The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Nucleolus: the fascinating nuclear body
Open accessAbstract
Nucleoli are the prominent contrasted structures of the cell nucleus. In the nucleolus, ribosomal RNAs are synthesized, processed and assembled with ribosomal proteins. RNA polymerase I synthesizes the ribosomal RNAs and this activity is cell cycle regulated. The nucleolus reveals the functional organization of the nucleus in which the compartmentation of the different steps of ribosome biogenesis is observed whereas the nucleolar machineries are in permanent exchange with the nucleoplasm and other nuclear bodies. After mitosis, nucleolar assembly is a time and space regulated process controlled by the cell cycle. In addition, by generating a large volume in the nucleus with apparently no RNA polymerase II activity, the nucleolus creates a domain of retention/sequestration of molecules normally active outside the nucleolus. Viruses interact with the nucleolus and recruit nucleolar proteins to facilitate virus replication. The nucleolus is also a sensor of stress due to the redistribution of the ribosomal proteins in the nucleoplasm by nucleolus disruption. The nucleolus plays several crucial functions in the nucleus: in addition to its function as ribosome factory of the cells it is a multifunctional nuclear domain, and nucleolar activity is linked with several pathologies. Perspectives on the evolution of this research area are proposed.
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Cites
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Cited by
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The nucleolus: structure/function relationship in RNA metabolism
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Self-citationThe role of transcription in shaping the spatial organization of the genome
van Steensel, B., & Furlong, E. E. M. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0114-6 · Cited by 247
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Metadata
- Authors
- Sirri, V., Urcuqui-Inchima, S., Roussel, P., & Hernandez-Verdun, D.
- Venue
- Histochemistry and Cell Biology
- Published
- 2007-11-29
- Volume
- 129
- Issue
- 1
- Pages
- 13-31
- ISSN
- 0948-6143 (ISSN-L)
- 1432-119X
- OpenAlex
- W1982447331
- Cited by
- 385
- References
- 169
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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