The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects
Abstract
The purpose of the present study was to investigate the possible relationship between a change in Thr(389) phosphorylation of p70S6 kinase (p70(S6k)) after a single resistance training session and an increase in skeletal muscle mass following short-term resistance training. Eight male subjects performed an initial resistance training session in leg press, six sets of 6RM with 2 min between sets. Muscle biopsies were obtained from the vastus lateralis before (T1) and 30 min after the initial training session (T2). Six of these subjects completed a 14-week resistance-training programme, three times per week (nine exercises, six sets, 6RM). A third muscle biopsy was obtained at the end of the 14-week training period (T3). One repetition maximum (1RM) squat, bench press and leg press strength as well as fat-free mass (FFM, with dual energy X-ray absorptiometry) were determined at T1 and T3. The results show that the increase in Thr(389) phosphorylation of p70(S6k) after the initial training session was closely correlated with the percentage increase in whole body FFM (r = 0.89, P < 0.01), FFM(leg) (r = 0.81, P < 0.05), 1RM squat (r = 0.84, P < 0.05), and type IIA muscle fibre cross sectional area (r = 0.82, P < 0.05) after 14 weeks of resistance training. These results may suggest that p70(S6k) phosphorylation is involved in the signalling events leading to an increase in protein accretion in human skeletal muscle following resistance training, at least during the initial training period.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“acute increases in mTOR signaling markers following one bout of resistance exercise are associated with muscle hypertrophy following weeks of resistance training (Terzis et al., 2008; Hulmi et al., 2009; Mayhew et al., 2009; Mitchell et al., 2013)”
From Skeletal Muscle Ribosome and Mitochondrial Biogenesis in Response to Different Exercise Training Modalities (2021) · cites this paper as Terzis et al., 2008
In the citing paper
“This finding in rats has since been demonstrated in humans [10], suggesting that activation of mTORC1 is key to increasing muscle mass and strength.”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [10]
Citations
Cites
Muscle Fiber Types: How Many and What Kind?
Brooke, M. H., & Kaiser, K. K. (1970) · Archives of Neurology · doi:10.1001/archneur.1970.00480280083010 · Cited by 2,179
Essentials of Strength Training and Conditioning
Phillips, N. (1997) · Physiotherapy · doi:10.1016/s0031-9406(05)66120-2 · Cited by 1,914
Essentials of Strength Training and Conditioning
Baechle, T. R., & Earle, R. (1994) · Cited by 1,535
Mixed muscle protein synthesis and breakdown after resistance exercise in humans
Phillips, S. M., Tipton, K. D., Aarsland, A., Wolf, S. E., & Wolfe, R. R. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.273.1.e99 · Cited by 1,132
Brooke, M. H., & Kaiser, K. K. (1970) · Journal of Histochemistry & Cytochemistry · doi:10.1177/18.9.670 · Cited by 1,116
Aagaard, P., Andersen, J. L., Dyhre‐Poulsen, P., Leffers, A., Wagner, A., Magnusson, S. P., Halkjær‐Kristensen, J., & Simonsen, E. B. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00613.x · Cited by 733 · cited 1×
“muscle Wbre CSA) in relatively untrained individuals ( Aagaard et al. 2001 ).”
BackgroundBaar, K., & Esser, K. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.1.c120 · Cited by 726
Dreyer, H. C., Fujita, S., Cadenas, J. G., Chinkes, D. L., Volpi, E., & Rasmussen, B. B. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.113175 · Cited by 570 · cited 5×
“The increase in Ser phosphorylation is consistent with results on human subject performing heavy resistance exercise (Dreyer et al. 2006) but in contrast to others in which the exercise was less intense (Creer et al.”
BackgroundResultInfluentialFujita, S., Abe, T., Drummond, M. J., Cadenas, J. G., Dreyer, H. C., Sato, Y., Volpi, E., & Rasmussen, B. B. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00195.2007 · Cited by 501
Atherton, P. J., Babraj, J. A., Smith, K., Singh, J., Rennie, M. J., & Wackerhage, H. (2005) · The FASEB Journal · doi:10.1096/fj.04-2179fje · Cited by 475 · cited 1×
“way in stimulating protein translation and muscle growth in animals ( Atherton et al. 2005; Bolster et al. 2004; Nader 2005; Tidball 2005).”
Background
Cited by
Sorted by citations
Items 201–239 of 239
Kumar, V. (2010) · Nottingham ePrints (University of Nottingham)
Laakso, M. (2015) · Jyväskylä University Digital Archive (University of Jyväskylä)
Hulmi, J. J. (2009) · Jyväskylä University Digital Archive (University of Jyväskylä)
Acute regulation of skeletal muscle protein metabolism by nutrients, exercise and hypoxia
Etheridge, T. (2010) · University of Brighton Repository (University of Brighton)
Correction: Molecular Networks of Human Muscle Adaptation to Exercise and Age
Phillips, B. E., Williams, J. P., Gustafsson, T. P., Bouchard, C., Rankinen, T., Knudsen, S., Smith, K. D., Timmons, J. A., & Atherton, P. J. (2013) · PLoS Genetics · doi:10.1371/annotation/35682594-0e72-496b-8641-f956d22c391e
Apró, W. (2014) · Diva portal (Dalarna University Library)
signalingmuscle protein synthesis and mTORC1 Nutritional and contractile regulation of human
Rasmussen, B. B., Drummond, M. J., Dreyer, H. C., Fry, C. S., Glynn, E. L., Hayasaka, M., Tsunekawa, H., Yoshinaga, M., Murakami, T., Cardin, J. M., et al. (2015)
You, J., Anderson, G. B., Dooley, M. S., & Hornberger, T. A. (2016)
Tangen, D. S. (2015) · NORA - Norwegian Open Research Archives
DOCTEUR DE L'UNIVERSITÉ DE GRENOBLE
Robineau, J. (2013)
Cotter, J. A., & Barr, D. (2012) · CRC Press eBooks · doi:10.1201/b11928-5
Hibbert, J. E. (2016) · The Scholarship East Carolina University's Institutional Repository (East Carolina University)
Seeberg, F. (2015) · BIBSYS Brage (BIBSYS (Norway))
of a protein-carbohydrate drink following resistance exercise in the fasted state
Deldicque, L., Bock, K. D., Maris, M., Ramaekers, M., Nielens, H., Francaux, M., & Hespel, P. (2010)
Dietary factors modulating postprandial protein handling
Gorissen, S. H. M. (2016) · Research Publications (Maastricht University) · doi:10.26481/dis.20160623sg
Protein feeding and exercise recovery
Witard, O. C. (2009) · University of Birmingham Institutional Research Archive (University of Birmingham)
Regulation of Protein Turnover during Hyper-osmotic Stress in Skeletal Muscle
Vandommele, C. (2013) · Brock University Digital Repository (Brock University)
Effects of upper body concurrent training in trained individuals: a review
Hansson, B. (2017) · DiVA (Linnaeus University)
Damas, F. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.39.2017.tde-11102017-092823
Corrêa, M. (2018) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2018.tde-24042018-170314
Qian, C. (2021) · Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal · doi:10.26685/urncst.226
“MPS is activated and regulated through the mammalian target of rapamycin complex 1 (mTORC1), a complex commonly associated with tissue growth and MPS [8-12].”
BackgroundInflammatory signaling in skeletal muscle cell growth
Markworth, J. F. (2012)
Effects of single ingestion of arginine on mTORC1 activation in rat fast- and slow-twitch muscles
Kanzaki, K., Yamasaki, Y., & Wada, M. (2022) · 体力科學 · doi:10.7600/jspfsm.71.213
Phillips, S. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735535309.793571148
Muscle Growth, Repair, and Preservation
Erskine, R. M., & Degens, H. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813922-6.00025-4 · Cited by 1
Effects of Age on Exercise Metabolism
Hinkley, J. M., Coen, P. M., & Goodpaster, B. H. (2022) · Physiology in health and disease · doi:10.1007/978-3-030-94305-9_14
Hypertrophy of paravertebral muscles after epidural electrical stimulation shifted: A case report
Li, S., Rong, H., Hao, Z., Tan, R., Li, H., & Zhu, Τ. (2022) · Frontiers in Surgery · doi:10.3389/fsurg.2022.936259
Strength Gains Across Performance Levels and Sexes: A Meta-Analytical PerspectivePreprint
Held, S., Havers, T., Gavanda, S., Geisler, S., & Isenmann, E. (2025) · Research Square · doi:10.21203/rs.3.rs-6938909/v1
Potential muscular doping effects of anti-depressants
Tutakhail, A. (2019) · theses.fr (ABES) · doi:10.70675/f3cbba2dza035z4ef0zaebbz68fe16432b48
Valero‐Breton, M., Portal-Rodríguez, M., Tacchi, F., Salgado-Valdovinos, J., Miranda‐Pilar, M. C., Cifuentes-Silva, E., Martínez‐Pérez, M. I., Godoy, M., Bonicioli, J., Olguín, H. C., et al. (2026) · Acta Physiologica · doi:10.1111/apha.70274
“It is well documented that resistance exercise activates the mTOR/p70S6K/4E-BP1 pathway for regulating protein synthesis and muscle size [8, 9, 19–21].”
mTOR Pathway Activation Following Resistance Exercise with Vibration in Human Subjects
Leavitt, M. G. (2013) · ScholarsArchive (Brigham Young University)
Marcotte, G. R. (2013) · MacSphere (McMaster University) · doi:10.71548/8042
Resistance Training: Identifying Best Practices?
Vickers, J., Barnard Ross, R., Hervig Amanda, C., & Linda, K. (2010) · Defense Technical Information Center (DTIC) · doi:10.21236/ada539764
Metadata
- Authors
- Terzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Mascher, H., & Blomstrand, E.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Harokopio University of Athens (GR)
- Swedish School of Sport and Health Sciences (SE)
- Corresponding author
- Terzis, Gerasimos
- Venue
- European Journal of Applied Physiology
- Published
- 2007-09-14
- Volume
- 102
- Issue
- 2
- Pages
- 145-152
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W1964076858
- Cited by
- 242
- References
- 35
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 9 · 2021: 5 · 2020: 11 · 2019: 11 · 2018: 19 · 2017: 16 · 2016: 20 · 2015: 16 · 2014: 17 · 2013: 24 · 2012: 18
- FWCI
- 6.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National and Kapodistrian University of Athens
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- resistance training, p70 S6 kinase, skeletal muscle hypertrophy, fat-free mass, muscle strength, protein accretion, mTOR signaling, vastus lateralis
- MeSH terms
- Exercise Test, Physical Exertion, Humans, Male, Muscle Contraction, Phosphorylation, Statistics as Topic, Exercise, Muscle, Skeletal, Ribosomal Protein S6 Kinases, 70-kDa, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
