Cited by 185Inhalation and Respiratory Drug DeliveryTuberculosis Research and EpidemiologyAdvanced Drug Delivery Systems

Pulmonary drug delivery systems for tuberculosis treatment

Pham, Dinh-Duy, Fattal, Elias, Tsapis, Nicolas·2015·International Journal of Pharmaceutics

Abstract

Tuberculosis (TB) remains a major global health problem as it is the second leading cause of death from an infectious disease worldwide, after the human immunodeficiency virus (HIV). Conventional treatments fail either because of poor patient compliance to the drug regimen or due to the emergence of multidrug-resistant tuberculosis. The aim of this review is to give an update on the information available on tuberculosis, its pathogenesis and current antitubercular chemotherapies. Direct lung delivery of anti-TB drugs using pulmonary delivery systems is then reviewed since it appears as an interesting strategy to improve first and second line drugs. A particular focus is place on research performed on inhalable dry powder formulations of antitubercular drugs to target alveolar macrophages where the bacteria develop. Numerous studies show that anti-TB drugs can be incorporated into liposomes, microparticles or nanoparticles which can be delivered as dry powders to the deep lungs for instantaneous, targeted and/or controlled release. Treatments of infected animals show a significant reduction of the number of viable bacteria as well as a decrease in tissue damage. These new formulations appear as interesting alternatives to deliver directly drugs to the lungs and favor efficient TB treatment.

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Crossref · 10.1016/j.ijpharm.2014.12.009

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  • Parenteral and pulmonary routes have higher bioavailability than the oral route because they bypass first-pass metabolism.

    “On the other hand, the parenteral and pulmonary routes have higher bioavailability due to bypassing the first-pass metabolism.196”
  • Nanodrug delivery system reduces adverse systemic side effects and frequency of drug administration, leading to better patient compliance.

    “Furthermore, the nanodrug delivery system reduces the adverse systemic side effects and frequency of drug administration, which eventually leads to better patient compliance.196,197”

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Authors
Pham, D.-D., Fattal, E., & Tsapis, N.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
  • Pham, Dinh-Duy
  • Tsapis, Nicolas
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2015-01
Volume
478
Issue
2
Pages
517-529
ISSN
0378-5173 (ISSN-L)
OpenAlex
W2076894650
Cited by
185
References
121
Citations by year
2026: 5 · 2025: 11 · 2024: 11 · 2023: 23 · 2022: 15 · 2021: 12 · 2020: 26 · 2019: 25 · 2018: 16 · 2017: 14 · 2016: 18 · 2015: 9
FWCI
2.34
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Funders
ANR (ANR-10-LABX-33)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
  • Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
pulmonary drug delivery, tuberculosis, antitubercular agents, dry powder inhaler, liposomes, microparticles, nanoparticles, alveolar macrophages, multidrug-resistant tuberculosis, medication adherence, controlled drug release, targeted drug delivery
MeSH terms
Administration, Inhalation, Animals, Antitubercular Agents, Humans, Powders, Tuberculosis, Pulmonary, Drug Delivery Systems

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