citing works
Monocyte Recruitment in Tuberculosis and Sarcoidosis
Schmitt, E., Meuret, G. H., & Stix, L. (1977) · British Journal of Haematology · doi:10.1111/j.1365-2141.1977.tb00557.x · Cited by 47 · see citing works
Pharmaceutical aerosols for the treatment and prevention of Tuberculosis
Hanif, S. N. M., & Garcia‐Contreras, L. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00118 · Cited by 45 · see citing works
Tomoda, K., & Makino, K. (2006) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2006.11.030 · Cited by 44 · see citing works
Changsan, N., Nilkaeo, A., Pungrassami, P., & Srichana, T. (2009) · Journal of drug targeting · doi:10.3109/10611860903079462 · Cited by 42 · see citing works
Kumar, G. S. V., Vadakkan, M. V., Annapoorna, Sivakumar, M., & Mundayoor, S. (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s47456 · Cited by 41 · see citing works
Yadav, A. B., Sharma, R., Muttil, P., Singh, A. K., Verma, R. K., Mohan, M., Patel, S. K. S., & Misra, A. (2009) · PubMed · Cited by 36 · see citing works
Biggs, D. L., Lengsfeld, C., Hybertson, B. M., Ng, K., Manning, M. C., & Randolph, T. W. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00325-0 · Cited by 34 · see citing works
Overview of Clinical Tuberculosis
Hopewell, P. C., & Jasmer, R. M. (2004) · doi:10.1128/9781555817657.ch2 · Cited by 31 · see citing works
Old and New TB Drugs: Mechanisms of Action and Resistance
Anastasia, S., & Petros, C. (2012) · InTech eBooks · doi:10.5772/30992 · Cited by 30 · see citing works
Antituberculosis therapy for 2012 and beyond
Lauzardo, M., & Peloquin, C. A. (2012) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2012.657176 · Cited by 24 · see citing works
(2013) · Wiley eBooks · doi:10.1002/9781118397145 · Cited by 23 · see citing works
Kurunov, I. N., Ursov, I. G., Va, K., Petrenko, T. I., Nn, I., Владимирович, С. А., & Pa, F. (1995) · PubMed · Cited by 21 · see citing works
Panchal, R., Patel, H., Patel, V. A., Joshi, P. U., & Parikh, A. R. (2012) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/0975-7406.94160 · Cited by 20 · see citing works
Kundawala, A. J., Patel, V. A., Patel, H. V., & Choudhary, D. (2018) · International Journal of Pharmaceutical Sciences and Drug Research · doi:10.25004/ijpsdr.2011.030405 · Cited by 16 · see citing works
Quinolones for mycobacterial infections
Rubinstein, E., & Keynan, Y. (2013) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2013.03.005 · Cited by 12 · see citing works
Venkataraman, M. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90142-t · Cited by 10 · see citing works
Sawatdee, S., Worakul, N., & Srichana, T. (2006) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 9 · see citing works
Flagged first, then by citations
4 of the 121 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Singh, A. P., Biswas, A., Shukla, A., & Maiti, P. (2019) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-019-0068-3 · Cited by 645 · see citing works
Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems
Baryakova, T. H., Pogostin, B. H., Langer, R., & McHugh, K. J. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00670-0 · Cited by 499 · see citing works
The Multirole of Liposomes in Therapy and Prevention of Infectious Diseases
Nisini, R., Poerio, N., Mariotti, S., Santis, F. D., & Fraziano, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00155 · Cited by 299 · see citing works
A roadmap to pulmonary delivery strategies for the treatment of infectious lung diseases
He, S., Gui, J., Xiong, K., Chen, M., Gao, H., & Fu, Y. S. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01307-x · Cited by 188 · see citing works
Soy Lecithin-Derived Liposomal Delivery Systems: Surface Modification and Current Applications
Le, N. T. T., Cao, V. D., Nguyen, T. N. Q., Le, T. T. H., Tran, T. T., & Thi, T. T. H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194706 · Cited by 180 · see citing works
Versatility of hydrogel-forming microneedles in in vitro transdermal delivery of tuberculosis drugs
Anjani, Q. K., Permana, A. D., Cárcamo-Martínez, Á., Domínguez‐Robles, J., Tekko, I. A., Larrañeta, E., Vora, L. K., Ramadon, D., & Donnelly, R. F. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.12.003 · Cited by 148 · see citing works
Mohd, R. R., Muniandy, M. T., Zakaria, Z., Shah, K. U., Chee, C. F., Dabbagh, A., Rahman, N. A., & Wong, T. W. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.116800 · Cited by 139 · see citing works
The formulation of nanomedicines for treating tuberculosis
Costa, A., Pinheiro, M., Magalhães, J., Ribeiro, R., Seabra, V., Reis, S., & Sarmento, B. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.012 · Cited by 123 · see citing works
Costa-Gouveia, J., Pancani, E., Jouny, S., Machelart, A., Delorme, V., Salzano, G., Iantomasi, R., Piveteau, C., Queval, C. J., Song, O., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-05453-3 · Cited by 102 · see citing works
Pulmonary inhalation for disease treatment: Basic research and clinical translations
Wang, B., Wang, L., Yang, Q., Zhang, Y., Qinglai, T., Yang, X., Xiao, Z., Lei, L., & Li, S. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100966 · Cited by 98 · see citing works
Advanced drug delivery and therapeutic strategies for tuberculosis treatment
Nair, A., Greeny, A., Nandan, A., Sah, R. K., Jose, A., Dyawanapelly, S., Junnuthula, V., Athira, K. V., & Sadanandan, P. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02156-y · Cited by 99 · see citing works
Shah, K. U., Chan, L. W., & Wong, T. W. (2017) · Drug Delivery · doi:10.1080/10717544.2017.1384298 · Cited by 90 · see citing works
Abdelghany, S. M., Parumasivam, T., Pang, A., Roediger, B., Tang, P., Jahn, K. A., Britton, W. J., & Chan, H. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.05.025 · Cited by 89 · see citing works
Nanocarriers in Tuberculosis Treatment: Challenges and Delivery Strategies
Kumar, M., Virmani, T., Kumar, G., Deshmukh, R., Sharma, A., Duarte, S. O. D., Brandão, P., & Fonte, P. (2023) · Pharmaceuticals · doi:10.3390/ph16101360 · Cited by 87 · see citing works
Iron-Based Metal-Organic Frameworks as a Theranostic Carrier for Local Tuberculosis Therapy
Wyszogrodzka, G., Dorożyński, P., Gil, B., Roth, W. J., Strzempek, M., Marszałek, B., Węglarz, W. P., Menaszek, E., Strzempek, W., & Kulinowski, P. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2425-2 · Cited by 82 · see citing works
Engineering of Nebulized Metal–Phenolic Capsules for Controlled Pulmonary Deposition
Ju, Y., Cortez‐Jugo, C., Chen, J., Wang, T., Mitchell, A. J., Tsantikos, E., Bertleff‐Zieschang, N., Lin, Y., Song, J., Cheng, Y., et al. (2020) · Advanced Science · doi:10.1002/advs.201902650 · Cited by 77 · see citing works
Wyszogrodzka, G., Dorożyński, P., Giovagnoli, S., Strzempek, W., Pesta, E., Węglarz, W. P., Gil, B., Menaszek, E., & Kulinowski, P. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11120687 · Cited by 75 · see citing works
Maniar, K., Moideen, A., Mittal, A., Patil, A., Chakrabarti, A., & Banerjee, D. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.12.003 · Cited by 75 · see citing works
Carneiro, S. P., Carvalho, K. V., Aguiar‐Soares, R. D. D. O., Carneiro, C. M., de Andrade, M. H. G., Duarte, R. S., & dos Santos, O. D. H. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.12.003 · Cited by 73 · see citing works
Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis
Grotz, E., Tateosian, N. L., Salgueiro, J., Bernabeu, E., González, L., Manca, M. L., Amiano, N. O., Valenti, D., Manconi, M., García, V., et al. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101170 · Cited by 71 · see citing works
How can nanoparticles contribute to antituberculosis therapy?
Costa-Gouveia, J., Aínsa, J. A., Brodin, P. M., & Lucía, A. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.01.011 · Cited by 68 · see citing works
Costa, A., Carvalho‐Wodarz, C. D. S., Seabra, V., Sarmento, B. F. C. C., & Lehr, C. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.04.037 · Cited by 66 · see citing works
Maretti, E., Costantino, L., Rustichelli, C., Leo, E., Croce, M. A., Buttini, F., Truzzi, E., & Iannuccelli, V. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.045 · Cited by 64 · see citing works
Truzzi, E., Nascimento, T. L., Iannuccelli, V., Costantino, L., Lima, E. M., Leo, E., Siligardi, C., Gualtieri, M. L., & Maretti, E. (2020) · Nanomaterials · doi:10.3390/nano10030568 · Cited by 63 · see citing works
Hussain, A., Shakeel, F., Singh, S. K., Alsarra, I. A., Faruk, A., Alanazi, F. K., & Christoper, G. V. P. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.05.061 · Cited by 63 · see citing works
Praphakar, R. A., Munusamy, M. A., Sadasivuni, K. K., & Rajan, M. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.09.080 · Cited by 62 · see citing works
Harrison, K. R., Kappell, A. D., & McNamara, P. J. (2019) · Environmental Pollution · doi:10.1016/j.envpol.2019.113472 · Cited by 58 · see citing works
Chae, J., Choi, Y., Tanaka, M., & Choi, J. H. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.08.009 · Cited by 56 · see citing works
Extended Release of Highly Water Soluble Isoniazid Attained through Cocrystallization with Curcumin
Xuan, B., Wong, S. N., Zhang, Y., Weng, J., Tong, H. H. Y., Wang, C., Sun, C. C., & Chow, S. F. (2020) · Crystal Growth & Design · doi:10.1021/acs.cgd.9b01619 · Cited by 56 · see citing works
Lessons from black pepper: piperine and derivatives thereof
Chavarria, D., Silva, T., Silva, D., Remião, F., & Borges, F. (2015) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2016.1118057 · Cited by 54 · see citing works
High dose dry powder inhalers to overcome the challenges of tuberculosis treatment
Momin, M. A. M., Tucker, I. G., & Das, S. C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.08.061 · Cited by 53 · see citing works
Role of Novel Drug Delivery Vehicles in Nanobiomedicine
Tyagi, R. K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.77468 · Cited by 50 · see citing works
Maretti, E., Rustichelli, C., Romagnoli, M., Balducci, A. G., Buttini, F., Sacchetti, F., Leo, E., & Iannuccelli, V. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.07.062 · Cited by 49 · see citing works
Kia, P., Ruman, U., Pratiwi, A. R., & Hussein, M. Z. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s364634 · Cited by 51 · see citing works
Inhalable Antitubercular Therapy Mediated by Locust Bean Gum Microparticles
Alves, A. P. N. N., Cavaco, J., Guerreiro, F., Lourenço, J. P., da Costa, A. M. R., & Grenha, A. (2016) · Molecules · doi:10.3390/molecules21060702 · Cited by 48 · see citing works
Shah, S. R., Cristopher, D., Sharma, S., Soniwala, M. M., & Chavda, J. R. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102013 · Cited by 48 · see citing works
Analysis of cohesion forces between monodisperse microparticles with rough surfaces
Baldelli, A., & Vehring, R. (2016) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2016.06.009 · Cited by 47 · see citing works
Momin, M. A. M., Sinha, S., Tucker, I. G., Doyle, C., & Das, S. C. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.06.004 · Cited by 47 · see citing works
Momin, M. A. M., Tucker, I. G., Doyle, C., Denman, J. A., Sinha, S., & Das, S. C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.02.026 · Cited by 47 · see citing works
Nanotechnology in Drug Discovery and Development
Gutiérrez, L., Stepien, G., Gutiérrez, L., Pérez-Hernández, M., Pardo, J., Pardo, J., Grazú, V., & de la Fuente, J. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.12292-9 · Cited by 46 · see citing works
DPI formulations for high dose applications – Challenges and opportunities
Scherließ, R., & Etschmann, C. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.06.038 · Cited by 46 · see citing works
Rojo, L., García‐Fernández, L., Aguilar, M. R., & Vázquez‐Lasa, B. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102752 · Cited by 45 · see citing works
Miranda, M. S., Rodrigues, M. T., Domingues, R. M. A., Costa, R. R., Paz, E., Rodríguez‐Abreu, C., Freitas, P. P., Almeida, B. G., Carvalho, M. A., Gonçalves, C. M., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800124 · Cited by 45 · see citing works
Chronic respiratory diseases: An introduction and need for novel drug delivery approaches
Shukla, S. D., Vanka, K. S., Chavelier, A., Shastri, M. D., Tambuwala, M. M., Bakshi, H. A., Pabreja, K., Mahmood, M. Q., & O’Toole, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820658-4.00001-7 · Cited by 47 · see citing works
Viswanathan, V., Pharande, R. R., Bannalikar, A. S., Gupta, P., Gupta, U. D., & Mukne, A. (2018) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2018.1513025 · Cited by 43 · see citing works
Pulmonary drug delivery: an effective and convenient delivery route to combat COVID-19
Alipour, S., Mahmoudi, L., & Ahmadi, F. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01251-1 · Cited by 42 · see citing works
The Anti-Tuberculosis Agents Under Development and the Challenges Ahead
Kumar, D., Negi, B., & Rawat, D. S. (2015) · Future Medicinal Chemistry · doi:10.4155/fmc.15.128 · Cited by 42 · see citing works
Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
Miranda, M. S., Rodrigues, M. T., Domingues, R. M. A., Torrado, E., Reis, R. L., Pedrosa, J., & Gomes, M. E. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.09.004 · Cited by 42 · see citing works
Guerreiro, F., Pontes, J. F., da Costa, A. M. R., & Grenha, A. (2018) · Powder Technology · doi:10.1016/j.powtec.2018.09.068 · Cited by 42 · see citing works
Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease
Hetzel, M., Ackermann, M., & Lachmann, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073308 · Cited by 37 · see citing works
Pulmonary delivery of pyrazinamide-loaded large porous particles
Pham, D.-D., Grégoire, N., Couet, W. R., Gueutin, C., Fattal, E., & Tsapis, N. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.05.021 · Cited by 39 · see citing works
Self-citationPolymeric nanotherapeutics acting at special regions of body
Feczkó, T. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102597 · Cited by 38 · see citing works
Hamed, A. I., Osman, R., Al‐Jamal, K. T., Holayel, S. M., & Geneidi, A. S. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.03.032 · Cited by 37 · see citing works
Metal–Organic Framework Microsphere Formulation for Pulmonary Administration
Fernández-Paz, C., Rojas, S., Salcedo‐Abraira, P., Simón‐Yarza, T., Remuñán‐López, C., & Horcajada, P. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c07356 · Cited by 37 · see citing works
Liu, S., Chen, D., Li, X., Guan, M., Zhou, Y., Li, L., Jia, W., Zhou, C., Shu, C., Wang, C., et al. (2020) · Nanoscale · doi:10.1039/d0nr04401f · Cited by 37 · see citing works
Nanopolymersomes as potential carriers for rifampicin pulmonary delivery
Moretton, M. A., Cagel, M., Bernabeu, E., González, L., & Chiappetta, D. A. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.10.049 · Cited by 36 · see citing works
Rifampicin Nanoformulation Enhances Treatment of Tuberculosis in Zebrafish
Trousil, J., Syrová, Z., Dal, N. K., Rak, D., Konefał, R., Pavlová, E., Matějková, J., Cmarko, D., Kubíčková, P., Pavliš, O., et al. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00214 · Cited by 36 · see citing works
Mannose-Decorated Solid-Lipid Nanoparticles for Alveolar Macrophage Targeted Delivery of Rifampicin
Bera, H., Zhao, C., Tian, X., Cun, D., & Yang, M. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16030429 · Cited by 35 · see citing works
Targeted delivery of anti-tuberculosis drugs to macrophages: targeting mannose receptors
Filatova, L. Y., Klyachko, N. L., & Kudryashova, E. V. (2018) · Russian Chemical Reviews · doi:10.1070/rcr4740 · Cited by 35 · see citing works
Nano-based drug delivery optimization for tuberculosis treatment: A review
Dahanayake, M. H., & Jayasundera, A. C. A. (2020) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2020.106127 · Cited by 35 · see citing works
Mireles, L. K., Sacher, E., Yahia, L., Laurent, S., & Stanicki, D. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.12.002 · Cited by 35 · see citing works
Current advances in drug delivery of nanoparticles for respiratory disease treatment
de Menezes, B. R. C., Rodrigues, K. F., Schatkoski, V. M., Pereira, R. M., Ribas, R. G., Montanheiro, T. L. D. A., & Thim, G. P. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01783c · Cited by 34 · see citing works
Zhou, S.-F., Niu, N., Yin, J., Yang, Y., Wang, Z., Zhou, Z.-W., He, Z., Chen, X., Zhang, X., Duan, W., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s79369 · Cited by 34 · see citing works
Carvalho, R. D. S. F., Pereira, M. A., Linhares, L. D. A., Nogueira, M. C. D. B. L., Cavalcanti, I. M. F., Santos-Magalhães, N. S., & Montenegro, L. M. L. (2016) · Memórias do Instituto Oswaldo Cruz · doi:10.1590/0074-02760150454 · Cited by 33 · see citing works
A review of formulations and preclinical studies of inhaled rifampicin for its clinical translation
Khadka, P., Dummer, J. F., Hill, P. C., Katare, R., & Das, S. C. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01238-y · Cited by 32 · see citing works
Drug Delivery for tuberculosis: is Inhaled Therapy the Key to success?
Traini, D., & Young, P. M. (2017) · Therapeutic Delivery · doi:10.4155/tde-2017-0050 · Cited by 31 · see citing works
Poh, W., Rahman, N. B. A., Ostrovski, Y., Sznitman, J., Pethe, K., & Loo, S. C. J. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1676841 · Cited by 29 · see citing works
Grenha, A., Alves, A. D., Guerreiro, F., Pinho, J. O., Simões, S., Almeida, A. J., & Gaspar, M. M. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.11.009 · Cited by 29 · see citing works
Verma, N., Arora, V., Awasthi, R., Chan, Y., Jha, N. K., Thapa, K., Jawaid, T., Kamal, M., Gupta, G., Liu, G., et al. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103690 · Cited by 29 · see citing works
Spray-Dried Nanolipid Powders for Pulmonary Drug Delivery: A Comprehensive Mini Review
Elella, M. H. A., Khatib, A. O. A., & Al-Obaidi, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16050680 · Cited by 29 · see citing works
Kalombo, L., Lemmer, Y., Semete‐Makokotlela, B., Ramalapa, B., Nkuna, P., Booysen, L., Naidoo, S., Hayeshi, R. K., Verschoor, J. A., & Swai, H. (2019) · Nanomaterials · doi:10.3390/nano9081167 · Cited by 28 · see citing works
Hatae, A. C., Roque‐Borda, C. A., & Pavan, F. R. (2023) · OpenNano · doi:10.1016/j.onano.2023.100171 · Cited by 28 · see citing works
Future of nanomedicines for treating respiratory diseases
Scherließ, R. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1553955 · Cited by 27 · see citing works
Liposomes-and niosomes-based drug delivery systems for tuberculosis treatment
Bekraki, A. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819811-7.00007-2 · Cited by 28 · see citing works
Changsan, N., & Sinsuebpol, C. (2020) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2020.1852570 · Cited by 27 · see citing works
Garg, T., Goyal, A. K., Rath, G., & Murthy, R. S. R. (2015) · Pharmaceutical Development and Technology · doi:10.3109/10837450.2015.1081613 · Cited by 26 · see citing works
Electrostatically entrapped colistin liposomes for the treatment of Pseudomonas aeruginosa infection
Yang, L., Tang, C., Zhang, E., & Yang, L. (2016) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2016.1228666 · Cited by 25 · see citing works
Shah, S. R., Prajapati, H. R., Sheth, D. B., Gondaliya, E. M., Vyas, A. J., Soniwala, M. M., & Chavda, J. R. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13275 · Cited by 25 · see citing works
Gholap, A. D., Pardeshi, S. R., Giram, P. S., Nangare, S., Sodha, S., Kapare, H. S., More, M. P., Sonar, Y. A., Shukla, R., Naik, J., et al. (2025) · Beni-Suef University Journal of Basic and Applied Sciences · doi:10.1186/s43088-025-00646-6 · Cited by 25 · see citing works
Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis
Man, D. K.-W., Chow, M. Y. T., Casettari, L., Juarrero, M. G., & Lam, J. K. W. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.04.013 · Cited by 25 · see citing works
Wankar, J., Salzano, G., Pancani, E., Benkovics, G., Malanga, M., Manoli, F., Gref, R., Fenyvesi, É., & Manet, I. G. J. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.05.041 · Cited by 24 · see citing works
Drug delivery systems for fluoroquinolones: New prospects in tuberculosis treatment
Le‐Deygen, I. M., Скуредина, А. А., & Kudryashova, E. V. (2017) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162017050077 · Cited by 24 · see citing works
Tongkanarak, K., Loupiac, C., Neiers, F., Chambin, O., & Srichana, T. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.113964 · Cited by 23 · see citing works
In silico identification and synthesis of a multi-drug loaded MOF for treating tuberculosis
Acharya, A. P., Sezginel, K. B., Gideon, H. P., Greene, A. C., Lawson, H., Inamdar, S., Tang, Y., Fraser, A. J., Patel, K. V., Liu, C., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.10.024 · Cited by 22 · see citing works
Tousian, B., & Khosravi, A. (2023) · Results in Chemistry · doi:10.1016/j.rechem.2023.101146 · Cited by 21 · see citing works
Nano-Drug Delivery Systems: Possible End to the Rising Threats of Tuberculosis
Sheikh, B. A., Bhat, B. A., Alshehri, B., Mir, R. A., Mir, W. R., Parry, Z. A., & Mir, M. A. (2021) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2021.3201 · Cited by 20 · see citing works
Polymeric micelle-based drug delivery systems for tuberculosis treatment
Gorain, B., Choudhury, H., Sisinthy, S. P., & Kesharwani, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819811-7.00011-4 · Cited by 20 · see citing works
Indurkhya, A., Patel, M., Sharma, P. A., Abed, S. N., Shnoudeh, A. J., Maheshwari, R., Deb, P. K., & Tekade, R. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814423-7.00006-x · Cited by 19 · see citing works
Lipid nanoparticles with improved biopharmaceutical attributes for tuberculosis treatment
Gordillo-Galeano, A., Ospina-Giraldo, L. F., & Mora‐Huertas, C. E. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120321 · Cited by 19 · see citing works
Corrêa, A. F., Bastos, I. M. D., Neves, D., Kipnis, A., Junqueira‐Kipnis, A. P., & Santana, J. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00504 · Cited by 18 · see citing works
The long and winding road to inhaled TB therapy: not only the bug’s fault
Giovagnoli, S., Schoubben, A., & Ricci, M. (2016) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2016.1272119 · Cited by 17 · see citing works
Jafari, A., Nagheli, A., Foumani, A. A., Tehrani, B. S., & Goswami, R. (2020) · Oman Medical Journal · doi:10.5001/omj.2020.78 · Cited by 17 · see citing works
Patil, S. M., Barji, D. S., Chavan, T., Patel, K., Collazo, A. J., Prithipaul, V., Muth, A., & Kunda, N. K. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02510-1 · Cited by 17 · see citing works
Manufacturing processes for polymeric micro and nanoparticles and their biomedical applications
Braz, A. L., & Ahmed, I. (2017) · AIMS bioengineering · doi:10.3934/bioeng.2017.1.46 · Cited by 17 · see citing works
Ahuja, N. A., Sznajder, K. K., Patil, R., & Shaikh, B. (2021) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2021.100234 · Cited by 16 · see citing works
Parhizkar, E., Sadeghinia, D., Hamishehkar, H., Yaqoubi, S., Nokhodchi, A., & Alipour, S. (2021) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2022.032 · Cited by 16 · see citing works
Momin, M. A. M., Rangnekar, B., & Das, S. C. (2018) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2018.1437748 · Cited by 16 · see citing works
Shah, S. R., Maheshwari, H., Soniwala, M. M., & Chavda, J. R. (2020) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-020-09491-9 · Cited by 16 · see citing works
Modern Strategies of Drug Therapy: Multi-Target Drug Delivery, Bioimaging, Diagnostics
Fedorova, O. V., Ovchinnikova, I. G., Rusinov, G. L., Avdeeva, V. V., Zhdanov, А. P., Zhizhin, K. Y., Kuznetsov, N. T., Zakharova, L. Y., Kuznetsova, D. A., Razuvayeva, Y. S., et al. (2025) · Russian Journal of General Chemistry · doi:10.1134/s1070363225606726 · Cited by 15 · see citing works
Data-Driven Prediction of the Formation of Co-Amorphous Systems
Fink, E., Brunsteiner, M., Mitsche, S., Schröttner, H., Paudel, A., & Zellnitz, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020347 · Cited by 15 · see citing works
- Authors
- Pham, D.-D., Fattal, E., & Tsapis, N.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Pham, Dinh-Duy
- Tsapis, Nicolas
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 478
- Issue
- 2
- Pages
- 517-529
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2076894650
- Cited by
- 185
- References
- 121
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 11 · 2023: 23 · 2022: 15 · 2021: 12 · 2020: 26 · 2019: 25 · 2018: 16 · 2017: 14 · 2016: 18 · 2015: 9
- FWCI
- 2.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- ANR (ANR-10-LABX-33)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- pulmonary drug delivery, tuberculosis, antitubercular agents, dry powder inhaler, liposomes, microparticles, nanoparticles, alveolar macrophages, multidrug-resistant tuberculosis, medication adherence, controlled drug release, targeted drug delivery
- MeSH terms
- Administration, Inhalation, Animals, Antitubercular Agents, Humans, Powders, Tuberculosis, Pulmonary, Drug Delivery Systems
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review