The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Physical inactivity in Parkinson’s disease
Open accessAbstract
Patients with Parkinson's disease (PD) are likely to become physically inactive, because of their motor, mental, and emotional symptoms. However, specific studies on physical activity in PD are scarce, and results are conflicting. Here, we quantified daily physical activities in a large cohort of PD patients and another large cohort of matched controls. Moreover, we investigated the influence of disease-related factors on daily physical activities in PD patients. Daily physical activity data of PD patients (n = 699) were collected in the ParkinsonNet trial and of controls (n = 1,959) in the Longitudinal Aging Study Amsterdam (LASA); data were determined using the LAPAQ, a validated physical activity questionnaire. In addition, variables that may affect daily physical activities in PD were recorded, including motor symptoms, depression, disability in daily life, and comorbidity. Patients were physically less active; a reduction of 29% compared to controls (95% CI, 10-44%). Multivariate regression analyses demonstrated that greater disease severity, gait impairment, and greater disability in daily living were associated with less daily physical activity in PD (R (2) = 24%). In this large study, we show that PD patients are about one-third less active compared to controls. While disease severity, gait, and disability in daily living predicted part of the inactivity, a portion of the variance remained unexplained, suggesting that additional determinants may also affect daily physical activities in PD. Because physical inactivity has many adverse consequences, work is needed to develop safe and enjoyable exercise programs for patients with PD.
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Citations
Cites
Parkinsonism: onset, progression, and mortality
Hoehn, M. M., & Yahr, M. D. (1967) · Neurology · doi:10.1212/wnl.17.5.427 · Cited by 12,107
Health benefits of physical activity: the evidence
Warburton, D. E. R. (2006) · Canadian Medical Association Journal · doi:10.1503/cmaj.051351 · Cited by 8,007
Compendium of Physical Activities: Classification of energy costs of human physical activities
AINSWORTH, B. E., HASKELL, W. L., LEON, A. S., JACOBS, D. R., MONTOYE, H. J., SALLIS, J. F., & PAFFENBARGER, R. S. (1993) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199301000-00011 · Cited by 4,102
Diagnostic Criteria for Parkinson Disease
Gelb, D. J., Oliver, E., & Gilman, S. (1999) · Archives of Neurology · doi:10.1001/archneur.56.1.33 · Cited by 2,822
Effects of exercise training on older patients with major depression
Blumenthal, J. A., Babyak, M. A., Moore, K. A., Craighead, W. E., Herman, S., Khatri, P., Waugh, R., Napolitano, M. A., Forman, L. M., Appelbaum, M., et al. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.19.2349 · Cited by 1,277 · cited 1×
“Moreover, in older subjects, physical activity was reported to suppress typical PD symptoms such as depression and cognitive decline [4, 18].”
BackgroundGoodwin, V. A., Richards, S. H., Taylor, R. S., Taylor, A. H., & Campbell, J. L. (2008) · Movement Disorders · doi:10.1002/mds.21922 · Cited by 922 · cited 1×
“A meta-analysis found exercise to be effective at improving physical functioning, health-related quality of life, strength, balance, and gait speed for people with PD [15].”
BackgroundDiurnal effects of motor activity and fatigue in Parkinson's disease.
van Hilten, J. J., Hoogland, G., van der Velde, E. A., Middelkoop, H. A., Kerkhof, G. A., & Roos, R. A. (1993) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.56.8.874 · Cited by 105
Mondolo, F., Jahanshahi, M., Granà, A., Biasutti, E., Cacciatori, E., & Di Benedetto, P. (2006) · Behavioural Neurology · doi:10.1155/2006/136945 · Cited by 88 · cited 2×
“Disease-related factors associated with daily physical activity in PD In the ParkinsonNet trial, a wide range of variables were assessed: disease severity (H&Y stages and motor section of the unified Parkinson's Disease Rating Scale [23]), fear of falling (Falls Efficacy Scale-International [34]), anxiety and depressi…”
Method
Cited by
Remote Physical Activity Monitoring in Neurological Disease: A Systematic Review.
Block, V. A. J., Pitsch, E., Tahir, P., Cree, B. A. C., Allen, D. D., & Gelfand, J. M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154335 · Cited by 198
Uhrbrand, A., Stenager, E., Pedersen, M. S., & Dalgas, U. (2015) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2015.04.004 · Cited by 190
Emerging therapies for gait disability and balance impairment: Promises and pitfalls
Maetzler, W., Nieuwhof, F., Hasmann, S. E., & Bloem, B. R. (2013) · Movement Disorders · doi:10.1002/mds.25682 · Cited by 57
Self-citationNero, H., Benka Wallén, M., Franzén, E., Conradsson, D., Ståhle, A., & Hagströmer, M. (2016) · Journal of Parkinson’s Disease · doi:10.3233/jpd-160826 · Cited by 18
“Previous studies have revealed a significant relationship between disease severity, gait impairment, level of disability, higher age, lower physical fitness and PA in individuals with PD [2, 10, 11].”
InfluentialAhern, L., Timmons, S., Lamb, S. E., & McCullagh, R. (2024) · HRB Open Research · doi:10.12688/hrbopenres.13843.1 · Cited by 2
Metadata
- Authors
- Nimwegen, M., Speelman, A. D., Hofman-van Rossum, E. J. M., Overeem, S., Deeg, D. J. H., Borm, G. F., Horst, M. H. L., Bloem, B. R., & Munneke, M.
- Venue
- Journal of Neurology
- Published
- 2011-05-26
- Volume
- 258
- Issue
- 12
- Pages
- 2214-2221
- ISSN
- 0012-1037 (ISSN-L)
- 0340-5354
- 1432-1459
- OpenAlex
- W2061731279
- Cited by
- 366
- References
- 9
- FWCI
- 7.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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